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De Man

Adrianus Petrus Antonius De Man, Oss NL

Patent application numberDescriptionPublished
20090062262NON STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS - The present invention relates to compounds having general Formula (I) or a pharmaceutically acceptable salt thereof. In this formula R03-05-2009

Bruno K.b. De Man, Clifton Park, NY US

Patent application numberDescriptionPublished
20100061512X-RAY SOURCE AND DETECTOR CONFIGURATION FOR A NON-TRANSLATIONAL X-RAY DIFFRACTION SYSTEM - A system and method for scanning objects using a non-translational x-ray diffraction (XRD) system is disclosed. The system includes a scanning area through which an object to be scanned traverses and a distributed x-ray source having a plurality of focal spot locations. The distributed x-ray source is affixed on the scanning area and is configured to emit x-rays towards the object as a series of parallel x-ray beams. A stationary detector arrangement is affixed on another side of the scanning area generally opposite the distributed x-ray source and is configured to measure a coherent scatter spectra of the x-rays after passing through the object. A data acquisition system (DAS) is connected to the detector arrangement and is configured to measure the coherent scatter spectra, which is utilized to generate XRD data and determine a material composition of at least a portion of the object from the XRD data.03-11-2010

Bruno Kristiaan Bernard De Man, Clifton Park, NY US

Patent application numberDescriptionPublished
20080304726METHODS AND SYSTEMS FOR IMPROVING SPATIAL AND TEMPORAL RESOLUTION OF COMPUTED IMAGES OF MOVING OBJECTS - A method of improving a resolution of an image using image reconstruction is provided. The method includes acquiring scan data of an object and forward projecting a current image estimate of the scan data to generate calculated projection data. The method also includes applying a data-fit term and a regularization term to the scan data and the calculated projection data and modifying at least one of the data fit term and the regularization term to accommodate spatio-temporal information to form a reconstructed image from the scan data and the calculated projection data.12-11-2008
20090161816METHOD AND SYSTEM FOR X-RAY IMAGING - A technique is provided for imaging a field of view using an X-ray source comprising two or more emission points. The two or more emission points may be independently operated. Independent operation of the two or more emission points in performed in accordance with a list of commands that specifies the operation of the emission points. The list of commands, in one embodiment, is stored in a sequence buffer. In other embodiments, the list of commands is generated for a given usage, without being stored in a sequence buffer.06-25-2009
20100054561SYSTEM AND METHOD FOR IMAGE RECONSTRUCTION - A tomographic imaging apparatus is provided for generating images. The tomographic apparatus includes a computer programmed to access a data sinogram representative of the image, reconstruct the image, divide the image into a plurality of sub-regions, define a region of interest including at least one sub-region, reprojecting a region of interest or a complement of the region of interest to generate a region of interest sinogram or a sinogram representative of the complement of the region of interest and reconstructing a resultant sinogram using iterative methods to generate an image.03-04-2010
20110097007Iterative Reconstruction - An improved iterative reconstruction method to reconstruct a first image includes generating an imaging beam, receiving said imaging beam on a detector array, generating projection data based on said imaging beams received by said detector array, providing said projection data to an image reconstructor, enlarging one of a plurality of voxels and a plurality of detectors of the provided projection data, reconstructing portions of the first image with the plurality of enlarged voxels or detectors, and iteratively reconstructing the portions of the first image to create a reconstructed image.04-28-2011
20110142314SYSTEM AND METHOD OF INCREASING TEMPORAL RESOLUTION OF AN X-RAY IMAGE - A system, method, and apparatus includes a computed tomography (CT) system having a rotatable gantry, an x-ray source, a generator, a detector having pixels and positioned to receive x-rays, and a computer. The computer is programmed to acquire CT data representative of an object, determine a first subset of the CT data, determine a second subset of the CT data, and determine a difference between the first and second subsets of the CT data to identify a motion region in the object. The computer is also programmed to update image data reconstructed from a first portion of the first subset of the CT data and corresponding to the region and reconstruct an image based on the updated image data and non-updated image data. The non-updated image data is reconstructed from a second portion the first subset of the CT data.06-16-2011
20110150308SYSTEM AND METHOD OF ITERATIVE IMAGE RECONSTRUCTION FOR COMPUTED TOMOGRAPHY - A system and method include acquisition of a set of image data corresponding to a time period of data acquisition, the set of image data corresponding to a plurality of voxels, wherein each of the plurality of voxels corresponds to a distinct acquisition time within the time period of data acquisition. The system and method further include the modeling of the plurality of voxels as a function of time based on a plurality of kinetic parameters associated therewith and reconstruction of an image from the set of image data based on the modeled plurality of voxels.06-23-2011
