Conn, US
Andrew R. Conn, Mount Vernon, NY US
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20160032692 | INDUCED CONTROL EXCITATION FOR ENHANCED RESERVOIR FLOW CHARACTERIZATION - A system, method and a computer program product may be provided for characterizing natural resource subsurface attributes and compositions. The system prescribes alterations of one or more controls of a natural resource. The system applies the altered controls to the natural resource wells. The system collects measurement data of the natural resource wells that responds to the applied altered controls. The system determines, based on the collected measurement data, the natural resource subsurface attributes and compositions that pertain to the natural resource. | 02-04-2016 |
Benjamin R. Conn, Wildwood, MO US
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20140280348 | EDUCATIONAL LIBRARY SYSTEM - Methods, systems and computer readable media for educational library management are described. | 09-18-2014 |
Brian Conn, San Diego, CA US
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20100125239 | Selective Drug Delivery In a Lumen - Methods and systems are disclosed for selective drug or fluid delivery in a lumen through a coating or fluid delivery channels. One system includes an elongate catheter having a proximal end and a distal end with an axis therebetween, the catheter having a radially expandable balloon near the distal end and an energy delivery portion proximate the balloon for transmission of energy, a thermally changeable coating having a releasable drug coupled to the balloon, the thermally changeable coating being oriented to be urged against the body tissue when the expandable balloon expands and an energy source operatively coupled to the energy delivery portion configured to energize the energy delivery portion to heat and liquefy the thermally changeable coating to release the drug to the body tissue. | 05-20-2010 |
Brian D. Conn, San Diego, CA US
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20110130708 | Directional Delivery of Energy and Bioactives - Systems and methods are disclosed for the treatment of a target tissue by directionally delivering energy and/or bioactive materials to achieve a therapeutic effect. A balloon catheter system having a balloon portion and a plurality of electrodes may be energized to selectively deliver energy, bioactive materials, or a combination thereof to target tissue including tissues disposed about a lumen. The tissue may be targeted by applying energy, making tissue impedance analysis, and further selectively energizing electrodes through the use of an energy source with a controller. | 06-02-2011 |
20130172815 | SELECTIVE DRUG DELIVERY IN A LUMEN - Methods and systems are disclosed for selective drug or fluid delivery in a lumen through a coating or fluid delivery channels. One system includes an elongate catheter having a proximal end and a distal end with an axis therebetween, the catheter having a radially expandable balloon near the distal end and an energy delivery portion proximate the balloon for transmission of energy, a thermally changeable coating having a releasable drug coupled to the balloon, the thermally changeable coating being oriented to be urged against the body tissue when the expandable balloon expands and an energy source operatively coupled to the energy delivery portion configured to energize the energy delivery portion to heat and liquefy the thermally changeable coating to release the drug to the body tissue. | 07-04-2013 |
Brian M. Conn, Boomfield, CO US
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20100317913 | IMPLANTABLE AUDITORY STIMULATION SYSTEM AND METHOD WITH OFFSET IMPLANTED MICROPHONES - An improved implantable auditory stimulation system includes two or more implanted microphones for transcutaneous detection of acoustic signals. Each of the implanted microphones provides an output signal. The microphone output signals may be combinatively utilized by an implanted processor to generate a signal for driving an implanted auditory stimulation device. The implanted microphones may be located at offset subcutaneous locations and/or may be provided with different design sensitivities, wherein combinative processing of the microphone output signals may yield an improved drive signal. In one embodiment, the microphone signal may be processed for beamforming and/or directionality purposes. | 12-16-2010 |
Brian M. Conn, Broomfield, CO US
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20090240099 | BI-MODAL COCHLEA STIMULATION - An improved implantable hearing instrument and associated method utilize a transducer to mechanically stimulate a patient's cochlea (e.g. via the round window or oval window) in response to a first electrical drive signal, and a supply electrode to electrically stimulate the patient's cochlea in response to a second drive signal. The first and second drive signals may be provided to affect mechanical stimulation across a first predetermined frequency range and electrical stimulation across a second predetermined frequency range, respectively, wherein the predetermined frequency ranges are at least partially non-overlapping. In one embodiment an electromechanical transducer, having the supply member supportably interconnect thereto, may be selectively positioned via a mounting member fixedly interconnected to a patient's skull. The supply electrode may define a distal tip that is supportably interconnected to a vibratory member of the electromechanical transducer. In another embodiment, an implantable transducer may be employed that includes an external housing and an active transducer element located within an internal chamber of the external housing for receiving the first electrical signal. Further, the supply electrode may be one of electrically connected to and defined by at least an electrically-conductive portion of the external housing of the transducer. | 09-24-2009 |
