| Patent application number | Description | Published |
|---|
| 20090148862 | Evaluation method of organic or bio-conjugation on nanoparticles using imaging of time-of-flight secondary ion mass spectrometry - A method of evaluating conjugation between materials using imaging of time-of-flight secondary ion mass spectrometry (TOF-SIMS) according to the present invention is carried out by following the steps which comprise, a) forming a spontaneous pattern on a substrate with a mixture comprising nanoparticles and a conjugation material selected from organic, bio or inorganic material, b) obtaining an ion detection pattern from said conjugation material and said nanoparticles, respectively, depending on their position on the substrate by using time-of-flight secondary ion mass spectrometry, and c) determining whether the conjugation is formed between said conjugation material and said nanoparticles by comparing the ion detection pattern of said conjugation material with the ion detection pattern of said nanoparticles. | 06-11-2009 |
| 20100020318 | 3-Color multiplex cars spectrometer - The present invention relates to a 3-color multiplex CARS spectrometer. In the 3-color multiplex CARS spectrometer, Raman resonance is achieved for multiple molecular vibrations of a sample by the combination of a short-wavelength pump beam generated by a broadband laser light source and a long-wavelength Stokes beam generated by a stable laser light source, and another short-wavelength laser beam having a narrow linewidth is then introduced separately to serve as a probe beam that interacts with the laser-driven sample, thereby generating CARS spectral signals whose wavelength components can be resolved. Accordingly, the 3-color multiplex CARS spectrometer solves problem of the conventional 2-color multiplex CARS spectroscopy in which the wavelength decomposition of CARS signals, necessary for high spectral resolution, is not possible with broadband pump light causing the CARS spectrum distortion. | 01-28-2010 |
| 20100174145 | SPECTRALLY ENCODED COHERENT ANTI-STOKES RAMAN SCATTERING ENDOSCOPE - Disclosed is a spectrally encoded coherent anti-Stokes Raman scattering (CARS) endoscope that is capable of spatially encoding spectral dispersions of two light sources having frequency difference as much as a Raman shift and overlapping two laser beams on a position where a sample to be measured is placed, thereby acquiring a spatial distribution of CARS signals. | 07-08-2010 |
| 20110095179 | Disease Diagnosis Method, Marker Screening Method and Marker Using TOF-SIMS - The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/s) peaks of biological samples measured using a time-of- flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks. | 04-28-2011 |
| 20110101217 | Mass Spectrometric Method for Matrix-Free Laser Desorption/Ionization of Self-Assembled Monolayers - Disclosed is a method for carrying out matrix-free mass spectrometry, which includes subjecting an analyte sample containing a self-assembled monolayer on the surface of a substrate to laser desorption/ionization. The method for carrying out matrix-free mass spectrometry involves simple pretreatment of an analyte sample with a cationic solution without using any solid matrix to cause effective laser desorption/ionization of the analyte sample, and minimizes a biochemical and physiological change in the sample that may occur during the pretreatment of the sample. In addition, the method is applicable to quantitative analysis because it provides high reproducibility of the results by virtue of the uniform treatment with the cationic solution over the whole areas of the sample. Further, the method enables two-dimensional mapping analysis. | 05-05-2011 |
| 20110133081 | Spectrophotometer Using Medium Energy Ion - Provided is a spectrophotometer using medium energy ion. The spectrophotometer using medium energy ion is configured to include: an ion source | 06-09-2011 |
| 20110152119 | Quantification Method of Biochemical Substances Using Ion Scattering Spectroscopy and Specific-Binding Efficiency Quantification Method of Biochemical Substances Using Ion Scattering Spectroscopy - A method for direct quantification of the areal density (number per surface area of a substrate) of an analyte including a biochemical substance bound on the surface of a substrate and for direct quantification of the binding efficiency of biochemical substances is disclosed. Specifically, the areal density of an analyte including a biochemical substance bound on the surface of a substrate, and the binding efficiency between a first biochemical substance fixed on the substrate surface and a second biochemical substance is measured by ion scattering spectroscopy (ISS). | 06-23-2011 |
| 20110163228 | QUANTIFICATION METHOD OF FUNCTIONAL GROUPS OF ORGANIC LAYER - A quantification method of functional groups in an organic thin layer includes: a) measuring an absolute quantity per unit area of an analysis reference material having functional groups included in a reference organic thin layer by means of MEIS spectroscopy; b) carrying out spectrometry for the same reference organic thin layer as in a) and thereby obtaining peak intensities of the functional groups in the reference organic thin layer; c) carrying out the same spectrometry as in b) for an organic thin layer to be analyzed having the same functional groups and thereby measuring peak intensities of the functional groups with unknown quantity; and d) comparing the peak intensities of the functional groups measured in b) with respect to the absolute quantity of the analysis reference material in a) and thereby determining the absolute quantity per unit area of the functional groups with unknown quantity measured in c). | 07-07-2011 |
