Patent application number | Description | Published |
20080306143 | Cathechins for the Treatment of Fibrillogenesis in Alzheimer's Disease, Parkinson's Disease, Systemic AA Amyloidosis, and Other Amyloid Disorders - A method of treating an amyloid disease, or a disease characterized by alpha-synuclein or NAC fibrillogenesis, in a mammalian subject. The method includes administering to the mammal a therapeutically effective amount of a various disclosed catechins or green tea extract. A pharmaceutical composition comprising a therapeutically effective amount of a catechin and a pharmaceutically acceptable excipient. The therapeutic amount of the catechin or green tea extract is selected for efficacy in treating amyloid, alpha-synuclein or NAC fibrillogenesis in a mammalian subject. | 12-11-2008 |
20090111863 | Compounds, Compositions and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies - Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment. | 04-30-2009 |
20090214555 | Proteoglycan Splice Variants as Therapeutics and Diagnostics for Amyloid Diseases - The identification of novel Syndecan-2 splice variants and their use in the diagnosis and therapeutic intervention of Alzheimer's disease and other amyloid diseases. In addition the use of new animal models expressing or devoid of syndecan-2 splice variants to effectively screen and identify potential therapeutic compounds for Alzheimer's disease. | 08-27-2009 |
20100179223 | Compounds, Compositions, and Methods for the Treatment of Synucleinopathies - Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment. | 07-15-2010 |
20100331380 | Compounds, Compositions, and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies - Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment. | 12-30-2010 |
20110098349 | CATHECHINS FOR THE TREATMENT OF SYSTEMIC AA AMYLOIDOSIS - A method of treating an amyloid disease characterized by AA amyloid fibrillogenesis, in a mammalian subject. The method includes administering to the mammal a therapeutically effective amount of a various disclosed catechins. The therapeutic amount of the catechin is selected for efficacy in treating AA amyloid fibrillogenesis in a mammalian subject. | 04-28-2011 |
20110275080 | PROTEOGLYCAN SPLICE VARIANTS AS THERAPEUTICS AND DIAGNOSTICS FOR AMYLOID DISEASES - The identification of novel Syndecan-2 splice variants and their use in the diagnosis and therapeutic intervention of Alzheimer's disease and other amyloid diseases. In addition the use of new animal models expressing or devoid of syndecan-2 splice variants to effectively screen and identify potential therapeutic compounds for Alzheimer's disease. | 11-10-2011 |
20120035230 | Compounds, Compositions, and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies - Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment. | 02-09-2012 |
20120058998 | Compounds, Compositions and Methods for the Treatment of Inflammatory Diseases - A method of inhibiting the inflammatory process, the method comprising administering to a mammal suffering from inflammation a therapeutically effective amount of a pharmaceutical composition comprising a compound | 03-08-2012 |
20120251448 | Compounds for Use in the Detection of Neurodegenerative Diseases - Provided are the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of pathological characteristics unique to synuclein diseases, such as Parkinson's disease. | 10-04-2012 |
20120252858 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF BETA-AMYLOID DISEASES AND SYNUCLEINOPATHIES - Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment. | 10-04-2012 |
20120252886 | CATECHINS FOR THE TREATMENT OF AMYLOIDOSIS - A method of treating an amyloid disease characterized by AL amyloid fibrillogenesis, in a mammalian subject. The method includes administering to the mammal a therapeutically effective amount of a various disclosed catechins. The therapeutic amount of the catechin is selected for efficacy in treating AL amyloid fibrillogenesis in a mammalian subject. | 10-04-2012 |
20130137775 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF SYSTEMIC AA AMYLOID DISEASES - Bis- and tris-dihydroxyaryl compounds their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially AA amyloidosis, and the manufacture of medicaments for such treatment. | 05-30-2013 |
20130338202 | COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES - Compounds and their pharmaceutically acceptable salts for treatment of synucleinopathies, such as Parkinson's disease and tauopathies. | 12-19-2013 |
20140194447 | CAFFEINATED COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES - Compounds and their pharmaceutically acceptable salts for treatment of β-amyloid diseases, such as observed in Alzheimer's disease and synucleinopathies, such as Parkinson's disease. | 07-10-2014 |
