| Patent application number | Description | Published |
|---|
| 20080280327 | Novel P-Selectin Ligand Protein - A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed. | 11-13-2008 |
| 20090028883 | Novel P-selectin Ligand Protein - A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed. | 01-29-2009 |
| 20090104180 | NOVEL P-SELECTIN LIGAND PROTEIN - A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed. | 04-23-2009 |
| Patent application number | Description | Published |
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| 20110313519 | Accommodating Intraocular Lens - An intraocular lens for insertion into a capsular bag of an eye comprises: an optic; and at least one plate haptic coupled to the optic by one or more flexible connecting members. The plate haptic with flexible finger extensions is designed to engage the periphery of the capsular bag. An increase in radial pressure upon constriction of the ciliary muscle causes the rigid posteriorly vaulted plate haptics to move centrally to further increase the vitreous cavity pressure with constriction of the ciliary muscle: the optic with its thin stretchable hinge across the connecting member is then displaced anteriorly along the axis of the eye. The haptic includes a longitudinally rigid frame to restrict deformation of the haptic in a longitudinal direction while permitting deformation in a transverse direction. Furthermore, the flexible connecting members include one or more hinged straps that extend radially and/or longitudinally from the optic. The optic can move forwards and backwards, relative to both the distal and proximal ends of the plate haptics, in response to ciliary muscle contraction and relaxation with an increase and decrease of vitreous cavity pressure. Finger-like projection extends from the plate haptic to engage the capsular bag to center and fixate the accommodating lens within the capsular bag. | 12-22-2011 |
| 20110313524 | Vitreous Compressing Plate Haptic - A plate haptic is used with an intraocular lens optic displaceable in response to vitreous pressure changes. The plate haptic comprises: a plurality of opposing lateral portions; a distal portion having a plurality of opposing projections extending substantially laterally therefrom; and a proximal portion comprising a strap across which is a hinge connecting the lens optic to the haptic. The intersection of the proximal portion with each lateral portion forms a plurality of appendages, or paddles, to partially surround the optic. The appendages, projections, and hinged straps combine to substantially aid displacement of the lens optic in response to changes in vitreous pressure. | 12-22-2011 |
| 20110313525 | Tilt Stabilizing Accommodating Intraocular Lens - An intraocular lens for insertion into a capsular bag of an eye. A plurality of flexible connecting members couples a lens optic to a pair of opposing of plate haptics. The coupling members stabilize the optic with respect to the haptics. The coupling members are spaced apart straps having grooves that increase lens response to changes in vitreous pressure. | 12-22-2011 |
| 20110313526 | Semi-Rigid Framework For A Plate Haptic Accommodating Intraocular Lens - A plate haptic for an accommodating intraocular lens. The plate haptic has a haptic body that is substantially rigid in a longitudinal direction and substantially flexible in a transverse direction. A chassis is integral to the haptic body. The chassis causes the haptic body to be substantially more rigid in a longitudinal direction than in a transverse direction. | 12-22-2011 |
| 20120296425 | Variable Focus Intraocular Lens - A variable focus intraocular lens comprises an optic coupled to at least one haptic at a flexion that sets a non-zero angle between the optic and the haptic. | 11-22-2012 |
| 20120310344 | Biased accommodating intraocular lens - An accommodating intraocular lens has a lens optic that is coupled to at least one haptic and is anteriorly biased with respect thereto. | 12-06-2012 |
| Patent application number | Description | Published |
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| 20080200445 | Heterocyclic aspartyl protease inhibitors -
Disclosed are compounds of the formula I
| 08-21-2008 |
| 20090258868 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 10-15-2009 |
| 20090306047 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 12-10-2009 |
| 20090312341 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A HETEROCYCLIC SUBSTITUENT - Disclosed are novel compounds of the formula | 12-17-2009 |
| 20100152138 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT - Disclosed are compounds of the formula | 06-17-2010 |
| 20100292203 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 11-18-2010 |
| 20110218194 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 09-08-2011 |
| 20120148603 | PENTAFLUOROSULFUR IMINO HETEROCYCLIC COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides provides certain pentafluorosulfur imino heterocyclic compounds, including compounds Formula (I): and tautomers thereof, and solvates, prodrugs, esters, and deuterates of said compounds and said tautomers, and pharmaceutically acceptable salts of said compounds, tautomers, solvates, prodrugs, esters, and deuterates, wherein each of R | 06-14-2012 |
| 20120183563 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): (I) and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R | 07-19-2012 |
| 20120189642 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (a) and include tautomers, solvates, prodrugs, esters, and deuterates thereof, and pharmaceutically acceptable salts of said compounds, tautomers, solvates, prodrugs, esters, and deuterates, wherein each of R | 07-26-2012 |
| 20120195881 | PENTAFLUOROSULFUR IMINO HETEROCYCLIC COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS AND THEIR USE - In its many embodiments, the present invention provides certain pentafluorosulfur imino heterocyclic compounds, including compounds Formula (a) and pharmaceutically acceptable salts thereof. Compounds of Formula (a) have the general structure: (a) wherein each variable is selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimers Disease, are also disclosed. | 08-02-2012 |
