Inventors list |
Assignees list |
Classification tree browser |
Top 100 Inventors |
Top 100 Assignees |
Damiano, US
Bruce Damiano, Warrington, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090118258 | COMBINATION THERAPY COMPRISING ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND VASOPRESSIN RECEPTOR ANTAGONISTS - The present invention relates to certain pharmaceutical compositions containing at least one vasopressin receptor antagonist and at least one angiotensin converting enzyme (ACE) inhibitor and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of vasopressin and/or angiotensin converting enzyme mediated disorders. | 05-07-2009 |
Bruce Damiano, Lansdale, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100093701 | COMBINATION THERAPY COMPRISING ANGIOTENSIN RECEPTOR BLOCKERS AND VASOPRESSIN RECEPTOR ANTAGONISTS - The present invention relates to certain pharmaceutical compositions containing at least one vasopressin receptor antagonist and at least one angiotensin receptor blocker (ARB) and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of vasopressin and/or angiotensin-mediated disorders. | 04-15-2010 |
Bruce P. Damiano, Warrington, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100189654 | ANIMAL MODEL FOR EVALUATING VASOMOTOR RESPONSE IN VIVO - A method for evaluating the effect of a compound on vasomotor response in vivo comprises the steps of administering said compound to a rabbit and measuring the diameter of the vessel lumen of a central ear artery of said rabbit in comparison with the baseline diameter of the vessel lumen of said central ear artery of said rabbit, said baseline diameter being measured prior to the administration of said compound. | 07-29-2010 |
Edward Damiano, Acton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080208113 | Fully Automated Control System for Type I Diabetes - An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with an MPC algorithm to regulate blood glucose online, where the subject model is recursively adapted, and the control signal for delivery of insulin and a counter-regulatory agent such as glucagon is based solely on online glucose concentration measurements. The MPC signal is synthesized by optimizing an augmented objective function that minimizes local insulin accumulation in the subcutaneous depot and control signal aggressiveness, while simultaneously regulating glucose concentration to a preset reference set point. The mathematical formulation governing the subcutaneous accumulation of administered insulin is derived based on nominal temporal values pertaining to the pharmacokinetics (timecourse of activity) of insulin in human, in terms of its absorption rate, peak absorption time, and overall time of action. | 08-28-2008 |
| 20110106049 | FULLY AUTOMATED CONTROL SYSTEM FOR TYPE 1 DIABETES - An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with an MPC algorithm to regulate blood glucose online, where the subject model is recursively adapted, and the control signal for delivery of insulin and a counter-regulatory agent such as glucagon is based solely on online glucose concentration measurements. The MPC signal is synthesized by optimizing an augmented objective function that minimizes local insulin accumulation in the subcutaneous depot and control signal aggressiveness, while simultaneously regulating glucose concentration to a preset reference set point. The mathematical formulation governing the subcutaneous accumulation of administered insulin is derived based on nominal temporal values pertaining to the pharmacokinetics (time-course of activity) of insulin in human, in terms of its absorption rate, peak absorption time, and overall time of action. The MPC algorithm is also formulated to provide control action with an integral effect, and in essence minimizes overall drug consumption. When employed as a modulator in an automated integrated glucose-control system for type 1 diabetes, the control algorithm provides the system with self-learning capability that enables it to operate under unrestricted activity of the subject. | 05-05-2011 |
Jason Damiano, Emeryville, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080292620 | PRLR-Specific Antibody and Uses Thereof - PRLR-specific antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of preventing and treating cancer. | 11-27-2008 |
Jason Damiano, Moraga, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110150760 | PRLR-Specific Antibody and Uses Thereof - PRLR-specific antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of preventing and treating cancer. | 06-23-2011 |
Jason S. Damiano, La Jolla, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110008319 | CARD DOMAIN CONTAINING POLYPEPTIDES, ENCODING NUCLEIC ACIDS, AND METHODS OF USE - The invention provides caspase recruitment domain (CARD)-containing polypeptides, CARD, NB-ARC, ANGIO-R, LRR and SAM domains therefrom, as well as encoding nucleic acid molecules and specific antibodies. The invention also provides related screening, diagnostic and therapeutic methods. | 01-13-2011 |
John Damiano, Apex, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20110032611 | SPECIMEN MOUNT FOR MICROSCOPY - Devices, mounts, stages, interfaces and systems to be developed that allow for in situ manipulation, experimentation and analysis of specimens directly within an electron microscope. | 02-10-2011 |
John Damiano, Easton, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080236778 | Wire injection lance nozzle insert - A lance nozzle insert for a refractory lance for feeding an additive wire into a quantity of molten metal below the surface of the molten metal surface is made of a material comprising stabilized zirconium oxide and graphite substantially increasing the corrosion resistance of the lance nozzle insert. | 10-02-2008 |
| 20090057964 | Rotary lance - A process and apparatus for feeding an additive to a molten metal in a vessel to achieve a uniform dispersion of the additive are provided. In one example, the outlet of the lance is positioned below the surface of the molten metal. The lance is moved with a reciprocating motion, so that the outlet of the lance moves below the surface of the molten metal. The additive is dispensed through the outlet of the lance along a path traversed by the outlet in the molten metal while the lance reciprocates. | 03-05-2009 |
Robert F. Damiano, Lake Oswego, OR US
| Patent application number | Description | Published |
|---|---|---|
| 20080250376 | Integrating a boolean SAT solver into a router - One embodiment of the present invention provides a system that routes a set of pairs of points during the design of an integrated circuit (IC) chip. The system comprises a routing engine which is configured to search for a path to connect a current pair of points in the set of pairs of points, wherein the path comprises a set of rectangles and vertices. The routing engine uses a routing database, which keeps track of previously routed nets that can obstruct the routing of the current pair of points. The system further comprises a satisfiability (SAT) solver which is capable of solving a set of constraints, wherein the set of constraints are associated with the routability of the set of pairs of points. The SAT solver additionally comprises a SAT database which maintains the set of constraints and a current partial solution to the set of constraints. The SAT database is used to update the routing database if the current partial solution changes. | 10-09-2008 |