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David Epstein
David Epstein, London GB
| Patent application number | Description | Published |
|---|---|---|
| 20110029456 | System and Method for a Risk Management Framework for Hedging Mortality Risk in Portfolios Having Mortality-Based Exposure - The invention comprises a system and method for hedging or mitigating mortality exposure risk in a portfolio of mortality-dependent instruments. A mortality risk or longevity risk of the portfolio is calculated or otherwise determined. Then the sensitivity of the portfolio to mortality risk or longevity risk is calculated or otherwise determined, in other words, how much is cost or value of the portfolio affected by a change in mortality rate. To account for that mortality exposure, a selection is made of building block mortality derivatives that include age-based mortality derivatives. The selected plurality of building block mortality derivatives are used to create a hedge against the mortality risk or longevity risk of the portfolio. | 02-03-2011 |
David Epstein, Huntington, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090053138 | Stabilized Aptamers to Platelet Derived Growth Factor and their Use as Oncology Therapeutics - Materials and methods are provided for producing and using aptamers as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and/or VEGF receptor or any combination thereof with affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto. | 02-26-2009 |
| 20090269356 | Complement Binding Aptamers and Anti-C5 Agents Useful in the Treatment of Ocular Disorders - Methods of treating complement-mediated ocular disorders by administering agents that inhibit a subject's complement component in an amount sufficient to treat the ocular disorder wherein, in a selected embodiment, said agent is an anti-complement aptamer that, in a preferred embodiment, is an anti-C5 aptamer. | 10-29-2009 |
David Epstein, Belmont, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090018093 | Nucleic Acid Ligands Specific to Immunoglobuline E and Their Use as Atopic Disease Therapeutics - The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE. | 01-15-2009 |
| 20090258425 | GENE KNOCK-DOWN BY INTRACELLULAR EXPRESSION OF APTAMERS - Materials and Methods are provided for target validation by gene knock-down with intracellularly expressed aptamers and siRNAs. The aptamers produced by the materials and methods of the invention are useful in target validation for therapeutics development. | 10-15-2009 |
David Epstein, Philadelphia, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090215986 | Solution Synthesis of Peptide Cell Growth Stimulators - A solution phase synthetic method for preparing basic tripeptides of the formula Gly-Xaa-Gly-X which have in various biological properties such as stimulating protein production when used as additives in a bioreactor. The basic tripeptides of the invention may be produced on gram or kilogram scale. | 08-27-2009 |
David Epstein, Hartford, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20080291901 | Network architecture for call processing - A network system for call processing, including customer premises equipment originating a call across a network, wherein the call includes private and public information; a session border controller directing the call information from the customer premises equipment to a public switched telephone network gateway, wherein the session border controller parses out the private information from the call information transmitted to the gateway; and one or more servers coupled to the session border controller, routing only the non-private call information to the public switched telephone network gateway. | 11-27-2008 |
David Epstein, New York, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20080270456 | Method and Apparatus for Access, Integration, and Analysis of Heterogeneous Data Sources Via the Manipulation of Metadata Objects - A computer-based method represents a subset of a dataset table of rows and columns. The method includes selecting a set of blocking variables corresponding to blocking columns of the dataset table. For each row in the dataset table, a tuple of values for the blocking columns uniquely identifies the row within the dataset table. The method also includes selecting a set of non-blocking variables that correspond to columns of the subset. The set of non-blocking variables does not intersect the set of blocking variables. The method also includes creating a block information structure that includes both the set of non-blocking variables and, for each blocking variable in the set of blocking variables, a set of values. | 10-30-2008 |