20090287277 | IMPLANTABLE NEUROSTIMULATION ELECTRODE INTERFACE - An implantable neurostimulation electrode interface and related system arrangements and methods are provided. The implantable interface may include at least a first stimulation signal channel for receiving a first electrode stimulation signal and a plurality of electrode signal channels electrically interconnected or interconnectable to a plurality of electrodes for neurostimulation. The interface may further include a router electrically interconnected to the first stimulation signal channel and to the plurality of electrode signal channels. The router is controllable to directly route the first electrode stimulation signal to different first successive sets of one or more of the plurality of electrode signal channels. The router may be adapted for routing the first electrode stimulation signal as an electrical current signal, without modification of the signal. Stimulation signal generation componentry and power source componentry may be located remotely from the implantable interface. Such componentry may be selectively interconnectable to and disconnectable from the implantable interface. | 11-19-2009 |
20100042119 | SYSTEMS AND METHODS FOR SECURING SUBCUTANEOUS IMPLANTED DEVICES - A system for reducing subcutaneous migration of an implantable device or housing relative to surrounding soft tissue. For instance, the implantable housing may support a microphone diaphragm. The system includes at least one securement member having at least one aperture extending therethrough that may selectively receive one of a soft tissue securement device (e.g., soft tissue suture) and soft tissue growth therethrough. The securement member is at least one of interconnected to and disposable over at least a portion of the housing and at least one of extends away from and is selectively extendable away from a periphery of the housing. In one arrangement, at least one mesh member may be optionally included with the system that may allow for tissue growth to enhance securement of the implanted device relative to the soft tissue. | 02-18-2010 |
20100268313 | REFERENCE ELECTRODE APPARATUS AND METHOD FOR NEUROSTIMULATION IMPLANTS - An implantable apparatus and method are provided for use in conjunction with an implantable neurostimulation signal generator that provides an electrical stimulation signal to an active electrode. In auditory stimulation applications, the apparatus includes at least one anchor member having a distal end portion for directly contacting a patient's cranial bone and an electrically conductive portion extending from the distal end portion to a contact location proximal to the distal end portion. An electrical connection line may be electrically interconnected at a first end to the contact location of the anchor member and electrically interconnected at a second end to an implantable auditory neurostimulation signal generator to define a reference electrode. A bracket member may be mounted to a patient's cranial bone utilizing the anchor member, wherein an electrically conductive pathway extends from a first contact location to a second contact location of the bracket member. The first contact location may selectively contact the contact location of the anchor member and the second location of the bracket member may be adapted for electrical interconnection to the electrical connection line. | 10-21-2010 |
20100318167 | NEUROSTIMULATION ELECTRODE ARRAY AND METHOD OF MANUFACTURE - An implantable neurostimulation electrode array may include a flexible, electrically non-conductive carrier, and a plurality of electrodes supportably interconnected to and spaced along a length of a carrier. In various embodiments, different ones of at least some of the plurality of electrodes may comprise corresponding contact surfaces having different areas. The different surface areas may be achieved by defining a different area per unit length of the carrier and/or by defining a different total length (e.g. as measured along a length of the carrier). In some embodiments, insulator portions having different corresponding lengths may be disposed between different adjacent ones of the electrodes. The insulated portions may be integrally defined with the carrier. Electrical connection lines may be embedded within the carrier. In a manufacturing method, a plurality of electrodes may be supportably interconnected to a first side of a sacrificial substrate and a carrier may be interconnected to the electrodes. In turn, at least a portion of the substrate may be removed from the electrodes to yield at least a partially completed electrode array. The substrate may be configured into a predetermined configuration wherein the carrier material may be formed within an internal volume thereof to define at least a portion of the configuration of the carrier of the electrode array. | 12-16-2010 |
20130079844 | Implantable Neurostimulation Electrode Interface - An implantable neurostimulation electrode interface and related system arrangements and methods are provided. The implantable interface may include at least a first stimulation signal channel for receiving a first electrode stimulation signal and a plurality of electrode signal channels electrically interconnected or interconnectable to a plurality of electrodes for neurostimulation. The interface may further include a router electrically interconnected to the first stimulation signal channel and to the plurality of electrode signal channels. The router is controllable to directly route the first electrode stimulation signal to different first successive sets of one or more of the plurality of electrode signal channels. The router may be adapted for routing the first electrode stimulation signal as an electrical current signal, without modification of the signal. Stimulation signal generation componentry and power source componentry may be located remotely from the implantable interface. Such componentry may be selectively interconnectable to and disconnectable from the implantable interface. | 03-28-2013 |
20130204340 | NEUROSTIMULATION ELECTRODE ARRAY AND METHOD OF MANUFACTURE - A tissue stimulation assembly, including an elongate electrode assembly having a longitudinal axis and including a contact electrode, the contact electrode including a contact surface, wherein at least a portion of the contact surface has a width that gradually increases as the contact surface progresses in a lateral direction. | 08-08-2013 |
20140316190 | IMPLANTABLE AUDITORY STIMULATION SYSTEM AND METHOD WITH OFFSET IMPLANTED MICROPHONES - An improved implantable auditory stimulation system includes two or more implanted microphones for transcutaneous detection of acoustic signals. Each of the implanted microphones provides an output signal. The microphone output signals may be combinatively utilized by an implanted processor to generate a signal for driving an implanted auditory stimulation device. The implanted microphones may be located at offset subcutaneous locations and/or may be provided with different design sensitivities, wherein combinative processing of the microphone output signals may yield an improved drive signal. In one embodiment, the microphone signal may be processed for beamforming and/or directionality purposes. | 10-23-2014 |
