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| 20090181116 | AXMI-031, AXMI-039, AXMI-040 AND AXMI-049, A FAMILY OF NOVEL DELTA-ENDOTOXIN GENES AND METHODS FOR THEIR USE - Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 4, 6, 8, 10, 12, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, or 38, or the nucleotide sequence set forth in SEQ ID NO:1, 3, 5, 7, 9, 11, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, or 37, as well as variants and fragments thereof. | 07-16-2009 |
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| 20100166723 | GENES ENCODING NEMATODE TOXINS - Compositions and methods for conferring nematicidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions including a coding sequence for nematicidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated nematicidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules including nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:4, 5, 8, 9, 13, 14, 47, 48, or 49, the nucleotide sequence set forth in SEQ ID NO:1, 2, 3, 6, 7, 10, 11, 12, 15, 45, or 46, as well as variants and fragments thereof. | 07-01-2010 |
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| 20090081202 | IMMUNOGENIC COMPOSITIONS AND METHODS - Disclosed are immunogenic compositions, and methods for their use in the formulation and administration of therapeutic and prophylactic pharmaceutical agents. In particular, the invention provides immunogenic compositions and methods for preventing, treating, and/or ameliorating microbial infection, including, for example, influenza, or one or more symptoms thereof. | 03-26-2009 |
| 20090098527 | BIOLOGICAL ORGANISM IDENTIFICATION PRODUCT AND METHODS - A biological organism identification product, and methods of using the same, that include a collection device to collect one or more sample organisms, a fixing and transporting composition present in an amount sufficient to kill the sample organism(s) associated with the collection device, an extraction member to extract a sufficient amount of genomic nucleic acid from the sample organism(s) to facilitate identification; and a polymerase chain reaction component into which the sufficient amount of genomic nucleic acid can be dissolved. The amplified genomic material is exposed to molecules that bind to predetermined genomic sequences, providing the identification feature of the product. The biological organism identification product may be portable, durable, and self-contained. | 04-16-2009 |
| 20090233309 | BIOLOGICAL SPECIMEN COLLECTION/TRANSPORT COMPOSITIONS AND METHODS - Disclosed are compositions for collecting, storing, and transporting populations of nucleic acids from biological specimens, and clinical, forensic, or environmental samples. Also disclosed are methods for using these compositions as one-step formulations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or assay. In particular embodiments, the invention provides a single, one-step, sample collection/transport/storage formulation containing a known quantity of a non-genomic, nucleic acid carrier molecule that serves as an internal reference control to monitor the fidelity of the collection/transportation medium, and measure the integrity of nucleic acids subsequently isolated and purified from the processed sample. | 09-17-2009 |
| 20090312285 | BIOLOGICAL SPECIMEN COLLECTION AND TRANSPORT SYSTEM AND METHODS OF USE - Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using these compositions as one-step formulations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or assay. The disclosed compositions safely facilitate rapid sample collection, and provide extended storage and transport of the samples at ambient or elevated temperature without contamination of the sample or degradation of the nucleic acids contained therein. This process particularly facilitates the collection of specimens from remote locations, and under conditions previously considered hostile for preserving the integrity of nucleic acids released from lysed biological samples without the need of refrigeration or freezing prior to molecular analysis. | 12-17-2009 |
| 20100009343 | COMPOSITIONS AND METHOD FOR RAPID, REAL-TIME DETECTION OF INFLUENZA A VIRUS (H1N1) SWINE 2009 - Disclosed are oligonucleotide amplification primers and detection probes specific for the amplification and detection of pathogenic organisms, including for example, specific Influenza A H1N1 viral isolates. Also disclosed is a biological organism identification kit including the disclosed nucleic acid probes and primers, as well as thermal cycling reagents that is both portable and durable, and may also be self-contained for remote, or in-field analysis and identification of particular influenza isolates from a variety of biological specimen types. | 01-14-2010 |
| 20110281754 | COMPOSITIONS AND METHODS FOR DETECTING, IDENTIFYING AND QUANTITATING MYCOBACTERIAL-SPECIFIC NUCLEIC ACIDS - Disclosed are compositions and methods for isolating, detecting, amplifying, and quantitating | 11-17-2011 |
| 20120088231 | Biological Specimen Collection/Transport Compositions and Methods - Disclosed are compositions for collecting, storing, and transporting populations of nucleic acids from biological specimens, and clinical, forensic, or environmental samples. Also disclosed are methods for using these compositions as one-step formulations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or assay. In particular embodiments, the invention provides a single, one-step, sample collection/transport/storage formulation containing a known quantity of a non-genomic, nucleic acid carrier molecule that serves as an internal reference control to monitor the fidelity of the collection/transportation medium, and measure the integrity of nucleic acids subsequently isolated and purified from the processed sample. | 04-12-2012 |
