Datta, NJ
Antara Datta, Hillsborough, NJ US
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20120190046 | DEK as a urine based biomarker for bladder cancer - The present invention is directed to a method of detecting DEK protein in a urine sample. Methods and compositions are provided herein for detecting and diagnosing bladder cancer by chemical-induced precipitation of urine proteins, followed by filtration-induced concentration and Western blot analysis to specifically detect DEK protein. The present method permits specific detection of DEK protein in urine as a biomarker for bladder cancer in humans. | 07-26-2012 |
20120196305 | Detection of a specific DEK isoform as a urine-based biomarker for bladder cancer - The present invention is directed to a method of detecting a DEK protein isoform 2 in a human urine sample using ELISA. Methods and compositions for detection of DEK isoform 2 in human urine are provided herein. The presence of DEK isoform 2 in urine is shown to correlate with bladder cancer in humans. | 08-02-2012 |
Antara Datta, Piscataway, NJ US
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20140295463 | ELISA Detection of Urine DEK to Predict and Diagnose Bladder Cancer in Humans - The present invention is directed to a method of detecting a DEK protein in a human urine sample using an ELISA assay. Methods and compositions for detection of DEK using mAb 260-6F9F6 (as detection antibody) and mAb 16-2C9C3 (as capture antibody) in human urine are provided herein. Specifically, the ELISA assay utilizes a capture mAb and a detection mAb to yield a high sensitivity of <50 ng/mL. The presence of DEK in urine is useful in predicting or diagnosing the occurrence of bladder cancer in humans. | 10-02-2014 |
Arindam Datta, Hillsborough, NJ US
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20080281350 | Aneurysm Occlusion Devices - An implantable occlusion device for bridging the neck of an aneurysm comprises a biocompatible matrix. The device is movable between a compressed position prior to implantation and a generally concave or cup-shaped position following implantation. The device may comprise a frame having a plurality of elements. The frame elements have a first pre-deployment position generally parallel to a major axis of the delivery lumen, and a second post-deployment position spread radially from the major axis of the delivery lumen. The biocompatible matrix and/or the frame elements may also form or be manipulated to form a generally concave or cupped shape. The matrix can be porous or semiporous, such as a foam or a reticulated matrix. The occlusion device can be folded, twisted and/or stretched to adopt a narrow profile for loading into a coaxial delivery device and expand in place as it adopts its original shape on release. The device may be released or manipulated to a desired shape to occlude an aneurysm. Methods of using the implantable device are also provided. | 11-13-2008 |
20090297582 | VASCULAR OCCLUSION DEVICES AND METHODS - A device for in situ treatment of vascular or cerebral aneurysms comprises an occlusion device having a flexible, longitudinally extending elastomeric matrix member that assumes a non-linear shape to conformally fill a targeted site. The occlusion device comprises a flexible, longitudinally extending elastomeric matrix member, wherein the device assumes a non-linear shape capable of fully, substantially, or partially conformally filling a targeted vascular site. In one embodiment the vascular occlusion device comprises a first longitudinally extending structural element having a longitudinally extending lumen and an outer surface; a second longitudinally extending structural element extending through the lumen; and an elastomeric matrix member surrounding the outer surface, wherein the second structural member does not engage or attach to the first structural element or the elastomeric matrix. | 12-03-2009 |
20090318941 | Self-Expandable Endovascular Device For Aneurysm Occlusion - The self-expandable endovascular apparatus for aneurysm occlusion of the invention comprises a deformable shape memory frame with at least a partial segment covering comprised of a matrix implant material. The device can be folded and/or stretched to adopt a narrow profile for loading into a coaxial delivery device and expands in place as it adopts its original shape on release from the device into an aneurysm. A method of treating an aneurysm, comprises the steps of: (a) providing the self-expandable endovascular apparatus inserted into a lumen of a delivery device comprising a proximal end and a distal end, the distal end having a distal tip; (b) advancing the distal tip of the delivery device into an opening in an aneurysm having an interior sac; (c) advancing the apparatus through the lumen into the opening; and (d) withdrawing the delivery device, whereby the apparatus expands into the sac and covers the opening. | 12-24-2009 |
20090319046 | HYOID SUSPENSION FOR OBSTRUCTIVE SLEEP APNEA - In an improved method for surgically treating a sleep-related breathing disorder, comprising hyoid distruction/expansion and hyo-mandibular suspension, an implant comprises a polypropylene and/or reticulated elastomeric biostable polyurethane matrix. The matrix is positioned between two or more segments of the distructed hyoid bone. A single or multiple midline or paramedian incisions are made under a patient's chin; soft tissues overlying the mandible are cleaned; a first screw is inserted into the edge of the mandible; a second screw is inserted into the inferior edge of the mandible; a second horizontal incision is made over the body of the hyoid; the infrahyoid muscles are separated from the body of the hyoid bone; the hyoid is refracted and stabilized; the sternohyoid and thyrohyoid muscles are detached from the body of the hyoid between the lesser cornuae; the hyoid bone is divided midline or paramedian into two or more segments; and an absorbable or nonabsorbable, rigid or semirigid, implant is positioned between segments of the hyoid bone. The hyoid bone is stabilized by the implant; and sutures or portions of polypropylene and/or polyurethane matrix are passed around the hyoid bone segments and implant to connect to muscle still attached to the upper portion of the hyoid bone, wherein the hypopharyngeal airway is expanded. | 12-24-2009 |
20100249913 | Reticulated elastomeric matrices, their manufacture and use in implantable devices - This invention relates to biodurable, reticulated elastomeric matrices that are resiliently-compressible, their manufacture and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for therapeutic, nutritional, or other useful purposes. | 09-30-2010 |
