D'Amato, US
Andrea D'Amato, Kirkland, WA US
Patent application number | Description | Published |
---|---|---|
20090077562 | Client Affinity in Distributed Load Balancing Systems - Aspects of the subject matter described herein relate to client affinity in distributed load balancing systems. In aspects, a request from a requester is sent to each server of a cluster. Each server determines whether it has affinity to the requester. If so, the server responds to the request. Otherwise, if the request would normally be load balanced to the server, the server queries the other servers in the cluster to determine whether any of them have affinity to the requester. If one of them does, the server drops the request and allows the other server to respond to the request; otherwise, the server responds to the request. | 03-19-2009 |
20090327798 | Cluster Shared Volumes - Described is a technology by which a storage volume is shared by cluster nodes of a server cluster. In one implementation, each node includes a redirector that provides shared access to the volume from that node. The redirector routes file system metadata requests from applications and the like through a first (e.g., SMB) communications path to the owning node, and routes file system read and write data to the storage device through a second, high-speed communications path such as direct direct block level I/O. An owning node maintains ownership of the storage device through a persistent reservation mechanism that writes a key to a registration table associated with the storage device. Non-owning nodes write a shared key. The owning node validates the shared keys against cluster membership data, and preempts (e.g., removes) any key deemed not valid. Security mechanisms for controlling access are also described. | 12-31-2009 |
20100057923 | Maintaining Client Affinity in Network Load Balancing Systems - Described is a technology in a network load balancing system (node cluster), by which client affinity is preserved across cluster configuration changes, including for new connections from a previous client. Each node maintains a list of the clients that are to remain (have affinity, or “stickiness”) with that node, including following bucket redistribution resulting from convergence. Each affinity list is communicated during convergence so that other nodes may build an exception list or lists. Via a node's exception list, the node that owns a bucket corresponding to a client knows of the affinity with another node and thus drops any packets from that client. Affinity may expire, whereby the node having affinity with that client releases it and notifies the node owning the bucket for that client that the client is no longer to be treated as an exception. | 03-04-2010 |
20120158662 | BACKUP AND RESTORE OF DATA FROM ANY CLUSTER NODE - Implementing point in time back-up. A method that may be practiced in a distributed computing environment. The distributed computing environment includes a number of computing system nodes. The method includes at a first node in the computing environment, taking a snapshot of a cluster volume. The cluster volume stores data items (e.g. files/blocks). Taking a snapshot includes marking a point in time for data items in the volume. The method further includes receiving a notification that a different node in the computing environment than the first node, has determined to change a data item in the cluster volume at a point after the marked point in time from an old version of the data item to a new version of the data item. The method further includes at the first node, saving the old version of the data item prior to modification. | 06-21-2012 |
20120158681 | VOLUMES AND FILE SYSTEM IN CLUSTER SHARED VOLUMES - The present invention extends to methods, systems, and computer program products for sharing volumes between clustered nodes. Embodiments of the invention include a Clustered Shared Volume File System (CsvFs) that appears to clients as a local file system. The CsvFs communicates to a node where a disk is mounted to coordinate access to files on the disks. CsvFs uses Opportunistic Locks (oplocks) to decide when direct access to a volume is safe. CsvFs can be extended with oplock upgrade mechanisms that allow a coordinating node to tell CsvFs when it is safe to attempt to upgrade oplock. CsvFs also uses a transitivity property of oplocks to be able to grant (delegate) oplocks to clients that are on top of CsvFs. | 06-21-2012 |
20120159005 | COORDINATION OF DIRECT I/O WITH A FILTER - Coordinating methods of I/O access to a shared data store. A method includes at a node, in a distributed system, performing one or more I/O operations on the shared data store using direct I/O access on a virtual data container. Direct I/O access includes performing I/O operations directly from the node to the shared data store including not having an owner node perform the I/O operation on the shared data store on the node's behalf. The owner node is a different node than the node doing the direct I/O operation. The owner node accesses the shared data store through a local data container. The method further includes determining that one or more subsequent I/O operations should be performed using redirected I/O access, where I/O operations are directed through a centralized node. The method further includes indicating to nodes in the distributed system to switch to redirected I/O access method. | 06-21-2012 |