| 20120231017 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 09-13-2012 |
| 20120231018 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 09-13-2012 |
| 20120232064 | ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of formula I | 09-13-2012 |
| 20120276118 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 11-01-2012 |
| 20130018066 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 01-17-2013 |
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| 20090299259 | Head trauma cap bandage and method - An emergency head trauma cap bandage and method of use, which, when applied, applies compression pressure to stop bleeding, doesn't compromise cervical spine immobilization, doesn't come apart during treatment and transport, and doesn't require a caregiver to re-wrap the dressing. | 12-03-2009 |
| 20100016775 | Head trauma bandage and method - An emergency head trauma bandage and method of use, which, when applied, applies minimal pressure to stop bleeding, doesn't compromise cervical spine immobilization, allows for fast and effective application of ice/cold packs to control intracranial/internal swelling, doesn't come apart during treatment and transport, and doesn't require a caregiver to re-wrap the dressing. | 01-21-2010 |
| 20100331752 | Helmet trauma bandage and method - An emergency helmet trauma bandage and method of use, which, when applied, applies minimal pressure to stop bleeding, doesn't compromise cervical spine immobilization, allows for fast and effective application of ice/cold packs to control intracranial/internal swelling, doesn't come apart during treatment and transport, and doesn't require a caregiver to re-wrap the dressing. | 12-30-2010 |
| 20120296252 | Head Trauma Bandage Cap and Method - An emergency head trauma bandage cap with a detachable strap system and method of use, which, when applied to the head, delivers minimal pressure to control bleeding, doesn't compromise cervical spine immobilization, allows for fast and effective application of cold packs to control intracranial/internal swelling or hot packs to prevent hypothermia in non-trauma situations, doesn't come apart during treatment and transport, and doesn't require a caregiver to re-wrap the dressing. | 11-22-2012 |
| Patent application number | Description | Published |
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| 20080234660 | Steerable Catheter Using Flat Pull Wires and Method of Making Same - A catheter assembly includes an inner liner made of flexible material and an outer layer having a steering mechanism. The steering mechanism includes at least one flat wire and a corresponding lumen through which the flat wire may travel. The steering mechanism may also include at least one pull ring to which the flat wires are attached. A layer of heat shrink material may encompass the outer layer. A braided wire assembly, which may have a braid density that varies along the length of the catheter, may also be provided in the outer layer. The overall cross-section of the catheter assembly is preferably substantially circular. A catheter shaft may include a plurality of segments of differing hardness characteristics. The outer layer typically comprises a melt processing polymer such that the catheter assembly may be laminated using heat. | 09-25-2008 |
| 20090024110 | CATHETER AND INTRODUCER CATHETER HAVING TORQUE TRANSFER LAYER AND METHOD OF MANUFACTURE - The instant invention relates generally to catheters and to introducer catheters used to help deliver catheters or other medical devices to locations within the human body. In particular, the instant invention relates to large diameter catheters and introducer catheters having a torque transfer layer that includes at least two flat wires braided into a wire mesh. The flat wires have a width of at least about 0.007 inches and a depth of at least about 0.003 inches. The lumen diameter of the catheter is at least about 6 French. The torque transfer layer provides increased strength, flexibility, and kink resistance. | 01-22-2009 |
| 20100314031 | Steerable Catheter Using Flat Pull Wires and Having Torque Transfer Layer Made of Braided Flat Wires - A catheter assembly includes an inner liner made of flexible material and an outer layer having a steering mechanism. The steering mechanism includes at least one flat wire and a corresponding lumen through which the flat wire may travel. The steering mechanism may also include at least one pull ring to which the flat wires are attached. A layer of heat shrink material may encompass the outer layer. A braided wire assembly may also be provided in the outer layer, and may be formed by braiding a plurality of flat wires into a wire mesh. The overall cross-section of the catheter assembly is preferably substantially circular. A catheter shaft may include a plurality of segments of differing hardness characteristics. The outer layer typically comprises a melt processing polymer such that the catheter assembly may be laminated using heat. | 12-16-2010 |
| 20110154640 | CATHETER AND INTRODUCER CATHETER HAVING TORQUE TRANSFER LAYER AND METHOD OF MANUFACTURE - The instant invention relates generally to catheters and to introducer catheters used to help deliver catheters or other medical devices to locations within the human body. In particular, the instant invention relates to large diameter catheters and introducer catheters having a torque transfer layer that includes at least two flat wires braided into a wire mesh. The flat wires have a width of at least about 0.007 inches and a depth of at least about 0.003 inches. The lumen diameter of the catheter is at least about 6 French. The torque transfer layer provides increased strength, flexibility, and kink resistance. | 06-30-2011 |