Bryan Conn, New York, NY US
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20110275155 | ENTRAPPED STEM CELLS AND USES THEREOF - The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells. | 11-10-2011 |
David Conn, Madison, MS US
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20100109884 | SYSTEM AND METHOD FOR FOOD SAFETY INSPECTION - A system and a method for monitoring and inspecting food safety is disclosed. The system adopts insert and use concept that only requires an initial push on a button to begin its function. The system provides visual alert for different conditions if food products are in unsafe status. The system is pre-calibrated during manufacture without complicated or multi-step calibration or recalibration procedures during application. The system relies on modern surface-mount microprocessor technology that enables long-term calibration stability along with very low power consumption for extended battery life. | 05-06-2010 |
20110276297 | SYSTEM AND METHOD FOR FOOD SAFETY INSPECTION - A system and a method for monitoring and inspecting food safety is disclosed. The system adopts insert and use concept that only requires an initial push on a button to begin its function. The system provides visual alert for different conditions if food products are in unsafe status. The system is pre-calibrated during manufacture without complicated or multi-step calibration or recalibration procedures during application. The system relies on modern surface-mount microprocessor technology that enables long-term calibration stability along with very low power consumption for extended battery life. | 11-10-2011 |
20150285689 | SYSTEM AND METHOD FOR FOOD SAFETY INSPECTION - A system and a method for monitoring and inspecting food safety is disclosed. The system adopts insert and use concept that only requires an initial push on a button to begin its function. The system provides visual alert for different conditions if food products are in unsafe status. The system is pre-calibrated during manufacture without complicated or multi-step calibration or recalibration procedures during application. The system relies on modern surface-mount microprocessor technology that enables long-term calibration stability along with very low power consumption for extended battery life. | 10-08-2015 |
David Conn, Sugar Land, TX US
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20130082845 | ESTIMATION AND COMPENSATION OF PRESSURE AND FLOW INDUCED DISTORTION IN MUD-PULSE TELEMETRY - A method for reconstituting a signal due to a flow distortion in a mud-pulse telemetry system, having steps of obtaining at least one parameter to be transmitted by a transmitter to a receiver through the mud-pulse telemetry system, estimating a change in a flow rate in a borehole fluid along a trajectory of the mud-pulse telemetry system undergoing a fluid distortion, estimating a Doppler rate of the signal traveling through the borehole fluid along the trajectory of the mud-pulse telemetry system, calculating a Doppler compensation value for the signal sent along the trajectory in the borehole fluid, transmitting the signal of the at least one parameter through the mud-pulse telemetry system, receiving a portion of the signal of the at least one parameter and reconstituting at least a portion of the signal using the Doppler compensation value. | 04-04-2013 |
20130118249 | Method and Apparatus for Detecting Fluid Flow Modulation Telemetry Signals Transmitted from and Instrument in A Wellbore - An apparatus for detecting fluid modulation signals transmitted by an instrument in a wellbore includes a motion sensor coupled to a selected position on an exterior of a conduit coupled between a discharge side of a fluid pump and an inlet to a pipe string suspended in the wellbore. The instrument is coupled to the pipe string. A signal detector is in signal communication with the motion sensor. | 05-16-2013 |
20130168084 | Determination of Stick Slip Conditions - A method for determining stick slip conditions. The method may include disposing an operating apparatus in fluid communication with a pressure wave transmission medium. At least one pressure measurement device may be disposed at least partially within the pressure wave transmission medium and at some distance from the operating apparatus. One or more pressure waves generated by the operating apparatus may be measured within the pressure wave transmission medium with the at least one pressure measurement device and pressure measurement data may be generated therefrom. The pressure measurement data from the at least one pressure measurement device may be transmitted to a data acquisition system. The pressure measurement data may be analyzed to detect one or more stick slip conditions from one or more variations in the pressure measurement data. | 07-04-2013 |
20150218929 | Well-Logging System With Data Synchronization And Methods - A well-logging system may include a tool assembly to be positioned within a borehole of a subterranean formation and to store second data including a second time marker related to a first time marker. The well-logging system may include a controller above the subterranean formation. The controller may process first data including the first time marker, recover the second data, and synchronize the second data based upon the second time marker and the first time marker. | 08-06-2015 |
David Kirk Conn, Houston, TX US
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20100245121 | DIGITAL SIGNAL PROCESSING RECEIVERS, SYSTEMS AND METHODS FOR IDENTIFYING DECODED SIGNALS - A digital signal processing receiver, a system and/or a method identifies a decoded signal. The receiver, system and/or method extract at least one sequence of one or more symbols from a digital incoming signal to generate an extracted sequence of symbols. The receiver, system and/or method generate a first result based on a comparison of the extracted sequence of symbols and one or more possible matching digital signals of a set of idealized model data according to a Bayesian probability theory. The receiver, system and/or method generates a second result based on a comparison of an equalized version of the digital incoming signal and the one or more possible matching digital signals. The receiver, system and/or method generates a third result based on a comparison of the extracted sequence of symbols and one or more possible matching digital signals of a modified set of idealized model data. The receiver, system and/or method compare the first, second and third results to determine an idealized result, and identify a decoded signal for the actual incoming signal based on the idealized result. | 09-30-2010 |