20120159021 | STORAGE TOPOLOGY MANAGER - Defining a storage topology of a distributed computing system including a set of machine nodes. A method includes dynamically receiving from a number of nodes in the distributed computing system information about storage devices. Each node sends information about storage devices connected to that particular node. The information is sent dynamically from each node as conditions related to storage change and as a result of conditions related to storage changing. From the received information, the method includes dynamically constructing a storage topology representation of the distributed computed system. | 06-21-2012 |
20120311003 | Clustered File Service - A cluster based file service may operate on a cluster of two or more independent devices that have access to a common data storage. The file service may have a namespace definition with each device in the cluster, but may be modified by any device operating the file service. Each instance of the file service may identify and capture a command that changes the namespace structure and cause the change to be propagated to the other members of cluster. If one of the devices in the cluster does not successfully perform an update to the namespace structure, that device may be brought offline. The cluster based file service may permit adding or removing devices from the cluster while the file service is operating, and may provide a high throughput and high availability file service. | 12-06-2012 |
20120311685 | DISTRIBUTED NETWORK NAME - Aspects of the subject matter described herein relate to a distributed network name. In aspects, computers of a cluster have components of a distributed network name service. The network name service has a leader and clones that are hosted on the computers of the cluster. The leader is responsible for updating a name server with network names and addresses of the computers. The leader is also responsible for configuring a security server that allows clients to securely access the computers. The network name service provides credentials to local security authorities of the computers so that a client that attempts to access a service of the computers can be authenticated. | 12-06-2012 |
20130067188 | STORAGE DEVICE DRIVERS AND CLUSTER PARTICIPATION - The representation of storage devices on computers (e.g., as logical volumes) may be complicated by the pooling of multiple storage devices in order to apply redundancy plans such as mirroring and checksumming. Presented herein is a storage device driver configured to operate as a storage device interface generating representations of the storage regions of the storage devices; to claim those regions as a storage controller; and to expose pooled storage regions as logical disks. Additionally, the storage device driver may support the inclusion of storage devices in a cluster, comprising nodes that may be appointed as managers of the storage pool configuration; as managers of the storage devices; as owners having exclusive read/write access to the storage pool or cluster resources; and as cluster resource writers having excusive write access to a cluster resource. The nodes of the cluster may interoperate to share the storage devices while avoiding write conflicts. | 03-14-2013 |
20130067267 | RESOURCE AWARE PLACEMENT OF APPLICATIONS IN CLUSTERS - Placing an application on a node in a cluster. A method includes detecting an unexpected event indicating that an application should be placed on a node in the cluster. Real time information about resource utilization on one or more nodes in the cluster is received. Based on the real time information, a determination of a node to place the application is made. The application is placed on the determined node. | 03-14-2013 |
20130166863 | APPLICATION CONSISTENT SNAPSHOTS OF A SHARED VOLUME - The present invention extends to methods, systems, and computer program products for creating a snapshot of a shared volume that is application consistent across various nodes of a cluster. The invention enables a snapshot of a volume to be initiated on one node which causes all applications in the cluster that use the volume to persist their data to the volume prior to the snapshot being created. Accordingly, the snapshot is application consistent to all applications in the cluster that use the volume. The invention also enables applications on various nodes to perform post snapshot processing on the created snapshot. The invention can be used in an existing backup system that is not cluster aware to enable the existing backup system to create application consistent snapshots of a volume shared by applications across multiple nodes of a cluster. | 06-27-2013 |
