Patent application number | Description | Published |
20090004302 | Methods and Therapeutic Compositions Comprising Plant Extracts for the Treatment of Cancer - A method of treating cancer by targeting two proteases, MMP-9 and cathepsin B is provided. Therapeutic compositions comprising one or more plant extracts that inhibit MMP-9 and/or cathepsin B, which are capable of inhibiting neoplastic and/or endothelial cell migration, tumour growth, tumour-induced angiogenesis and/or metastasis are also provided. The therapeutic compositions of the invention can be used in the treatment of cancer, and, methods of inhibiting tumour growth, tumour metastasis, and/or tumour-induced angiogenesis using the therapeutic compositions alone or in combination with an anti-cancer agent are, therefore, also provided. | 01-01-2009 |
20090068291 | Plant extracts and compositions comprising extracellular protease inhibitors - The present invention provides a plant derived extract comprising inhibitory activity against one or more extracellular proteases which degrade human tissue matrix. Moreover, the amount of inhibitory activity in an extract can be increased by stressing the plant prior to forming an extract. These extracts are each prepared by a standard process and demonstrate the ability to inhibit one or more extracellular proteases which degrade human tissue matrix. Libraries of extracts can be prepared from stressed and non-stressed plants, wherein each of the extracts demonstrate inhibitory activity against one or more extracellular protease inhibitors. Alternatively, semi-purified and purified inhibitory compounds can be isolated from the extracts following standard procedures. In one aspect, these extracts with inhibitory activity can be used during protein purification to minimize the degradation due to extracellular proteases. | 03-12-2009 |
20090263516 | Plant Extract Composition and Their Use to Modulate Cellular Activity - Extracts from plant material, or semi-purified/purified molecules or compounds prepared from the extracts that demonstrate the ability to modulate one or more cellular activities are provided. The extracts are capable of slowing down, inhibiting or preventing cell migration, for example, the migration of endothelial cells or neoplastic cells and thus, the use of the extracts to slow down, inhibit or prevent abnormal cell migration in an animal is also provided. Methods of selecting and preparing the plant extracts and methods of screening the extracts to determine their ability to modulate one or more cellular activity are described. The purification or semi-purification of one or more molecules from the described extracts is also contemplated as well as the use of these molecules, alone or in combination with an extract, to slow down, inhibit or prevent abnormal cell migration in an animal. | 10-22-2009 |
20110177014 | EXTRACTS FROM PLANTS OF THE TSUGA GENUS AND USES THEREOF IN THE TREATMENT OF INFLAMMATION, IRRITATION AND/OR INFECTION - Extracts derived from plants of the | 07-21-2011 |
20110217753 | INHIBITORS OF EXTRACELLULAR PROTEASES - Provided is a plant derived extract including inhibitory activity against one or more extracellular proteases which degrade human tissue matrix. Moreover, the amount of inhibitory activity in an extract can be increased by stressing the plant prior to forming an extract. These extracts are each prepared by a process and demonstrate the ability to inhibit one or more extracellular proteases which degrade human tissue matrix. Libraries of extracts can be prepared from stressed and non-stressed plants, where each of the extracts demonstrate inhibitory activity against on or more extracellular protease inhibitors. Alternatively, semi-purified and purified inhibitory compounds can be isolated from the extracts. In one aspect, these extracts with inhibitory activity can be used during protein purification to minimize degradation due to extracellular proteases. | 09-08-2011 |
20130316432 | INHIBITORS OF EXTRACELLULAR PROTEASES - Provided is a plant derived extract including inhibitory activity against one or more extracellular proteases which degrade human tissue matrix. Moreover, the amount of inhibitory activity in an extract can be increased by stressing the plant prior to forming an extract. These extracts are each prepared by a process and demonstrate the ability to inhibit one or more extracellular proteases which degrade human tissue matrix. Libraries of extracts can be prepared from stressed and non-stressed plants, where each of the extracts demonstrate inhibitory activity against on or more extracellular protease inhibitors. Alternatively, semi-purified and purified inhibitory compounds can be isolated from the extracts. In one aspect, these extracts with inhibitory activity can be used during protein purification to minimize degradation due to extracellular proteases | 11-28-2013 |
