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David Baker
David Baker, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110053247 | LARGE-SCALE PRODUCTION OF SOLUBLE HYALURONIDASE - Provided are methods for preparing large-scale preparations of soluble hyaluronidases. The methods employ cells that contain a plurality of active copies of nucleic acid encoding the soluble hyaluronidase and a plurality of feedings and temperature changes, whereby the encoded soluble hyaluronidase is secreted into the cell culture medium. | 03-03-2011 |
David Baker, Greene, RI US
| Patent application number | Description | Published |
|---|---|---|
| 20100241073 | Heat exchanger connector assembly - A connector assembly for a heat exchanger has a fitting and a mount to which the fitting couples. The fitting has an elongate body having a proximal portion and a distal portion. At the proximal portion there is a crossbar, and at the distal portion there are an inlet and an outlet that protrude away from the body. Two wings extend from the body in a direction opposite to that of the inlet and outlet. There is formed on each of the wings a locking protrusion. The mount has a top portion where there is a groove dimensioned to accept the crossbar of the fitting. A longitudinal channel is formed orthogonal to the groove in the mount. Two sidewalls extend from the mount each for accepting a corresponding one of the wings, when the fitting is coupled to the mount. Apertures are provided at the sidewalls to engage the protrusion at the wings so that, once the fitting is coupled to the mount, it is secured thereto, until a force is exerted to compress the wings towards each other to disengage the protrusions from the apertures. To couple the fitting to the mount, a user first positions the crossbar of the fitting onto the groove of the mount, with the body of the fitting at an angle relative to the mount. With the crossbar resting on the groove, a pivot point is established between the fitting and the mount, so that the body of the fitting can be pivotally positioned within the channel of the mount. At that time the inlet and outlet of the fitting are mated to an output port and an input port, respectively, of the mount; and the protrusions at the wings of the fitting are engaged to the apertures at the sidewalls of the mount. An infusate line and a heat exchanger are connected to the proximal end and distal end, respectively, of the fitting. | 09-23-2010 |
David Baker, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090155873 | BIOFUEL PRODUCTION - Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched refinery-produced petroleum products are also provided, as well as methods for producing the same. | 06-18-2009 |
| 20090191607 | SYNTHETIC ENZYMES DERIVED FROM COMPUTATIONAL DESIGN - Disclosed herein are techniques for computationally designing enzymes. These techniques can be used to design variations of naturally occurring enzymes, as well as new enzymes having no natural counterparts. The techniques are based on first identifying functional reactive sites required to promote the desired reaction. Then, hashing algorithms are used to identify potential protein backbone structures (i.e., scaffolds) capable of supporting the required functional sites. These techniques were used to design 32 different protein sequences that exhibited aldol reaction catalytic function, 31 of which are defined in the Sequence Listing. Details of these 31 different synthetic aldolases are provided, including descriptions of how such synthetic aldolases can be differentiated from naturally occurring aldolases. | 07-30-2009 |
| 20100068217 | EPITOPE-TRANSPLANT SCAFFOLDS AND THEIR USE - Computational protocols for the design of epitope-protein scaffolds which elicit selected neutralizing antibodies are disclosed, and related compositions and uses. | 03-18-2010 |
| 20100184954 | MONOMERIC RED FLUORESCENT PROTEINS - Disclosed are sequences encoding monomeric variants of DsRed fluorescent proteins and methods of use. | 07-22-2010 |
| 20100204085 | STRUCTURE-BASED DESIGN OF PEPTIDE INHIBITORS OF AMYLOID FIBRILLATION - The invention provides methods for designing peptides that inhibit aggregation in target polypeptides. The candidate inhibitory peptidic compounds have an oligomeric sequence that forms energetically-favorable interactions with the amino acid sequence of the steric zipper region of the target protein, and also possess a zipper-disrupting feature that disrupt the peptide stacking at the steric zipper region. This method can be used to obtain inhibitory peptides to disrupt fibril formation involving any protein for which a steric zipper sequence can be identified. The invention also provides inhibitory peptidic compounds, which can be used in pharmaceutical compositions and methods for treating polypeptide aggregation-associated diseases or conditions. | 08-12-2010 |
David Baker, London GB
| Patent application number | Description | Published |
|---|---|---|
| 20080262011 | Modulator - The present invention relates to a compound of formula I, or a pharmaceutically acceptable salt thereof. Formula (I), wherein R | 10-23-2008 |
