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Dai, MA
Chaoyang Dai, Acton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090137586 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): | 05-28-2009 |
| 20090156586 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): | 06-18-2009 |
| 20090170875 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): | 07-02-2009 |
| 20100120838 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): | 05-13-2010 |
| 20100145048 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): | 06-10-2010 |
| 20110123435 | COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY - The present invention relates to compounds of Formula (I), below, (wherein X, R1, R2, R3, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity. Formula I | 05-26-2011 |
| 20110150757 | COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY - The present invention relates to compounds of Formula (I), below, (wherein R1, R2, R3, R27, R28, R29, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity. | 06-23-2011 |
Guangping Dai, Action, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090030618 | SYSTEM, METHOD AND SOFTWARE ARRANGEMENT FOR ANALYZING AND CORRELATING MOLECULAR PROFILES ASSOCIATED WITH ANATOMICAL STRUCTURES - A system, method and software arrangement according to exemplary embodiments of the present invention are provided which can use molecular profiles obtained from unaltered human tissue specimens for clinical purposes including disease diagnoses and treatment evaluations. For example, spatial distributions of chemical species including metabolites within the tissue may be obtained using radiological techniques such as magnetic resonance spectroscopy imaging. Disease-specific profiles may be obtained by comparing the distributions of chemical species obtained in ex vivo tissues with pathological observations made on them using statistical analysis. The disease-specific profiles may then be correlated with in vivo or ex vivo molecular profiles to obtain spatial maps that can provide a more sensitive and accurate detection of diseased tissue. Thus, such exemplary systems, methods and software arrangements can include the ability to receive information relating to the distribution of at least three chemical species in the tissue of interest, compare this information statistically to a predetermined profile and, based on the statistical correlation between the information and the profile, determine certain characteristics of the tissue of interest such as, e.g., the presence or absence of diseased tissue. | 01-29-2009 |
Hongyue Dai, Chestnut Hill, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100169025 | METHODS AND GENE EXPRESSION SIGNATURE FOR WNT/B-CATENIN SIGNALING PATHWAY - Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of Wnt/β-catenin signaling pathway in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating Wnt/β-catenin pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated Wnt/β-catenin signaling pathway; determining whether an agent modulates the Wnt/β-catenin signaling pathway in sample; predicting response of a subject to an agent that modulates the Wnt/β-catenin signaling pathway; assigning treatment to a subject; and evaluating the pharmacodynamic effects of therapies designed to regulate Wnt/β-catenin pathway signaling. | 07-01-2010 |
| 20100284915 | GENES ASSOCIATED WITH CHEMOTHERAPY RESPONSE AND USES THEREOF - The invention provides molecular markers that are associated with responsiveness of a cancer patient to a chemotherapy treatment, and methods and computer systems for determining such responsiveness based on measurements of these molecular markers. The present invention also provides methods and compositions for enhancing the efficacy of chemotherapies in patients by modulating the expression or activity of genes encoding these molecular markers and/or their encoded proteins. | 11-11-2010 |
| 20110166200 | METHODS OF USING MIR210 AS A BIOMARKER FOR HYPOXIA AND AS A THERAPEUTIC AGENT FOR TREATING CANCER - The present invention provides compositions and methods for predicting the hypoxia response in tumor cells, methods for predicting the likelihood of cancer metastasis, and methods for inhibiting tumor cell proliferation using a microRNA comprising miR-210. | 07-07-2011 |
Jianwu Dai, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090162452 | EB Matrix Production From Animal Tissue And Its Use For Tissue Repair - A method of forming and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue to chemical and mechanical processing. In addition to skin tissue, another source of EBM is a blood vessel. EBM may be used for hernia repair, colon, rectal, vaginal and or urethral prolapse treatment; pelvic floor reconstruction; muscle flap reinforcement; lung tissue support; rotator cuff repair or replacement; periosteum replacement; dura repair; pericardial membrane repair; soft tissue augmentation; intervertebral disk repair; and periodontal repair. EBM may also be used as a urethral sling, laminectomy barrier or spinal fusion device. | 06-25-2009 |
Lillian Lei Dai, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080232344 | Systems and methods for synchronizing communication networks - In many aspects, the invention relates to systems and methods for synchronizing a communication network, particularly a slotted communication network, having a plurality of nodes. In slotted communication networks, the nodes are configured to transmit or receive data during selected time slots. During a selected time slot, each node transmits a synchronization message that is received by a neighboring node. The neighboring node adjusts its time slot boundary to coincide with the time of receipt of the synchronization message, thereby synchronizing each node with a neighboring node. Such systems and methods are energy efficient, accurate, fast, fault tolerant and easy to implement. | 09-25-2008 |
Miao Dai, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110015232 | Pyrrolydine Derivatives as IAP Inhibitors - The present invention relates to novel IAP inhibitor compounds of: Formula (I). | 01-20-2011 |
| 20110065726 | Organic Compounds - The present invention is directed to a compound of the formula: | 03-17-2011 |
Mingshi Dai, Billerica, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080269217 | Melanocortin-4 receptor binding compounds and methods of use thereof - Provided are MC4-R binding compounds of the formula XVII: | 10-30-2008 |
| 20090275556 | Aryl sulfonamides useful as inhibitors of chemokine receptor activity - The present invention provides compounds of general formula I: | 11-05-2009 |
Wei Dai, St. Beileme, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090150968 | Method and apparatus for managing and displaying contact authentication in a peer-to-peer collaboration system - Proper user-to-data associations are maintained in shared spaces created in a peer-to-peer collaborative system by means of a simplified and minimal user interface that permits users to easily authenticate other members of a shared space. In particular, support is provided for automatically building authenticated relationships even if users do not take the time to authenticate other users. When a user enters a shared space and views the contacts in that space, the display names of each contact are accompanied by distinctive icons that identify that authentication status of that contact. A mechanism is provided for resolving conflicts between contacts with the same display names to prevent confusion and contact “spoofing.” Security policies can be established to provide a uniform approach to authentication. These policies can be set by a user or, alternatively, the policies can be set by an administrator. | 06-11-2009 |
Wen Dai, Ashland, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090233225 | Low chlorine epoxy resin formulations - This invention relates to the need to improve the corrosion resistance of very low total chlorine epoxy resins which contain very low contents of organically bound chlorine. The invention relates to the improvement of corrosion resistance of such epoxy resins for electronic applications by the addition of specific additives acceptable to the electronics industry. The use of these low chlorine resins in combination with said additives has been shown to be corrosion-free on highly corrosive surfaces such as aluminum and copper, which are frequently encountered in electronic applications. | 09-17-2009 |
Yong Dai, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110021744 | PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES - The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step. | 01-27-2011 |
Yong Dai, Northborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110166319 | PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES - The invention provides processes for preparing a cell-binding agent chemically coupled to a drug. A first process comprises covalently attaching a linker to a cell-binding agent, an optional purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, and optional holding steps. A second process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, holding steps, and optionally a tangential flow filtration (TFF) step. | 07-07-2011 |