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De Lange, NL
Ben De Lange, Munstergeleen NL
| Patent application number | Description | Published |
|---|---|---|
| 20090012300 | Process for the Preparation of an (Hetero) Arylamine - The present invention relates to a process for the preparation of an (hetero)arylamine, wherein an optionally substituted (hetero)aromatic bromide compound is contacted with a nucleophilic organic nitrogen-containing compound in the presence of a base, and a catalyst comprising a copper atom or ion and at least one ligand, said ligand comprising at least one coordinating oxygen atom, and if said oxygen atom is part of an OH group, then said OH group is attached to an aliphatic spa carbon atom or to a vinylic carbon atom. | 01-08-2009 |
| 20090043112 | Process for the Preparation of Enantiomerically Enriched Indoline-2-Carboxylic Acid - The present invention relates to a process for the preparation of an enantiomerically enriched optionally substituted indoline-2-carboxylic acid or a salt thereof, wherein an enantiomerically enriched chiral ortho-X-substituted phenylalanine compound, wherein X is a leaving group, is subjected to cyclisation, preferably at a temperature of below about 140° C., upon formation of the enantiomerically enriched indoline-2-carboxylic acid compound. | 02-12-2009 |
| 20100143981 | WHOLE-CELL CATALYTIC SYSTEM COMPRISING A HYDANTOINASE, A RACEMASE AND A CARBAMOYLASE - The present invention relates to a whole cell catalytic system for the preparation of an enantiomerically enriched α-amino acid from a corresponding hydantoin wherein hydantoinase, L-carbamoylase and hydantoin racemase are coexpressed in a recombinant micro-organism wherein the genes coding for these three enzymes are located on a single replicon. The present invention further relates to the use of such a whole cell catalytic system according in the preparation of an enantiomerically enriched L-α-amino acid from a corresponding hydantoin. | 06-10-2010 |
| 20100174092 | NOVEL 5 SUBSTITUTED HYDANTOINS - The present invention relates to 5-substituted hydantoins, a process for the preparation of 5-substituted hydantoins and the use of 5-substituted hydantoins in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel 5-substituted hydantoins. | 07-08-2010 |
| 20100221796 | NOVEL CARBAMOYLGLYCINE DERIVATIVES - The present invention relates to carbamoylglycine derivatives, a process for the preparation of carbamoylglycine derivatives and the use of carbamoylglycine derivatives in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel carbamoylglycine derivatives. | 09-02-2010 |
| 20100324304 | IMPROVED RAMIPRIL SYNTHESIS - The present invention relates to the preparation of ramipril (formula [1]) from unprotected (2S,3S,6S)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid and to a method for preparing unprotected (2S,3S,6S)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid. | 12-23-2010 |
| 20110008852 | CONVERGENT SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES USEFUL THEREIN - Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R | 01-13-2011 |
| 20110263871 | METHOD FOR THE SYNTHESIS OF A RAMIPRIL INTERMEDIATE - The present invention relates to a process for the preparation of octahydrocyclopenta[b]pyrrole-2-carboxylic acid and esters thereof of general formula (1) in the presence of a cobalt and/or nickel comprising catalyst and to the use of compounds of general formula (1) in the synthesis of ramipril. | 10-27-2011 |
Dirk-Jan Jeroen De Lange, Den Haag NL
| Patent application number | Description | Published |
|---|---|---|
| 20100053333 | METHOD FOR DETECTING A MOVING OBJECT IN A SEQUENCE OF IMAGES CAPTURED BY A MOVING CAMERA, COMPUTER SYSTEM AND COMPUTER PROGRAM PRODUCT - The invention relates to a method for detecting a moving object in a sequence of images captured by a moving camera. The method comprises the step of constructing a multiple number of difference images by subtracting image values in corresponding pixels of multiple pairs of images being based on captured images. Further, the method comprises the step of retrieving a moving object by extracting spatial information of pixels in the multiple number of constructed difference images having relatively large image values. In addition, from a pair of images in the construction step an image is a representation of a high resolution image having a higher spatial resolution than original captured images on which the high resolution image is based. | 03-04-2010 |
Gerben Frank De Lange, Best NL
| Patent application number | Description | Published |
|---|---|---|
| 20110216301 | LITHOGRAPHIC APPARATUS AND SCANNING METHOD - A lithographic apparatus includes a first support to support a first patterning device; a second support to support a second patterning device, each of the first and the second patterning device capable of imparting a radiation beam with a pattern in its cross-section to form a patterned radiation beam; a substrate table constructed to hold a substrate; a projection system to project the patterned radiation beam onto a target portion of the substrate; a controller to drive the first support and the second support and arranged to: drive the first support to perform a scanning movement; drive the second support to accelerate during at least part of the scanning movement of the first support; and drive the second support to perform a scanning movement upon completion of the scanning movement of the first support, so as to scan a die adjacent a die previously scanned during the scanning movement of the first support. | 09-08-2011 |
Linda De Lange, Delfgauw NL
| Patent application number | Description | Published |
|---|---|---|
| 20090004693 | Production of Polypeptides by Improved Secretion - The present invention relates to polypeptides that have an activity corresponding to at least one activity of the SEC61 polypeptide, polynucleotides encoding these polypeptides and the use thereof in the preparation of host cells suitable for production of a polypeptide of interest. Such host cells may have an increased capacity to secrete a polypeptide of interest. | 01-01-2009 |
Michel De Lange, Bk Enkhuizen NL
| Patent application number | Description | Published |
|---|---|---|
| 20120117683 | PLANT RESISTANT TO A PATHOGEN - The present invention relates to novel | 05-10-2012 |
Robertus Petrus Johannes De Lange, Hilversum NL
| Patent application number | Description | Published |
|---|---|---|
| 20100093680 | USE OF 3-ALPHA-ANDROSTANEDIOL, OPTIONALLY IN COMBINATION WITH A 5-HT1A AGONIST, IN THE TREATMENT OF SEXUAL DYSFUNCTION - The invention relates to the field of male and/or female sexual dysfunction. The invention specifically relates to the use of 3-alpha-androstanediol, preferably in combination with a 5-HT1A agonist. Optionally, said 3-alpha-androstanediol and said 5HT1 | 04-15-2010 |
| 20100152145 | USE OF 3-ALPHA-ANDROSTANEDIOL, OPTIONALLY IN COMBINATION WITH A PDE5 INHIBITOR, IN THE TREATMENT OF SEXUAL DYSFUNCTION - The invention relates to the field of male and/or female sexual dysfunction. The invention specifically relates to the use of 3-alpha-androstanediol, preferably in combination with a type 5 phosphodiesterase (PDE5) inhibitor. | 06-17-2010 |
| 20100160270 | USE OF TESTOSTERONE AND A 5-HT1A AGONIST IN THE TREATMENT OF SEXUAL DYSFUNCTION - The invention relates to the field of male and/or female sexual dysfunction. The invention specifically relates to the use of testosterone and a 5-HT1A agonist. | 06-24-2010 |