| Patent application number | Description | Published |
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| 20090004302 | Methods and Therapeutic Compositions Comprising Plant Extracts for the Treatment of Cancer - A method of treating cancer by targeting two proteases, MMP-9 and cathepsin B is provided. Therapeutic compositions comprising one or more plant extracts that inhibit MMP-9 and/or cathepsin B, which are capable of inhibiting neoplastic and/or endothelial cell migration, tumour growth, tumour-induced angiogenesis and/or metastasis are also provided. The therapeutic compositions of the invention can be used in the treatment of cancer, and, methods of inhibiting tumour growth, tumour metastasis, and/or tumour-induced angiogenesis using the therapeutic compositions alone or in combination with an anti-cancer agent are, therefore, also provided. | 01-01-2009 |
| 20090068291 | Plant extracts and compositions comprising extracellular protease inhibitors - The present invention provides a plant derived extract comprising inhibitory activity against one or more extracellular proteases which degrade human tissue matrix. Moreover, the amount of inhibitory activity in an extract can be increased by stressing the plant prior to forming an extract. These extracts are each prepared by a standard process and demonstrate the ability to inhibit one or more extracellular proteases which degrade human tissue matrix. Libraries of extracts can be prepared from stressed and non-stressed plants, wherein each of the extracts demonstrate inhibitory activity against one or more extracellular protease inhibitors. Alternatively, semi-purified and purified inhibitory compounds can be isolated from the extracts following standard procedures. In one aspect, these extracts with inhibitory activity can be used during protein purification to minimize the degradation due to extracellular proteases. | 03-12-2009 |
| 20090263516 | Plant Extract Composition and Their Use to Modulate Cellular Activity - Extracts from plant material, or semi-purified/purified molecules or compounds prepared from the extracts that demonstrate the ability to modulate one or more cellular activities are provided. The extracts are capable of slowing down, inhibiting or preventing cell migration, for example, the migration of endothelial cells or neoplastic cells and thus, the use of the extracts to slow down, inhibit or prevent abnormal cell migration in an animal is also provided. Methods of selecting and preparing the plant extracts and methods of screening the extracts to determine their ability to modulate one or more cellular activity are described. The purification or semi-purification of one or more molecules from the described extracts is also contemplated as well as the use of these molecules, alone or in combination with an extract, to slow down, inhibit or prevent abnormal cell migration in an animal. | 10-22-2009 |
| 20110177014 | EXTRACTS FROM PLANTS OF THE TSUGA GENUS AND USES THEREOF IN THE TREATMENT OF INFLAMMATION, IRRITATION AND/OR INFECTION - Extracts derived from plants of the | 07-21-2011 |
| 20110217753 | INHIBITORS OF EXTRACELLULAR PROTEASES - Provided is a plant derived extract including inhibitory activity against one or more extracellular proteases which degrade human tissue matrix. Moreover, the amount of inhibitory activity in an extract can be increased by stressing the plant prior to forming an extract. These extracts are each prepared by a process and demonstrate the ability to inhibit one or more extracellular proteases which degrade human tissue matrix. Libraries of extracts can be prepared from stressed and non-stressed plants, where each of the extracts demonstrate inhibitory activity against on or more extracellular protease inhibitors. Alternatively, semi-purified and purified inhibitory compounds can be isolated from the extracts. In one aspect, these extracts with inhibitory activity can be used during protein purification to minimize degradation due to extracellular proteases. | 09-08-2011 |
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| 20090244522 | Polarization Optical Time Domain Reflectometer and Method of Determining PMD - In a method of measuring cumulative polarization mode dispersion (PMD) along the length of a fiber-under-test (FUT), a polarization-sensitive optical time domain reflectometer (POTDR) is used to inject into the FUT plural series of light pulses arranged in several groups. Each group comprises at least two series of light pulses having different but closely-spaced wavelengths and the same state of polarization (SOP). At least two, and preferably a large number of such groups, are injected and corresponding OTDR traces obtained for each series of light pulses by averaging the impulse-response signals of the several series of light pulses in the group. The process is repeated for a large number of groups having different wavelengths and/or SOPs. The PMD then is obtained by normalizing the OTDR traces of all of the groups, then computing the difference between each normalized OTDR trace in one group and the corresponding normalized OTDR trace in another group, followed by the mean-square value of the differences. Finally, the PMD is computed as a predetermined function of the mean-square difference. The function may, for example, be a differential formula, an arcsine formula, and so on. | 10-01-2009 |
| 20100073667 | Method and Apparatus for Determining Differential Group Delay and Polarization Mode Dispersion - A method and apparatus for measuring at least one polarization-related characteristic of an optical path (FUT) uses an optical source means connected to the FUT at or adjacent a proximal end of the FUT and an analyzing-and-detection unit connected to the FUT at or adjacent its proximal or distal end. The optical source means injects into the FUT at least partially polarized light having a controlled state of polarization (I-SOP). The analyzer-and-detection unit extracts corresponding light from the FUT, analyzes and detects the extracted light corresponding to at least one transmission axis (A-SOP), and processes the corresponding electrical signal to obtain transmitted coherent optical power at each wavelength of light in each of at least two groups of wavelengths, wherein the lowermost (λ | 03-25-2010 |
| 20110091206 | IN-BAND OPTICAL NOISE MEASUREMENT USING DIFFERENTIAL POLARIZATION RESPONSE - A method comprises: acquiring, for a number nSOP of varied State-Of-Polarization analysis conditions of the input optical signal, nSOP polarization-analyzed optical spectrum traces; mathematically discriminating said signal contribution from said noise contribution within said optical signal bandwidth using said polarization-analyzed optical spectrum traces, said mathematically discriminating comprising: obtaining a differential polarization response that is related to the optical spectrum of said signal contribution by a constant of proportionality; estimating the constant of proportionality of a differential polarization response to the optical spectrum of said signal contribution; estimating the optical spectrum of said noise contribution from said input optical signal, within said optical signal bandwidth using said constant of proportionality and said differential polarization response; and determining said in-band noise parameter on said input optical signal from the mathematically discriminated noise contribution. | 04-21-2011 |
