Inventors list

Assignees list

Classification tree browser

Top 100 Inventors

Top 100 Assignees


Courtney, GB

Alistair G. Courtney, Oxford GB

Patent application numberDescriptionPublished
20090015259SYSTEMS AND METHODS FOR MOUNTING INSTRUMENTS ON NMR SYSTEMS - According to one aspect, a suspended mounting bridge is used to attach a nuclear magnetic resonance (NMR) instrument assembly including shim coils and/or an NMR probe to an NMR magnet cryostat. The mounting bridge is suspended across a central region of an end cover (e.g. bottom plate) of the cryostat. Consequently, flexing of the end cover center in response to changes in environmental pressure does not cause displacement of the shim coils and/or RF coils relative to the NMR magnet center. The mounting bridge may be attached to a peripheral region of the end cover (e.g. along its perimeter), and/or to a cryostat side wall. The mounting bridge may be shaped as a quasi-rectangular strip or may include multiple spokes.01-15-2009

Christopher George Hamilton Courtney, Dundee GB

Patent application numberDescriptionPublished
20100190213METHOD AND APPARATUS FOR CONTROLLING THE TEMPERATURE OF REACTION VOLUMES - A method and apparatus for controlling the temperature of one or more reaction volumes contained in respective reaction vessel(s) through absorption of electromagnetic energy by a reactant medium of the reaction volume(s). The method comprises providing one or more-reaction volumes (07-29-2010

Patrick Courtney, Buckinghamshire GB

Patent application numberDescriptionPublished
20110297847Fluorescence Microscopy Methods and Apparatus - Methods and apparatus are provided concerning the control of photobleaching of fluorescent labels during the study of samples by fluorescence microscopy. A method is described for operating fluorescence microscopy apparatus to analyse a sample (12-08-2011

Patrick Courtney, Beaconsfield GB

Patent application numberDescriptionPublished
20090173892IMAGING OF BIOLOGICAL SAMPLES - Methods and apparatus relating to the imaging of biological samples are provided. More particularly, they relate to the detection of light emanating from fluorescent species present in a sample in order to study the structure and dynamics of such a sample. Such a method of analysis comprises irradiating the sample with a pulse of excitation energy causing fluorescent species in the sample to fluoresce; detecting light emanating from the sample during a predetermined period of time after the pulse; generating and storing data recording at least the wavelength of the detected light against time; and analysing the data with reference to the respective lifetimes of the fluorescent species to detect the presence of the respective emissions from three or more different fluorescent species which emit light simultaneously during at least part of said predetermined period, which are indistinguishable from each other on the basis of their wavelength or lifetime alone.07-09-2009
20090298114APPARATUS AND METHODS FOR IMAGING AND MODIFICATION OF BIOLOGICAL SAMPLES - This invention relates to enrichment of a biological sample comprising a plurality of cells to assist further analysis thereof. It provides a technique comprising the steps of: (a) providing a sample comprising a plurality of cells which include a photosensitive compound that can be induced by light irradiation to inactivate or kill at least part of the respective cell; (b) acquiring an image of at least a portion of the sample; (c) identifying cells of interest in the sample image; (d) selecting cells other than the cells identified in step (c); and (e) irradiating only those cells selected in step (d) with a light beam so as induce the photosensitive compound therein to inactivate or kill at least part of those cells, and thereby enrich the sample with respect to the cells of interest for further analysis.12-03-2009

Patrick Courtney, Ealing GB

Patent application numberDescriptionPublished
20080217557Method and Apparatus For Analyzing a Dynamic Sample - A method of analysing a sample of biological material including components (09-11-2008

Patrick Courtney, London GB

Patent application numberDescriptionPublished
20080315119Method of Analysing a Sample and Apparatus Therefor - A method for performing photo-modification of a biological sample, the method comprising: (a) irradiating the sample; (b) detecting one or more signals based on the irradiated sample; (c) using one or more processor means to analyze the detected signals and determine one or more irradiation parameters, and, (d) returning to (a) conditioned on the irradiation parameters. Thus modifications may be determined and executed interactively as an experiment progresses, and therefore directed towards specific structures and/or events identified as of particular interest in the course of the experiment.12-25-2008