20140093596 | EXTRACTS FROM PLANTS OF THE TSUGA GENUS AND USES THEREOF IN THE TREATMENT OF INFLAMMATION, IRRITATION AND/OR INFECTION - Extracts derived from plants of the | 04-03-2014 |
20140205686 | INHIBITORS OF EXTRACELLULAR PROTEASES - Provided is a plant derived extract including inhibitory activity against one or more extracellular proteases which degrade human tissue matrix. Moreover, the amount of inhibitory activity in an extract can be increased by stressing the plant prior to forming an extract. These extracts are each prepared by a process and demonstrate the ability to inhibit one or more extracellular proteases which degrade human tissue matrix. Libraries of extracts can be prepared from stressed and non-stressed plants, where each of the extracts demonstrate inhibitory activity against on or more extracellular protease inhibitors. Alternatively, semi-purified and purified inhibitory compounds can be isolated from the extracts. In one aspect, these extracts with inhibitory activity can be used during protein purification to minimize degradation due to extracellular proteases | 07-24-2014 |
Patent application number | Description | Published |
20110174501 | CABLE BYPASS AND METHOD FOR CONTROLLED ENTRY OF A TUBING STRING AND A CABLE ADJACENT THERETO - A system and methodology for controlled entry of a tubing string, and cable adjacent thereto, into a wellbore. A stationary housing is fit to a wellhead and has a bore in communication with the wellbore. The cable can be laterally displaced from the bore into a cable access formed into the housing's side wall for fitting a sealing assembly to the bore and engages a sealing surface therein. The sealing assembly seals tubulars passing therethrough. The cable access interrupts the sealing surface. A cable bypass sub is fit to the cable access and permits the cable to extend sealingly from above the sealing surface to the wellbore wherein the cable bypasses the sealing assembly and sealing surface. A seal reconstitutes the interrupted portion of the sealing surface at the cable access. | 07-21-2011 |
20120217022 | UNIVERSAL ROTATING FLOW HEAD HAVING A MODULAR LUBRICATED BEARING PACK - A rotating flow head has a lubricated bearing pack for isolating bearing elements from wellbore fluids under pressure. The bearing pack, having a rotating cylindrical sleeve, bearing elements and two seal assemblies, is secured within an assembly bore of a stationary housing by a retainer plate accepting a plurality of lag bolts circumferentially spaced around a top portion of the stationary housing. Each of the seal assemblies have at least one sealing element having a body, an annular cavity, an inner sealing surface, and a flange that distends radially outwardly when axially compressed. A loading ring fit to the annular cavity urges the inner sealing surface radially inwardly to sealingly engage the rotating cylindrical sleeve. The inner sealing surface further comprises a first and second sealing surface and a debris channel therebetween. | 08-30-2012 |
20130292139 | CABLE BYPASS AND METHOD FOR CONTROLLED ENTRY OF A TUBING STRING AND A CABLE ADJACENT THERETO - A system and method is provided for the controlled entry of a tubing string, and cable adjacent thereto, into a wellbore. A stationary housing is fit to a wellhead and has a bore in communication with the wellbore. The cable can be laterally displaced from the bore into a cable access formed into the side wall of the stationary housing for fitting a sealing assembly to the bore and engages a sealing surface therein. The sealing assembly seals tubulars passing therethrough. The cable access interrupts the sealing surface. A cable bypass sub is fit to the cable access and permits the cable to extend sealingly from above the sealing surface to the wellbore wherein the cable bypasses the sealing assembly and sealing surface. A seal reconstitutes the interrupted portion of the sealing surface at the cable access. | 11-07-2013 |
Patent application number | Description | Published |
