Darrah
Erika Lynn Darrah, Baltimore, MD US
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20140127720 | HUMAN AUTOANTIBODIES SPECIFIC FOR PAD3 WHICH ARE CROSS-REACTIVE WITH PAD4 AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED DISEASES - In one or more embodiments, the present invention provides a novel biomarker which provides a link between a distinct clinical phenotype and a biochemical effect of an autoantibody on an enzyme implicated in disease pathogenesis. In particular, the present invention provides an isolated or purified human autoantibody to PAD3 protein. Methods of diagnosis of subjects for rheumatoid arthritis (RA) using these antibodies as well as diagnosis of the severity of RA in the subject, and methods for monitoring treatment of a subject with RA are also provided. The biomarkers provided herein are also useful in the diagnosis of connective tissue-interstitial lung disease (CT-ILD) in patients having or suspected of having RA. | 05-08-2014 |
20150198609 | HUMAN AUTOANTIBODIES SPECIFIC FOR PAD3 WHICH ARE CROSS-REACTIVE WITH PAD4 AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED DISEASES - In one or more embodiments, the present invention provides a novel biomarker which provides a link between a distinct clinical phenotype and a biochemical effect of an autoantibody on an enzyme implicated in disease pathogenesis. In particular, the present invention provides an isolated or purified human autoantibody to PAD3 protein. Methods of diagnosis of subjects for rheumatoid arthritis (RA) using these antibodies as well as diagnosis of the severity of RA in the subject, and methods for monitoring treatment of a subject with RA are also provided. The biomarkers provided herein are also useful in the diagnosis of connective tissue-interstitial lung disease (CT-ILD) in patients having or suspected of having RA. | 07-16-2015 |
Gordon Shannon Darrah, Acworth, GA US
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20110066970 | PROVIDING A VISUAL REPRESENTATION OF VARIOUS RESOURCES RELATED TO PASSAGES OF CLASSIC LITERATURE - Systems and methods for providing graphical representations of resources related to passages of classic literature are provided. According to one implementation, a graphical user interface (GUI) is provided in which the GUI includes a search field configured to enable a user to enter a search term. The search term may be recognized as a subject focus element. The GUI also includes a bloom diagram window configured to display an initial bloom diagram having the subject focus element at a center location and resource elements related to the subject focus element at locations surrounding the center location. A passage window is configured to display one or more passages of a classic literary work, wherein the passages related to the subject focus element. Also, the GUI includes a resource window configured to display a description of the resource elements. | 03-17-2011 |
20130219326 | PROVIDING A VISUAL REPRESENTATION OF VARIOUS RESOURCES RELATED TO PASSAGES OF CLASSIC LITERATURE - Systems and methods for providing graphical representations of resources related to passages of classic literature are provided. According to one implementation, a graphical user interface (GUI) is provided in which the GUI includes a search field configured to enable a user to enter a search term. The search term may be recognized as a subject focus element. The GUI also includes a bloom diagram window configured to display an initial bloom diagram having the subject focus element at a center location and resource elements related to the subject focus element at locations surrounding the center location. A passage window is configured to display one or more passages of a classic literary work, wherein the passages related to the subject focus element. Also, the GUI includes a resource window configured to display a description of the resource elements. | 08-22-2013 |
Harlan J. Darrah, Sparks, NV US
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20090048012 | Networked Gaming System and Method Providing Multiple Group Play Awards Based on Different Criteria - Disclosed are systems and methods for group play gaming including multiple variations of awards. Upon a triggering event, gaming machines operate in a group play mode which includes multiple award opportunities for each player which may include a grand prize award, one or more mystery prize awards, and one or more progressive awards. | 02-19-2009 |
20100203941 | BONUS GAMES COORDINATED OVER NETWORK - A bonusing game and method usable with games of chance in which all participating machines are synchronized so their independent bonus rounds play simultaneously. In one embodiment, one player terminal triggers a bonus round and is deemed a “seller” in a simulated auction, and all other active player terminals in a bank also participate as simulated “buyers.” The “seller” makes choices of items to sell which are communicated to the “buyers.” The “seller” watches as simulated bids are placed on their items, and “buyers” participate in simulated bidding of items shown on their screens. The seller and all buyers are awarded some winnings, enabling all players' terminals that run the simultaneous simulated auction bonus round to win each time the simulated auction bonus game is invoked. | 08-12-2010 |
20130172066 | NETWORK SYSTEM FOR COORDINATING BONUS GAMES - A bonusing game system and method usable with games of chance in which all participating machines are synchronized so their independent bonus rounds play simultaneously. In one embodiment, one player terminal triggers a bonus round and is deemed a “seller” in a simulated auction, and all other active player terminals in a bank also participate as simulated “buyers.” The “seller” makes choices of items to sell which are communicated to the “buyers.” The “seller” watches as simulated bids are placed on their items, and “buyers” participate in simulated bidding of items shown on their screens. The seller and all buyers are awarded some winnings, enabling all players' terminals that run the simultaneous simulated auction bonus round to win each time the simulated auction bonus game is invoked. | 07-04-2013 |
James F. Darrah, Austin, TX US