20150034385 | Moveable Element to Create Pressure Signals in A Fluidic Modulator - A fluidic modulator in accordance to an aspect includes a body forming a flow aperture between an inlet and an outlet, the flow aperture providing a constriction to a fluid flowing axially from the inlet to the outlet, and a moveable element having a shaft portion disposed through the body and a tip end selectively positionable in the flow aperture to alter the flow aperture. | 02-05-2015 |
20150034386 | Fluidic Modulators and Along String Systems - A well system includes a first fluidic modulator (FM) located at the bottom of the tubular string and a repeater fluidic modulator (FM) located in the tubular string between the first FM and the surface, the repeater FM including a body forming a flow aperture between an inlet and an outlet, the flow aperture providing a constriction to a fluid flowing axially through the tubular string, and a moveable portion operable to alter the flow aperture. To create a modulated pressure pulse the moveable portion may be for example radially shifted in the flow aperture, rotated in the flow aperture, or the rotation of the moveable portion in the flow aperture may be controlled. | 02-05-2015 |
20150218937 | System and Method for Downhole Signal Enhancement - A system and method for downhole signal enhancement. The system includes a downhole tool having one or more sensors coupled thereto. The one or more sensors may measure internal pressure and one or more parameters selected from the group consisting of external pressure, pressure sensor temperature, weight on bit, torque on bit, bending moment, roll gyro, tangential acceleration, radial acceleration, and axial acceleration. A noise estimator may be coupled to the downhole tool and estimate a downhole noise component in the one or more parameters. A telemetry modulator may be coupled to the downhole tool and generate a signal that includes the estimated downhole noise component and a telemetry component. The downhole noise component in the signal may be reduced based at least partially upon the estimate. | 08-06-2015 |
David Kirk Conn, Sugar Land, TX US
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20150034165 | Fluidic Modulators - A fluidic modulator having a body forming a flow aperture between an inlet and an outlet, the flow aperture having a nominal diameter less than the inlet diameter and the outlet diameter whereby the flow aperture provides a constriction to a fluid flowing axially from the inlet to the outlet, and a moveable portion operable to alter the flow aperture. To create a modulated pressure pulse the moveable portion may be for example radially shifted in the flow aperture, rotated in the flow aperture, or the rotation of the moveable portion in the flow aperture may be controlled. | 02-05-2015 |
Earl Dewayne Conn, Washington, WI US
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20130133562 | BUS SEAT BACK TRIM AND METHOD AND APPARATUS FOR MAKING - A bus seat for use in a bus comprises a frame and a seat back secured to a portion of the frame. The bus seat further comprises a seat cushion secured to another portion of the frame. The bus seat also comprises a removable two piece cover arranged over the seat back, wherein the cover pieces are secured to one another with a zipper. The zippered two piece seat back cover allows for easy installation, removal or replacement of any damaged or worn portions of the seat back trim cover. | 05-30-2013 |
20150224900 | BUS SEAT BACK TRIM AND METHOD AND APPARATUS FOR MAKING - A bus seat for use in a bus comprises a frame and a seat back secured to a portion of the frame. The bus seat further comprises a seat cushion secured to another portion of the frame. The bus seat also comprises a removable two piece cover arranged over the seat back, wherein the cover pieces are secured to one another with a zipper. The zippered two piece seat back cover allows for easy installation, removal or replacement of any damaged or worn portions of the seat back trim cover. | 08-13-2015 |
Edward L. Conn, Griswold, CT US
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20100292205 | Pyrimidone Compounds As GSK-3 Inhibitors - The invention pertains to pyrimidone compounds that serve as effective GSK-3 inhibitors. The invention further relates to pharmaceutical compositions and methods comprising such pyrimidone compounds; and the use of such compounds for treating certain disorders. | 11-18-2010 |
20130123230 | 2-Thiopyrimidinones - Myeloperoxidase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, cardiovascular conditions. | 05-16-2013 |
20130296351 | 2-Thiopyrimidinones - Myeloperoxidase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, cardiovascular conditions. | 11-07-2013 |
20140288049 | 2-Thiopyrimidinones - Myeloperoxidase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, cardiovascular conditions. | 09-25-2014 |
Edward Lee Conn, Griswold, CT US
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20130072519 | 2-PHENYL BENZOYLAMIDES - Compounds of Formula I that inhibit microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion and their uses in the treatment of diseases linked thereto in animals are described herein. | 03-21-2013 |
Eric Conn, Woodbine, MD US
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20080275881 | Real time collaborative on-line multimedia albums - Methods and systems for creating, editing and monitoring real-time collaborative on-line multimedia albums at a host site. The invention facilitates the construction of the multimedia albums which comprise digital content, such as photos and video clips, provided by multiple digital content contributors, taken from each contributor's unique perspective. The invention uniquely creates these multimedia albums to be optimized for dynamic updating, real-time interaction, and rapid dissemination to a viewing audience, for public and/or private viewing, either one photo/video clip at a time or as a slide-show. | 11-06-2008 |