20100318108 | COMPOSITE MESH DEVICES AND METHODS FOR SOFT TISSUE REPAIR - A composite implantable device for promoting tissue ingrowth therein comprising a biodurable reticulated elastomeric matrix having a three-dimensional porous structure having a continueous network of interconnected and intercommunicating open pores and a support structure is disclosed. The support structure may be a polymeric surgical mesh comprising a plurality of intersecting one-dimensional reinforcement elements, wherein said mesh is affixed to a face of said first matrix. Methods of making and using the implantable device are also provided. | 12-16-2010 |
20110014289 | Reticulated Elastomeric Matrices, Their Manufacture and Use in Implantable Devices - This invention relates to biodurable, reticulated elastomeric matrices that are resiliently-compressible, their manufacture and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for therapeutic, nutritional, or other useful purposes. | 01-20-2011 |
20110184530 | High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair - This invention relates to reticulated elastomeric matrices, their manufacture, their post-processing, such as their reinforcement, compressive molding or annealing, and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for surgical devices, tissue augmentation, tissue repair, therapeutic, nutritional, or other useful purposes. | 07-28-2011 |
20120239161 | AT LEAST PARTIALLY RESORBABLE RETICULATED ELASTOMERIC MATRIX ELEMENTS AND METHODS OF MAKING SAME - The present disclosure relates to reticulated elastomeric matrices, and more particularly to at least partially degradable elastomeric elements that are compressible and exhibit resilience in their recovery and that can be employed in diverse applications including, without limitation, biological implantation, especially in humans. | 09-20-2012 |
Debarshi Datta, Old Bridge, NJ US
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20080222121 | System for Adaptively Querying a Data Storage Repository - An input processor receives a plurality of different first query messages in a corresponding plurality of different formats. A repository includes stored data elements in a first storage data structure. An intermediary processor automatically: parses the plurality of first query messages to identify requested data elements; maps the identified requested data elements to stored data elements in the first storage data structure of the repository; generates a plurality of second query messages in a format compatible with the repository for acquiring the stored data elements; acquires the stored data elements from the repository using the generated plurality of second query messages; and processes the acquired stored data elements in the plurality of second query messages for output in a format compatible with the corresponding plurality of different formats of the first query messages. | 09-11-2008 |
20090125334 | Method and System for Radiation Oncology Automatic Decision Support - A method for providing automatic decision support for the selection of a treatment protocol includes receiving information pertaining to the patient, the condition and the preferences partially or wholly by automatically parsing patient records. The information pertaining to the patient, the condition and the preferences may be partially or wholly ascertained by prompting a user for manual input of the desired data. The information is used to calculate one or more surrogate variables. A knowledge base including a plurality of treatment protocols is accessed and one or more of the plurality of treatment protocols are selected from the knowledge base based on the received information pertaining to the patient, the condition, and the preferences, the surrogate variables, and using a probabilistic framework. The selected treatment protocols are provided as treatment guidance. | 05-14-2009 |
Shubhashish Datta, Princeton, NJ US
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20120043584 | Low-noise large-area photoreceivers with low capacitance photodiodes - A quad photoreceiver includes a low capacitance quad InGaAs p-i-n photodiode structure formed on an InP (100) substrate. The photodiode includes a substrate providing a buffer layer having a metal contact on its bottom portion serving as a common cathode for receiving a bias voltage, and successive layers deposited on its top portion, the first layer being drift layer, the second being an absorption layer, the third being a cap layer divided into four quarter pie shaped sections spaced apart, with metal contacts being deposited on outermost top portions of each section to provide output terminals, the top portions being active regions for detecting light. Four transimpedance amplifiers have input terminals electrically connected to individual output terminals of each p-i-n photodiode. | 02-23-2012 |
Souptik Datta, Jersey City, NJ US
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20130191329 | SYSTEMS, METHODS AND SOFTWARE FOR ENTITY RELATIONSHIP RESOLUTION - A method includes receiving an entity record, wherein the entity record comprising at least one entity field element, and resolving the entity record to an authority record being associated with an initial authority file, wherein the authority record comprising at least one authority field element. The method further includes calculating a field element update measurement, the field element update measurement being associated with the at least one entity field element and the at least one authority field element and if the field element update measurement meets or exceeds a threshold, updating the authority record, or if the field element update measurement does not meet or exceed a threshold, not updating the authority record. The method further includes developing, in response to updating the authority record, an updated authority file associated with at least one updated authority record. The method also includes incorporating an additional authority record to the updated authority file. | 07-25-2013 |
Souptik Datta, Cedar Grove, NJ US
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20150161191 | SYSTEMS, METHODS AND SOFTWARE FOR ENTITY RELATIONSHIP RESOLUTION - A method includes receiving an entity record, wherein the entity record comprising at least one entity field element, and resolving the entity record to an authority record being associated with an initial authority file, wherein the authority record comprising at least one authority field element. The method further includes calculating a field element update measurement, the field element update measurement being associated with the at least one entity field element and the at least one authority field element and if the field element update measurement meets or exceeds a threshold, updating the authority record, or if not, not updating the authority record. The method further includes developing, in response to updating the authority record, an updated authority file associated with at least one updated authority record. The method also includes incorporating an additional authority record to the updated authority file. | 06-11-2015 |