20150274681 | Compounds for the treatment of Neurodegenerative Diseases - Compounds and their pharmaceutically acceptable salts for treatment of tauopathies, such as Alzheimer's disease, Pick's disease, progressive supranuclear palsy, corticobasal degeneration, familial frontotemporal dementia/Parkinsonism linked to chromosome 17, amyotrophic lateral sclerosis/Parkinsonism-dementia complex, argyrophilic grain dementia, dementia pugilistic, diffuse neurofibrillary tangles with calcification, progressive subcortical gliosis and tangle only dementia. | 10-01-2015 |
Patent application number | Description | Published |
20130110264 | Wearable Device Having Athletic Functionality | 05-02-2013 |
20130213147 | Footwear Having Sensor System - A sensor system is adapted for use with an article of footwear and includes an insert member including a first layer and a second layer, a port connected to the insert and configured for communication with an electronic module, a plurality of force and/or pressure sensors on the insert member, and a plurality of leads connecting the sensors to the port. | 08-22-2013 |
20140201570 | Reset Supervisor - Multiple processor systems are provided. A first processor is configured to monitor the state of at least one other processor by comparing received signals. When the first processor determines that another processor needs to be reset, the first processor provides a reset signal to a reset pin of the processor that needs to be reset. The first processor may reset itself after providing the reset signal. | 07-17-2014 |
20140358472 | DYNAMIC SAMPLING - A wrist-worn athletic performance monitoring system, including an analysis processor, configured to execute an activity recognition processes to recognize a sport or activity being performed by an athlete, and a sampling rate processor, configured to determine a sampling rate at which an analysis processor is to sample data from an accelerometer. The sampling rate processor may determine the sampling rate such that the analysis processor uses a low amount of electrical energy while still being able to carry out an activity classification process to classify an activity being performed. | 12-04-2014 |
20140358473 | DYNAMIC SAMPLING - A wrist-worn athletic performance monitoring system, including an analysis processor, configured to execute an activity recognition processes to recognize a sport or activity being performed by an athlete, and a sampling rate processor, configured to determine a sampling rate at which an analysis processor is to sample data from an accelerometer. The sampling rate processor may determine the sampling rate such that the analysis processor uses a low amount of electrical energy while still being able to carry out an activity classification process to classify an activity being performed. | 12-04-2014 |
20150046886 | GESTURE RECOGNITION - A wrist-worn athletic performance monitoring system, including a gesture recognition processor configured to execute gesture recognition processes. Interaction with the performance monitoring system may be based, at least in part, on gestures performed by the user, and offer an alternative to making selections on the performance monitoring system using physical buttons, which may be cumbersome and/or inconvenient to use while performing an athletic activities. Additionally, recognized gestures may be used to select one or more operational modes for the athletic performance monitoring systems such that a reduction in power consumption may be achieved. | 02-12-2015 |
20150313308 | Footwear Having Sensor System - A sensor system is adapted for use with an article of footwear and includes an insert member including a first layer and a second layer, a port connected to the insert and configured for communication with an electronic module, a plurality of force and/or pressure sensors on the insert member, and a plurality of leads connecting the sensors to the port. | 11-05-2015 |
20160026225 | RESET SUPERVISOR - Multiple processor systems are provided. A first processor is configured to monitor the state of at least one other processor by comparing received signals. When the first processor determines that another processor needs to be reset, the first processor provides a reset signal to a reset pin of the processor that needs to be reset. The first processor may reset itself after providing the reset signal. | 01-28-2016 |
Patent application number | Description | Published |
20110193770 | DEVICE AND METHOD FOR WAVELENGTH FILTERING - Embodiments include devices and methods for wavelength filtering. For example, one embodiment includes a display comprising a plurality of the display elements each comprising a movable reflector, a first partial reflector, and a second partial reflector. The first partial reflector is positioned at a first distance from the movable reflector and forms a first optical resonant cavity therebetween. The second partial reflector is positioned at a second distance from said first partial reflector and forming a second optical resonant cavity therebetween. In various embodiments, the movable reflector is movable with respect to the first partial reflector to alter the first optical cavity. Other embodiments include a method of making devices. | 08-11-2011 |