20080293387 | SYSTEM AND METHOD FOR RESPONDING TO INFORMATION REQUESTS FROM USERS OF PERSONAL COMMUNICATION DEVICES - There are provided methods and systems for responding to information requests from users of personal communication devices, such as mobile telephones and more particularly cellular telephones. In one embodiment, information requests issued from a plurality of user's cellular telephones are received and processed at a central host site. Processing comprises parsing the user requests to determine the content and category type of the request and retrieving relevant content configured as a sequence of images (frames), referred to as a “video strip”. When a user plays back a video strip on his or her personal communication device, the sequence of images appear on the user's display as a sequence of still images, played back at a slow rate, unlike conventional movie playback frame rates. When viewing a video strip, a viewer may stop, start, and pause the video strip. Pausing playback of a video strip enables the user to easily peruse the contents of each video strip frame. | 11-27-2008 |
20090193457 | Systems and methods for providing run-time enhancement of internet video files - Methods and systems are provided for enhancing Internet video files at run-time with supplemental multimedia content constructed in real-time. The supplemental multimedia content may comprise any type of content that cannot be known and practically constructed prior to run-time of an Internet video file. The supplemental multimedia content may include locally and globally derived information, for example, advertising, alerts (e.g. weather, disaster), messaging, user-generated content, and proprietary content. According to one aspect, a browser cookie is stored onto the user's remote computing device. The browser cookie is capable of collecting various types of information about the user's behavior while visiting a web-site including Internet source video. This information collected within browser cookie may be periodically uploaded to a personal profile database for later use in assisting third party content providers with the targeting of future dynamic supplemental content based on the on-going collected demographic, behavioral, and geographical information of users. | 07-30-2009 |
20100262923 | Methods and systems for displaying information on a graphical user interface - Systems and methods, operable on a mobile device for facilitating communication between at least one user and a plurality of participating product or service providers via an intermediary third-party communication management system. Users who respond to solicitations of the plurality of participating product or service providers have the option of remaining anonymous while communicating with the plurality of participating product and service providers by utilizing an internal email service of the third-party communication management system or by other anonymous communication formats. In one embodiment, users are automatically notified of changes and updates to user selected participating product or service provider web sites, via the intermediary third-party communication management system and may communicate with the changed websites anonymously. At any point, the users may elect to communicate in a non-anonymous communication format, thus protecting the user's identity and privacy with the plurality of participating product or service providers. | 10-14-2010 |
20120150608 | SYSTEM AND METHOD FOR RESPONDING TO APERIODIC INFORMATION REQUESTS FROM USERS OF PERSONAL COMMUNICATION DEVICES BY PROVIDING TARGETED ADVERTISEMENTS - There are provided methods and systems for responding to aperiodic information requests from users of personal communication devices, such as mobile telephones and more particularly cellular telephones. In one embodiment, information requests issued from a plurality of user's cellular telephones are received and processed at a central host site. Processing comprises parsing the user requests to determine the content and category type of the request and retrieving relevant content configured as a sequence of images (frames), referred to as a “video strip”. When a user plays back a video strip on his or her personal communication device, the sequence of images appear on the user's display as a sequence of still images, played back at a slow rate, unlike conventional movie playback frame rates. | 06-14-2012 |
Frank Conn, Hermosa Beach, CA US
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20150284109 | SYSTEM AND METHOD FOR MATCHING OF SPACE LAUNCH, SATELLITE, AND MISSION PAYLOAD OPPORTUNITIES - A system and a related method are disclosed for matching space launch vehicle, satellite, and mission hosted payload opportunities utilizing multi-level, priority algorithms. The potential matches include numerous mission-matching scenarios, e.g., 1) matching hosted payload and host spacecraft, and 2) matching spacecraft(s) and launch opportunities, to include rideshare opportunities. The matching opportunities can be pursued by any interested project team, e.g., hosted payload, spacecraft, and space launch vehicle. | 10-08-2015 |
Gregory Conn, Lawrenceburg, IN US
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20110110972 | STIMULATION OF AN IMMUNE RESPONSE BY ENANTIOMERS OF CATIONIC LIPIDS - Compositions and methods for treating immune cells and activating immune responses are disclosed. The compositions comprise one or more optically active chiral cationic lipids. | 05-12-2011 |
20150110823 | PARTICULATE VACCINE FORMULATIONS - The present disclosure provides vaccine formulations comprising at least one peptide antigen assembly and at least one adjuvant. The disclosure also provides methods of inducing an immune response in a mammal and methods of treating a disease in a mammal utilizing the vaccine formulations. | 04-23-2015 |
Gregory Conn, Cincinnati, OH US
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20090017057 | STIMULATION OF AN IMMUNE RESPONSE BY CATIONIC LIPIDS - The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens. | 01-15-2009 |
Heath Alan Conn, Bothell, WA US
