Patent application number | Description | Published |
20150355685 | SEALED STORAGE CANISTER - A sealed storage canister is provided. The sealed storage canister in one example includes a sealed enclosure configured to be substantially hermetically sealed for retaining a predetermined gas or gas mixture, multiple unsealed Hard Disk Drives (HDDs) located within the sealed enclosure, with the multiple unsealed HDDs configured to allow the predetermined gas or gas mixture to move through the multiple unsealed HDDs, at least one mounting element configured to receive the multiple HDDs, and an external connector configured to be externally accessible, with the external connector being directly or indirectly electrically coupled to the multiple unsealed HDDs. | 12-10-2015 |
20150359115 | STORAGE CANISTER WITH MULTIPLE STORAGE DEVICE MOUNTING ELEMENTS - A storage canister is provided. The storage canister in one example includes an enclosure, multiple Hard Disk Drives (HDDs) located within the enclosure, a plurality of mounting elements configured to receive the multiple HDDs, wherein each mounting element of the plurality of mounting elements is configured to receive a HDD, a plurality of suspension elements supporting the plurality of mounting elements, with each suspension element of the plurality of suspension elements supporting and providing vibration isolation to a corresponding HDD of the multiple HDDs, and an external connector configured to be externally accessible, with the external connector being electrically coupled to the plurality of mounting elements. | 12-10-2015 |
Patent application number | Description | Published |
20100304436 | Fucosylation-Deficient Cells - An isolated nucleic acid encoding an FX protein having a serine at position | 12-02-2010 |
20130164786 | FUCOSYLATION-DEFICIENT CELLS - An isolated nucleic acid encoding an FX protein having a serine at position | 06-27-2013 |
20130323788 | PRODUCTION CELL LINE ENHANCERS - The present invention relates to discovery of the ectopic expression of EDEM2 in a production cell to improve the yield of a useful multi-subunit protein. Thus, the present invention provides for production cell lines, such as the canonical mammalian biopharmaceutical production cell—the CHO cell, containing recombinant polynucleotides encoding EDEM2. Also disclosed is a production cell containing both an EDEM2-encoding polynucleotide as well an XBP1-encoding polynucleotide. Improved titers of antibodies produced by these cell lines are disclosed, as well as the improved cell densities attained by these cells in culture. | 12-05-2013 |
20140072979 | ISOLATING CELLS EXPRESSING SECRETED PROTEINS - A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule. | 03-13-2014 |
20140072980 | ISOLATING CELLS EXPRESSING SECRETED PROTEINS - A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule. | 03-13-2014 |
20140134719 | RECOMBINANT CELL SURFACE CAPTURE PROTEINS - Recombinant cell surface capture proteins and detection molecules that are useful for isolating and detecting cells that produce a secreted heterodimeric protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain are provided. Recombinant cell surface capture proteins and detection molecules that isolate and detect bispecific antibodies are also provided. The invention also provides recombinant antigen-binding proteins that are capable of recognizing and binding to proteins of interest that contain a CH3 domain and/or a modified CH3 domain, such as a CH3 domain with or without amino acid substitutions at H95 and Y96 (IMGT). | 05-15-2014 |
20150175688 | PRODUCTION CELL LINE ENHANCERS - The present invention relates to discovery of the ectopic expression of EDEM2 in a production cell to improve the yield of a useful multi-subunit protein. Thus, the present invention provides for production cell lines, such as the canonical mammalian biopharmaceutical production cell—the CHO cell, containing recombinant polynucleotides encoding EDEM2. Also disclosed is a production cell containing both an EDEM2-encoding polynucleotide as well an XBP1-encoding polynucleotide. Improved titers of antibodies produced by these cell lines are disclosed, as well as the improved cell densities attained by these cells in culture. | 06-25-2015 |
20150299309 | PRODUCTION CELL LINE ENHANCERS - The present invention relates to discovery of the ectopic expression of EDEM2 in a production cell to improve the yield of a useful multi-subunit protein. Thus, the present invention provides for production cell lines, such as the canonical mammalian biopharmaceutical production cell—the CHO cell, containing recombinant polynucleotides encoding EDEM2. Also disclosed is a production cell containing both an EDEM2-encoding polynucleotide as well an XBP1-encoding polynucleotide. Improved titers of antibodies produced by these cell lines are disclosed, as well as the improved cell densities attained by these cells in culture. | 10-22-2015 |