20110221798 | LINE MULTIPLYING TO ENABLE INCREASED REFRESH RATE OF A DISPLAY - This disclosure provides systems, methods, and apparatus for reducing a frame write time or increasing a refresh rate of a display. In one aspect, displays may include a plurality of pixels arranged along segment lines and common lines, and all or a portion of the display may be driven in a manner which simultaneously addresses multiple common lines. Display resolution or color range of all or a portion of the display may thus be temporarily sacrificed in exchange for a reduced frame write time, enabling the use of higher refresh rates. | 09-15-2011 |
20110242529 | METHODS FOR VISUALLY INSPECTING INTERFEROMETRIC MODULATORS FOR DEFECTS - A method is provided for visual inspection of an array of interferometric modulators in various driven states. This method may include driving multiple columns or rows of interferometric modulators via a single test pad or test lead, such as test pad, and then observing the array for discrepancies between the expected optical output and the actual optical output of the array. This method may particularly include, for example, driving a set of non-adjacent rows or columns to a state different from the intervening rows or columns and then observing the optical output of the array. | 10-06-2011 |
20110285683 | SYSTEM AND METHOD FOR CHOOSING DISPLAY MODES - This disclosure provides apparatus, systems, and methods for updating display devices. In one aspect, a line time addressing mode may be used to update the display by changing the amount of time that a common line has to address a display element. A shorter line time results in a higher frame rate, but may result in increased display errors. Therefore, an appropriate line time addressing mode may be selected based on the update rate of images to be displayed. | 11-24-2011 |
20110285757 | SYSTEM AND METHOD FOR CHOOSING DISPLAY MODES - This disclosure provides apparatus, systems, and methods for updating display devices. In one aspect, a multi-line addressing mode may be used to update the display by writing data to multiple display lines in order to increase display refresh rate and reduce power consumption. In another aspect, a line order addressing mode may be used to write data to display lines in a random or quasi-random sequence in order to minimize visible display updates. In another aspect, a color processing mode may be used to forego processing color information in order to reduce power consumption and processing time. | 11-24-2011 |
20110290552 | METHOD AND SYSTEM FOR PACKAGING MEMS DEVICES WITH INCORPORATED GETTER - Methods and systems for packaging MEMS devices such as interferometric modulator arrays are disclosed. One embodiment of a MEMS device package structure includes a seal with a chemically reactant getter. Another embodiment of a MEMS device package comprises a primary seal with a getter, and a secondary seal proximate an outer periphery of the primary seal. Yet another embodiment of a MEMS device package comprises a getter positioned inside the MEMS device package and proximate an inner periphery of the package seal. | 12-01-2011 |
20110316861 | OPTICAL FILMS FOR DIRECTING LIGHT TOWARDS ACTIVE AREAS OF DISPLAYS - In various embodiments, an interferometric display device includes a plurality of structures that redirect light from an inactive area of the display to an active area of the display. Light incident on the structures that would normally continue towards an inactive area of the display is either reflected, refracted, or scattered towards an active area of the display including moveable and static reflective surfaces that form an optical cavity. | 12-29-2011 |
20120002266 | METHOD AND DEVICE FOR PACKAGING A SUBSTRATE - A package structure and method of packaging for an interferometric modulator. A thin film material is deposited over an interferometric modulator and transparent substrate to encapsulate the interferometric modulator. A gap or cavity between the interferometric modulator and the thin film provides a space in which mechanical parts of the interferometric modulator may move. The gap is created by removal of a sacrificial layer that is deposited over the interferometric modulator. | 01-05-2012 |