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20100001138 | DUAL VALVE APPARATUS FOR AIRCRAFT ENGINE ICE PROTECTION AND RELATED METHODS - A thermal anti-ice system in an aircraft. A controlled valve receives air from a compressor bleed port of an engine of the aircraft. A self-regulating valve is fluidly connected between the controlled valve and an inlet of the engine. A first pressure sensor senses pressure between the valves. A second pressure sensor senses pressure between the self-regulating valve and the inlet. The system can be used to de-ice aircraft inlet lip skins made of composite materials that have comparatively lower design temperatures than other comparable materials. | 01-07-2010 |
Jason Conn, San Francisco, CA US
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20100233960 | SERVICE DISCOVERY FUNCTIONALITY UTILIZING PERSONAL AREA NETWORK PROTOCOLS - Techniques to provide service discovery via personal area network protocols. A personal area network is generally a network that covers only a few feet or meters of physical space. Personal area networks can be wired or wireless. Wired personal area networks include, for example, Universal Serial Bus (USB) and IEEE 1394 (or FireWire) connections. Wireless personal area networks can include, for example, IrDA, Bluetooth, UWB, Z-Wave and ZigBee. Service discovery results in indication of services that are available via the personal area network and not necessarily the physical devices that provide the services. A wireless device may utilize DNS formatted data over a Bluetooth connection to determine services that are available from other Bluetooth devices within range. | 09-16-2010 |
20100235525 | EFFICIENT SERVICE DISCOVERY FOR PEER-TO-PEER NETWORKING DEVICES - Techniques for discovering and/or advertising services are described herein. A first bitmask is received from a remote device over a wireless network, the first bitmask having one or more bits that have a predetermined logical value. Each bit represents a particular service provided by the remote device. A logical operation is performed between the first bitmask and a second bitmask locally generated within a local device, where the second bitmask represents a service being searched by the local device. It is determined whether the remote device is potentially capable of providing the service being searched by the local device based on a result of the logical operation. | 09-16-2010 |
20130013779 | EFFICIENT SERVICE DISCOVERY FOR PEER-TO-PEER NETWORKING DEVICES - Techniques for discovering and/or advertising services are described herein. A first bitmask is received from a remote device over a wireless network, the first bitmask having one or more bits that have a predetermined logical value. Each bit represents a particular service provided by the remote device. A logical operation is performed between the first bitmask and a second bitmask locally generated within a local device, where the second bitmask represents a service being searched by the local device. It is determined whether the remote device is potentially capable of providing the service being searched by the local device based on a result of the logical operation. | 01-10-2013 |
20140052862 | EFFICIENT SERVICE DISCOVERY FOR PEER-TO-PEER NETWORKING DEVICES - Techniques for discovering and/or advertising services are described herein. A first bitmask is received from a remote device over a wireless network, the first bitmask having one or more bits that have a predetermined logical value. Each bit represents a particular service provided by the remote device. A logical operation is performed between the first bitmask and a second bitmask locally generated within a local device, where the second bitmask represents a service being searched by the local device. It is determined whether the remote device is potentially capable of providing the service being searched by the local device based on a result of the logical operation. | 02-20-2014 |
Jason C. Conn, San Francisco, CA US
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20130329597 | CACHING OF A REMOTE DATA STRUCTURE BASED ON REQUESTED INFORMATION - An electronic device is described. When this electronic device transmits a request packet to another electronic device with a discovery request, the electronic device stores information specifying the discovery request. If a response packet with an answer to the discovery request is received from the other electronic device, the electronic device stores additional information included in the answer. This additional information specifies a position in an information hierarchy in the other electronic device and a data format associated with the position. By partially caching the information and the additional information, the electronic device may significantly reduce the number of request and response messages, and thus the delay, when the electronic device subsequently accesses data in the information hierarchy. | 12-12-2013 |
20130329613 | IDENTIFYING A RANDOM ADVERTISING DEVICE AS A CONNECTED DEVICE - An electronic device is described. When this electronic device receives a packet containing an address from another electronic device, the electronic device determines if a connection has already been established with the other electronic device using another address. If so, instead of establishing another connection with the other electronic device using the address, the electronic device modifies the packet by replacing the address with the other address so that it appears as if the packet was received via the connection with the other electronic device using the other address. In this way, the electronic device may avoid duplicate connections with the other electronic device, which can occur in communication protocols in which encoded information in advertising frames that specifies an address of the other electronic device is periodically changed. | 12-12-2013 |
20140364089 | BLUETOOTH ALERT NOTIFICATION SERVICE - A central wireless communication device communicates with a peripheral wireless communication device to provide an interactive alert notification service. The central wireless communication device obtains alert notification settings for application categories for the peripheral wireless communication device. In response to receiving an alert notification belonging to an application category enabled for the peripheral wireless communication device, the central wireless communication device sends an alert notification message that includes a unique identifier associated with the alert notification to the peripheral wireless communication device. In response to receiving an information request message that includes the unique identifier and one or more parameters, the central wireless communication device sends one or more information response messages that include the unique identifier and values for at least one of the one or more parameters to the peripheral wireless communication device. | 12-11-2014 |
