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Criscuolo
Domenico Criscuolo, Milano IT
| Patent application number | Description | Published |
|---|---|---|
| 20110311451 | SYNTHESIS OF POLYMER CONJUGATES OF INDOLOCARBAZOLE COMPOUNDS - The present invention relates to a process for the preparation of polymer conjugates of iĻdolocarbazole compounds, in particular of polymer conjugates of K-252a and derivatives thereof, by a synthetic route which results in a highly pure product, with a high product yield. In a further aspect the present invention relates to novel polymer conjugates of K-252a and derivatives thereof, wherein the chemical group linking the polymer unity to the K-252a or to the K-252a derivative compound is characterised by a 5-member oxazolidindionic cyclic structure. These novel polymer conjugates are obtained through the novel synthetic route with high purity and high yields, | 12-22-2011 |
M. Criscuolo, Ciudad De Buenos Aires AR
| Patent application number | Description | Published |
|---|---|---|
| 20090187999 | Process for Producing Exogenous Protein in the Milk of Transgenic Mammals and a Process For Purifying Proteins Therefrom - The invention relates to a non-human transgenic mammal that is useful for the production of a protein of interest that may be toxic to the mammal. The mammal is characterized by the fact that it is transgenic for the production in its milk of an inactive form of the protein of interest, preferably recombinant human insulin. It is not possible to produce recombinant human insulin in transgenic mammals since this molecule has a certain degree of biological activity in the mammals and could be toxic to the mammal. Thus, the invention involves cloning a genetic construct comprising a sequence encoding a modified human insulin precursor under the control of a beta casein promoter in an expression vector. It also involves transfecting the expression plasmid into fetal bovine somatic cells, such as fibroblasts, and enucleating bovine oocytes by nuclear transfer to generate transgenic embryos. The invention gives rise to transgenic bovine that will be able to produce a modified human insulin precursor in their mammary glands. Afterwards, the milk of these transgenic mammals can be collected, the modified human insulin precursor can be converted in vitro into recombinant human insulin, and the recombinant human insulin can be purified to homogeneity as a pure biopharmaceutical product. | 07-23-2009 |
Marcelo Eduardo Criscuolo, Capital Federal AR
| Patent application number | Description | Published |
|---|---|---|
| 20100210508 | Method for the Massive Culture of Cells Producing Recombinant Human Erythropoietin - The present invention relates, in general, to a method for the massive culture of recombinant mammalian cells for the production of recombinant human erythropoietin (EPO) in culture medium containing insulin. The present invention also refers to a method of producing EPO and to the EPO thus produced. | 08-19-2010 |
Marcelo Eduardo Criscuolo, Buenos Aires AR
| Patent application number | Description | Published |
|---|---|---|
| 20090275645 | METHOD TO INDUCE NEOVASCULAR FORMATION AND TISSUE REGENERATION - The present invention relates, e.g., to a method for inducing arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or for inducing mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte, comprising administering to a cell or tissue in need thereof a dose of a polynucleotide that encodes a vascular endothelial growth factor (VEGF), or that encodes a polypeptide comprising an active site of the VEGF. The coding sequence is operably linked to an expression control sequence; and the dose is sufficient to induce arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or to induce mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte. In preferred embodiments of the invention, the method is a method of tissue regeneration, particularly of cardiomyogenesis; and the polynucleotide (or a polypeptide encoded by such a polynucleotide) is administered into the myocardium. | 11-05-2009 |
Matthew Criscuolo, Wilton, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20120085219 | Portable Musical Resonator - A portable reverberation device for attaching to a musical instrument with a distal end that can be adjusted to alter a distance between the ends of the portable reverberation device. The device includes a cup attached to a collar to receive incoming sound waves and a spring stretched inside the body. The device further includes an attachment mechanism with a clamp adapted to attach the portable reverberation device to the musical instrument. | 04-12-2012 |