20110211667DE-POPULATED DETECTOR FOR COMPUTED TOMOGRAPHY AND METHOD OF MAKING SAME - A system, method, and apparatus includes a computed tomography (CT) detector array having a central region with a plurality of central region detecting cells configured to acquire CT data of a first number of slices during a scan, a first wing along a first side of the central region, and a second wing along a second side of the central region opposite the first side. The first wing includes a plurality of first wing detecting cells configured to acquire CT data of a second number of slices during the scan. The second wing includes a plurality of second wing detecting cells configured to acquire CT data of a third number of slices during the scan. The second and third number of slices are less than the first number of slices. The first wing detecting cells are of a different type than the central region detecting cells.09-01-2011
20110243413METHOD AND SYSTEM FOR IMAGE DATA ACQUISITION - A technique for acquiring desired image data in an imaging system comprising at least one radiation source and a detector is described. Initially, preliminary image data corresponding to an object may be acquired. Further, at least one parameter associated with the radiation source and corresponding to a particular view angle of the radiation source may be determined based on the preliminary image data and a priori information. Similarly, at least one parameter associated with the detector and corresponding to the particular view angle may be determined based on a priori information and the preliminary image data. Efficient operating modes of the radiation source and the detector corresponding to the particular view angle may be selected based on the determined parameters to achieve a desired system performance. Subsequently, the final image data may be acquired using the selected operating modes of the radiation source and the detector.10-06-2011
20120014502ASYMMETRIC DE-POPULATED DETECTOR FOR COMPUTED TOMOGRAPHY AND METHOD OF MAKING SAME - A computed tomography (CT) detector array includes a central region substantially symmetric about a central axis thereof and includes a first plurality of x-ray detector cells configured to acquire CT data from a first number of detector rows during a scan, wherein the central axis is in a channel direction of the CT detector array and transverse to a slice direction of the CT detector array. A first wing is coupled to a first side of the central region, and a second wing is coupled to a second side of the central region opposite the first side. The first and second wings include respective second and third pluralities of x-ray detector cells and are each configured to acquire CT data from a number of detector rows that is less than the first number of detector rows. The CT detector array is asymmetric about the central axis of the central region.01-19-2012
20120039440SYSTEM AND METHOD OF OPTIMIZING A REPRESENTATION OF DUAL ENERGY SPECTRAL CT IMAGES - An imaging system includes an x-ray source, a detector, a data acquisition system (DAS) operably connected to the detector, and a computer operably connected to the DAS. The computer is programmed to obtain CT scan data with two or more incident energy spectra, decompose the obtained CT scan data into projection CT data of a first basis material and a second basis material, generate a first basis material image and a second basis material image using the decomposed projection CT data, generate a first monochromatic image from the first basis material image and the second basis material image at a first energy that is selected based on an amount of correlated noise at the first energy, noise-reduce the first monochromatic image to generate a noise-reduced first monochromatic image, and generate a final monochromatic image based at least on the noise-reduced first monochromatic image.02-16-2012
20120069953SYSTEM AND METHOD OF NOTCH FILTRATION FOR DUAL ENERGY CT - An imaging system includes an x-ray source that emits a beam of x-rays toward an object to be imaged, a detector that receives the x-rays attenuated by the object, a spectral notch filter positioned between the x-ray source and the object, a data acquisition system (DAS) operably connected to the detector, and a computer operably connected to the DAS and programmed to acquire a first image dataset at a first kVp, acquire a second image dataset at a second kVp that is greater than the first kVp, and generate an image of the object using the first image dataset and the second image dataset.03-22-2012
20120106816SYSTEM AND METHOD FOR MATERIAL DECOMPOSITION OPTIMIZATION IN IMAGE DOMAIN - A system and method for material decomposition optimization in the image domain include a non-transitory computer readable medium has stored thereon a sequence of instructions which, when executed by a computer, causes the computer to access a reconstructed basis material image. For a first voxel of the reconstructed basis material image, the instructions also cause the computer to optimize a concentration of a pair of materials (a,b) in the first voxel exclusively in the image domain and based on a first probability based on random perturbations and a second probability based on random perturbations. The optimization is further based on a third probability based on known materials and a fourth probability based on concentrations of the pair of materials in a pair of voxels neighboring the first voxel.05-03-2012