20120026176 | INTERFEROMETRIC MODULATOR WITH DIELECTRIC LAYER - By selectively placing color filters with different transmittance spectrums on an array of modulator elements each having the same reflectance spectrum, a resultant reflectance spectrum for each modulator element and it's respective color filter is created. In one embodiment, the modulator elements in an array are manufactured by the same process so that each modulator element has a reflectance spectrum that includes multiple reflectivity lines. Color filters corresponding to multiple colors, such as red, green, and blue, for example, may be selectively associated with these modulator elements in order to filter out a desired wavelength range for each modulator element and provide a multiple color array. Because the modulator elements are manufactured by the same process, each of the modulator elements is substantially the same and common voltage levels may be used to activate and deactivate selected modulation. | 02-02-2012 |
20120044563 | REDUCED CAPACITANCE DISPLAY ELEMENT - A display element, such as an interferometric modulator, includes a transparent conductor configured as a first electrode and a movable minor configured as a second electrode. Advantageously, the partial reflector is positioned between the transparent conductor and the movable mirror. Because the transparent conductor serves as an electrode, the partial reflector does not need to be conductive. Accordingly, a greater range of materials may be used for the partial reflector. In addition, a transparent insulative material, such as a dielectric, may be positioned between the transparent conductor and the partial reflector, for example, in order to decrease a capacitance of the display element without changing a gap distance between the partial reflector and the movable minor. Thus, a capacitance of the display element may be reduced without changing the optical characteristics of the display element. | 02-23-2012 |
20120099177 | SPATIAL LIGHT MODULATOR WITH INTEGRATED OPTICAL COMPENSATION STRUCTURE - A spatial light modulator comprises an integrated optical compensation structure, e.g., an optical compensation structure arranged between a substrate and a plurality of individually addressable light-modulating elements, or an optical compensation structure located on the opposite side of the light-modulating elements from the substrate. The individually addressable light-modulating elements are configured to modulate light transmitted through or reflected from the transparent substrate. Methods for making such spatial light modulators involve fabricating an optical compensation structure over a substrate and fabricating a plurality of individually addressable light-modulating elements over the optical compensation structure. The optical compensation structure may be a passive optical compensation structure. The optical compensation structure may include one or more of a supplemental frontlighting source, a diffuser, a black mask, a diffractive optical element, a color filter, an anti-reflective layer, a structure that scatters light, a microlens array, and a holographic film. | 04-26-2012 |
20120127556 | METHOD AND SYSTEM FOR PACKAGING A DISPLAY - A package structure and method of packaging for an interferometric modulator. A transparent substrate having an interferometric modulator formed thereon is provided. A backplane is joined to the transparent substrate with a seal where the interferometric modulator is exposed to the surrounding environment through an opening in either the backplane or the seal. The opening is sealed after the transparent substrate and backplane are joined and after any desired desiccant, release material, and/or self-aligning monolayer is introduced into the package structure. | 05-24-2012 |
20120236042 | WHITE POINT TUNING FOR A DISPLAY - This disclosure provides systems, methods and apparatus, including computer programs encoded on computer storage media, for tuning the white point of a display device. In one aspect, a display device includes a set of display elements configured to output light and electronics configured to drive the display elements. Each display element can have an on-state where a reflective surface can be positioned at a distance from a partially reflective surface such that the display element can reflect incident light. Each distance can be dependent on a bias voltage. At least one of the bias voltages for the display elements can be non-zero in the on-state, and one or more of the bias voltages may be adjustable to control a white point of the display device. The electronics can be electrically connected to the display elements to provide the at least one non-zero bias voltage. | 09-20-2012 |
