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De Kock

Andrew De Kock, Andover, MN US

Patent application numberDescriptionPublished
20100125320OVERMOLDED COMPONENTS FOR IMPLANTABLE MEDICAL LEADS AND RELATED METHODS - The various embodiments disclosed herein relate to medical electrical leads. More specifically, certain embodiments relate to leads having one or more drug-eluting components that are overmolded or otherwise positioned on the lead. Other embodiments relate to leads having one or more patterned surfaces, including some leads with one or more patterned surfaces over which one or more drug-eluting components are positioned. Further implementations relate to leads having one or more overmolded patterned surfaces, including some embodiments in which the overmolded surfaces contain at least one drug-eluting component.05-20-2010
20110156306IMPLANTABLE LEADS WITH A UNITARY SILICONE COMPONENT - A method of manufacturing a medical electrical lead includes molding a lead body pre-form, stringing an electrode onto the pre-form and overmolding the pre-form with a polymer to form a lead body portion. The pre-form has a proximal end, a distal end and at least one lumen extending between the proximal and distal ends. At least one asymmetric region of the pre-form has a transverse cross-section that has a non-circular outer dimension. The overmolding causes the asymmetric region to become substantially circular.06-30-2011
20110160819IMPLANTABLE LEADS WITH OPTIMIZED LEAD BODY CROSS-SECTION CONFIGURATION - The embodiments herein relate to medical lead body configurations that reduce conductor flexural fatigue. The various lead body embodiments include a support section and can also include other features such as a semi-straight portion of a lumen or semi-straight sides that optimize the reduction in conductor flexural fatigue.06-30-2011
20110160823IMPLANTABLE LEADS WITH A LOW COEFFICIENT OF FRICTION MATERIAL - A method of reducing a coefficient of friction between a medical electrical lead and a delivery system includes machining a mold for a lead, roughening at least a portion of the mold to an average surface roughness of at least about 7 micro-inches and injecting a polymer into the roughened mold to form a roughened portion of a lead body.06-30-2011
20110160825IMPLANTABLE LEADS WITH A CONDUCTOR COIL HAVING TWO OR MORE SECTIONS - Various coiled conductors having two or more sections and methods and devices for constructing such conductors are disclosed. The various embodiments of coiled conductors and related methods include two or more sections that can have different mechanical, structural, and/or electrical characteristics.06-30-2011
20110160828MRI CONDITIONALLY SAFE LEAD WITH LOW-PROFILE MULTI-LAYER CONDUCTOR FOR LONGITUDINAL EXPANSION - An implantable electrical lead having a flexible body and including a multi-layer coil conductor extending within the longitudinal body lumen from the connector assembly to at least the electrode, the multi-layer coil conductor including a first coil layer a second coil layer disposed about the first coil layer, wherein at least one parameter of the first and the second coil layer is configured such that the lead exhibits a predetermined axial stiffness or bending stiffness.06-30-2011
20110160830IMPLANTABLE LEADS WITH AN AXIAL REINFORCEMENT MEMBER - Implantable electrical leads including an axial reinforcement member are disclosed. In some embodiments, an implantable electrical lead can have a body, one or more electrodes, a cable conductor, a conductor coil, and a reinforcement member. A cable conductor can be disposed within the body and is configured to convey electrical signals between the proximal region and the distal region of the lead. The reinforcement member may be coupled to or integrally formed within the lead body and is configured to limit elongation of the lead body in response to a tensile force.06-30-2011
20110160831TAPERED DRUG-ELUTING COLLAR FOR A MEDICAL ELECTRICAL LEAD - A medical electrical lead includes a tapered distal tip having a tapered drug-eluting component incorporated therein. The drug-eluting component can be an overmolded drug-eluting collar or a pre-molded drug eluting collar. The drug-eluting collar is disposed in a recess formed in the tapered distal tip and maintains the overall tapered profile of the distal tip.06-30-2011

Herman De Kock, Arendonk BE

Patent application numberDescriptionPublished
20090118339LYSINE RELATED DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS - The present invention concerns lysine related derivatives, their use as protease inhibitors, in particular as HIV aspartyl protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. The present invention also concerns combinations of the present lysine related derivatives with another anti retroviral agent. It further relates to their use in assays as reference compounds or as reagents.05-07-2009
200902095832-(SUBSTITUTED-AMINO)-BENZOTHIAZOLE SULFONAMIDE HIV PROTEASE INHIBITORS - The present invention relates to 2-(substituted-amino)-benzothiazole sulfonamide compounds and derivatives, their use as protease inhibitors, in particular as broad-spectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. The present invention also concerns combinations of the present 2-(substituted-amino)-benzothiazole sulfonamide compounds and derivatives with another anti-retroviral agent. It further relates to their use in assays as reference compounds or as reagents.08-20-2009

