| Patent application number | Description | Published |
|---|
| 20090081786 | Peptide sequences for modulation of protein kinase C - Peptides found within an annexin protein can be used to modulate the activity of a protein kinase C are described. More particularly, peptides within annexin I, V, and VI, as well as variants and conservatively modified variants thereof, are described, and use of these peptides to regulate cellular responses mediated by β-protein kinase C, δ-protein kinase C, and α-protein kinase C, respectively, are described. | 03-26-2009 |
| 20090124553 | Suppression of inflammation associated with transplantation using an epsilon PKC inhibitor - The described compositions and methods relate to the suppression of inflammatory responses following allograft transplantation by administering an inhibitor of epsilon protein kinases c (εPKC) following transplantation. | 05-14-2009 |
| 20090137493 | Inhibition of tumor metastases using protein kinase C (PKC) inhibitors - Described are methods for reducing tumor metastasis in an animal by administering an inhibitor of a protein kinase C (PKC) isozyme. | 05-28-2009 |
| 20090155236 | Peptide sequence for modulation of delta protein kinase c - A peptide identified from the annexin V protein sequence and having the ability to modulate the activity of delta protein kinase C (PKC) is described. The peptide and variants thereof bind to delta PKC and are effective to regulate delta PKC mediated cellular responses. In particular the annexin V peptide is able to inhibit protein-protein interaction with delta PKC, blocking intracellular translocation of delta PKC. Inhibition of delta PKC translocation confers protection to tissue at risk of exposure to ischemia or hypoxia or to reperfusion injury. | 06-18-2009 |
| 20100286050 | METHOD OF PREVENTING PROGRESSION OF HYPERTENSION-INDUCED HEART FAILURE WITH PKC PEPTIDES - Methods are described for slowing or inhibiting the progression of heart failure in a mammalian subject suffering from chronic hypertension. The methods involve administering an εPKC, β1PKC, or βIIPKC peptide inhibitor, examples of which are provided. | 11-11-2010 |
| 20110082085 | PEPTIDES DERIVED FROM THE C2 DOMAIN OF EPSILON PKC AND METHODS OF USE, THEREOF - Peptides derived from the C2 regions of εPKC and methods of use, thereof, are described. These peptides modulate the activity of εPKC in an animal model of acute ischemic heart disease. | 04-07-2011 |
| 20110144034 | INHIBITION OF TUMOR METASTASES USING PROTEIN KINASE C (PKC) INHIBITORS - Described are methods for reducing tumor metastasis in an animal by administering an inhibitor of a protein kinase C (PKC) isozyme. | 06-16-2011 |
