Corless, US
Christopher C. Corless, Portland, OR US
Patent application number | Description | Published |
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20090280495 | ACTIVATING MUTATIONS OF PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA (PDGFRA) AS DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS - This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions. | 11-12-2009 |
20110081730 | ACTIVATING MUTATIONS OF PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA (PDGFRA) AS DIAGNOSTIC MARKERS AND THERAPEUTIC TARGET - This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions. | 04-07-2011 |
Christopher L. Corless, Portland, OR US
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20090221601 | Methods of identifying and treating individuals exhibiting mutant kit protein - The invention described herein relates to methods of identifying and treating individuals with protein tyrosine kinase associated disorders that have, or may, become resistant to treatment with a kinase inhibitor such as imatinib due to a gain-of-function mutation in KIT tyrosine kinase. | 09-03-2009 |
20110171216 | MONOCLONAL ANTIBODIES SPECIFIC FOR PANCREATIC NEOPLASIA CELLS - Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic cancer cells or precancerous pancreatic cancer cells. Humanized forms of these antibodies, functional fragments of these antibodies, and hybridomas producing these antibodies are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. The antibodies can be used for in vitro or in vivo pancreatic cancer diagnosis or disease monitoring via detection of pancreatic cancer cells or the pancreatic cancer cell surface antigen. Methods of treating a pancreatic cancer by administration of the antibodies are also disclosed. | 07-14-2011 |
Daniel G. Corless, Allen Park, MI US
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20090048055 | Differential With Cross Pin Retention System And Method For Assembly - A differential assembly includes a retainer for a cross pin having a bore aligned with a bore formed in a differential housing. The cross pin retainer is positionable at partially-inserted and fully-inserted positions within the cross pin and differential bores. At a first rotational orientation, the cross pin retainer is positionable in its partially-inserted position to temporarily retain the cross pin within the differential housing. At a second rotational orientation, the cross pin retainer is positionable in its fully-inserted position to retain the cross pin within the differential housing. Features of the cross pin retainer cooperate with surfaces formed in the differential housing to allow the cross pin retainer to be fixedly positioned and secured within the differential housing. | 02-19-2009 |
20100113207 | Differential With Cross Pin Retention System And Method For Assembly - A differential assembly includes a retainer for a cross pin having a bore aligned with a bore formed in a differential housing. The cross pin retainer is positionable at partially-inserted and fully-inserted positions within the cross pin and differential bores. At a first rotational orientation, the cross pin retainer is positionable in its partially-inserted position to temporarily retain the cross pin within the differential housing. At a second rotational orientation, the cross pin retainer is positionable in its fully-inserted position to retain the cross pin within the differential housing. Features of the cross pin retainer cooperate with surfaces formed in the differential housing to allow the cross pin retainer to be fixedly positioned and secured within the differential housing. | 05-06-2010 |
20130281251 | DIFFERENTIAL ASSEMBLY WITH FEATURES FOR IMPROVED LUBRICATION - A power transmitting component includes a housing having an interior cavity with a sump, a lubricant disposed in the sump, and a component mounted in the housing assembly for rotation about a first axis. The component rotates through the lubricant in the sump to generate a stream of lubricant that is slung from the component as it rotates at a speed in excess of a predetermined speed. The housing includes a deflector that extends into the interior cavity and has a first face having an impingement portion and a first edge adjacent the impingement portion. The impingement portion extends into the stream and deflects a portion of the stream towards the first edge. The first edge disperses the portion of the stream toward selected areas in the interior cavity. | 10-24-2013 |
Daniel Gatti Corless, Allen Park, MI US
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20110179904 | DIFFERENTIAL ASSEMBLY WITH FEATURES FOR IMPROVED LUBRICATION - An axle assembly includes an axle housing assembly including a housing structure having an interior cavity with a sump, a lubricant disposed in the sump having a liquid lubricant level, and a differential mounted in the axle housing assembly for rotation about a first axis. The differential includes a ring gear generating an annular stream of lubricant adjoining the ring gear above the liquid lubricant level during operation of the differential at a rotational speed greater than a predetermined rotational speed. The housing structure includes an interior surface on which a deflector is coupled. The deflector extends into the interior cavity and has a first face having an impingement portion and a first edge adjacent the impingement portion. The impingement portion extends into the stream and deflects a portion of the stream towards the first edge. The first edge disperses the portion of the stream into the cavity. | 07-28-2011 |
