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Creemers
Esther E. Creemers, Maastricht NL
| Patent application number | Description | Published |
|---|---|---|
| 20090325170 | MEANS AND METHODS FOR DIAGNOSING AND/OR TREATING A SUBJECT AT RISK OF DEVELOPING HEART FAILURE - The present invention relates to a method for identifying a subject at risk of developing heart failure, comprising: (a) determining the level of one or more biological markers in a biological sample of said subject; (b) comparing the level of said biological marker to a standard level of the same biological marker; and (C) determining whether the level of the marker is indicative of a risk for developing heart failure, wherein the biological marker is Krüppel Like Factor 15 (KLF-15) and/or lysosomal integral membrane protein-2 (LIMP-2) and/or fragments and/or variants thereof, and/or wherein the biological marker is a gene coding for KLF15 and/or LIMP-2, and/or fragments and/or variants thereof. The invention further relates to use of the KLF15 and/or LIMP-2 protein, and/or the gene coding for KLF15 and/or LIMP2, and/or fragments, and/or variants of said genes and/or proteins, for the preparation of a medicament for a prophylactic and/or a therapeutic medicament for prevention and/or treatment of heart failure. | 12-31-2009 |
Esther Elisa Johanna Maria Creemers, Amsterdam NL
| Patent application number | Description | Published |
|---|---|---|
| 20120115929 | Means And Methods For Counteracting, Preventing And/Or Determining Heart Failure, Or A Risk Of Heart Failure - The present invention relates to a method for diagnosing and/or prognosing heart failure in a subject the method comprising the step of determining the level of at least one genetic marker in a body fluid sample obtained from said subject, wherein said at least one genetic marker is an mi RNA. The invention further relates to a method for treating or preventing heart failure in a subject the method comprising the step of decreasing within said subject the expression, amount, and/or activity of at least one mi RNA, or decreasing within said subject the interaction of at least one mi RNA with its m RNA target or increasing within said subject the expression, amount, and/or activity of the m RNA target of at least one mi RNA. | 05-10-2012 |
Frank Creemers, Gl Leusden NL
| Patent application number | Description | Published |
|---|---|---|
| 20100011919 | DEVICE AND METHOD FOR LEVELLING OFF THE SURFACE OF A BRAKE DISC - There is disclosed a device ( | 01-21-2010 |