20130191453 | DYNAMIC QUORUM FOR DISTRIBUTED SYSTEMS - Managing a distributed system. Embodiments may allow for a quorum to dynamically change the quorum vote. One example is illustrated in a method. The method includes determining a change to a voter's level of participation in a cluster. A quorum of voters changes the voter's voting privileges, based on the change in the voter's level of participation. | 07-25-2013 |
20130219125 | CACHE EMPLOYING MULTIPLE PAGE REPLACEMENT ALGORITHMS - The present invention extends to methods, systems, and computer program products for implementing a cache using multiple page replacement algorithms. An exemplary cache can include two logical portions where the first portion implements the least recently used (LRU) algorithm and the second portion implements the least recently used two (LRU2) algorithm to perform page replacement within the respective portion. By implementing multiple algorithms, a more efficient cache can be implemented where the pages most likely to be accessed again are retained in the cache. Multiple page replacement algorithms can be used in any cache including an operating system cache for caching pages accessed via buffered I/O, as well as a cache for caching pages accessed via unbuffered I/O such as accesses to virtual disks made by virtual machines. | 08-22-2013 |
20130227009 | ARBITRATION OF DISK OWNERSHIP IN A STORAGE POOL - The present invention extends to methods, systems, and computer program products for implementing persistent reservation techniques for establishing ownership of one or more physical disks. These persistent reservation techniques can be employed to determine ownership of physical disks in a storage pool as well as in any other storage configuration. Using the persistent reservation techniques of the present invention, when a network partition occurs, a defender of a physical disk does not remove a challenger's registration key until the defender receives notification that the challenger is no longer in the defender's partition. In this way, pending I/O from applications executing on the challenger will not fail due to the challenger's key being removed until the proper ownership of the physical disk can be resolved. | 08-29-2013 |
20130346532 | VIRTUAL SHARED STORAGE IN A CLUSTER - The present invention minimizes the cost of establishing a cluster that utilizes shared storage by creating a storage namespace within the cluster that makes each storage device, which is physically connected to any of the nodes in the cluster, appear to be physically connected to all nodes in the cluster. A virtual host bus adapter (VHBA) is executed on each node, and is used to create the storage namespace. Each VHBA determines which storage devices are physically connected to the node on which the VHBA executes, as well as each storage device that is physically connected to each of the other nodes. All storage devices determined in this manner are aggregated into the storage namespace which is then presented to the operating system on each node so as to provide the illusion that all storage devices in the storage namespace are physically connected to each node. | 12-26-2013 |
20140007092 | AUTOMATIC TRANSFER OF WORKLOAD CONFIGURATION | 01-02-2014 |
20140281709 | RECOVERY OF APPLICATION FROM SNAPSHOT - The targeted recovery of application-specific data corresponding to an application without performing recovery of the entire volume. The recovery is initiated by beginning to copy the prior state of the content of an application-specific data container from a prior snapshot to the application-specific data container in an operation volume accessible by the application. However, while the content of the application-specific data container is still being copied from the snapshot to the application-specific data container, the application is still permitted to perform read and write operations on the application-specific data container. Thus, the application-specific data container appears to the application to be fully accessible even though recovery of the content of the application-specific data container is still continuing in the background. | 09-18-2014 |
20140310278 | CREATING GLOBAL AGGREGATED NAMESPACES FOR STORAGE MANAGEMENT - Embodiments are directed to creating global, aggregated namespaces for storage management and to providing consistent namespaces in a distributed storage system. In one scenario, a computer system defines data storage objects for each data storage node. The data storage objects uniquely identify storage elements of the data storage nodes, where each data storage object includes various associated attributes. The computer system replicates the defined data storage objects and any associated attributes from a first data storage node to a second, different data storage node among the data storage nodes. As such, the defined data storage objects are visible from any node in the data storage nodes. The computer system also aggregates the defined data storage objects for each of the data storage nodes and creates a global, aggregated namespace that includes the aggregated data storage objects for each of the data storage nodes. | 10-16-2014 |