Gerald W. Corless, Streetsboro, OH US
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20130335988 | TRAILER ADAPTER WITH LIGHT - A trailer adapter to connect a master electrical system of a towing vehicle with a subservient electrical system of a towed vehicle having a light connectable thereto is disclosed. In particular, the trailer adapter may include a body having at least one electrical interface, where the at least one electrical interface is capable of electrically engaging the electrical system of the towing vehicle. The trailer adapter may also include a light source operatively coupled to the body, where the light source is selectively changeable between at least two operative modes capable of providing illumination. | 12-19-2013 |
20140015225 | UNIVERSAL MOUNTING BRACKET FOR AN ADAPTABLE HITCH COVER - A hitch cover is shown and described. The hitch cover may include a base having first and second surfaces, the second surface having at least one engagement member attached thereto. The hitch cover may also include a mounting bracket selectively attached to the at least one engagement member of the base and extending from the second surface wherein the mounting bracket is configured to selectively engage a hitch receiver tube. | 01-16-2014 |
Jerry Corless, Streetsboro, OH US
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20090263979 | Retractable adapter - The present invention provides a retractable adapter for connecting a towed vehicle to a towing vehicle. The retractable adapter may include a lower housing, an upper housing and a retractable mechanism to store the wiring harness when not in use with the towed vehicle. The lower housing may be attached to the towing vehicle. The adapter may include a rotating disc assembly, a wire guide assembly and an electrical connector or wiring harness that may be coiled around the wire guide assembly. The adapter may also include a circuit tester with light emitting diodes (LEDs) and a backup alarm. In addition, the adapter may mate a seven-way blade connector to a four-flat connecter harness. | 10-22-2009 |
20100144197 | MOUNTING BRACKET FOR TRAILER WIRING CONNECTOR - A mounting bracket for a trailer wiring connector is described. The mounting bracket may attach the electrical connector to a cross bar of a towing vehicle. The mounting bracket may include an upper housing and a lower housing. The upper housing may include a mounting aperture and a plurality of slots. The lower housing may include a threaded aperture and a plurality of tabs. The tabs may be capable of engagement with the slots to secure the upper housing to the lower housing. The lower housing may also include a clamping fastener, such as a set screw, that may be capable of engagement with a threaded aperture, wherein the set screw may be capable of clamping engagement with the electrical connector. The mounting bracket may also include a cover capable of engagement with the electrical connector. | 06-10-2010 |
20120156896 | PIN ADAPTER WITH LED - A pin adapter to connect a master electrical system of a towing vehicle with a subservient electrical system of a towed vehicle is disclosed. In particular, the pin adapter allows for connection of a different master electrical interface with a different subservient electrical interface. The pin adapter may include a body, the body having a first electrical interface capable of electrically engaging the electrical system of the towing vehicle, and a second electrical interface capable of electrically engaging the electrical system of the towed vehicle. The second electrical interface may include a plurality of terminals. The pin adapter may further include a cover attached to the body, the cover capable of engaging only one of the plurality of terminals of the second electrical interface. | 06-21-2012 |
20150011098 | TRAILER ADAPTER WITH LIGHT - A trailer adapter to connect a master electrical system of a towing vehicle with a subservient electrical system of a towed vehicle having a light connectable thereto is disclosed. In particular, the trailer adapter may include a body having at least one electrical interface, where the at least one electrical interface is capable of electrically engaging the electrical system of the towing vehicle. The trailer adapter may also include a light source operatively coupled to the body, where the light source is selectively changeable between at least two operative modes capable of providing illumination. | 01-08-2015 |
John Douglas Corless, Dallas, TX US
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20090103081 | Calibration of a radiometric optical monitoring system used for fault detection and process monitoring - The present invention is directed to a system and method for radiometric calibration of spectroscopy equipment utilized in fault detection and process monitoring. Initially, a reference spectrograph is calibrated to a local primary standard (a calibrated light source with known spectral intensities and traceable to a reference standard). Other spectrographs are then calibrated from the reference spectrograph rather than the local primary calibration standard. This is accomplished by viewing a light source with both the reference spectrograph and the spectrograph to be calibrated. The output from the spectrograph to be calibrated is compared to the output of the reference spectrograph and then adjusted to match that output. The present calibration process can be performed in two stages, the first with the spectrographs calibrated to the reference spectrograph and then are fine tuned to a narrow band light source at the plasma chamber. Alternatively, the reference spectrograph can be calibrated to the local primary standard while optically coupled to the plasma chamber. There, the local primary standard calibration light source is temporarily positioned within the plasma chamber, or in a light chamber disposed along the interior of the chamber for calibrating the reference spectrograph. Other spectrographs can be calibrated to the reference spectrograph while coupled to the plasma chamber with the local primary standard calibration light source, thereby calibrating every component in the entire optical path to the reference spectrograph. | 04-23-2009 |