20150299310 | PRODUCTION CELL LINE ENHANCERS - The present invention relates to discovery of the ectopic expression of EDEM2 in a production cell to improve the yield of a useful multi-subunit protein. Thus, the present invention provides for production cell lines, such as the canonical mammalian biopharmaceutical production cell—the CHO cell, containing recombinant polynucleotides encoding EDEM2. Also disclosed is a production cell containing both an EDEM2-encoding polynucleotide as well an XBP1-encoding polynucleotide. Improved titers of antibodies produced by these cell lines are disclosed, as well as the improved cell densities attained by these cells in culture. | 10-22-2015 |
20150353634 | PRODUCTION CELL LINE ENHANCERS - The present invention relates to discovery of the ectopic expression of EDEM2 in a production cell to improve the yield of a useful multi-subunit protein. Thus, the present invention provides for production cell lines, such as the canonical mammalian biopharmaceutical production cell—the CHO cell, containing recombinant polynucleotides encoding EDEM2. Also disclosed is a production cell containing both an EDEM2-encoding polynucleotide as well an XBP1-encoding polynucleotide. Improved titers of antibodies produced by these cell lines are disclosed, as well as the improved cell densities attained by these cells in culture. | 12-10-2015 |
Patent application number | Description | Published |
20140071895 | Network Selection Based On Customizing Crowdsourced Connection Quality Data - Embodiments select networks for connection based on application-specific quality scores. A request is received from an application for a network connection. Connection quality data for nearby networks is accessed. The connection quality data is derived from crowdsourced data. The connection quality data is adjusted based on a device context to produce an application-specific quality score for each of the networks. One or more of the networks are selected for connection based on the application-specific quality scores. In some embodiments, a single network connection endpoint is provided to the application to abstract connection management details from the application. | 03-13-2014 |
20150124641 | COMMUNITY WI-FI NETWORK JOINED ACCESS POINT CONFIGURATION - Various technologies described herein pertain to configuring an access point in a local network for operation in a community Wi-Fi network. The community Wi-Fi network includes access points in differing local networks that share respective network bandwidth capacities with member computing devices of the community Wi-Fi network. A request to join the access point to the community Wi-Fi network is transmitted from the access point to a community aggregation system. Responsive to the request, the community aggregation system transmits a firmware update to the access point. The access point installs the firmware update in memory of the access point. Moreover, responsive to installation of the firmware update, the access point can share network bandwidth capacity with the member computing devices of the community Wi-Fi network. Further, the community aggregation system supports transparent handoffs between access points in to the community Wi-Fi network. | 05-07-2015 |
20150124791 | DELIVERY OF SHARED WIFI CREDENTIALS - Various technologies described herein pertain to delivering shared WiFi credentials. According to various embodiments, at least one server computing device is configured to transmit shared WiFi credentials to a mobile device. The at least one server computing device receives a request, where the request includes data that identifies the mobile device. Moreover, the request indicates that the mobile device desirably receives credentials for a shared WiFi network. Responsive to receiving the request, the at least one server computing device determines that the mobile device is authorized to receive the credentials for the shared WiFi network based at least in part upon the data that identifies the mobile device. Moreover, the at least one server computing device transmits the credentials for the shared WiFi network to the mobile device responsive to determining that the mobile device is authorized to receive the credentials for the shared WiFi network. | 05-07-2015 |