20140359054 | Distributed Storage Defense in a Cluster - Embodiments provide a method and system for enabling access to a storage device. Specifically, a node may request admittance to a cluster that has read and write access to a storage device. The node seeking access to the storage device must be first be approved by other nodes in the cluster. As part of the request, the node seeking access to the storage device sends a registration key to a storage device. Upon expiration of a registration timer, the node seeking access to the storage device receives a registration table from the storage device and determines whether its registration key is stored in the registration table. If the registration key is stored in the registration table the node has been accepted in the cluster and as a result, has been granted read and write access to the storage device. | 12-04-2014 |
20140359612 | Sharing a Virtual Hard Disk Across Multiple Virtual Machines - Embodiments provide a method and system for sharing storage among a plurality of virtual machines. Specifically, one or more embodiments are directed to sharing a virtual hard disk with various virtual machines in a virtual machine cluster. In embodiments, a command is sent from a virtual machine to a local parser. The parser prepares the command for transport over a file system protocol. The command is sent to a remote file server using the file system protocol. When the command is received by the file server, the file server unpacks the command, determines features about the command and converts the command to a format that executes the command on the virtual shared storage. | 12-04-2014 |
Anthony Mario D'Amato, Canton, MI US
Patent application number | Description | Published |
---|---|---|
20140316656 | STEERING SYSTEM CLATTER MITIGATION - A steering system clatter mitigation apparatus and method. The clatter mitigation apparatus excites the steering system at a frequency within a range of an existing engine noise. The excitation of the steering system at a different frequency than the clatter sound greatly reduces the clatter sound. The sound produced by the excitation of the steering system is masked by the existing sound of the engine. | 10-23-2014 |
Cara E. D'Amato, Peekskill, NY US
Patent application number | Description | Published |
---|---|---|
20080215432 | METHOD AND APPARATUS FOR SERVING A MESSAGE IN CONJUNCTION WITH AN ADVERTISEMENT FOR DISPLAY ON A WORLD WIDE WEB PAGE - A method and apparatus for serving at least one message in conjunction with an advertisement for display on a World Wide Web page. The advertisement and message may be thematically related and displayed close to each other on the Web page. The advertisement and message may form all or part of a rich media file that is called when the Web page is served to a user device for display on the user device. The message may be tailored to include information specific to a user viewing the Web page, message and advertisement to direct the user's attention to the advertisement or otherwise enhance the advertisement. | 09-04-2008 |
20080215433 | METHOD AND APPARATUS FOR SERVING A MESSAGE IN CONJUNCTION WITH AN ADVERTISEMENT FOR DISPLAY ON A WORLD WIDE WEB PAGE - A method and apparatus for serving at least one message in conjunction with an advertisement for display on a World Wide Web page. The advertisement and message may be thematically related and displayed close to each other on the Web page. The advertisement and message may form all or part of a rich media file that is called when the Web page is served to a user device for display on the user device. The message may be tailored to include information specific to a user viewing the Web page, message and advertisement to direct the user's attention to the advertisement or otherwise enhance the advertisement. | 09-04-2008 |
Charles D'Amato, Kent, WA US
Patent application number | Description | Published |
---|---|---|
20140326373 | FURNITURE COVER ASSEMBLY - A furniture cover assembly comprising side portions interconnected to define an interior area, wherein at least one side portion has an edge portion adjacent to an access opening to the interior area. The edge portion has a belt tunnel with opposing first and second open ends. An adjustment member is adjacent to the first open end, and a belt is slideably disposed in the belt tunnel. The belt has first and second free end portions projecting from and exterior of the belt tunnel. The belt's first free end portion is adjustably connected to the adjustment member and forms a first adjustable loop exterior of the belt tunnel and is configured to connect to a support structure of a furniture unit when positioned in the interior area. The belt's second free end portion forms a second loop exterior of the belt tunnel adjacent to the second open end and is configured to connect to a second support structure of the furniture unit with the belt tunnel extending between the first and second support structures. | 11-06-2014 |
Dante Pietro D'Amato, Bedford, NH US
Patent application number | Description | Published |
---|---|---|