20120025097 | Workpiece Characterization System - A workpiece characterization system for obtaining simultaneous measurement of layer and photoluminescence properties of a workpiece. The workpiece characterization system includes an excitation light and an illumination light each impinging upon a surface of a workpiece whereby the workpiece emits photoluminescent light and encodes light from said illumination source with layer information. The excitation light and the illumination light are generated from a single light source. The light from the single light source is filtered to remove wavelengths of light that correlate to light wavelengths emitted from the workpiece as a result of excitation. Wavelengths that correlate to light reflected from the workpiece that may contain encoded information are not filtered. | 02-02-2012 |
20120120387 | Workpiece Characterization System - A workpiece characterization system for obtaining simultaneous measurement of layer and photoluminescence properties of a workpiece. The workpiece characterization system includes an excitation light and an illumination light each impinging upon a surface of a workpiece whereby the workpiece emits photoluminescent light and encodes light from said illumination source with layer information. The excitation light and the illumination light are generated from a single light source. The light from the single light source is filtered to remove wavelengths of light that correlate to light wavelengths emitted from the workpiece as a result of excitation. Wavelengths that correlate to light reflected from the workpiece that may contain encoded information are not filtered. | 05-17-2012 |
20130016343 | REFERENCED AND STABILIZED OPTICAL MEASUREMENT SYSTEMAANM Corless; John DouglasAACI DallasAAST TXAACO USAAGP Corless; John Douglas Dallas TX USAANM Kueny; Andrew WeeksAACI DallasAAST TXAACO USAAGP Kueny; Andrew Weeks Dallas TX USAANM Meloni; Mark AnthonyAACI The ColonyAAST TXAACO USAAGP Meloni; Mark Anthony The Colony TX US - A referenced and stabilized optical measurement system includes a light source, a plurality of optical elements and optical fiber assemblies and a detector arranged to compensate for the effects of system variation which may affect measurement performance. A non-continuous light source provides a common source light on a common source path. A reference light and a measurement light are derived from the common source light and propagated across separate paths of optically matching optical components in order to produce a common signal variation on both the reference light signal and the measurement light signal. Light paths exposed to air are contained indiscrete volumes for purging gasses from the volumes. Ratios of the reference signal and measurement signal are acquired under various conditions for compensating the measurement signal for system variations. | 01-17-2013 |
Patrick J. Corless, Mahwah, NJ US
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20100205015 | ACCOUNT LEVEL PARTICIPATION FOR UNDERWRITING COMPONENTS - An account management system has been developed that enables customer or client-related information to be stored, viewed and manipulated in a manner that reflects the relationship among different customers. The account management system includes an account data structure that defines accounts and relates customers to accounts so that the accounts include a group of related customers. In addition, a method of managing an underwriting account for an insurance policy has been developed. In particular, a method comprises the steps of establishing a plurality of participants; assigning each participant of the plurality of participants to an account; establishing business rules at an account level; and providing an underwriting decision for an account based upon the business rules. | 08-12-2010 |
20120271664 | ACCOUNT LEVEL PARTICIPATION FOR UNDERWRITING COMPONENTS - An account management system has been developed that enables customer or client-related information to be stored, viewed and manipulated in a manner that reflects the relationship among different customers. The account management system includes an account data structure that defines accounts and relates customers to accounts so that the accounts include a group of related customers. In addition, a method of managing an underwriting account for an insurance policy has been developed. In particular, a method comprises the steps of establishing a plurality of participants, assigning each participant of the plurality of participants to an account, establishing business rules at an account level, and providing an underwriting decision for an account based upon the business rules. | 10-25-2012 |