Stephen Benjamin Courtney, Bath GB

Patent application numberDescriptionPublished
20080289140Cyclonic Separating Apparatus - A cyclonic separating apparatus includes a first cyclonic separating unit including at least one first cyclone, a second cyclonic separating unit located downstream of the first cyclonic separating unit and including at least one second cyclone, and a third cyclonic separating unit located downstream of the second cyclonic separating unit and including a plurality of third cyclones arranged in parallel. The separation efficiency of the first cyclonic separating unit is lower than the separation efficiency of the second cyclonic separating unit and the separation efficiency of the second cyclonic separating unit is lower than the separation efficiency of the third separating unit, thus achieving a higher separation efficiency than known separation apparatus.11-27-2008
20090031524Multistage Cyclonic Separating Apparatus - A cyclonic separating apparatus includes a first cyclonic separating unit including at least one first cyclone, a second cyclonic separating unit located downstream of the first cyclonic separating unit and including a plurality of second cyclones arranged in parallel, and a third cyclonic separating unit located downstream of the second cyclonic separating unit and including a plurality of third cyclones arranged in parallel. The number of second cyclones is higher than the number of first cyclones and the number of third cyclones is higher than the number of second cyclones, providing an apparatus which achieves a higher separation efficiency than known separation apparatus.02-05-2009
20090288268SURFACE TREATING APPLIANCE - A surface treating appliance, such as a vacuum cleaner, includes a main body, a surface treating head and a support assembly. The support assembly is rotatably mounted to the main body for allowing the main body to be rolled along a surface. The support assembly also houses a component of the appliance, such as a motor for driving a surface-agitating device. Alternatively, or additionally, the support assembly may accommodate a fluid inlet for receiving fluid flow, a fluid outlet for exhausting fluid and a device for acting on the fluid flow received by the inlet such as a filter or suction apparatus.11-26-2009
20110061351MULTISTAGE CYCLONIC SEPARATING APPARATUS - A cyclonic separating apparatus includes a first cyclonic separating unit including at least one first cyclone and an annular dust collecting chamber, a second cyclonic separating unit located downstream of the first cyclonic separating unit and including at least one second cyclone and a dust collecting chamber, and a third cyclonic separating unit located downstream of the second cyclonic separating unit and including a plurality of third cyclones arranged in parallel and a dust collecting chamber. The number of third cyclones is higher than the number of second cyclones, and the dust collecting chambers of the second and third cyclonic separating units are located inside of the annular dust collecting chamber of the first cyclonic separating unit.03-17-2011

Patent applications by Stephen Benjamin Courtney, Bath GB

Stephen M. Courtney, Abingdon GB

Patent application numberDescriptionPublished
20090281062NOVEL NITROSO COMPOUNDS AS NITROXYL DONORS AND METHODS OF USE THEREOF - The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.11-12-2009

Stephen Martin Courtney, Abingdon GB

Patent application numberDescriptionPublished
20090163487N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS - The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.06-25-2009
20110136827Bis-Acylated Hydroxylamine Derivatives - The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.06-09-2011
20110144067N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives - The invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.06-16-2011

Patent applications by Stephen Martin Courtney, Abingdon GB

Stephen Martin Courtney, Oxfordshire GB

Patent application numberDescriptionPublished
20100099736PHENYL SUBSTITUTED MALEIMIDES AS MEDICAMENTS FOR BLOCKING DEGENERATIVE TISSUE DAMAGES BY INHIBITING MPT - The invention discloses the use of a compound of formula (I), wherein R04-22-2010
20110118258QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS - Compounds of general formula (I); or a stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R8 and R9 are as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as cancers, viral infection and inflammatory diseases or conditions.05-19-2011
20110183957CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF - Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.07-28-2011
20110230428CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF - Certain chemical entities are provided herein. Pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.09-22-2011

Patent applications by Stephen Martin Courtney, Oxfordshire GB

Steve Courtney, Oxfordshire GB

Patent application numberDescriptionPublished
20090221599PHTHALAZINONE PYRAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS - Objects of the present invention are the compounds of formula I09-03-2009

Tony Courtney, Gravesent GB

Patent application numberDescriptionPublished
20080315731Flexible mount for a fan and like devices - A flexible and stretchable mounting device for a fan or the like which has a shaft, a series of enlarged undulations axially arranged at one end of the shaft, and a head at one end of the shaft, the mounting device being adapted when stretched for insertion into aligned apertures on a chassis and a frame and relaxed to permit a selected undulation to hold the frame in spaced relation to the chassis. The device also includes a break away grip secured to the head for guiding the device into the apertures when stretched and which can be severed from the head when the device is arranged mounted on the chassis and frame.12-25-2008