20090244522 | Polarization Optical Time Domain Reflectometer and Method of Determining PMD - In a method of measuring cumulative polarization mode dispersion (PMD) along the length of a fiber-under-test (FUT), a polarization-sensitive optical time domain reflectometer (POTDR) is used to inject into the FUT plural series of light pulses arranged in several groups. Each group comprises at least two series of light pulses having different but closely-spaced wavelengths and the same state of polarization (SOP). At least two, and preferably a large number of such groups, are injected and corresponding OTDR traces obtained for each series of light pulses by averaging the impulse-response signals of the several series of light pulses in the group. The process is repeated for a large number of groups having different wavelengths and/or SOPs. The PMD then is obtained by normalizing the OTDR traces of all of the groups, then computing the difference between each normalized OTDR trace in one group and the corresponding normalized OTDR trace in another group, followed by the mean-square value of the differences. Finally, the PMD is computed as a predetermined function of the mean-square difference. The function may, for example, be a differential formula, an arcsine formula, and so on. | 10-01-2009 |
20100073667 | Method and Apparatus for Determining Differential Group Delay and Polarization Mode Dispersion - A method and apparatus for measuring at least one polarization-related characteristic of an optical path (FUT) uses an optical source means connected to the FUT at or adjacent a proximal end of the FUT and an analyzing-and-detection unit connected to the FUT at or adjacent its proximal or distal end. The optical source means injects into the FUT at least partially polarized light having a controlled state of polarization (I-SOP). The analyzer-and-detection unit extracts corresponding light from the FUT, analyzes and detects the extracted light corresponding to at least one transmission axis (A-SOP), and processes the corresponding electrical signal to obtain transmitted coherent optical power at each wavelength of light in each of at least two groups of wavelengths, wherein the lowermost (λ | 03-25-2010 |
20110091206 | IN-BAND OPTICAL NOISE MEASUREMENT USING DIFFERENTIAL POLARIZATION RESPONSE - A method comprises: acquiring, for a number nSOP of varied State-Of-Polarization analysis conditions of the input optical signal, nSOP polarization-analyzed optical spectrum traces; mathematically discriminating said signal contribution from said noise contribution within said optical signal bandwidth using said polarization-analyzed optical spectrum traces, said mathematically discriminating comprising: obtaining a differential polarization response that is related to the optical spectrum of said signal contribution by a constant of proportionality; estimating the constant of proportionality of a differential polarization response to the optical spectrum of said signal contribution; estimating the optical spectrum of said noise contribution from said input optical signal, within said optical signal bandwidth using said constant of proportionality and said differential polarization response; and determining said in-band noise parameter on said input optical signal from the mathematically discriminated noise contribution. | 04-21-2011 |
20110293267 | METHOD AND APPARATUS FOR TESTING TRANSMISSION LINES NORMALLY PROPAGATING OPTICAL SIGNALS - Portable apparatus for measuring parameters of optical signals propagating concurrently in opposite directions in an optical transmission path between two elements, at least one of the elements being operative to transmit a first optical signal (S | 12-01-2011 |
20120093501 | In-Band Optical Noise Measurement Using Differential Polarization Response - A method comprises: acquiring, for a number nSOP of varied State-Of-Polarization analysis conditions of the input optical signal, nSOP polarization-analyzed optical spectrum traces, the distribution of the input optical signal of said SOP analysis conditions being approximately known; mathematically discriminating said signal contribution from said noise contribution within said optical signal bandwidth using said polarization-analyzed optical spectrum traces, said mathematically discriminating comprising: obtaining a differential polarization response that is related to the optical spectrum of said signal contribution by a constant of proportionality; estimating the constant of proportionality of a differential polarization response to the optical spectrum of said signal contribution as a function of said number nSOP; estimating the optical spectrum of said noise contribution from said input optical signal, within said optical signal bandwidth using said constant of proportionality and said differential polarization response; and determining said in-band noise parameter on said input optical signal from the mathematically discriminated noise contribution. | 04-19-2012 |
