David Cox
David Cox, Foster City, CA US
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20110052446 | FLOW CELLS AND METHODS OF FILLING AND USING SAME - Various flowcell configurations and systems are provided as are methods of making and using same. The flowcells, systems, and methods of use can be useful in carrying out sequencing reactions and next generation sequencing methods. | 03-03-2011 |
20110124111 | LOW-VOLUME SEQUENCING SYSTEM AND METHOD OF USE - Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 μl). The system can also include an automated reagent delivery mechanism configured to reversibly couple with the inlet port corresponding to a target reaction chamber thereby placing allowing for reagent to be accurately moved from a storage container to the reaction chamber with minimal reagent waste. The flowcells can include a plurality of reaction chambers (e.g., 6) thereby allowing for parallel analysis of multiple samples. Various methods of analyzing a biomolecule are also provided herein. | 05-26-2011 |
20110128545 | Fast-Indexing Filter Wheel and Method of Use - Various embodiments of a sequencing system capable of rapidly imaging samples at multiple wavelengths are provided herein. In one embodiment, the system includes a fast-indexing filter wheel having a plurality of excitation and emission filters capable of being rapidly rotated into and out of communication with an excitation source (e.g., an arc lamp, a laser. For example, the filter wheel can be configured to index in an amount of time falling within a range of about 40 ms to about 60 ms, preferably 50 ms. The system can also be configured to account for vibrations resulting from the quick starts and stops of the fast-indexing filter wheel as well as vibrations resulting from other sources. Various methods of rapidly imaging a sample at multiple wavelengths are also provided herein. | 06-02-2011 |
20110223680 | Microfluidic Device and Material Manipulating Method Using Same - Microfluidic devices for manipulating relatively dense materials, such as colloidal rod particles, are provided. Microfluidic devices for separating a denser first material from a less-dense second material are provided. Methods of manipulating a relatively dense first material, for example, colloidal rod particles, and separating the first material from a less-dense second material, are provided. Methods of marking samples or sample components with relatively dense materials, are also provided. | 09-15-2011 |
20130183210 | DEVICE AND METHOD FOR MAKING DISCRETE VOLUMES OF A FIRST FLUID IN CONTACT WITH A SECOND FLUID, WHICH ARE IMMISCIBLE WITH EACH OTHER - Various embodiments described in the application relate to an apparatus, system, and method for generating, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The system can comprise an apparatus comprising at least one conduit operatively connected to one or more pumps for providing discrete volumes separated from one another by a fluid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil. | 07-18-2013 |
20150191784 | Fast-Indexing Filter Wheel and Method of Use - Various embodiments of a sequencing system capable of rapidly imaging samples at multiple wavelengths are provided herein. In one embodiment, the system includes a fast-indexing filter wheel having a plurality of excitation and emission filters capable of being rapidly rotated into and out of communication with an excitation source (e.g., an arc lamp, a laser. For example, the filter wheel can be configured to index in an amount of time falling within a range of about 40 ms to about 60 ms, preferably 50 ms. The system can also be configured to account for vibrations resulting from the quick starts and stops of the fast-indexing filter wheel as well as vibrations resulting from other sources. Various methods of rapidly imaging a sample at multiple wavelengths are also provided herein. | 07-09-2015 |
David Cox, Belmont, CA US
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20090208962 | MARKERS FOR BREAST CANCER - Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described. | 08-20-2009 |
20090239226 | MARKERS FOR BREAST CANCER - Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described. | 09-24-2009 |
20090239763 | MARKERS FOR BREAST CANCER - Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described. | 09-24-2009 |
20110015092 | MARKERS FOR BREAST CANCER - Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described. | 01-20-2011 |
David Cox, Melbourne SE
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20100317330 | METHOD OF ENABLING A SERVICE AT A COMMUNICATION NETWORK NODE - A method enabling a service at a communication network node and a network node adapted to execute the method is provided, wherein a first request, requesting for one or more operations to be associated with a symbol, is received from a first user. The request comprises an instruction, identifying one or more operations. The request triggers the generating of a unique symbol identity, and the creation of a symbol record, associated with the symbol identity, wherein the symbol record, linking the symbol identity to the one or more operations. At the node the symbol identity is also associated with the generated symbol, which is created by a symbol server and forwarded to the first user. Once the symbol has been received by the node in a second request, the symbol identity corresponding to the symbol is retrieved from the symbol server, and the service is enabled by executing the one or more operations according to the symbol record identified by the symbol identity. | 12-16-2010 |
David Cox, Hertfordshire GB
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20100059133 | AXIALLY REINFORCED HOSE - A hose comprising a tubular body of flexible material arranged between an inner and an outer helically wound wire, the tubular body serving to transport fluid through the hose and to prevent fluid leakage through the body, the tubular body comprising a reinforcing layer and a sealing layer, wherein the hose further comprises axial strengthening strips extending along the length of the hose. | 03-11-2010 |
