| Patent application number | Description | Published |
|---|
| 20080247948 | STEREOISOMERS OF FATTY ACID ANALOGS FOR DIAGNOSTIC IMAGING - The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a fatty acid analog. The invention also provides methods for using the novel imaging agents, and kits containing one or more of the novel imaging agents of the invention. | 10-09-2008 |
| 20080267879 | Novel Imaging Tracers for Early Detection and Treatment of Amyloid Plaques Caused by Alzheimer's Disease and Related Disorders - The present invention relates to compounds and methods for imaging and treating Alzheimer's disease or an amyloidosis-associated pathological condition that utilize a novel amyloid imaging tracer for detecting amyloid deposits in a subject suffering from these conditions. In certain embodiments, the invention relates to [N-2[18F]fluoropropyl]-2-(4′-(methylamino)-phenyl)-6-hydroxybenzothiazole (F-18MHT) and dimers thereof. | 10-30-2008 |
| 20090010845 | Polybiotin Compounds of Magnetic Resonance Imaging and Drug Delivery - The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is a gadolinium. Another aspect of the invention relates to a compound comprising three biotin moieties and a pharmaceutical agent covalently bound to a heterocyclic core. In certain embodiments, the pharmaceutical agent is an antibiotic, antiviral, or radionuclide. Another aspect of the present invention relates to a method of treating disease involving administering the compounds of the invention to a mammal. Another aspect of the present invention relates to a method of acquiring a magnetic resonance image using the compounds of the invention. | 01-08-2009 |
| 20090117032 | Imaging Agents for Early Detection and Monitoring of Cardiovascular Plaque - The present invention relates in part to imaging agents comprised of a targeting moiety and a label, such as a radionuclide or paramagnetic contrast agent, and methods of use thereof. | 05-07-2009 |
| 20090191125 | Diagnostic and Therapeutic Alkyl Piperidine/Piperazine Compounds and Process - Piperidine or piperazine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The compounds are characterized by the formulae: | 07-30-2009 |
| 20090220433 | Novel biotinylated compositions - Novel biotinylated composition comprising a nucleic acid, e.g. siRNA, that are useful for targeting therapeutic and imaging agents to sites of infection and tumors are disclosed. | 09-03-2009 |
| 20100040504 | Reducing Global Warming - A system and method for reducing global warming. The system can include a container having a body portion for retaining a quantity of alkaline metal hydroxide and collecting a precipitate. At least one inlet on the container can be utilized for introducing a volume of air containing CO | 02-18-2010 |
| 20100204773 | DELIVERY SYSTEM FOR INTRAVASCULAR DEVICE WITH NETTING - In a cardiac double stent having an outer netting over an inner scaffolding, a limiting ridge for defining advancement of the outer netting over the inner scaffolding, and locking clips integrated in the outer netting for engaging the scaffolding at the insertion limit, assures definite placement and avoids shifting or movement from retracting of the delivery device. The delivery device further includes restricting ridges limiting advancement of the inner netting to overlie the inner scaffolding a substantially equal portion on the proximate and distal ends of a guide wire such that balloon catheter expands first at the overlying portion outside the inner scaffolding to sealably contact the lumen wall on each side of the scaffolding to prevent contamination. | 08-12-2010 |
| 20100208681 | INFRASTRUCTURE FOR WIRELESS TELECOMMUNICATION NETWORKS - A wireless network including a plurality of base stations operating at a public spectrum frequency, each base station capable of generating an adjustable size coverage area. Each base station utilizes dedicating channels for each user to permit avoidance of one or more sources of interference. A server supplies data to the base stations, and managing billing and access to the wireless network. A plurality of base stations employs transmissions in the unlicensed spectrum (i.e. 3.6 and 5.7 GHz in the US) for permitting flexibility in transmission power and additional subchannel/subcarrier interleaving capability for mitigating interference. | 08-19-2010 |
| 20100215578 | Catalytic Radiofluorination - One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to piperazine compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the piperazine compounds contain a quaternary amine. Another aspect of the invention relates to arylphosphonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the phosphonium compound is a tetraaryl phosphonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal. | 08-26-2010 |
| 20100298389 | Novel Imaging Tracers for Early Detection and Treatment of Amyloid Plaques Caused by Alzheimer's Disease and Related Disorders - The present invention relates to compounds and methods for imaging and treating Alzheimer's disease or an amyloidosis-associated pathological condition that utilize a novel amyloid imaging tracer for detecting amyloid deposits in a subject suffering from these conditions. In certain embodiments, the invention relates to [N-2[18F]fluoropropyl]-2-(4′-(methylamino)-phenyl)-6-hydroxybenzothiazole (F-18MHT) and dimers thereof. | 11-25-2010 |
| 20110044967 | Conjugates Comprising a Biodegradable Polymer and Uses Therefor - Biologically active agents covalently linked to a polymer. The polymer is preferably a biodegradable polymer are provided. The biologically active agent is preferably a protein, such as an extracellular soluble protein, e.g., an extracellular enzyme. The enzyme can be an apyrase, e.g., NTPDase. Conjugates of the invention can be used as therapeutics in subjects. For example, a conjugate comprising an apyrase can be used for treating and preventing thrombosis, atherosclerotic plaque complications and vascular disorders. | 02-24-2011 |
| 20110060138 | Compounds and Compositions for the Detection and Treatment of Alzheimer's Disease and Related Disorders - One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera. | 03-10-2011 |