| 20100144876 | MODULATOR - The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein Z is OR | 06-10-2010 |
David Baker, Winnipeg CA
| Patent application number | Description | Published |
|---|---|---|
| 20100017819 | Providing Targeted Multimedia Content - Targeted multimedia content stored on a computer system is selected and streamed to users on the network based on requests containing information about the user. A sequence of selected clips is streamed in the order in which they are to be rendered by the user's computing device and delivery of a second clip begins before delivery of the first clip ends, so there is substantially no gap in time between the end of the first clip and the beginning of the second clip from the user's perspective. | 01-21-2010 |
David Baker, Austin, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090204731 | AUTOMATICALLY DISABLING INPUT/OUTPUT SIGNAL PROCESSING BASED ON THE REQUIRED MULTIMEDIA FORMAT - A system and method operable to automatically disable input/output signal processing based on the required data format is provided. The need for an input/output module, such as an encoder, required to process input signal having a first data format (i.e. multimedia format) and produce an output signal having a second format (i.e. multimedia format) is determined. When the input/output module is not required to produce the output signal in the second format, the input/output module is disabled. | 08-13-2009 |
David Baker, Surrey GB
| Patent application number | Description | Published |
|---|---|---|
| 20110116876 | RETAINING WALL - A retaining wall for retaining matter on a side thereof comprising: a plurality of upwardly projecting primary sheet piles spaced apart from each other and having first structural properties comprising at least one of weight, size, strength and depth to be installed in a supporting body; and one or more intermediate panels of material arranged so as to span the gap between a pair primary sheet piles and to retain at least a portion of the retained matter, wherein the one or more intermediate panels have second structural properties different from the first structural properties. | 05-19-2011 |
David Baker, Bristol GB
| Patent application number | Description | Published |
|---|---|---|
| 20110209542 | FLOW SENSORS - A flow sensor and fastener assembly, is disclosed which includes at least the following modules: a sensor housing and a fastener element; wherein: the sensor housing is adapted to receive a flow-based sensor, e.g. a MEMS airflow sensor; the sensor housing includes a connection for transmitting sensing signals from a fitted flow-based sensor; the fastener element includes a head and a shank, at least part of the shank being externally threaded; the fastener element includes a bore extending through the whole length of the fastener element; and the bore is shaped at the head end of the fastener element to provide a sensor housing receiving part. | 09-01-2011 |
David Baker, San Jose, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110220180 | ELECTRICAL CONNECTORS FOR SOLAR MODULES - A solar module is disclosed that has one or more integrated electrical connectors. In addition, a solar module electrical connector holder is disclosed that has resilient wing portions and axial portions that mate with a first connector window in a frame of a solar module and allow the position of an electrical connector to be moved one of vertically, horizontally and angularly with respect to the frame. In addition, a solar module frame is disclosed that has a first connector window in one of the side frame members that is capable of accepting an electrical connection so that the electrical connection is integrated into the frame of the solar module. | 09-15-2011 |
David Baker, Jamestown, RI US
| Patent application number | Description | Published |
|---|---|---|
| 20120014547 | Hearing Instrument - A hearing instrument may include an enclosure adapted for behind-the-ear placement that houses a microphone for converting an acoustical input signal to an electrical signal and a sound processing circuit for processing the electrical signal; an earpiece adapted for in-the-canal placement that includes a receiver for converting the processed electrical signal to an acoustical output signal; a replaceable battery housed in the enclosure for powering the microphone, sound processing circuit and receiver; and an electrical cable extending from the enclosure that electrically couples the processed electrical signal from the sound processing circuit to the receiver. The enclosure includes a top portion and a bottom portion. The top portion and the bottom portion pivot about a hinge point at one end of the enclosure to open and closed positions. In the open position, the battery is accessible for replacement. A latch mechanism at the other end of the enclosure secures the top portion to the bottom portion in the closed position. The bottom portion may be detached from the top portion and may be replaced by the user. | 01-19-2012 |