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Craik
Charles S. Craik, San Francisco, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090136477 | Methods of generating and screening for proteases with altered specificity - Disclosed herein are methods for generating proteases with altered specificity for the target molecules they cleave. The invention further discloses methods of using these proteases to treat diseases in which the target proteins are involved with. Cleaving certain target proteins at certain substrate sequences with a protease is a method for treating these pathologies. | 05-28-2009 |
| 20090155248 | Antibodies to MT-SP1 serine protease - This invention provides a novel membrane-type serine protease (designated MT-SP1) elevated expression of which is associated with cancer. In one embodiment, this invention provides a method obtaining a prognosis or of detecting or staging a cancer in an organism. The method involves providing a biological sample from the organism and detecting the level of a membrane type serine protease 1 (MT-SP1) in the sample, where an elevated level of the membrane-type serine protease, as compared to the level of the protease in a biological sample from a normal healthy organism indicates the presence or stage of the cancer. | 06-18-2009 |
David J. Craik, Brisbane AU
| Patent application number | Description | Published |
|---|---|---|
| 20100093620 | TYROSINE-RICH CONOPEPTIDES - The invention relates to relatively short peptides (termed Conopeptide-Y family peptides or CPY family peptides or CPY peptides herein), about 30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which are rich in the amino acid tyrosine. | 04-15-2010 |
David J. Craik, Queensland AU
| Patent application number | Description | Published |
|---|---|---|
| 20110064668 | J-SUPERFAMILY CONOTOXIN PEPTIDES - The invention relates to relatively short peptides (termed J-Superfamily conotoxin peptides, J-conotoxins or J-conotoxin peptides herein), about 25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The J-conotoxins are useful for treating disorders involving voltage gated ion channels and/or receptors. | 03-17-2011 |
David James Craik, Chapel Hill AU
| Patent application number | Description | Published |
|---|---|---|
| 20100068762 | NOVEL NUCLEIC ACID MOLECULES - The present invention relates to a novel nucleic acid molecule encoding an amino acid sequence, which is capable of forming a cyclic structure. Cyclization may occur within a cell or cell membrane, or linear forms of the molecules may be circularised or partially circularised, in vitro using isolated enzyme systems or chemical means. The cyclised amino acid sequence is generally in the form of a stabilized folded structure such as acyclic knotted peptide, polypeptide or protein or functional equivalent. The nucleic acid molecules and cyclic and linear peptides are useful inter alia in the generation of molecules having animal or plant therapeutic properties, as well as in a range of diagnostic, industrial and agricultural, including horticultural, applications. Of particular importance is the use of these molecules in the protection of plants, such as crop plants, from pest and/or pathogen infestation. | 03-18-2010 |
| 20100298528 | Cystine knot molecules - The present invention relates generally to a molecular framework having a cyclic structure. More particularly, the present invention provides cyclic proteins and derivatives thereof in which particular turns and other elements of the molecular structure are held in defined orientations with respect to each other. The cyclic proteins of the present invention provide a molecular framework for the introduction of particular amino acids or heterologous amino acid sequences to facilitate the presentation of biological activities associated with these heterologous amino acid sequences. The molecular framework of the present invention may be naturally cyclic or may be a cyclized derivative of a linear molecular or may be a linear derivative of a cyclized molecule. The present invention contemplates the use of the molecular framework with or without particular amino acids inserted or substituted thereon for the treatment of or prophylaxis of disease conditions in animals, mammals (including humans) and plants. | 11-25-2010 |
David James Craik, Queensland AU
| Patent application number | Description | Published |
|---|---|---|
| 20100120670 | CYCLISED ALPHA-CONOTOXIN PEPTIDES - This invention relates to an oral or enteral pharmaceutical preparation comprising at least one synthetically cyclised alpha-conotoxin peptide having an amide cyclised backbone such that the peptide has no free N- or C-terminus, said peptide having the ability to inhibit a nicotinic acetylcholine receptor and comprising four cysteine residues bonded in pairs to form two disulfide bonds, wherein the N-terminus of the corresponding linear/non-cyclised conotoxin peptide is linked to the C-terminus by a peptide linker, in a vehicle which is pharmaceutically suitable for oral or enteral administration. | 05-13-2010 |
Graham N. Craik, Edinburgh GB
| Patent application number | Description | Published |
|---|---|---|
| 20090185132 | SYSTEMS AND METHODS OF PHASE DIVERSITY WAVEFRONT SENSING - A phase diversity wavefront sensor includes an optical system including at least one optical element for receiving a light beam; a diffractive optical element having a diffractive pattern defining a filter function, the diffractive optical element being arranged to produce, in conjunction with the optical system, images from the light beam associated with at least two diffraction orders; and a detector for detecting the images and outputting image data corresponding to the detected images. In one embodiment, the optical system, diffractive optical element, and detector are arranged to provide telecentric, pupil plane images of the light beam. A processor receives the image data from the detector, and executes a Gerchberg-Saxton phase retrieval algorithm to measure the wavefront of the light beam. | 07-23-2009 |
Ron Craik, Calgary CA
| Patent application number | Description | Published |
|---|---|---|
| 20080228347 | SYSTEM AND METHOD FOR STORING AND RETRIEVING EQUIPMENT INSPECTION AND MAINTENANCE DATA - An inspection and maintenance data storage and retrieval system features uniquely identified read/write memory buttons mounted in or on an equipment unit such as an aircraft, in association with specific components of the equipment unit. Technical information useful for inspection and maintenance of the components, plus historical inspection and maintenance information, is stored in a central database computer remote from the equipment unit. A memory button probe, used in conjunction with a portable computer, enables storage on the memory buttons of information relating to inspection and maintenance carried out on the corresponding equipment components, as well as technical information related to the components. The portable computer is connected to the central database computer, preferably through a wireless Internet connection, thus enabling downloading of technical information from the central database to the portable computer at the point of inspection or maintenance. Information relating to each inspection and maintenance task may be downloaded to the central database computer via the portable computer. The central database computer may be a network server providing authorized users with access to current maintenance and operational status information for the equipment units supported by the system. | 09-18-2008 |
| 20090051502 | SYSTEM AND METHOD FOR STORING AND RETRIEVING EQUIPMENT INSPECTION AND MAINTENANCE DATA - An inspection and maintenance data storage and retrieval system features one or more memory buttons mounted in association with an equipment item. Each memory button incorporates a uniquely identified read/write memory chip, and may comprise a contact memory button, an RFID chip, or other type of read-write memory. Technical information useful for inspection and maintenance of the equipment item, plus historical inspection and maintenance information, is stored in a central database computer remote from the equipment item. A memory button probe, used in conjunction with a portable computer, enables storage on the memory buttons of information relating to inspection and maintenance carried out on the equipment item, as well as related technical information. The portable computer is connected to the central database computer, preferably through a wireless Internet connection, thus enabling downloading of technical information from the central database to the portable computer at the point of inspection or maintenance. Information relating to each inspection and maintenance task may be downloaded to the central database computer via the portable computer. The central database computer may be a network server providing authorized users with access to current maintenance and operational status information for the equipment items supported by the system. | 02-26-2009 |