Patent applications by Bruno Kristiaan Bernard De Man, Clifton Park, NY US

Bruno Kristiaan Bernard De Man, Niskayuna, NY US

Patent application numberDescriptionPublished
20120076258MULTIPLE MATERIALS FOR THE ENHANCEMENT OF SPECTRAL NOTCH FILTRATION IN SPECTRAL IMAGING - An imaging system includes an x-ray source that emits a beam of x-rays toward an object to be imaged, a detector that receives the x-rays attenuated by the object, a spectral notch filter positioned between the x-ray source and the object, a data acquisition system (DAS) operably connected to the detector, and a computer operably connected to the DAS and programmed to acquire a first image dataset at a first kVp, acquire a second image dataset at a second kVp that is greater than the first kVp, and generate an image of the object using the first image dataset and the second image dataset.03-29-2012

Bruno Kristiann Bernard De Man, Clifton Park, NY US

Patent application numberDescriptionPublished
20120128120SYSTEM AND METHOD FOR BREAST IMAGING USING X-RAY COMPUTED TOMOGRAPHY - A system and method for breast imaging using x-ray computed tomography (CT) are provided. One system includes a rotating gantry, an x-ray source coupled to the gantry for generating an x-ray beam and an x-ray detector coupled to the gantry for detecting x-rays of the x-ray beam. The system further includes an adjustable collimator coupled to the x-ray source and configured to adjust a focus of the x-ray beam generated by the x-ray source. The x system also includes a controller configured to control the collimator to adjust the focus on a region of interest (ROI) and to control a beam intensity for the x-ray beam generated by the x-ray source during a scan.05-24-2012

Eelco De Man, Vlijmen NL

Patent application numberDescriptionPublished
20100006601METERING DEVICE FOR DISPENSING A DOSE OF PRESSURIZED FLUID - A novel metering device (01-14-2010

Eelco H. De Man, Vlijmen NL

Patent application numberDescriptionPublished
20090218372CARTRIDGE PISTOL WITH A CARTRIDGE HOLDER - A cartridge gun is provided. The cartridge gun comprises a cartridge holder, a plurality of resilient gripping elements, a displaceable piston rod for moving a piston in a cartridge, and an actuating device for displacing the piston rod. The cartridge holder comprises a cylindrical base for receiving the floor region of the cartridge in which the gripping elements project radially outwardly from the center of the cartridge holder in the direction towards the housing into an annular groove of the base up to the outside wall of the annular groove in the base and are held in the center of the base by means of a hub. Means are further arranged at the front end of the piston rod which are designated to press the ends of the resilient gripping elements in the direction towards the housing when the piston rod is fully retracted, allowing the removal of the cartridge from the cartridge gun.09-03-2009

Robert A. De Man, Rotterdam NL

Patent application numberDescriptionPublished
20100203506VIRAL VARIANTS AND METHODS FOR DETECTING SAME - The present invention relates generally to viral variants exhibiting reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B variants exhibiting complete or partial resistance to nucleoside analogs and/or reduced interactivity with antibodies to viral surface components. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic agents.08-12-2010

Rolf Erwin De Man, Eindhoven NL

Patent application numberDescriptionPublished
20090072703LOW-PRESSURE DISCHARGE LAMP - The invention relates to an improved low-pressure gas discharge lamp comprising a gas discharge vessel (03-19-2009

Patent applications by Rolf Erwin De Man, Eindhoven NL

Teunis De Man, Vlaardingen NL

Patent application numberDescriptionPublished
20110244111EDIBLE FAT POWDERS - The invention relates to edible fat powders having a full width at half maximum of the first order long spacing X-ray diffraction peak of 0.17 to 0.80 degrees and a free flowing density of 10 to 350 g/l; with the proviso that when the free flowing density is equal to or greater than C, the full width at half maximum is equal to or greater than ((A*free flowing density)+B), wherein A is 0.0005625, B is 0.213 degrees and C is 90 g/l. The invention further relates to a method of preparing a fat continuous spread comprising the use of such edible fat powder.10-06-2011