20150350766 | MANAGING CONNECTIONS OF A USER DEVICE - Systems, methods, and computer-readable medium are provided for managing connections of user devices. For example, two source devices may be configured to maintain a data stream with one another. The data stream may enable the two source devices to identify one or more connections between each other and at least a third device. In response to receiving an event that indicates content to be provided to the third device, the data stream may be used by the source devices to configure their network connections with the third device. | 12-03-2015 |
20150350813 | DYNAMIC TRANSPORT SWITCHING IN INTER-DEVICE COMMUNICATION - A transport for data communication can be selected based on current data communication activity. A master device and a slave device can establish a control channel on one transport and one or more data channels. A master device can determine which transport should be used for the data channel(s) based on real-time status information about the data exchange and can coordinate with the slave device to switch the data channel(s) to a different transport when appropriate. | 12-03-2015 |
20150350865 | PREDEFINED WIRELESS PAIRING - In order to reduce latency and overhead during the device discovery process, operations involved in pairing of two electronic devices may be predefined. In particular, when a user specifies a new electronic device in a list of their electronic devices, a computer provides a notification to these electronic devices. In response to the notification, a given one of the electronic devices generates encryption information and identification information for the given electronic device, and provides this encryption information and identification information to the new electronic device via a network (such as the Internet). Then, the new electronic device generates encryption information and identification information for the new electronic device, and provides this encryption information and identification information to the given electronic device via the network. This pairing information may subsequently facilitate secure wireless communication between the two electronic devices. | 12-03-2015 |
Jeffrey D. Conn, Wannaska, MN US
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20110192667 | SNOWMOBILE - The present invention generally relates to snowmobiles. More particularly, the present invention relates to the components of a snowmobile such as the frame, running boards and various other assemblies. | 08-11-2011 |
20130032418 | SNOWMOBILE - A snowmobile comprises a chassis with a front portion and a tunnel, and a power train unit supported by the chassis. The snowmobile further includes a plurality of ground-engaging members cooperating with the power train unit to operate the snowmobile. The plurality of ground-engaging members includes a pair of front skis and an endless track assembly. The snowmobile also includes a front suspension operably coupled to the pair of front skis. The front suspension includes a right control arm comprising a first right arm adhesively coupled to at least one right coupler, and a left control arm comprising a first left arm adhesively coupled to at least one left coupler. The first right arm and the left arm are comprised of a first material and the right and left couplers are comprised of a second material. | 02-07-2013 |
20130032419 | SNOWMOBILE - A snowmobile comprises a chassis with a front portion and a tunnel, and a power train unit supported by the chassis. The snowmobile further includes a plurality of ground-engaging members cooperating with the power train unit to operate the snowmobile. The plurality of ground-engaging members includes a pair of front skis and an endless track assembly. | 02-07-2013 |
20140332293 | SNOWMOBILE - A drive apparatus for a track of a snowmobile includes a drive shaft and a drive sprocket coupled to the drive shaft. The drive sprocket includes a first drive member having a plurality of teeth configured to engage drive lugs on an inner surface of the track and a second drive member having plurality of teeth configured to enter the openings formed in the track upon rotation of the drive shaft. First and second connecting webs extend between the teeth of the first and second drive members, respectively. The first and second connecting webs each have first and second side angled surfaces aligned an angle of less than 180° relative to each other to minimize snow build up on the first and second drive members, respectively. | 11-13-2014 |
Jeffrey P. Conn, Brentwood, TN US
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20140357615 | SUBSTITUTED 1H-PYRAZOLO[3',4',4,5]THIENO[2,3-B]PYRIDIN-3-AMINE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYCHOLINE RECEPTOR M4 - In one aspect, the invention relates to substituted 1H-pyrazolo[3′,4′:4,5]thieno[2,3-b]pyridin-3-amine analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 12-04-2014 |
Jeremy B. Conn, Hillsboro, OR US
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20150205505 | DYNAMIC ADJUSTMENT OF A USER INTERFACE - Apparatuses, methods and storage media for user interface adjustment are described. In one instance, an apparatus may include a processor and a user interface engine operated by the processor to detect a user interface to be provided on a computing device, with the user interface including at least one user interface component, identify one or more color characteristics of an image to be used as a background for the user interface, and adjust one or more color parameters of the at least one user interface component of the user interface or the background image identified, based at least in part on the identified color characteristics of the background image, or the at least one user interface component of the user interface. Other embodiments may be described and claimed. | 07-23-2015 |
Jeremy Bert Conn, Portland, OR US
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20150186022 | MECHANISM FOR FACILITATING DYNAMIC CHANGE ORIENTATION FOR EDIT MODES AT COMPUTING DEVICES - A mechanism is described for facilitating dynamic edit modes at computing devices according to one embodiment. A method of embodiments, as described herein, includes receiving a first request for accessing an edit mode at a computing device, where the first request is placed by turning the computing device from a first position to a second position, and allowing access to the edit mode, if the first request is determined to be intentional. | 07-02-2015 |