20080204578 | Image sensor dark correction method, apparatus, and system - A method of performing dark correction for signals generated by an image sensor is disclosed. Dark state signals are received from an image sensor and a dark correction ratio is determined for each pixel based on the dark state signals. Operational state signals are received from the image sensor and a pseudo dark signal is determined for each pixel based on the dark correction ratio and further based on the operational state signals. A corrected signal value based on the pseudo dark signal is determined. The method is capable of compensating for dark signals from the image sensor over a course of a series of measurements notwithstanding changes in temperature and exposure time. | 08-28-2008 |
David E. D'Amato, Wake Forest, NC US
Patent application number | Description | Published |
---|---|---|
20100246167 | FLASHLIGHT HOLDER AND ASSEMBLY - A flashlight assembly provides a convenient ability to turn the flashlight on and off, particularly for flashlights with a pressure activated power switch disposed on a rear portion of the flashlight. In one version, the flashlight assembly includes a flashlight holder that has a housing for receiving the flashlight's rear portion therein. The flashlight holder also has a handle connected to the housing that includes a support arm and an actuator arm. The support arm extends outwardly from the housing, while the actuator arm extends from the support arm back toward the housing, so as to overlie the power switch in spaced relation thereto. Disposed in this manner, the actuator arm is movable between depressed and released configurations. This movement allows the power switch to be selectively depressed and released, so as to turn the flashlight on and off. Other versions and methods are also disclosed. | 09-30-2010 |
Emily Catherine D'Amato, Grand Rapids, MI US
Patent application number | Description | Published |
---|---|---|
20150086480 | HETEROARYL INHIBITORS OF PDE4 - The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators. | 03-26-2015 |
Fernando D'Amato, Niskayuna, NY US
Patent application number | Description | Published |
---|---|---|
20110071692 | SYSTEM AND METHOD FOR SCHEDULING STARTUP OF A COMBINED CYCLE POWER GENERATION SYSTEM - A method for forecasting a start period for a combined cycle power generation system including a gas turbine engine, a steam turbine and a computer control system, the method including: inputting a desired time at which the power generation system is to reach a dispatchable load; inputting a current value of a predetermined operational condition of the power generation system; the computer control system retrieving historical data relating the predetermined operational condition to prior start periods of the power generation system or a similar power generation system; the computer control system executing an algorithm which generates a forecasted start time based on the desired time, current value and the retrieve data, wherein the power generation system is predicted to reach the dispatchable load at the desired time when started at the forecasted start time, and the computer system outputting the forecasted start time to the output device. | 03-24-2011 |
Fernando Javier D'Amato, Niskayuna, NY US
Patent application number | Description | Published |
---|---|---|
20090217665 | SYSTEMS AND METHODS FOR CHANNELING STEAM INTO TURBINES - A method of operating a steam turbine in a combined-cycle power system is provided. The method includes channeling a first amount of steam from a first steam generator to the steam turbine to facilitate powering the steam turbine, generating a second amount of steam within a second steam generator that is coupled in flow communication with the steam turbine, and calculating a predicted stress level within the steam turbine in the event the second amount of steam is channeled from the second steam generator into the steam turbine. An initiation time at which to channel the second amount of steam into the steam turbine is determined such that the calculated predicted stress level will not exceed a predetermined stress limit of the steam turbine. The second amount of steam is automatically channeled from the second steam generator to the steam turbine at the determined initiation time. | 09-03-2009 |
20090292436 | CONTROL OF COMBINED CYCLE POWER GENERATION SYSTEM - A control system for a combined cycle power generation system including a gas turbine engine (GT), a heat recovery steam generator (HRSG), and a steam turbine (ST) includes a display wherein an operator may observe information about predicted operating parameters; a user interface wherein an operator may provide additional operating constraints; and a controller configured to generate input profiles of the GT, the HRSG, and the ST that satisfy the nominal constraints and any additional constraints and to generate the information about the predicted operating parameters. The controller may be configured to detect a stage transition of power generation system operation and update the input profiles. The controller may be configured to generate alternative operating scenarios by mapping alternative control actions to an operating constraint of at least one of the system components. | 11-26-2009 |