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20130335506 | MANAGING THE LAYOUT OF MULTIPLE VIDEO STREAMS DISPLAYED ON A DESTINATION DISPLAY SCREEN DURING A VIDEOCONFERENCE - A system includes a network interface for sending and receiving at least video data between two or more endpoints, where each endpoint includes a display screen. A camera may be located at more than one endpoint capturing video data. The system also includes a control unit for controlling spatial arrangement of one or more video data streams displayed on a display screen of one or more endpoints. The control unit determines a state and configuration of a videoconference and accesses a route description corresponding to the state and configuration of the videoconference. The route description includes a video data stream destination, one or more video data stream sources, and layout information determining the spatial arrangement of one or more video data streams displayed on the video data stream destination. | 12-19-2013 |
Jim Darrah, Austin, TX US
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20140267576 | INTELLIGENT LAYOUTS FOR CALL SCALING AND LAYOUT PERSISTENCE - Disclosed herein are methods, systems, and techniques for creating media conferencing layouts that are intelligent (i.e., based on some underlying principle to enhance user-perceived conference quality) and persistent (i.e., consistent within a call and from one call to the next). | 09-18-2014 |
Kaysi Darrah, Cartersville, GA US
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20150306904 | WALL APPLIQUE - Implementations of a wall appliqué are provided. In some implementations, a wall appliqué may be used to decorate and/or accent a wall or other suitable surface of a building. In some implementations, a wall appliqué may be used in lieu of traditional shoe moulding, panel moulding, ceiling moulding, door moulding, stair brackets, chair rails, and/or window moulding. In some implementations, the wall appliqué may be applied to a wall or other suitable surface with an adhesive. In some implementations, the wall appliqué comprises a body portion having a front side and a back side. In some implementations, the body portion may have a decorative shape. In some implementations, the front side may have a three-dimensional relief thereon. In some implementations, the wall appliqué may be manufactured from a flexible, polyurethane material. In this way, the wall appliqué may be applied to both flat and irregular surfaces. | 10-29-2015 |
Mark I. Darrah, Cumming, IA US
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20100305412 | Device and system for wireless monitoring of the vital signs of patients - The present invention relates generally to the field of vital signs monitors, and particularly to a device and system for wireless monitoring of the vital signs of a plurality of patients simultaneously yet independently. The present invention is particularly adaptable for use by medical emergency personnel or medics in any setting, such as road accident, disaster sites, combat zones, or hospitals. The systems and methods of the present invention allows the monitoring of a plurality of patients by a single health care professional providing more effective monitoring and care for a large number of patients at any one time, and retaining all the information for more effective later triage and decision making by health care providers. | 12-02-2010 |
Rebecca Darrah, Strongsville, OH US
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20090162855 | Identification of Genetic Variants Associated with Increased Severity of Pulmonary Disease - A method of determining a genetic component contributing to the severity of a pulmonary disease in a patient comprises determining the presence or absence of one or more single nucleotide polymorphisms (SNPs) in the Endothelin Receptor A (EDNRA) gene or the Interleukin-8 (IL-8) gene of the patient. The SNPs are rs5335 or rs1801708 for EDNRA, or rs4O73 for IL-8. The pulmonary disease may be cystic fibrosis or lymphangioleimyomatosis. Determining the presence or absence of one or more of SNPs rs5335 or rs1801708 in the EDNRA gene or rs4073 in the IL-8 gene of the patient may also be used in a method of treating a patient having a pulmonary disease. A kit may comprise one or more probes for determining the presence or absence of one or more of SNPs rs5335 and rs1801708 in the EDNRA gene or the SNP rs4073 in the IL-8 gene. | 06-25-2009 |
Thomas Darrah, Wilburton, PA US
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20120134749 | Using noble gas geochemistry to evaluate fluid migration in hydrocarbon bearing black shales - American energy costs steadily increase leading to increased unconventional energy use. However, scientific barriers prevent widespread and economic development of these resources. In gas shale plays, resource utilization is limited by the understanding of how hydrocarbons and other fluids migrate in fractured rock. This limits industry's ability to extract hydrocarbons with enhanced recovery methods; prevents exploration in areas where hydrocarbons do not collect in traditional traps; and could unfortunately lead to dangerous environmental consequences such as contaminated groundwater. To address these concerns, the present invention integrates geochemical and geostructural techniques in a novel method for evaluating and optimizing the placement and drilling strategies of extraction wells in hydrocarbon rich black shales. By correctly choosing hydrocarbon “sweet spots” companies can reduce the number of unprofitable wells, choose directional drilling and completion strategies to accurately reflect the subsurface, and better select prime small- and full-field reservoirs. | 05-31-2012 |
Thomas Henry Darrah, Durham, NC US
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20130091925 | Method for Determining the Genetic Fingerpring of Hydrocarbons and Other Geological Fluids using Noble Gas Geochemistry - Black shales differ from conventional gas plays in that in most cases there exists minimal geological scale gas migration. Thus, it is difficult to perform accurate reservoir characterization using classic geophysical and geological techniques (i.e. seismic analysis, gravity anomalies, structural geology, etc.). The principal technique that has traditionally been applied to determine the genetic history of gases or other fluids in the Earth's crust is the analysis of carbon isotopic composition of hydrocarbon gases and carbon dioxide, which has significant gaps in differentiating thermal and migrational histories. The present invention describes a method to determine the genetic fingerprint (i.e. identify the source formation and migration histories) of hydrocarbon gases or other crustal fluids of a geological system at lower cost and greater accuracy than existing methods (carbon and hydrogen isotopes) by analyzing the intrinsic, atmospheric and radiogenic (i.e. | 04-18-2013 |