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Cummings, WA
Joel Cummings, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20080306143 | Cathechins for the Treatment of Fibrillogenesis in Alzheimer's Disease, Parkinson's Disease, Systemic AA Amyloidosis, and Other Amyloid Disorders - A method of treating an amyloid disease, or a disease characterized by alpha-synuclein or NAC fibrillogenesis, in a mammalian subject. The method includes administering to the mammal a therapeutically effective amount of a various disclosed catechins or green tea extract. A pharmaceutical composition comprising a therapeutically effective amount of a catechin and a pharmaceutically acceptable excipient. The therapeutic amount of the catechin or green tea extract is selected for efficacy in treating amyloid, alpha-synuclein or NAC fibrillogenesis in a mammalian subject. | 12-11-2008 |
| 20090111863 | Compounds, Compositions and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies - Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment. | 04-30-2009 |
| 20090214555 | Proteoglycan Splice Variants as Therapeutics and Diagnostics for Amyloid Diseases - The identification of novel Syndecan-2 splice variants and their use in the diagnosis and therapeutic intervention of Alzheimer's disease and other amyloid diseases. In addition the use of new animal models expressing or devoid of syndecan-2 splice variants to effectively screen and identify potential therapeutic compounds for Alzheimer's disease. | 08-27-2009 |
| 20100179223 | Compounds, Compositions, and Methods for the Treatment of Synucleinopathies - Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment. | 07-15-2010 |
| 20100331380 | Compounds, Compositions, and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies - Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment. | 12-30-2010 |
| 20110098349 | CATHECHINS FOR THE TREATMENT OF SYSTEMIC AA AMYLOIDOSIS - A method of treating an amyloid disease characterized by AA amyloid fibrillogenesis, in a mammalian subject. The method includes administering to the mammal a therapeutically effective amount of a various disclosed catechins. The therapeutic amount of the catechin is selected for efficacy in treating AA amyloid fibrillogenesis in a mammalian subject. | 04-28-2011 |
Robert V. Cummings, Anaortes, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100079220 | N-Channel Multiplexer - A radio frequency (RF) channelizer includes a first four-port balun, a second four part balun and a pair of filters coupled between the first and second four port baluns. The filters operate such that RF signals having a frequency within a desired frequency band (so-called “in-band” signals) can propagate between the first and second baluns (e.g. from the first balun to the second balun) while signals having a frequency outside the desired frequency band (so-called “out-of-band signals”) are reflected back to the first balun. One filter reflects out-of-band signals while maintaining the magnitude and phase of the signal (i.e. with a 0 degree phase shift), while the other filter reflects out-of-band signals with a phase-reversal (i.e. with a 180 degree phase shift). With this approach, the reflected signals propagate to a sum port (or even mode port) of the first balun. In this way, the balun-filter combination results in a channelizer which separates signals into different frequency bands. | 04-01-2010 |
Robert V. Cummings, Anacortes, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110148725 | METHODS AND APPARATUS FOR COINCIDENT PHASE CENTER BROADBAND RADIATOR - Methods and apparatus for a coincident phase center dual polarized slotline radiator. In one embodiment, a radiator includes, for each of two polarizations in a unit cell: first and second fins to provide an air transition for a signal, the radiator including a throat region between the first and second fins, a microstrip path transitioning to a slotline feed, a slotline split forming a part of the slotline feed to provide signal power division and 180 degree phase shift for rejoinder in the throat of the radiator to launch the signal into free space. In another embodiment, a four port radiator is provided. | 06-23-2011 |
William Cummings, Clinton, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110188109 | ELECTROMECHANICAL DEVICE WITH OPTICAL FUNCTION SEPARATED FROM MECHANICAL AND ELECTRICAL FUNCTION - A microelectromechanical (MEMS) device includes a substrate, a movable element over the substrate, and an actuation electrode above the movable element. The movable element includes a deformable layer and a reflective element. The deformable layer is spaced from the reflective element. | 08-04-2011 |
William J. Cummings, Clinton, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110193770 | DEVICE AND METHOD FOR WAVELENGTH FILTERING - Embodiments include devices and methods for wavelength filtering. For example, one embodiment includes a display comprising a plurality of the display elements each comprising a movable reflector, a first partial reflector, and a second partial reflector. The first partial reflector is positioned at a first distance from the movable reflector and forms a first optical resonant cavity therebetween. The second partial reflector is positioned at a second distance from said first partial reflector and forming a second optical resonant cavity therebetween. In various embodiments, the movable reflector is movable with respect to the first partial reflector to alter the first optical cavity. Other embodiments include a method of making devices. | 08-11-2011 |
W. Jason Cummings, Bellevue, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100093033 | INDUCIBLE MUTAGENESIS OF TARGET GENES - The present invention relates generally to mutagenesis of target genes that takes advantage of the natural mutagenic capabilities of B cells, and enhances those capabilities by bringing the process of diversification under control. The invention provides a method for rapidly and inducibly generating point mutations and other types of diversification in expressed genes, such as antibody genes. This method can be coupled with selection to identify B cell clones that produce, for example, antibodies of high affinity or specificity. The diversification process can be modulated, accelerated, halted, switched between methods of mutagenesis and the like. The modulation of diversification in accordance with the invention is both inducible and reversible. The invention provides a means of rapid and feasible development of a repertoire of variant immunoglobulins and other polypeptides. | 04-15-2010 |