20130116830 | Systems and Methods for Predicting Transient Operational Characteristics of a Power Plant - Certain embodiments of the invention may include systems and methods for predicting transient operational characteristics of a power plant. According to an example embodiment of the invention, a method is provided for predicting transient operational characteristics of a power plant. The method can include receiving operating information associated with the power plant; using a power plant dynamics model for determining a current operating state of the power plant based at least in part on the received operating information; and using the power plant dynamics model and a power plant controls model for predicting one or more future operating parameters associated with power plant based at least in part on the determined current operating state and the received operating information. | 05-09-2013 |
20140260288 | SYSTEM AND METHOD FOR START-UP OF A COMBINED CYCLE POWER PLANT - In accordance with one aspect of the present technique, a method is disclosed. The method includes modifying one or more operational parameters of a gas turbine (GT) to increase an exhaust gas temperature above a standard start-up temperature. The method also includes receiving at least one of GT operational data, heat recovery steam generator (HRSG) operational data, and steam turbine (ST) operational data from a plurality of sensors. The method further includes predicting a ST roll-off time based on at least one of the GT operational data, the HRSG operational data, and the ST operational data. The method further includes modifying the one or more operational parameters of the GT to satisfy one or more ST roll-off permissives at the predicted ST roll-off time. | 09-18-2014 |
James D'Amato, Glen Rock, NJ US
Patent application number | Description | Published |
---|---|---|
20110113974 | GRILL RACK SYSTEM - A grilling or cooking system is provided providing ready transport, rapid assembly, and secure use. A substantially rigid mounting member contains a plurality of stiffening elongate planar sections at off-set angles relative to one another. Outer opposed edges of outer opposed planar sections of the mounting member contain a respective plurality of mounting regions are shaped for receiving and removably portions of food to be grilled. The off-set angles aid for retention of the food members while serving to stiffen the system. The mounting regions are preferably a plurality of off-set slot members. The proposed cross-section structure allows for distribution of grilling fluid while securely regaining slippery food products during use. Removable and replaceable spring leg members engage opposing support holes on positions of planar sections on distal and proximate ends of the rigid mounting member, while also allowing easy cleaning, part replacement, and support of the food members at a fixed distance from a heat source. | 05-19-2011 |
Meryl D'Amato, Manalapan, NJ US
Patent application number | Description | Published |
---|---|---|
20100125926 | Protective swimwear garment/undergarment - This garment, undergarment and/or short is used as swimwear for any wearer from infant through adult, male or female. This garment, undergarment and/or short is used for but not limited to babies, children, adults, swimmers, beachgoers, sunbathers, surfers, bodyboarders, skimboarders, snorkelers, scuba divers, jetskiers, parasailers, sailors, waterskiiers, etc. | 05-27-2010 |
Nicholas C. D'Amato, Durham, NC US
Patent application number | Description | Published |
---|---|---|
20110085982 | DKAT CELL LINE, A MODEL FOR HUMAN TRIPLE-NEGATIVE BREAST CANCER - The present invention provides a human triple-negative breast cancer cell line designated DKAT. The DKAT cell line has a marker profile of high expression of Snail-1 and Snail-2 (Slug); and a p53 mutation in exon 8 at codon 273 (CGT>CAT). The present invention further provides methods of using the DKAT cell line. | 04-14-2011 |
Paul D'Amato, Grand Rapids, MI US
Patent application number | Description | Published |
---|---|---|
20090164588 | EMAIL CATEGORIZATION METHODS, CODING, AND TOOLS - An electronic mail management system is operable to receive electronic mail message components from a user. Prior to sending of the email message, a plurality of predetermined categories for classifying the electronic message are presented to the user. The email system receives a user selection from the predetermined categories. A determination is made as to whether or not the email recipient is a member of a predetermined class of recipients. The electronic mail is then sent to the recipient. The user selection is embedded within the email message if the recipient is a member of the predetermined class of recipients. Finally, the email is stored in a manner dependent upon the user selection. Similarly, the email management server may also be operable to categorize received email messages. Further, email messages may be selected or programmed to automatically be deleted upon certain events. | 06-25-2009 |