| 20120100529 | Biological Specimen Collection and Transport System and Methods of Use - Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using these compositions as one-step formulations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or assay. The disclosed compositions safely facilitate rapid sample collection, and provide extended storage and transport of the samples at ambient or elevated temperature without contamination of the sample or degradation of the nucleic acids contained therein. This process particularly facilitates the collection of specimens from remote locations, and under conditions previously considered hostile for preserving the integrity of nucleic acids released from lysed biological samples without the need of refrigeration or freezing prior to molecular analysis. | 04-26-2012 |
| 20120107799 | DISPOSABLE, RAPID EXTRACTION APPARATUS AND METHODS - An extraction apparatus and methods adapted to extract and preferably also isolate structures of interest from a test sample. The extraction apparatus contains a volume-dispensing mechanism that facilitates control over the injection of a sample suspected of containing a structure of interest into a filtration vessel that contains a membrane filter that associates with the structure of interest, preferably by adsorbing or binding thereto, and a collection container associated therewith. Methods of extracting, isolating, testing, and instructions regarding such methods are also included. | 05-03-2012 |
| 20120115126 | Compositions and Methods for Rapid, Real-Time Detection of Influenza A Virus (H1N1) Swine 2009 - Disclosed are oligonucleotide amplification primers and detection probes specific for the amplification and detection of pathogenic organisms, including for example, specific Influenza A H1N1 viral isolates. Also disclosed is a biological organism identification kit including the disclosed nucleic acid probes and primers, as well as thermal cycling reagents that is both portable and durable, and may also be self-contained for remote, or in-field analysis and identification of particular influenza isolates from a variety of biological specimen types. | 05-10-2012 |
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| 20080208196 | Method and device for restoring spinal disc function - The present invention relates to medical device, system and methods for restoring spinal disc function. The invention provides a curved path trough the vertebra into the disc through which the disc can be filled with an augmenting substance, balloon, or pallets. Further can the delivery device be used to access the disc with surgical instrumentation. The invention furthermore discloses a responsive disc augmentation system. | 08-28-2008 |
| 20100036495 | Device and method for treating spine - A device for treating a spine includes a proximal component positioned partially or entirely within a first vertebra and a distal component positioned partially or entirely within a second vertebra and may also include an intermediate component. A method for treating a spine includes forming a curved channel that extends through a first vertebra from a pedicle to an endplate, and advancing the components through the curved channel, the orientation of the proximal component relative to the distal component changing by at least 40 degrees while the proximal component passes through the curved channel. In another aspect, a method for treating a spine includes forming a curved channel that has a pedicle region, a central region, and an endplate region, where the channel diameter for the central region is larger than the channel diameter for the pedicle region or the endplate region, and advancing an implant through the channel. | 02-11-2010 |
| 20100119582 | Device for the Treatment and Prevention of Disease, and Methods Related Thereto - Disclosed are implantable devices for delivering a drug into the blood stream of a vessel or into the vessel wall of a subject's body to treat or prevent vascular or cardiovascular disease, such as vascular plaque, cardiovascular plaque, and diseases attributable to inflammation, such as arteriosclerosis, diabetes, rheumatoid arthritis, and Alzheimer's disease. The devices of the present invention comprise a biodegradable matrix that degrades gradually and vanishes over a period of time, and have a ring-like, flag-like, or plaster-like configuration. The flag-like configuration comprises a holding structure and at least one flag. These flags are preferably elastic, and may be constructed from fibers, woven tissue, strings, sheets, or any combination thereof. Disclosed devices may comprise more than one drug, or varying concentrations of the same drug. Also disclosed are methods related thereto. | 05-13-2010 |
| 20100274375 | Method and system for making reliefs and sculptures - Disclosed is a method and system for creating a relief or sculpture from an object. More specifically the present invention relates to methods for creating a relief or sculpture from a human model utilizing software to reconstruct a 3D data set from 2D images of the human model and shaping the relief or sculpture using computer numerical controlled milling machines. | 10-28-2010 |
| 20110137381 | Treatment of neurological disorders via electrical stimulation, and methods related thereto - Disclosed are medical devices for the prevention and/or treatment of neurological disorders via electrical stimulation, and methods related thereto. The devices may also be utilized to detect disorders before the prevention or treatment of a neurological disorder. These devices are minimally or non-invasive. The present medical devices comprise various components, which include electrodes and control electronics. The electrodes are targeting electrodes constructed from ring type structures or virtually connected disc type arrays. The electrodes are located entirely outside the skull. The present medical devices also comprise one or more subsystems, a control system, a battery unit, and wires connecting the one or more subsystems. These devices may also be used for acute seizure control. | 06-09-2011 |