20100229991 | HOSE - The invention relates to composite hose, which is capable of being used without leakage, and which has a longer length and/or diameter than has been previously achievable. A composite hose comprises a tubular body of flexible material arranged between an inner and an outer helically wound wire. The hose further comprises an axial strengthening means adapted to reduce deformation of the tubular body when the tubular body is subjected to axial tension, the axial strengthening means being adapted to exert a radially inward force on at least part of the tubular body when axial strengthening means is subjected to axial tension. The hose can have length above 30 m and a diameter above 400 mm. A method of, and apparatus for, making the hose are also described, which involves the use of a non-metallic mandrel. | 09-16-2010 |
20100229992 | HOSE - The invention relates to a bellows hose, which is capable of being used without leakage, and which has a longer length and/or diameter than has been previously achievable. A bellows hose comprises an inner tubular bellows and an outer tubular bellows. An insulation layer is provided between the bellows. An armoured layer is provided around the outer bellows, to improve the insulation further. The hose can have length above 30 m and a diameter above 400 mm. A method of, and apparatus for, making the hose are also described, which involves the use of a non-metallic mandrel. | 09-16-2010 |
David Cox, London GB
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20100192923 | INTERNAL COMBUSTION ENGINES - The invention provides a 2-stroke internal combustion engine comprising two opposed cylinders, each cylinder housing two opposed pistons and having at least one exhaust port and at least one intake port, and a crankshaft having asymmetrically arranged journals and scotch-yoke mechanisms for driving the journals from the pistons. The pistons in each cylinder operate to open its exhaust port or ports before its intake port or ports and to close its exhaust port or ports before its intake port or ports. | 08-05-2010 |
David Cox, Greensboro, NC US
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20100168043 | METHOD FOR THE PROTECTION OF TREES - The present invention provides a method for the prevention/treatment of hark beetle and/or wood borer infestation of trees comprising treatment of the tree with a composition comprising a macroyclic lactone. | 07-01-2010 |
20120245114 | METHOD FOR THE PROTECTION OF TREES - The present invention provides a method for the prevention/treatment of bark beetle and/or wood borer infestation of trees comprising treatment of the tree with a composition comprising a macroyclic lactone. | 09-27-2012 |
20140107055 | METHOD FOR THE PROTECTION OF TREES - The present invention provides a method for the prevention/treatment of bark beetle and/or wood borer infestation of trees comprising treatment of the tree with a composition comprising a macroyclic lactone. | 04-17-2014 |
David Cox, Austin, TX US
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20100114110 | INTERVERTEBRAL DISC ACCESS ASSEMBLY - A surgical access system for managing the minimally invasive access of treatment electrodes to an intervertebral disc, when treating spine abnormalities such as disc herniations. The system includes an access port and a cannula assembly. The access port provides atraumatic access to the target area for the cannula system and a subsequent treatment electrode. The access port also manages the insertion travel and penetration depth of the cannula assembly, so as to minimize unintended damage to local tissue during use. The cannula system includes an adjustable and removable stop to mate with the access port that limits the extension of the cannula beyond the distal tip of the access port and into the target tissue. | 05-06-2010 |
20140200581 | SYSTEMS AND METHODS FOR TURBINATE REDUCTION - The present disclosure includes an electrosurgical apparatus for treating tissue at a target site. The apparatus has a shaft with a proximal end and a distal portion, the distal portion comprising a return electrode and electrode support. There is also at least one active electrode on the shaft distal portion, which has a proximal portion and a distal portion and a plurality of aspiration apertures disposed therebetween. These apertures are fluidly connected to a fluid aspiration cavity that is located within the electrode support, and the cavity is connected with a fluid aspiration element that is located along the shaft. The plurality of apertures vary in size and are generally arranged so that the larger sized apertures are disposed towards the electrode proximal portion and the smaller sized apertures are generally located towards the electrode distal portion. | 07-17-2014 |
David Cox, Romford GB
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20100096300 | Chutes for Sorting and Inspection Apparatus - A chute for inspection and sorting apparatus has first and second flat sections, with the lower end of the first section being disposed over the second section to form a step from which product falls onto the second section. Additional sections may be included. In one variant a third channelled section is included, with the lower end of the second section being disposed over the third section forming a second step from which product falls onto the third section. | 04-22-2010 |
David Cox, Woodbury, MN US
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20090287313 | TISSUE ADHESIVE SEALANT - A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1. | 11-19-2009 |
David Cox, Ayr AU
