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Davies, MA
Audrey Davies, Waltham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080293744 | Enantiomers of Selected Fused Pyrimidones and Uses in the Treatment and Prevention of Cancer - This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer. | 11-27-2008 |
| 20090099210 | ENANTIOMERS OF SELECTED FUSED HETEROCYCLICS AND USES THEREOF - This invention relates to novel compounds having the structural formula (I) | 04-16-2009 |
| 20100204246 | 5-AMINOPYRAZOL-3-YL-3H-IMIDAZO (4,5-B) PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER - The present invention relates to compounds of Formula (I) and to their pharmaceutical compositions, and to their methods of use. These novel compounds provide a treatment for myeloproliferative disorders and cancer. | 08-12-2010 |
| 20100324040 | 9-(PYRAZOL-3-YL)-9H-PURINE-2-AMINE AND 3-(PYRAZOL-3-YL) -3H-IMIDAZO[4,5-B] PYRIDIN-5- AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER - The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer. | 12-23-2010 |
Brian F. Davies, Acton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110244710 | TOOL-RELEASABLE SOLAR POWER CONNECTOR - An electrical connector housing system includes a plug housing, a receptacle housing, and a latching mechanism. The latching mechanism pivots on pivot posts on one housing and hooks to latching posts on the other housing, thereby securing the mated housings together. Catches on the latch mechanism engage with tabs near the latching posts when the latching mechanism is latched. The catches must be released using a screwdriver or similar tool before opening the latching mechanism and separating the mated housings. A protective barrier can be included to block direct access to the engaged catches and tabs. The housings include overlapping shells which exclude water and dirt, and the latching mechanism at least partially covers and further protects the shells when closed. In embodiments, a retaining mechanism automatically holds the latch open against gravity, facilitating connection and release of the housings with one hand and/or while wearing gloves. | 10-06-2011 |
Bryan W. Davies, Allston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100222410 | Nuclease compositions and methods - The present invention generally relates to various nucleases and uses thereof, and in some cases, to the UPF0054 protein superfamily. Members of the UPF0054 protein superfamily, such as the | 09-02-2010 |
John T. Davies, Blackstone, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090140463 | GOLF BALL MIXING AND DISPENSING PROCESS - The present invention provides an improved process for mixing castable polyurethanes and polyureas and for prolonging the dispensing time for dispensing them into a golf ball mold for application to a golf ball sub-assembly. A nozzle framework includes support housing heaters and heater adaptors for each dispensing port to delay the onset of drool and improve cut off in the dispensing tubes. The combination of fluorinated dispensing ports, the heating of the polyureas or polyurethanes, and inclusion of a capillary orifice in each dispensing port significantly prolongs the time before the advent of drool is detected. | 06-04-2009 |
Michael Allan Martin Davies, Concord, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100179454 | Animal Instrumentation - An approach to monitoring, evaluation, diagnosis, treatment or conditioning of animals such as horses does not require use of restrictive equipment such as treadmills or force plates and that can provide either or both of more or less immediate or continuous processing of data to perform the monitoring or diagnosis. One or more wireless sensors are attached to the animal, for example, to measure motion-related parameter associated with one or more parts of the animal. Sensor data is received from the sensors and processed to identify a characteristic of the motion of the animal, such as a quality of gait. The sensor data can also be used to avoid injury to the animal and/or the rider, and to verify the identity of an animal. | 07-15-2010 |
Monique V. Davies, Harpswell, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110020330 | ANTIBODY INHIBITORS OF GDF-8 AND USES THEREOF - The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism. | 01-27-2011 |
| 20110243953 | NEUTRALIZING ANTIBODIES AGAINST GDF-8 AND USES THEREFOR - The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism. | 10-06-2011 |
Robert Davies, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090012149 | PRODRUG OF AN ICE INHIBITOR - This invention describes an ICE inhibitor prodrug (I) having good bioavailability. | 01-08-2009 |
Robert Davies, Watertown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110301096 | PRODRUG OF AN ICE INHIBITOR - This invention describes an ICE inhibitor prodrug (I) having good bioavailability. | 12-08-2011 |
| 20120004226 | Modulators of Muscarinic Receptors - The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. | 01-05-2012 |
Robert J. Davies, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120039849 | TETRAHYDROTHIAZOLOPYRIDINE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE - The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 02-16-2012 |
Robert J. Davies, Somerville, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100063021 | Modulators of muscarinic receptors - The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. | 03-11-2010 |
Robert J. Davies, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090048226 | Inhibitors of caspases - The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1β converting enzyme (“ICE”) inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1-(“IL-1”), apoptosis-, interferon-γ inducing factor-(IGIF), or interferon-γ-(“IFN-γ”) mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to methods for inhibiting caspase activity and decreasing IGIF production and IFN-γ production and methods for treating interleukin-1, apoptosis-, and interferon-γ-mediated diseases using the compounds and compositions of this invention. This invention also relates to methods of preparing the compounds of this invention. | 02-19-2009 |
Robert J. Davies, Watertown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090099222 | Modulators of muscarinic receptors - The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. | 04-16-2009 |
| 20100316605 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE - The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 12-16-2010 |
| 20110059936 | C-MET PROTEIN KINASE INHIBITORS - The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders. | 03-10-2011 |
| 20110081316 | PYRAZOLE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE - The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 04-07-2011 |
| 20120040950 | ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE - The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 02-16-2012 |