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| 20090029419 | Expression of modified antibodies in avian cells - The present invention relates to construct and methods which allow the expression of immunoglobulins or functional fragments thereof which have been altered to that they are humanised. The expression of the immunoglobulins or fragments thereof takes place in avian cells, and the constructs used have been altered such that the expression levels in avian cells are higher than what would have been expected by simply using a humanised construct. The alterations are based on changing codons so that each amino acid of the codon that is used is the one which is most often found in avians. | 01-29-2009 |
| 20090176203 | Mutant HSV, Materials and Methods for Generation of Mutant HSV - A method of generating a mutant Herpes Simplex Virus (HSV) is disclosed, wherein the generated HSV genome comprises nucleic acid encoding a nucleic acid sequence of interest, the method comprising the steps of: i. providing a nucleic acid vector comprising nucleic acid encoding first and second site specific recombination sequences and a nucleic acid encoding a nucleic acid sequence of interest between said site specific recombination sequences; ii. providing an HSV, the genome of which comprises third and fourth site specific recombination sequences; iii. contacting said nucleic acid vector of (i) with said HSV of (ii) together with one or more recombinase enzymes capable of catalysing site specific recombination between the site specific recombination sequences of said nucleic acid vector and said HSV; iv. identifying HSV containing the nucleic acid sequence of interest, wherein steps i-iii are conducted in a cell-free system. | 07-09-2009 |
| 20100092515 | HERPES SIMPLEX VIRUSES AND METHODS OF VIRAL REPLICATION - A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide. | 04-15-2010 |
| 20100272691 | Viruses - Herpes Simplex Viruses are disclosed having single-chain antibodies (scFv) embedded in the viral envelope via fusion with glycoprotein D and with glycoprotein H and L. | 10-28-2010 |
| 20110244576 | Herpes Simplex Virus Complex - There is provided an HSV complex which comprises an avirulent HSV and a targeting agent which allows the HSV particle to infect and lyse a specific targeted cell. The inventors have found a way in which avirulent HSV can be targeted to disease cells, e.g. cancer cells, by incorporating an antibody binding domain into one or more viral glycoproteins. | 10-06-2011 |
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| 20100264082 | SUSPENDED MEDIA GRANULAR ACTIVATED CARBON MEMBRANE BIOLOGICAL REACTOR SYSTEM AND PROCESS - A system and process for treating an industrial wastewater stream is provided using a membrane biological reactor in which granular activated carbon material is introduced into an aeration portion and maintained upstream of a membrane operating system. The size of the granules of activated carbon is selected so that they can be screened or otherwise readily separated from the mixed liquor stream before the mixed liquor enters the membrane operating system tank(s) containing the submerged membranes, thereby preventing abrasion of the membrane by the carbon granules. The aeration portion includes a waste discharge port whereby a portion of spent granular activated carbon can be removed when the effluent concentration of chemical oxygen demand compounds approaches limits typically set by governmental agencies, and replaced by addition of fresh or regenerated granular activated carbon having greater adsorbent capacity. | 10-21-2010 |
| 20110005284 | WASTEWATER TREATMENT SYSTEM AND PROCESS INCLUDING IRRADIATION OF PRIMARY SOLIDS - The present invention provides a system and method for treating wastewater in which the majority of solids and biological oxygen demand compounds are separated from the wastewater feed using a primary separation process, to produce a solids phase and a water phase. The solids phase is irradiated to reduce the level of pathogens such that it is safe to use as a soil substitute and/or additive so that the solids can thus be disposed of in an environmentally-friendly manner. In additional embodiments, the solids that have been disinfected by radiation are mixed with a suitable inert filler material to produce a soil substitute, fertilizer, compost, or other soil additive. The liquid phase is treated in a substantially smaller system than would be required for treating the full-strength wastewater that can include a suspended media biological regeneration reactor system. The liquid treatment system can include a high flux adsorbent material treatment system integrated with a low flux adsorbent material biological regeneration reactor. | 01-13-2011 |
| 20110006002 | LOW CONCENTRATION WASTEWATER TREATMENT SYSTEM AND PROCESS - A low concentration wastewater treatment system is provided that includes a high flux adsorbent material treatment system integrated with a low flux adsorbent material biological regeneration reactor. The high flux adsorbent material treatment system includes one or more unit operations for mixing low concentration wastewater with adsorbent material that is fresh, recycled, or a combination of both, and for decanting a liquid effluent having a reduced level of contaminants. The adsorbent material with adsorbed contaminants is regenerated in a low flux adsorbent material biological regeneration reactor in which a biological reaction occurs, such as biological oxidation, wherein organic contaminants in the wastewater are metabolized generally into carbon dioxide and water. Excess biomass is removed from the adsorbent material, and the thus-regenerated adsorbent material is recycled to the high flux adsorbent material treatment system. | 01-13-2011 |
| 20110017664 | SUSPENDED MEDIA MEMBRANE BIOLOGICAL REACTOR SYSTEM AND PROCESS INCLUDING SUSPENSION SYSTEM AND MULTIPLE BIOLOGICAL REACTOR ZONES - A wastewater treatment system is provided comprising a biological reactor having a separation subsystem, a suspension system and a membrane operating system. The separation subsystem is constructed and arranged to maintain adsorbent material in the biological reactor with a mixed liquor. The suspension system is positioned in the biological reactor and is constructed and arranged to maintain adsorbent material in suspension with mixed liquor. The membrane operating system is located downstream of the biological reactor and is constructed and arranged to receive treated mixed liquor from the biological reactor and discharge a membrane permeate. In addition, a wastewater treatment system is provided comprising a first biological reaction zone, a second biological reaction zone and a membrane operating system. The first biological reaction zone is constructed and arranged to receive and treat the wastewater. The second biological reaction zone includes a separation subsystem and is constructed and arranged to receive effluent from the first biological reaction zone. A suspension system for adsorbent material is provided in the second biological reaction zone. The membrane operating system is located downstream of the second biological reaction zone and is constructed and arranged to receive treated wastewater from the second biological reaction zone and discharge a membrane permeate. | 01-27-2011 |
| 20110247978 | SUSPENDED MEDIA GRANULAR ACTIVATED CARBON MEMBRANE BIOLOGICAL REACTOR SYSTEM AND PROCESS - A system and process for treating an industrial wastewater stream is provided using a membrane biological reactor in which granular activated carbon material is introduced into an aeration portion and maintained upstream of a membrane operating system. The size of the granules of activated carbon is selected so that they can be screened or otherwise readily separated from the mixed liquor stream before the mixed liquor enters the membrane operating system tank(s) containing the submerged membranes, thereby preventing abrasion of the membrane by the carbon granules. The aeration portion includes a waste discharge port whereby a portion of spent granular activated carbon can be removed when the effluent concentration of chemical oxygen demand compounds approaches limits typically set by governmental agencies, and replaced by addition of fresh or regenerated granular activated carbon having greater adsorbent capacity. | 10-13-2011 |
