Patent application number | Description | Published |
20080269305 | Dual-acting antihypertensive agents - The invention is directed to compounds having the formula: | 10-30-2008 |
20080318951 | Dual-acting benzoimidazole antihypertensive agents - The invention is directed to compounds having the formula: | 12-25-2008 |
20090023228 | Dual-acting Imidazole antihypertensive agents - The invention is directed to compounds having the formula: | 01-22-2009 |
20100158921 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY - The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful. | 06-24-2010 |
20100179134 | PYRIMIDINEDIAMINE KINASE INHIBITORS - The present invention provides pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also provided are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders. | 07-15-2010 |
20110092551 | DUAL-ACTING IMIDAZOLE ANTIHYPERTENSIVE AGENTS - The invention is directed to compounds having the formula: | 04-21-2011 |
20110281925 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS - The invention is directed to compounds having the formula: | 11-17-2011 |
20120165381 | DUAL-ACTING IMIDAZOLE ANTIHYPERTENSIVE AGENTS - The invention is directed to compounds having the formula: | 06-28-2012 |
20120264752 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS - The invention is directed to compounds having the formula: | 10-18-2012 |
20120301486 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY - The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful. | 11-29-2012 |
20130012501 | PYRIMIDINEDIAMINE KINASE INHIBITORS - Disclosed embodiments provide pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders. | 01-10-2013 |
20130096162 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS - The invention is directed to compounds having the formula: | 04-18-2013 |
20130245087 | DUAL-ACTING IMIDAZOLE ANTIHYPERTENSIVE AGENTS - The invention is directed to compounds having the formula: | 09-19-2013 |
20130309228 | PYRIMIDINEDIAMINE KINASE INHIBITORS - Disclosed embodiments provide pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders. | 11-21-2013 |
20140024835 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS - The invention is directed to compounds having the formula: | 01-23-2014 |
20140107120 | DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS - The invention is directed to compounds having the formula: | 04-17-2014 |
20140163022 | PROTEIN KINASE C INHIBITORS AND USES THEREOF - This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions that include these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes. | 06-12-2014 |
20150065543 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS - The invention is directed to compounds having the formula: | 03-05-2015 |