20130021303 | TOUCH SENSING DISPLAY DEVICES AND RELATED METHODS - The present disclosure provides systems, methods, and apparatus relating to touch sensing display devices that include a sensing device and a display device. In one aspect, a touch sensing display device can include adaptive addressing architecture to adjust an addressing characteristic based at least in part in a sensing characteristic of a sensing device. In another aspect, a touch sensing display device can include adaptive sensing architecture to adjust a sensing characteristic of a sensing device based at least in part on an addressing characteristic of a display device and/or on an electrical interference characteristic altered by an addressing circuit of the display device. | 01-24-2013 |
20130049844 | CAPACITIVE TOUCH SENSOR HAVING LIGHT SHIELDING STRUCTURES - This disclosure provides systems, methods, and apparatus related to a capacitive touch sensor with light shielding structures. In one aspect, a device includes an array formed by a plurality of row electrodes and a plurality of non-transparent column electrodes, wherein at least a first portion of the row electrodes is non-transparent and coplanar with the column electrodes and at least a second portion of the row electrodes is non-coplanar with the column electrodes. The device further includes light shielding structures that are non-transparent and coplanar with the column electrodes, wherein the light shielding structures substantially overlap the second portion. | 02-28-2013 |
20130100176 | SYSTEMS AND METHODS FOR OPTIMIZING FRAME RATE AND RESOLUTION FOR DISPLAYS - This disclosure describes systems, methods, and apparatus for increasing the frame rate of a display, while maintaining or improving image resolution. In one aspect, displays may include a plurality of pixels arranged along segment lines and common lines, and the common lines may be associated with one or more colors. In one implementation, one set of common lines is written independently of the other common lines, and at least one other set of common lines is written simultaneously. The resolution is preserved by the independent writing of one set of common lines, while the frame rate is increased by the line multiplication of another set of common lines. | 04-25-2013 |
20130106712 | METHOD OF REDUCING GLARE FROM INNER LAYERS OF A DISPLAY AND TOUCH SENSOR STACK | 05-02-2013 |
20130135269 | TWO STATE THREE ELECTRODE DRIVE SCHEME - This disclosure provides systems, methods and apparatus, including computer programs encoded on computer storage media, for driving electromechanical display devices that suffer from adhesion forces. In one aspect, a method for driving a display element is provided that includes applying a first series of voltages to a first electrode and applying a second series of voltages from a set of voltage levels to a second electrode to selectively place a movable layer into an actuated state or un-actuated state based on a voltage difference between the first and second electrodes. The method further includes applying a third series of voltages levels from the set of voltage levels to a third electrode. The third series of voltage levels are applied to the third electrode such that a non-zero voltage exists between the third and second electrodes during a release time period where a desired state is the un-actuated state. | 05-30-2013 |
20130321380 | SYSTEM AND METHOD OF SENSING ACTUATION AND RELEASE VOLTAGES OF INTERFEROMETRIC MODULATORS - This disclosure provides methods and apparatus for calibrating display arrays. In one aspect, a method of calibrating a display array includes determining a particular drive response characteristic and updating a particular drive scheme voltage between updates of image data on the display array. The drive response characteristic may be determined by applying a ramped voltage to a line of the array and detecting a current pulse due to a capacitance change on the line. The drive response characteristic can be determined based on data representing a width of a current pulse in the waveform or a weighted or unweighted area of a current pulse in the waveform. | 12-05-2013 |
20150351207 | ELECTROSTATIC DISCHARGE MITGATION IN DISPLAY DEVICES - This disclosure provides apparatus and methods for mitigating electrostatic discharge (ESD) in display devices. In one aspect, a display device includes an encapsulation substrates having an anti-static coating on one or more of surfaces of the encapsulation substrate. The display devices can include transparent substrates having display elements thereon such that the encapsulation substrate that covers the display elements. The anti-static coating on one or more surfaces of the encapsulation substrate can dissipate charge that may build up during fabrication or operation of the display device. The anti-static coating can be conductive and transparent, with examples of such coatings including transparent conducting oxides (TCOs), thin metal films, thin carbon films, and networks of conductive nanostructures. | 12-03-2015 |
Patent application number | Description | Published |