20140071436 | DETERMINING A POLARIZATION-RELATED CHARACTERISTIC OF AN OPTICAL LINK - A polarization-related characteristic of an optical path is determined from a predetermined function of the mean-square of a plurality of differences between polarization-analyzed optical power parameters corresponding to pairs of wavelengths mutually spaced about a midpoint wavelength by a small optical frequency difference. At least some of the said differences correspond to wavelength pairs measured under conditions where at least one of midpoint wavelength, input state of polarization (I-SOP) or analyzed state of polarization (A-SOP) of a pair is different. | 03-13-2014 |
20140327735 | PORTABLE DIGITAL HOLOGRAPHIC PROBE FOR THE INSPECTION OF OPTICAL FIBER CONNECTORS, AND INSPECTION SYSTEM AND METHOD FOR THE SAME - A portable inspection probe for the inspection of a recessed mating surface of an optical fiber connector is provided. In one variant, the portable inspection probe includes a digital holographic detection module operable to digitally record a hologram of the recessed mating surface, and a rigid probe tip configured to be optically coupled to the digital holographic detection module and shaped to provide optical access to the recessed mating surface. In another variant, the portable inspection probe is to be used with a rigid probe tip connectable thereto, and the digital holographic detection module includes a probing optical assembly not traversed by a reference beam and configured to direct an object beam onto the recessed mating surface and to collect the object beam upon reflection thereof by the recessed mating surface. An inspection system and an inspection method are also provided. | 11-06-2014 |
20140363157 | METHOD AND APPARATUS FOR TESTING TRANSMISSION LINES NORMALLY PROPAGATING OPTICAL SIGNALS - A portable apparatus for measuring parameters of optical signals propagating concurrently in opposite directions in an optical transmission path between two elements, at least one of the elements being operative to transmit a first optical signal (S | 12-11-2014 |
Patent application number | Description | Published |
20120208315 | THREE-DIMENSIONAL BICONTINUOUS HETEROSTRUCTURES, METHOD OF MAKING, AND THEIR APPLICATION IN QUANTUM DOT-POLYMER NANOCOMPOSITE PHOTODETECTORS AND PHOTOVOLTAICS - Provided herein are embodiments of a three-dimensional bicontinuous heterostructure, a method of producing same, and the application of this structure. The three-dimensional bicontinuous heterostructure includes two interpenetrating layers which are spatially continuous, include only protrusions or peninsulas, and have no islands. The method of producing the three-dimensional bicontinuous heterostructure includes forming an essentially planar continuous bottom layer of a first material; forming a layer of this first material on top of the bottom layer that is textured to produce protrusions for subsequent interpenetration with a second material, coating this second material onto this structure, and forming a coating with the second material that ensures that only the second material is contacted by subsequent layer. One of the materials includes visible and/or infrared-absorbing semiconducting quantum dot nanoparticles, and one of materials is a hole conductor and the other is an electron conductor. | 08-16-2012 |
20130244366 | THREE-DIMENSIONAL BICONTINUOUS HETEROSTRUCTURES, METHOD OF MAKING, AND THEIR APPLICATION IN QUANTUM DOT-POLYMER NANOCOMPOSITE PHOTODETECTORS AND PHOTOVOLTAICS - The present invention provides of a three-dimensional bicontinuous heterostructure, a method of producing same, and the application of this structure towards the realization of photodetecting and photovoltaic devices working in the visible and the near-infrared. The three-dimensional bicontinuous heterostructure includes two interpenetrating layers which are spatially continuous, they are include only protrusions or peninsulas, and no islands. The method of producing the three-dimensional biocontinuous heterostructure relies on forming an essentially planar continuous bottom layer of a first material; forming a layer of this first material on top of the bottom layer which is textured to produce protrusions for subsequent interpenetration with a second material, coating this second material onto this structure; and forming a final coating with the second material that ensures that only the second material is contacted by subsequent layer. One of the materials includes visible and/or infrared-absorbing semiconducting quantum dot nanoparticles, and one of materials is a hole conductor and the other is an electron conductor. | 09-19-2013 |