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| 20080214614 | CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE - The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with cytoskeletal reorganization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or Formula II, wherein said amount is effective to influence the actomyosin interactions, for example by leading to cellular relaxation and alterations in cell-substratum adhesions. | 09-04-2008 |
| 20090076256 | DEGRADATION-RESISTANT MONONUCLEOSIDE PHOSPHATE COMPOUNDS - The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that has been modified by attaching a degradation-resistant substituent on the terminal phosphate of a polyphosphate mononucleotide. By attaching this degradation-resistant substituent, the stability from degradation matches or exceeds those of certain dinucleotides. The mononucleoside phosphate compounds of the present invention are useful in preventing and treating epithelial tissue diseases or diseases or disorders associated with platelet aggregation. | 03-19-2009 |
| 20100022517 | OPHTHALMIC FORMULATION OF RHO KINASE INHIBITOR COMPOUND - The present invention relates to an aqueous pharmaceutical formulation comprising at least one inhibitor of Rho-associated protein kinase (ROCK). The aqueous pharmaceutical formulation comprises 0.01-0.4% w/v of ROCK inhibitor(s), a non-ionic surfactant in an amount of 0.01-2% w/v, and a tonicity agent to maintain a tonicity between 220-360 mOsm/kG, at a pH between 6.3 to 7.8, wherein the ROCK inhibitor, the surfactant, and the tonicity agent are compatible in the formulation. The aqueous ophthalmic formulations of this invention have an increased ocular bioavailability and/or aqueous humor concentrations without a concomitant increase in systemic concentrations. The present invention further provides a method of reducing intraocular pressure, particularly a method of treating glaucoma, by administering the aqueous pharmaceutical formulation to a subject. | 01-28-2010 |
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| 20080228658 | DEAL IDENTIFICATION SYSTEM - A method and system for identifying deals to facilitate travel planning is provided. In one embodiment, a deal identification system identifies deals on travel items and presents those deals to a person in a way that facilitates travel planning and travel shopping. The deal identification system may include an entity attributes service component that provides attributes of entities associated with the items. The deal identification system may also include a historical price service component that provides historical pricing information for the items. The deal identification system may also include a deal component that receives a criterion that defines a deal based on a combination of attributes of entities, historical pricing information, and current pricing information and identifies those items that match the criterion as deals. | 09-18-2008 |
| 20090063167 | HOTEL RATE ANALYTIC SYSTEM - A hotel deal system provides an observation store with observations that identify a hotel, a stay, a room type, a room rate, and observation date. The hotel deal system receives a request for rate information for a desired hotel for a desired stay. The hotel deal system retrieves current room rate information for the desired hotel for the desired stay. The hotel deal system then analyzes the observations of the observation store to identify a deal rating for the desired hotel for the desired stay at the current room rate. | 03-05-2009 |
| 20110046989 | SYSTEM AND METHOD OF PROTECTING PRICES - A method and system for protecting prices is provided. The price protection system increases consumer confidence when making purchases by reducing the risk associated with fluctuating prices. The price protection system receives a purchase specification from a consumer. Next, the price protection system determines the risk that the prices of items matching the purchase specification will change and reports a protected price to the consumer that represents the price that the price protection system will protect based on the determined risk for a protection period. Finally, the price protection system receives a request from the consumer to purchase protection of the protected price. | 02-24-2011 |
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| 20090161163 | Parallel RIP with Preamble Caching - A method and system is provided for splitting a print job into its preamble and at least one chunk. The splitter maintains a collection of RIP node addresses to which chunks of the job currently being split have already been sent. When a new chunk is about to be sent, the splitter checks whether each RIP node address has already received a chunk. If the RIP node has not already received a chunk, the splitter sends the preamble as well as the chunk to an available RIP associated with the RIP node. If, however, the RIP node address has already received a chunk, only the portion of the chunk after the preamble is sent to an available RIP associated with the RIP node and communicate the location of the preamble to the available RIP node. The preamble may contain common content for each job. | 06-25-2009 |
| 20090324303 | HYBRID SINGLE PASS, MULTI-PASS FULL COLOR PRINTING SYSTEM - A hybrid single pass, multi-pass full color printing system is provided and includes (a) a moveable intermediate transfer belt (ITB) mounted within a machine frame and having a path of movement; (b) a plurality of single pass image output modules mounted along the path of movement, each having imaging devices including an image carrying member and a single developer housing containing a single color developer for forming an image in a single pass on the image carrying member for transfer onto the ITB; and (c) at least one single pass, multi-pass image output module mounted along the path of movement and having imaging devices including an image bearing member and a plural number of selectable developer housings, and each of the selectable developer housings containing a single spot color developer for forming spot color images in single passes and in multiple passes on the image bearing member for transfer onto the ITB. | 12-31-2009 |
| 20100103440 | IMAGE PATH UTILIZING SUB-SAMPLED CROSS-CHANNEL IMAGE VALUES - A technique for cross-channel correction in real time for digital color printing in which the full resolution value of a selected colorant is combined with low resolution versions of the remaining colorants to provide a basis for correcting the selected colorant based upon the data for the other colorants employed. The pixel values of sub-samples of the remaining colorants are derived from the cell in which the full resolution selected colorant is taken; and, the desired output value is selected from a look-up table established for the known printing process. | 04-29-2010 |