Joel A. De Kock, New Richmond, WI US

Patent application numberDescriptionPublished
20110062128Multiple laser beam focusing head - An apparatus that divides a single laser beam into two or more beams that can be directed at an object, such as a work piece, to perform laser heat treatment is disclosed. An adapter stage is in optical communication with a light source, such as a laser source, and arranged to receive a light beam from the light source. A focus stage in optical communication with the adapter stage is arranged to receive the light beam from the adapter stage and to focus the light beam. A beam splitting stage in optical communication with the focus stage is arranged to receive the focused light beam and to split the focused light beam into a multiple light beams. A redirection stage in optical communication with the beam splitting stage is arranged to receive the multiple light beams and to direct them toward a plurality of target locations on the object.03-17-2011

Joery De Kock, Willebroek BE

Patent application numberDescriptionPublished
20100278782DIFFERENTIATION OF RAT LIVER EPITHELIAL CELLS INTO HEPATOCYTE-LIKE CELLS - Methods for differentiation of cells of a rat liver epithelial (RLEC) cell line to hepatocyte-like cells are disclosed. In particular, methods involve sequential exposure of the RLEC to two or more differentiation agents. Cells obtained by the method are described as well as their uses in various pharmacological, toxicological, therapeutic, diagnostic and research applications.11-04-2010

Maarten Johannes David De Kock, Voorhout NL

Patent application numberDescriptionPublished
20100041038METHOD FOR DISCRIMINATING SINGLE NUCLEOTIDE POLYMORPHISMS - A method for discriminating single nucleotide polymorphisms (SNPs) offers improved sensitivity and specificity. A test kit is also provided. The method may be for genotyping in typing assays applied to a biological sample. The method may include steps of performing a real-time amplification of the target, generating multiple copies of amplicons, in presence of at least two different labeled probes, each probe allowing real-time detection at the SNP position of both the wildtype and at least one possible mutation, assessing the discriminatory variable value(s) based on the signals of each combination of two detection probes, and discriminating between the genotypes. The methods may be for diagnostic, preventive and therapeutic applications.02-18-2010

Paul De Kock, Numansdorp NL

Patent application numberDescriptionPublished
20100000832LOW-NOISE SHOCK ABSORBER - Shock absorber provided with a piston having a number of constantly open connecting channels which connect the two sides of the piston, and having a number of connecting channels to be opened and closed by element of a valve. The valve includes a plate valve which under the influence of flow therethrough, i.e. the pressure difference over the piston, on the outward movement of the shock absorber can be closed to a greater or lesser extent. On the inward movement, unimpeded flow of fluid through the piston can occur. A flow-through path is bounded by the corresponding connecting channels and the valve together with the upper side of the piston. In the rest position there is a flow-through possibility for fluid when the shock absorber fixings move away from each other, and when the shock absorber fixings move away from each other more quickly the flow-through cross section gradually decreases until the valve closes completely.01-07-2010
20100193310YAW DAMPER WITH PUMP - Yaw damper for damping yaw motions between two vehicle parts. This includes in the customary manner a piston part and a cylinder part, wherein that piston part is provided with a piston which divides that cylinder part into two chambers. Between these two chambers, connecting lines are present. The embodiment of these connecting lines determines the damping characteristic which governs the motion between the piston and the cylinder part. Especially for vehicle parts which move at higher speeds and/or high frequencies, such as train sets, it is desirable to provide a damper which is as stiff as possible. For this purpose, the present invention proposes the installation of pumping elements which, as far as possible, increase the pressure in the chambers which are formed by the piston in the cylinder part. Preferably, this construction is realized such that this pressure automatically decreases at lower speeds and/or low frequencies.08-05-2010

Patent applications by Paul De Kock, Numansdorp NL

Philip De Kock, Kapellen BE

Patent application numberDescriptionPublished
20080281130PROCESS FOR PRODUCING BISPHENOL A WITH AN EXTENDED SERVICE LIFE IN THE CRYSTALLISATION - The invention describes a process for producing bisphenol with a content of less than 15 wt. % of phenol, wherein a suspension crystallisation of a product mixture containing bisphenol A, minor components and phenol is performed in a crystalliser, the product mixture being pumped through a heat exchanger. Due to deposition (fouling, i.e. crystallisation and deposition on the surface of the heat exchangers) in the heat exchanger, the pressure difference increases from 0.5 to 3 bar across the heat exchanger. The resulting reduced flow rate, which would lead to increased fouling in the crystalliser, is offset by continuously increasing the speed of the pump, the pump speed being regulated in such a way that the current consumption of the pump is maintained such that it fluctuates by a maximum of 5%.11-13-2008