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David Powell
David Powell, Verdun CA
| Patent application number | Description | Published |
|---|---|---|
| 20090270434 | AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE - Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis. | 10-29-2009 |
| 20100004245 | AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE - Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis. | 01-07-2010 |
| 20100152208 | BICYCLIC HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE - Bicyclic heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I). | 06-17-2010 |
| 20110021532 | NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE - Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I). | 01-27-2011 |
| 20110183958 | AZETIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE - Azetidine derivatives of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis. | 07-28-2011 |
| 20110301143 | HETEROCYCLIC DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE - Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R | 12-08-2011 |
| 20120010186 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE - Heterocyclic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer, liver steatosis; and non-alcoholic steatohepatitis. | 01-12-2012 |
David Powell, Loudon, TN US
| Patent application number | Description | Published |
|---|---|---|
| 20090022793 | MESALAMINE SUPPOSITORY - The present invention relates to a mesalamine rectal suppository designed to provide improved comfort of use. One embodiment of the invention is a mesalamine rectal suppository comprising mesalamine and one or more pharmaceutically acceptable excipients, wherein the drug load of the suppository ranges from 35% to 50%. Another embodiment of the invention is a mesalamine rectal suppository comprising from about 850 to about 1150 mg mesalamine and one or more pharmaceutically acceptable excipients, wherein the total weight of the suppository ranges from about 2250 to about 2700 mg. Yet another embodiment of the invention is a mesalamine rectal suppository comprising mesalamine having a tap density ranging from about 600 to about 800 g/L (as measured by USP <616>) and a hard fat having an ascending melting point of 32 to 35.5° C. Methods of preparing and methods of treatment with mesalamine suppositories are also provided. The invention further provides a method of determining a dissolution parameter (such as dissolution rate) of a mesalamine rectal suppository, such as a 1 g mesalamine suppository, by measuring its dissolution with USP Apparatus #2 at 40° C. and a paddle rotation speed of 125 rpm in 0.2 M phosphate buffer at a pH of 7.5. | 01-22-2009 |
| 20090264386 | MESALAMINE SUPPOSITORY - The present invention relates to a mesalamine rectal suppository designed to provide improved comfort of use. One embodiment of the invention is a mesalamine rectal suppository comprising mesalamine and one or more pharmaceutically acceptable excipients, wherein the drug load of the suppository ranges from 35% to 50%. Another embodiment of the invention is a mesalamine rectal suppository comprising from about 850 to about 1150 mg mesalamine and one or more pharmaceutically acceptable excipients, wherein the total weight of the suppository ranges from about 2250 to about 2700 mg. Another embodiment of the invention is a mesalamine rectal suppository comprising from about 400 to about 600 mg mesalamine and one or more pharmaceutically acceptable excipients, wherein the total weight of the suppository ranges from about 870 to about 1715 mg. Yet another embodiment of the invention is a mesalamine rectal suppository comprising mesalamine having a tap density ranging from about 600 to about 800 g/L (as measured by USP <616>) and a hard fat having an ascending melting point of 32 to 35.5° C. Methods of preparing and methods of treatment with mesalamine suppositories are also provided. The invention further provides a method of determining a dissolution parameter (such as dissolution rate) of a mesalamine rectal suppository, such as a 1 g mesalamine suppository, by measuring its dissolution with USP Apparatus #2 at 40° C. and a paddle rotation speed of 125 rpm in 0.2 M phosphate buffer at a pH of 7.5. | 10-22-2009 |
| 20100105639 | MESALAMINE SUPPOSITORY - The present invention relates to a mesalamine rectal suppository designed to provide improved comfort of use. One embodiment of the invention is a mesalamine rectal suppository comprising mesalamine and one or more pharmaceutically acceptable excipients, wherein the drug load of the suppository ranges from 35% to 50%. Yet another embodiment of the invention is a mesalamine rectal suppository comprising mesalamine having a tap density ranging from about 600 to about 800 g/L (as measured by USP <616>) and a hard fat having an ascending melting point of 32 to 35.5° C. Yet another embodiment is a mesalamine rectal suppository comprising mesalamine particles and one or more pharmaceutically acceptable excipients, where the mesalamine particles have a surface area of from about 0.1 m | 04-29-2010 |
David Powell, Meath IE
| Patent application number | Description | Published |
|---|---|---|
| 20100057855 | TRACKING SUBJECT MATTER IN AN E-MAIL DISCUSSION - Methods, systems, and computer readable media for tracking subject matter of an e-mail discussion are described. A query e-mail is received, wherein the query e-mail includes an initial request and wherein the query e-mail commences the e-mail discussion. At least one marked response e-mail is received, wherein the at least one marked response e-mail includes information responsive to the query e-mail and is marked with an indication that the initial request has been resolved, and wherein the at least one marked response e-mail is appended to the e-mail discussion. At least one visual indicator in the e-mail discussion is provided that distinguishes at least one of the query e-mail and the at least one marked response e-mail when the e-mail discussion is opened at a later time. | 03-04-2010 |
David Powell, Kirkland CA
| Patent application number | Description | Published |
|---|---|---|
| 20090176823 | Secondary Amines as Renin Inhibitors - The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin. | 07-09-2009 |
David Powell, Montreal CA
| Patent application number | Description | Published |
|---|---|---|
| 20090170828 | Azetidine Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase - Azetidine derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis. (I) | 07-02-2009 |
