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Contag, CA
Christopher H. Contag, Stanford, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090312402 | ENCAPSULATED NANOPARTICLES FOR DRUG DELIVERY - Compositions and methods are provided for preparing nanosized biologically nucleic acids, including agents formulated for target specific drug delivery. In some embodiments, the nanoparticles comprise a polymer coating, which can provide for controlled delivery, targeting, controlled release, and the like. In other embodiments, the nanoparticles comprise a target specific tag for targeting the nanoparticles to a site of interest, e.g. tissue, cell, etc. | 12-17-2009 |
| 20100034777 | Method for Regulating Protein Function in Cells In Vivo Using Synthetic Small Molecules - Methods and compositions for the rapid and reversible destabilizing of specific proteins in vivo using cell-permeable, synthetic molecules are described. | 02-11-2010 |
| 20110160146 | Conjungation of Small Molecules to Octaarginine Transporters for Overcoming Multi-Drug Resistance - Many cancer therapeutic agents elicit resistance that renders them ineffective and often produces cross resistance to other drugs. One of the most common mechanisms of resistance involves P-glycoprotein (Pgp) mediated drug efflux. Here we provide compositions and methods that restore the efficacy of a therapeutic agent reduced by resistance by conjugation of the same agent to an oligoarginine transporter comprising from about 5 to about 25 guanidino or amidino moieties. We specifically show that the widely used chemotherapeutic agent taxol, ineffective against taxol-resistant human ovarian cancer cell lines, can be incorporated into an octaarginine conjugate that is effective against the same taxol-resistant cell lines. Significantly, the ability of the taxol conjugates to overcome taxol resistance is observed both in cell culture and in animal models of ovarian cancer. The generality and mechanistic basis for this effect were also explored with other Pgp substrate. This approach shows generality for overcoming the multidrug resistance elicited by small molecule cancer chemotherapeutics and could improve the prognosis for many cancer patients and fundamentally alter search strategies for novel therapeutic agents effective against resistant disease. | 06-30-2011 |
Christopher H. Contag, San Jose, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080226563 | Non-invasive localization of a light-emitting conjugate in a mammal - Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen. | 09-18-2008 |
| 20090041668 | Non-invasive localization of a light-emitting conjugate in a mammal - Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen. | 02-12-2009 |
Pamela R. Contag, San Jose, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080226563 | Non-invasive localization of a light-emitting conjugate in a mammal - Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen. | 09-18-2008 |
| 20090041668 | Non-invasive localization of a light-emitting conjugate in a mammal - Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen. | 02-12-2009 |
Pamela Reilly Contag, San Jose, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080293086 | REAL TIME MONITORING OF MICROBIAL ENZYMATIC PATHWAYS - This invention provides compositions and methods for monitoring and regulating the production of a target product of a biochemical pathway in an organism, such as butanol. A gene encoding a light-emitting reporter molecule, such as luciferase, is operatively linked with a transcription regulatory nucleotide sequence that regulates transcription of an enzyme in the pathway that signals the rate of production of the target product, such as butanol dehyrogenase. When a microorganism is transfected with such a reporter construct and cultured, the reporter is expressed contemporaneously with the enzyme. The amount of light produced by the reporter indicates amount of enzyme being produced which, in turn, signals the amount of target product being produced. When the reporter is measured in real time, it provides information that can be used to regulate culture conditions and to optimize production of the target product. | 11-27-2008 |
| 20090081715 | Engineered Light-Emitting Reporter Genes - Compositions and methods are provided for enhanced expression of light emitting reporters. Such reporters are used in methods for monitoring cultures for production of target compounds. | 03-26-2009 |
| 20110129887 | IMMOBILIZED PRODUCT TOLERANT MICROORGANISMS - Methods for adapting or selecting microorganisms with increased product tolerance are provided Additionally, a bioreactor capable of operation in either packed bed or fluidized bed is disclosed along with methods to use the bioreactor for culturing microorganisms adapted or selected increased product tolerance | 06-02-2011 |