David M. Lyerly, Radford US
David M. Lyerly, Radford, VA US
Patent application number | Description | Published |
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20110318240 | DEVICE AND METHOD FOR DETECTION OF ANALYTES - The present invention provides assays and devices for detection of substances in liquid samples. The assays and devices utilize passive diffusion between a porous material and a porous membrane containing a specific binding pair member to enable detection of the substance of interest. | 12-29-2011 |
20120276059 | FECAL LACTOFERRIN AS A BIOMARKER FOR DETERMINING DISEASE SEVERITY AND FOR MONITORING INFECTION IN PATIENTS WITH CLOSTRIDIUM DIFFICILE DISEASE - disease involves a range of clinical presentations ranging from mild to self-limiting diarrhea to life-threatening pseudomembranous colitis and megacolon. Cases of | 11-01-2012 |
20120276060 | FECAL LACTOFERRIN AS A BIOMARKER FOR DETERMINING DISEASE SEVERITY AND FOR TREATING INFECTION IN PATIENTS WITH CLOSTRIDIUM DIFFICILE DISEASE - disease involves a range of clinical presentations ranging from mild to self-limiting diarrhea to life-threatening pseudomembranous colitis and megacolon. Cases of | 11-01-2012 |
20130052640 | CLOSTRIDIUM DIFFICILE DEHYDROGENASE AND TOXIN AS A BIOMARKER FOR MONITORING INFECTION IN PATIENTS WITH CLOSTRIDIUM DIFFICILE DISEASE AND DIFFERENTIATING CARRIER STATE FROM ACTIVE DISEASE - disease involves a range of clinical presentations ranging from carrier status with other causes of symptoms to mild and self-limiting diarrhea to life-threatening pseudomembranous colitis and megacolon. Cases of | 02-28-2013 |
20130130281 | CYSTEINE PROTEASE Cwp84 (CD2787) AS A DIAGNOSTIC MARKER FOR CLOSTRIDIUM DIFFICILE - Accurate and fast detection of the presence of | 05-23-2013 |
20130273642 | DEVICE AND METHOD FOR DETECTION OF ANALYTES - The present invention provides assays and devices for detection of substances in liquid samples. The assays and devices utilize passive diffusion between a porous material and a porous membrane containing a specific binding pair member to enable detection of the substance of interest. | 10-17-2013 |
20130302813 | CELL WALL PROTEIN CwpV (CD0514) AS A DIAGNOSTIC MARKER FOR CLOSTRIDIUM DIFFICILE RIBOTYPE 027 - Accurate and rapid differentiation of the outbreak strain ribotype 027 from other possible | 11-14-2013 |
20140219966 | FECAL LACTOFERRIN AS A BIOMARKER FOR DETERMINING DISEASE SEVERITY AND FOR TREATING INFECTION IN PATIENTS WITH CLOSTRIDIUM DIFFICILE DISEASE - Clostridium difficile disease involves a range of clinical presentations ranging from mild to self-limiting diarrhea to life-threatening pseudomembranous colitis and megacolon. Cases of C. difficile are treated differently depending on severity of disease. Mild and moderate cases may be treated with metronidazole while moderate-to-severe and relapsing cases are often treated with vancomycin or fidaxomicin. The presence of C. difficile disease is detected using a biomarker panel that includes C. difficile antigen (GDH), toxins A and B, and fecal lactoferrin. In patients suspected of C. difficile disease, if GDH is detected indicating the presence of C. difficile, and then toxins A and/or B are detected to indicate toxigenic C. difficile and support a diagnosis of C. difficile-associated disease, fecal lactoferrin concentrations are measured to determine severity of the disease by indicating the amount of intestinal inflammation. | 08-07-2014 |
20150044697 | OUTER MEMBRANE PROTEIN 18 AS A DIAGNOSTIC MARKER FOR CAMPYLOBACTER - Accurate and fast detection of the presence of | 02-12-2015 |
20150044698 | OUTER MEMBRANE PROTEIN 18 AS A DIAGNOSTIC MARKER FOR CAMPYLOBACTER - Accurate and fast detection of the presence of Campylobacter disease is important for the proper treatment of patients with Campylobacter infection. Present tests depend upon culture of viable bacteria and identification by microscopy, which requires care, skill, and two or more days for conclusive results. The current invention improves the ease of use and overcomes the limitations of loss of viability and delay inherent in Campylobacter bacterial culture and provides a more rapid alternative for the identification and diagnosis of Campylobacter and campylobacteriosis. The invention provides a new method of detecting Campylobacter by utilizing an outer membrane protein (OMP 18) to develop antibodies for use in immunoassays of bacterial cultures or human fecal samples. | 02-12-2015 |