20100093033 | INDUCIBLE MUTAGENESIS OF TARGET GENES - The present invention relates generally to mutagenesis of target genes that takes advantage of the natural mutagenic capabilities of B cells, and enhances those capabilities by bringing the process of diversification under control. The invention provides a method for rapidly and inducibly generating point mutations and other types of diversification in expressed genes, such as antibody genes. This method can be coupled with selection to identify B cell clones that produce, for example, antibodies of high affinity or specificity. The diversification process can be modulated, accelerated, halted, switched between methods of mutagenesis and the like. The modulation of diversification in accordance with the invention is both inducible and reversible. The invention provides a means of rapid and feasible development of a repertoire of variant immunoglobulins and other polypeptides. | 04-15-2010 |
20120258121 | GENERATION OF ANTI-FN14 MONOCLONAL ANTIBODIES BY EX-VIVO ACCELERATED ANTIBODY EVOLUTION - The present invention relates generally to anti-FN14 antibodies. In particular, the anti-FN14 antibodies described herein are useful for the treatment of diseases, such as a variety of cancers, associated with expression of FN14. | 10-11-2012 |
20130095104 | ANTI-FZD10 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE - The present invention relates generally to anti-FZD10 antibodies and to methods of using anti-FZD10 antibodies. In particular, the anti-FZD10 antibodies described herein are useful for altering one or more of survival, replication, differentiation and epithelial-to-mesenchymal cell transition of embryonic stem cells and/or for the treatment of diseases, such as a variety of cancers, associated with expression of FZD10, including as stand-alone therapies and in combination therapies with other agents. | 04-18-2013 |
20130261012 | COMPOSITION AND METHOD FOR DIVERSIFICATION OF TARGET SEQUENCES - The disclosure relates generally to the targeting of genes to, and their integration into, an immunoglobulin (antibody) heavy chain locus. In particular, the methods described herein contemplate replacing the single rearranged heavy chain V, D, and J genes of a B cell lymphoma such as DT40 with independently rearranged V | 10-03-2013 |
20140178385 | Generation of Anti-FN14 Monoclonal Antibodies by Ex-Vivo Accelerated Antibody Evolution - The present invention relates generally to anti-FN14 antibodies. In particular, the anti-FN14 antibodies described herein are useful for the treatment of diseases, such as a variety of cancers, associated with expression of FN14. | 06-26-2014 |
20140363433 | Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same - In one aspect, the invention provides a method of making a bioactive peptide-bearing antibody, or fragment thereof, comprising (a) engrafting the amino acid sequence of at least one bioactive peptide of interest into (i) at least one of CDR-H1, CDR-H2 or CDR-H3 of a heavy chain variable region comprising one or more chicken framework regions and/or (ii) at least one of CDR-L1, CDR-L2 or CDR-L3 of the light chain variable region comprising one or more chicken framework regions, and (b) determining whether the antibody has substantially the same biological activity as the bioactive peptide. | 12-11-2014 |
20150017162 | Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same - In one aspect, the invention provides an isolated antibody, or antigen-binding fragment thereof, comprising a bioactive peptide amino acid sequence, wherein the bioactive peptide amino acid sequence is an inhibitor of the complement system and is fused to at least one of: (i) the amino terminal region of at least one of: a light chain variable region and/or a heavy chain variable region; or (ii) the carboxy terminal region of at least one of: a light chain constant region and/or a heavy chain constant region, wherein the antibody inhibits complement activation. | 01-15-2015 |
20150322134 | INDUCIBLE MUTAGENESIS OF TARGET GENES - The present invention relates generally to mutagenesis of target genes that takes advantage of the natural mutagenic capabilities of B cells, and enhances those capabilities by bringing the process of diversification under control. The invention provides a method for rapidly and inducibly generating point mutations and other types of diversification in expressed genes, such as antibody genes. This method can be coupled with selection to identify B cell clones that produce, for example, antibodies of high affinity or specificity. The diversification process can be modulated, accelerated, halted, switched between methods of mutagenesis and the like. The modulation of diversification in accordance with the invention is both inducible and reversible. The invention provides a means of rapid and feasible development of a repertoire of variant immunoglobulins and other polypeptides. | 11-12-2015 |