20150127436 | COMMUNITY WI-FI NETWORK - Various technologies described herein pertain to joining a computing device in a local network to a community Wi-Fi network. The community Wi-Fi network includes disparate computing devices that share respective network bandwidth capacities with member consumer devices of the community Wi-Fi network. The computing device receives an opt-in signal indicating that the computing device desirably be added to the community Wi-Fi network. Responsive to receiving the opt-in signal, the computing device retrieves account parameters. The account parameters include data indicating a network bandwidth capacity allocated to the account, which is usable by the computing device. A shared portion of the network bandwidth capacity is determined based at least in part upon the parameters of the account. The computing device is configured to share the shared portion of the network bandwidth capacity for consumption by member consumer device(s). The computing device communicates with the member consumer device(s) over a Wi-Fi connection | 05-07-2015 |
20150127939 | SHARING BASED ON SOCIAL NETWORK CONTACTS - Various technologies described herein pertain to sharing Wi-Fi credentials based upon relationships in a computer-implemented social network. At least one server computing device of a Wi-Fi credential sharing service receives an identifier from a mobile device and credentials for a Wi-Fi network from the mobile device. The identifier identifies a user of the mobile device. Moreover, the credentials for the Wi-Fi network are desirably shared by the user. Further, contacts of the user are retrieved from the social network. The credentials for the Wi-Fi network are retained in respective accounts of the contacts of the user from the social network. Further, an account of a contact includes credentials for Wi-Fi networks shared with the contact. | 05-07-2015 |
20150139074 | Adaptive Generation of Network Scores From Crowdsourced Data - Embodiments generate and provide connection quality data for networks based on past performance of those networks. Network experience data and corresponding device context are received from a first set of mobile devices. The received data is processed to generate the connection quality data, which is distributed to a second set of mobile devices for use in selecting a network and establishing a connection. Feedback describing performance of the selected network is received and applied to adjust the previously generated connection quality data. In some embodiments, the connection quality data represents voice over Internet Protocol (VoIP) call quality. | 05-21-2015 |
20150139082 | Generating Sequenced Instructions For Connecting Through Captive Portals - Embodiments produce a set of instructions for connecting to a network through a network access point based on data crowdsourced from mobile computing devices. The crowdsourced data describes interactions between the mobile computing devices and the network access point when establishing a connection to the network. A cloud service analyzes the crowdsourced data to identify a set of instructions for association with the network access point. The mobile computing devices replay the set of instructions when subsequently attempting to connect to the network access point. | 05-21-2015 |
20150142946 | Applying Sequenced Instructions to Connect Through Captive Portals - Embodiments apply a set of sequenced instructions to connect to a network through a captive portal. A computing device detects a network access point and obtains the instruction set corresponding to the network access point. The instruction set is derived by a cloud service from crowdsourced data describing interactions between mobile computing devices and the network access point. Applying the instruction set includes performing actions such as navigating web pages to accept terms and conditions, provide user or device information, and more. | 05-21-2015 |
20150142947 | Configuring Captive Portals With a Cloud Service - Embodiments provision captive portals on network access points (NAPs). In response to a request from a NAP owner, a cloud service associates a NAP with the NAP owner and provides a control channel for configuring the NAP. The NAP owner inputs configuration settings describing the captive portal. The cloud service processes the configuration settings to generate configuration data. The cloud service transmits the configuration data to the NAP. The NAP applies the configuration data to configure the NAP. Some embodiments configure Wi-Fi hotspots with captive portals for gated access to the Internet. | 05-21-2015 |
20150142980 | Context-Based Selection of Instruction Sets for Connecting Through Captive Portals - Embodiments personalize a set of network access points (NAPs) acting as captive portals for each user and/or user device. A cloud service, or the user device, accesses context describing the user device. The context identifies at least one NAP, and may include accounting data. One of the NAP is selected for connection based on the context, and an instruction set associated with the selected NAP is provided for replay by the user device to connect through the NAP. In some embodiments, instructions within the instruction set are also personalized to the user and/or user device based on the context. | 05-21-2015 |