Peter L. D'Amato, Woodbury, CT US
Patent application number | Description | Published |
---|---|---|
20110087571 | System and Method for Providing Redundant Customer Communications Delivery Using Hybrid Delivery Channels - A system and method for providing redundant customer communications delivery using hybrid delivery channels is provided. In one configuration, the system utilizes an initial delivery channel to send a batch of customer communications and later utilizes a different, delayed backup delivery channel to resend only a subset of those communications as deemed necessary. | 04-14-2011 |
20140114828 | SYSTEM AND METHOD FOR PROVIDING REDUNDANT CUSTOMER COMMUNICATIONS DELIVERY USING HYBRID DELIVERY CHANNELS - A system and method for providing redundant customer communications delivery using hybrid delivery channels is provided. In one configuration, the system utilizes an initial delivery channel to send a batch of customer communications and later utilizes a different, delayed backup delivery channel to reseed only a subset of those communications as deemed necessary. | 04-24-2014 |
Raymond A. D'Amato, Enfield, CT US
Patent application number | Description | Published |
---|---|---|
20080311343 | Highly Resilient, Dimensionally Recoverable Nonwoven Material - A microcreped wet laid nonwoven with recoverable stretch suitable for apparel applications such as waistbands and interlinings. The microcreping and heat setting improves dimensional stability after washing and drying cycles, minimizes shrinkage and substantially eliminates the surface wrinkling phenomenon, known in the industry as “alligatoring”, associated with wet laid and other apparel nonwovens. | 12-18-2008 |
Robert D'Amato, Lancaster, PA US
Patent application number | Description | Published |
---|---|---|
20120142734 | METHODS FOR TREATING TUMORS WITH THALIDOMIDE - The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis and to treat disease states resulting from angiogenesis. Importantly, these compounds can be administered orally. | 06-07-2012 |
Robert D'Amato, Lexington, MA US
Patent application number | Description | Published |
---|---|---|
20100111894 | METAP-2 INHIBITOR POLYMERSOMES FOR THERAPEUTIC ADMINISTRATION - Described herein are MetAP-2 inhibitors and compositions and formulations thereof, and more particularly compositions and formulations of MetAP-2 inhibitors wherein the MetAP-2 inhibitor is associated with a block copolymer comprising a hydrophilic polymer moiety and a hydrophobic polymer moiety. The present invention also relates to compositions and formulations comprising MetAP-2 inhibitors for oral administration or administration via routes such as topical or ocular administration. The present invention also provides methods to treat conditions associated with or related to the over-expression or over-activity of MetAP-2 by administering the compositions and formulations comprising MetAP-2 inhibitors as disclosed herein. | 05-06-2010 |
20100158855 | METAP-2 INHIBITOR POLYMERSOMES FOR THERAPEUTIC ADMINISTRATION - The present invention provides methods to treating inflammation related disease and disorders such as an autoimmune disease and autoimmune related uveitis by administering compositions and formulations comprising MetAP-2 inhibitors as disclosed herein. The composition comprises a formulation of a fumagillol derivative that retains anti-inflammation activity and is associated with a block copolymer comprising a hydrophilic polymer moiety and a hydrophobic polymer moiety. | 06-24-2010 |
20110190210 | PROMININ-1 PEPTIDE FRAGMENTS AND USES THEREOF - Described herein are peptide compositions of a prominin-1, which have regenerative activity. As such the peptides are useful when regeneration is needed, for example, to enhance angiogenesis, increase VEGF binding to endothelial cells, promote vasodilation, enhance cell migration, enhance cell proliferation, stimulate neuronal growth, prevent neurodegeneration, and/or promote neuroregeneration. | 08-04-2011 |
20120114668 | METHOD FOR MODULATING ANGIOGENESIS USING FIBROMODULIN - Described herein are compositions and uses thereof to inhibit or enhance the activity of fibromodulin (FMOD). Such compositions are useful in methods for treatment of age-related macular degeneration involving choroid neovascularization in a subject comprising administering a therapeutically effective amount of a fibromodulin activity inhibitor to the subject. | 05-10-2012 |
20130045922 | PRO-ANGIOGENIC FRAGMENTS OF PROMININ-1 AND USES THEREOF - Described have herein are peptide analogs of a prominin-1 peptide, DRVQRQTTTVVA (SEQ. ID. NO:1) which have enhanced regenerative and/or angiogenesis activity, increase VEGF binding to endothelial cells, and/or increase wound healing activity relative to the peptide of SEQ ID NO: 1. Provided herein are fusion proteins and compositions comprising these pep tide analogs and uses thereof. | 02-21-2013 |