David Powell, Kent GB
| Patent application number | Description | Published |
|---|---|---|
| 20090154919 | PULSED HIGH LOSS LOOP BACK SIGNALLING SCHEME - An optical transmission system comprises two optical fibbers carrying optical signal traffic between two terminals, and a plurality of optical repeaters coupled to the two fibers each repeater having a permanently connected passive high loss loop back circuit between the two fibers. One terminal includes a transmitter, which launches a pulsed supervisory signal on a dedicated supervisory wavelength into one optical fiber, and a receiver, which detects a portion of the supervisory signal looped back from each repeater in order to identify the existence and location of faults in the transmission system. The pulsed supervisory signal is of sufficiently short duration such that portions of the signal returned from each repeater do not overlap with one another and interference with the counter-propagating traffic is avoided by utilising a dedicated supervisory wavelength. Each return pulse is integrated sequentially by a single detector and processed by heterodyne reception and synchronous demodulation. | 06-18-2009 |
David Powell, Dublin IE
| Patent application number | Description | Published |
|---|---|---|
| 20090097097 | EC MIRROR ASSEMBLY - The present invention provides an EC mirror assembly that include s an EC mirror cell and control means for controlling the reflectivity of the mirror cell, the assembly also including a pair of contact elements independently displaceable relative to the mirror cell while maintaining an electrical connection with the control means, the contact elements also being engageable with opposite edges of the mirror cell in order to provide an electrical connection between the control means and the mirror cell. | 04-16-2009 |
| 20110213214 | MECHANICALLY DEPLOYABLE TRACHEAL TUBE SENSOR - Various embodiments of a tracheal tube having a mechanically deployable sensor are provided. Certain embodiments of the tracheal tube may be capable of mechanically deploying the sensor during intubation to sense one or more indicators of blood flow characteristics, such as a level of blood gases and/or blood analytes, in the respiratory tract. The mechanically deployable sensor may be configured to abut the tracheal mucosa of a patient or not contact the tracheal wall at all during deployment. The sensor may be further adapted to remain in a recess disposed in the tracheal tube prior to deployment and exit the recess when acquiring measurements. | 09-01-2011 |
| 20110213264 | SENSOR ON NON-SEALING PORTION OF TRACHEAL TUBE CUFF - Various embodiments of a tracheal tube having a sensor disposed on a non-sealing portion of a cuff are provided. Certain embodiments of the tracheal tube may be capable of deploying the sensor during intubation to sense one or more indicators of blood flow characteristics, such as a level of blood gases and/or blood analytes, in the respiratory tract. The sensor on the cuff may be configured to deploy upon inflation of the cuff and to return to its predeployment position upon deflation of the cuff. The sensor may be further adapted to abut the tracheal mucosa of a patient or not contact the tracheal wall at all during deployment. | 09-01-2011 |
David Powell, Galesburg, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20090056095 | Rail Fence Retractor - A rail fence retractor allowing removal of a fence rail engaged with a fence post comprising a blade having a first and second end. The first end of the blade has a thickness and width allowing insertion into a fence post slot having a rail inserted therein. The rail has self-locking tabs which must be depressed for removal of the rail from the fence post slot. The fence rail retractor also has a handle which is attached to the second end of the blade. The handle allows the application of force against handle to fix the position of the handle against the fence post during removal of said rail from said fence post slot. The handle is also useful in carrying the rail fence retractor when not in use. The handles of the rail fence retractor may be configured to allow integration with the blade. The handles may be also be configured to allow a pair of rail fence retractors to fit or snap together when not in use. | 03-05-2009 |
David Powell, Dublin GB
| Patent application number | Description | Published |
|---|---|---|
| 20110230742 | TRACHEAL TUBE SENSOR DISPOSED ON PERMEABLE MEMBRANE - Various embodiments of an tracheal tube having a sensor coupled to a selectively permeable membrane are provided. In some embodiments, the membrane may be permeable to one or more blood gases and/or blood analytes. Certain embodiments of the endotracheal tube may be capable of deploying the sensor during intubation to sense one or more indicators of blood flow characteristics, such as a level of blood gases and/or blood analytes, in the respiratory tract. Embodiments of the present invention may include positioning of the sensor in a variety of suitable positions with respect to the permeable membrane, such as mounting the sensor to the underside of an inflatable permeable membrane. | 09-22-2011 |
David Powell, Houston, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20110243948 | Monoclonal Antibodies Against ANGPTL3 - Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided. | 10-06-2011 |
David Powell, South Yorkshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20120094555 | ELECTRIC MARINE PROPULSION DEVICE WITH INTEGRAL MAGNETIC GEARING - A propulsion device for a marine vessel, the propulsion device comprising an electrical machine with integral magnetic gearing, which comprises three members, namely a first or inner rotor comprising a first plurality of permanent magnets, a second rotor in the form of a plurality of ferromagnetic pole pieces, and a stator which is associated with a plurality of 3-phase windings and to the periphery of which a plurality of second permanent magnets are fixed. The magnetic pole piece rotor is connected to a drive shaft provided with a propulsion means for providing propulsion to the marine vessel. The first or inner rotor is free to rotate about the drive shaft. The pole pieces of the second rotor are arranged to magnetically couple the permanent magnets of the first or inner rotor to the second permanent magnets on the stator. | 04-19-2012 |