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20090071667 | METHOD AND SYSTEM FOR OPTIMISING LAND LEVELLING DESIGNS - A method and system for creating a levelling surface for use in levelling a substantially uneven ground surface, optimised for a single plane, row cropping, or dryland cropping with no rows (a surface for row cropping will typically optimise the surface with a defined water flow direction and a surface for dryland cropping will typically optimise the surface to allow water flow in any direction). Terrain data is collected, at least one constraint corresponding to desired surface characteristics is inputted, and a data transformation engine is operated, wherein the data transformation engine optimises the terrain data for at least one terrain variable, generates an optimised terrain model that substantially complies with the at least one constraint, and outputs a levelling surface. The levelling surface may be outputted to a three-dimensional controller for land-levelling machinery which could then shift the soil from the existing terrain to match the levelling surface. | 03-19-2009 |
David Cox, Surrey GB
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20120067718 | METHOD AND APPARATUS FOR PRODUCING THREE DIMENSIONAL NANO AND MICRO SCALE STRUCTURES - A three-dimensional milling method and apparatus is disclosed for milling micrometre and a nanometre scale three-dimensional structures. The apparatus includes an ion column operable to generate a milling beam onto a substrate held on an instrument stage. A patterning computer is operable to control the ion column to generate varying ion beam and/or dwell times or to produce a plurality of milling passes, in which subsequent passes overlap previous passes at least partially to create three-dimensional structures. Optionally, an SEM column may be provided. | 03-22-2012 |
David Cox, Melbourne AU
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20120124650 | Reactive Authorization for Publications - Systems and methods for reactively authorizing publication of information by a third party are coordinated through the use of a presence server. The presence server communicates with other communication nodes/devices to determine and relay publication information. Publication requests that are initially unauthorized, from the perspective of the presence server, are resolved. | 05-17-2012 |
20120304252 | METHOD AND SYSTEM FOR AUTHORIZATION OF PRESENCE INFORMATION - Embodiments of the present invention include a system and method for implementing a presence system. According to an embodiment of the present invention, responsive to receiving a request for presence information associated with a presentity from a watcher, the presence system receives instructions indicating that an authorization instance other than the presentity shall be given an opportunity to change or verify an authorization rule associated with the request for presence information. As a consequence, the presence system notifies the authorization instance of the request for presence information, thereby enabling the authorization instance to change or verify the authorization rule. The presence system also makes a final decision on the authorization rule on the basis of the instructions and a notification indicating a change or verification of the authorization rule. | 11-29-2012 |
David Cox, Redmond, WA US
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20120159468 | SOFTWARE DEPLOYMENT TO MULTIPLE COMPUTING DEVICES - A particular method includes storing a manifest file and a parameters file at a data store. The manifest file and the parameters file are associated with a software deployment package. An application associated with the software deployment package is published to a first remote computing device and to a second remote computing device. The method includes receiving first parameter values from the first remote computing device and receiving second parameter values from the second remote computing device. The first parameter values are stored in a first region of the data store that is specific to the first computing device. The second parameter values are stored in a second region of the data store that is specific to the second computing device. | 06-21-2012 |
David Cox, Newbury GB
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20130084801 | Positioning Guidance for Increasing Reliability of Near-Field Communications - To promote ease of use, as well as a reduction in bit error rates during extended data exchange between a coupled NFC tag/reader pair, signal strength is measured from a plurality of NFC tag antennas each positioned differently with respect to a common reader field, and differences in signal strength are used to determine an optimum positioning of the tag, or tag emulator, with respect to the reader. Alternative embodiments may include signal time of flight for determining orientation of the NFC antennas within the reader field. Information is generated by the tag, or tag emulator, and output by the tag, or tag emulator, such that a user may direct the positioning of the tag, or tag emulator, for improved communication with the reader. | 04-04-2013 |
David Cox, San Diego, CA US
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20130207791 | HAPTIC DIRECTIONAL FEEDBACK HANDLES FOR LOCATION DEVICES - Locating devices and systems providing haptic tactile feedback are disclosed. In one embodiment, a locator includes a haptic handle configured to provide directional signals through an operator's sense of touch to aid in locating and tracing a buried conductor or other object such as a pipe or cable. | 08-15-2013 |
20140063229 | ADJUSTABLE VARIABLE RESOLUTION INSPECTION SYSTEMS AND METHODS - Camera heads configured to provide digitally articulated images or video, at adjustable resolutions and/or offsets and orientations, to a camera control unit (CCU) or other electronic computing system for display, storage, and/or transmission to other systems are disclosed. | 03-06-2014 |
20140313316 | ADJUSTABLE VARIABLE RESOLUTION INSPECTION SYSTEMS AND METHODS USING MULTIPLE IMAGE SENSORS - Camera heads having multiple image sensors, configured to provide digitally articulated images or video, at adjustable resolutions and/or offsets and orientations, to a camera control unit (CCU) or other electronic computing system for display, storage, and/or transmission to other systems are disclosed. | 10-23-2014 |