20140194358 | PROMININ-1 PEPTIDE FRAGMENTS AND USES THEREOF - Described herein are peptide compositions of a prominin-1, which have regenerative activity. As such the peptides are useful when regeneration is needed, for example, to enhance angiogenesis, increase VEGF binding to endothelial cells, promote vasodilation, enhance cell migration, enhance cell proliferation, stimulate neuronal growth, prevent neurodegeneration, and/or promote neuroregeneration. | 07-10-2014 |
20140301969 | METAP-2 INHIBITOR POLYMERSOMES FOR THERAPEUTIC ADMINISTRATION - The present invention provides methods to treating inflammation related disease and disorders such as an autoimmune disease and autoimmune related uveitis by administering compositions and formulations comprising MetAP-2 inhibitors as disclosed herein. The composition comprises a formulation of a fumagillol derivative that retains anti-inflammation activity and is associated with a block copolymer comprising a hydrophilic polymer moiety and a hydrophobic polymer moiety. | 10-09-2014 |
Robert J. D'Amato, Lexington, MA US
Patent application number | Description | Published |
---|---|---|
20080306113 | Methods for treating macular degeneration using 4-(amino)-2-(2,6-dioxo(3-piperidyle))-isoindoline-1,3-dione - Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione, or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, alone or in combination with a second active agent and/or surgery. | 12-11-2008 |
20090092652 | Method for the inhibition of angiogenesis or cancer using protective antigen related molecules - The present invention is based on the discovery that protective antigen related molecules (PARMs) without anthrax lethal factor have antiangiogenic or anticancer properties. The invention is directed to a method of inhibiting an angiogenic disease/disorder or cancer. Additionally, the invention can be applied to those at risk for developing cancer or an angiogenic disease/disorder comprising administering to a mammal an angiogenesis-inhibiting or cancer inhibiting amount of an PARM (including analogs, or derivative thereof having angiogenesis-inhibiting or anticancer activity, consisting of PA, PA fragment, analog, or derivative that is administered in a composition substantially free of anthrax lethal factor or other toxins). | 04-09-2009 |
20100280249 | SYNTHESIS OF 4-AMINO-THALIDOMIDE ENANTIOMERS - The invention provides new and useful analogs of 4-amino-thalidomide. These analogs include S(−)-4-amino-thalidomide and R(+)-4-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds. | 11-04-2010 |
Robert J. D'Amato, Cambridge, MA US
Patent application number | Description | Published |
---|---|---|
20090036412 | Methods and Compositions for Inhibition of Angiogenesis - The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis and to treat disease states resulting from angiogenesis. Additionally, antiinflammatory drugs, such as steroids and NSAIDs can inhibit angiogenesis dependent diseases either alone or in combination with thalidomide and related compounds. Importantly, these compounds can be administered orally. | 02-05-2009 |
Salvatore F. D'Amato, Mocksville, NC US
Patent application number | Description | Published |
---|---|---|
20090251749 | OVD CONTAINING DEVICE - A holographic overlay is provided, including: a polycarbonate substrate having a first side and a second side, a diffractive structure cast upon the first side of the polycarbonate substrate, and a reflection-enhancing coating on at least a part of the diffractive structure; wherein the second side of the polycarbonate substrate provides a substantially flat external surface of the overlay capable of fusing to a conforming surface in the presence of heat and pressure without an adhesive. Optionally, the overlay is laser-engraved so as to form ablated voids in the metal coating and carbonize the laser engravable polycarbonate under the ablated voids. According to another aspect of the invention, a metal coating on a hologram is made substantially transparent using a laser to form a transparent portion of a hologram. Optionally, it is done after applying the hologram to an object such as a card, a document, etc., in register with underlying information to ensure its visibility and continuity of the hologram. | 10-08-2009 |
20090324907 | TAMPER EVIDENT AND RESISTING INFORMATIONAL ARTICLE AND METHOD OF PRODUCING SAME - A method of protecting an informational article including providing an informational article substrate having a zone for inserting variable information within the zone, and securing a transparent tape, preferably see-through holographic layer having a write-resistant exposed surface over the information. | 12-31-2009 |
20130082458 | OVD CONTAINING DEVICE - A holographic overlay is formed using casting a diffractive structure upon a first side of a polycarbonate substrate, and providing a reflection-enhancing coating on at least a part of the diffractive structure. A second side of the substrate provides a substantially flat external surface of the overlay capable of fusing to a conforming surface in the presence of heat and pressure without an adhesive. Optionally, the overlay is laser-engraved so as to form ablated voids in the metal coating and carbonize the laser engravable polycarbonate under the ablated voids. | 04-04-2013 |