David Cox, Hartland, WI US
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20140115906 | POWER ACTUATED WHEEL CLAMP - A wheel clamp attaches to a vehicle wheel for performing a wheel alignment on the vehicle. The wheel clamp has a body for supporting a target or measuring head, and three elongated arms mounted to the body. Each arm has a gripping portion for gripping the tire's tread surface. A self-centering linkage has enmeshed gears that, when rotated, cause the elongated arms to simultaneously proportionally move relative to the clamp body. An attachment interface mechanically connected to the self-centering linkage is configured to engage with a rotational actuator. Alternatively, the wheel clamp includes an actuator mechanically coupled to the self-centering mechanism. Activation of the actuator causes the gripping portions of the arms to engage and grip the tire tread surface and tighten the clamp onto the tire. | 05-01-2014 |
David Cox, San Clemente, CA US
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20140064538 | CLUTCH SPEAKER - A clutch speaker system includes top and bottom sides, a speaker enclosure with a speaker and first and second flexible side wings. The top side and speaker enclosure are hingedly affixed to the bottom side, and the speaker enclosure is slideably engaged with the top side, forming a hinged clutch with left and right sides and an interior. The first flexible side wing is disposed along the left side of the hinged clutch and is affixed along the left edge of the top and bottom sides to form a first flexible interface. The second flexible side wing is disposed along the right side of the clutch and is affixed along the right edge of the top and bottom sides to form a second flexible interface. The speaker enclosure includes a firing port that is directed into the interior of the hinged clutch. The speaker is positioned opposite the firing port. | 03-06-2014 |
20140219491 | PILLAR SPEAKER - A loudspeaker system including a top firing, 360 degree, time aligned, powered loudspeaker system that comprises a cylindrical body, having a top end and a bottom end, and an upper interior compartment and a lower interior compartment; a first speaker driver and a second speaker driver, each being positioned within the upper interior compartment, and each being oriented to face towards the top end of the cylindrical body; at least one subwoofer having an upper end and a lower end, the at least one subwoofer being positioned within the lower interior compartment and oriented to face towards the bottom end of the cylindrical body; and a narrow band of multiple openings on the cylindrical body, proximate the bottom end of the cylindrical body, and adjacent to the lower end of the at least one subwoofer, the narrow band of multiple openings spanning 360 degrees around the cylindrical body. The first and second speaker drivers are outwardly angled from the vertical. | 08-07-2014 |
David Cox, Guildford GB
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20130284697 | TECHNIQUES FOR GENERATING THREE DIMENSIONAL STRUCTURES - Techniques for forming a three dimensional (3D) feature on a substrate are disclosed. In one exemplary embodiment, the technique may be realized as a method comprising: forming a resist structure on the substrate, the resist structure having a first resist portion with a first thickness, a second resist portion with a second thickness, and a third resist portion with a third thickness, where the first thickness may be less than the second thickness, and where the second thickness may be less than the third thickness; implanting charged particles into the substrate through the first and second resist portions and forming an implanted region in the substrate; and etching the substrate to form the 3D feature on the substrate. | 10-31-2013 |
David Cox, Hertford GB
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20130042478 | Hose - The invention relates to a bellows hose, which is capable of being used without leakage, and which has a longer length and/or diameter than has been previously achievable. A bellows hose comprises an inner tubular bellows and an outer tubular bellows. An insulation layer is provided between the bellows. An armoured layer is provided around the outer bellows, to improve the insulation further. The hose can have length above 30 m and a diameter above 400 mm. A method of, and apparatus for, making the hose are also described, which involves the use of a non-metallic mandrel. | 02-21-2013 |
David Cox, Destin, FL US
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20150127451 | SYSTEM AND METHOD FOR CONTROLLING AD IMPRESSION VIOLATIONS - A method of controlling ads includes receiving a beacon over a network identifying an ad, an end user and a content source; querying a database of unauthorized content sources based on the beacon; determining whether the ad is an unauthorized impression; and storing information from the beacon in a database, including whether the impression was authorized or unauthorized. The database may include a list of unauthorized sites and the querying may include checking whether the content source is one of the unauthorized sites. Querying also may be used by advertising exchanges and networks to determine whether to place an ad on a particular publisher's site. | 05-07-2015 |
David Cox, Charlotte, NC US
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20150247270 | INSULATION PAD FOR PIPES AND VESSELS - An insulation pad includes a binderless pack of glass fibers and an envelope around the binderless pack of glass fibers. The glass fibers are mechanically entangled by needling such that the binderless pack has a density of from 4.5 to 5.5 pounds per cubic foot. The insulation pad is used to insulate pipes and vessels. | 09-03-2015 |