John Conn, San Diego, CA US
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20100280312 | Self-Contained Medical Applicators for Surgical Sealants, and Methods of Use Thereof - Aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which components can then be easily combined at the time of use without assembly by the user. In certain embodiments, a device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues. In certain embodiments, a device of the invention can be configured to apply a spray or a stream of a liquid formulation to a surface. In certain embodiments, a device of the invention can be configured to deliver the formulation through an endoscope or laparoscope. | 11-04-2010 |
John Miller Conn, Pueblo, CO US
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20120130235 | RETROGRADE ENTRY ANTEGRADE PLACEMENT FOR FEMORAL ARTERY ACCESS - A Retrograde Entry Antegrade Placement (REAP) method and apparatus facilitate the antegrade (i.e., in the direction of blood flow) placement of endovascular devices for treatment of lower extremity arterial disease. Initially, a retrograde entry is made into the arterial system of a patient at an entry point with a curved needle, which then exits at an exit point proximal to the entry point, with a first wire then passed through the lumen of the curved needle. From the skin exit point, a Dual-Lumen Access Director (DAD) device is advanced in the antegrade direction down the first wire in a first lumen and enters the CFA | 05-24-2012 |
20150126855 | RETROGRADE ENTRY ANTEGRADE PLACEMENT FOR FEMORAL ARTERY ACCESS - A Retrograde Entry Antegrade Placement (REAP™) method and apparatus facilitate the antegrade (i.e., in the direction of blood flow) placement of endovascular devices for treatment of lower extremity arterial disease. Initially, a retrograde entry is made into the arterial system of a patient at an entry point with a curved needle, which then exits at an exit point proximal to the entry point, with a first wire then passed through the lumen of the curved needle. From the skin exit point, a Dual-Lumen Access Director (DAD) device is advanced in the antegrade direction down the first wire in a first lumen and enters the CFA lumen. A second wire is passed down a second lumen in the DAD device and follows the SFA lumen in the antegrade direction. The DAD device is removed, and a standard dilator sheath is inserted over the second wire and the endovascular treatment begins. | 05-07-2015 |
20150126936 | RETROGRADE ENTRY ANTEGRADE PLACEMENT FOR FEMORAL ARTERY ACCESS - A Retrograde Entry Antegrade Placement (REAP™) method and apparatus facilitate the antegrade (i.e., in the direction of blood flow) placement of endovascular devices for treatment of lower extremity arterial disease. Initially, a retrograde entry is made into the arterial system of a patient at an entry point with a curved needle, which then exits at an exit point proximal to the entry point, with a first wire then passed through the lumen of the curved needle. From the skin exit point, a Dual-Lumen Access Director (DAD) device is advanced in the antegrade direction down the first wire in a first lumen and enters the CFA | 05-07-2015 |
John Paul Conn, San Marino, CA US
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20110208548 | SYSTEMS AND METHODS FOR DATA INSURANCE - An agreement is created between a first entity and a second entity under which the second entity agrees to provide data protection services for use by a third entity. A backup copy of the third entity's data is created and maintained at a location controlled by the second entity. If the third entity suffers a data loss, a replacement copy of the data is generated from the backup copy. The first entity provides compensation for the second entity's efforts to restore the third entity's lost data. If the second entity is unable to restore the data, the third entity is compensated for its data loss. | 08-25-2011 |
Joseph D. Conn, St. Louis, MO US
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20110198396 | CARD HOLDER DEVICE - A card storage device for storing payment cards, such as credit and debit cards or other media in an orderly fashion. The device may be used at a food and/or drink establishment. The device securely stores a number of cards for a number of patrons who wish to open a tab at a bar, pub, restaurant, or other service environment. | 08-18-2011 |
Kevin D. Conn, Montgomery, TX US
Patent application number | Description | Published |
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20110043986 | POWER SUPPLY ASSEMBLY FOR SERVER RACK AND METHOD FOR MOUNTING POWER SUPPLY FOR SERVER RACK - A power supply assembly for electronic components, such as servers, can include a power supply and a mount. The power supply is connected to the mount and is configured to power a plurality of electronic components. The power supply assembly can include a connection between the power supply and mount that is configured to permit the power supply to pivot about an axis in relation to the mount. | 02-24-2011 |
20110127895 | GEARED LATCH APPARATUS - In at least some embodiments, an apparatus is provided that comprises a frame and a cover removably attached to the frame. The apparatus further comprises a geared latch assembly attached to the cover, the geared latch assembly having a geared latch. If the geared latch is rotated from a first position to a second position, the cover moves linearly from a closed state to an open state. | 06-02-2011 |
20130007329 | HINGED BEZEL HAVING A PORTABLE DISPLAY DOCK - A bezel includes a dock for a portable display device. The bezel also includes a hinge component that, when coupled to an enclosure, allows the bezel to be rotatably moved with respect to the enclosure. | 01-03-2013 |
20150027969 | RELEASE LATCH - A release latch apparatus can include a locking mechanism coupled to a first position of a rocker and a spring mechanism coupled to a second position of the rocker. | 01-29-2015 |
Laurie Adriane Conn, Highland Beach, FL US
Patent application number | Description | Published |
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20140222820 | APPARATUS, SYSTEM, AND METHOD FOR VEHICULAR CHARACTERISTIC MONITORING AND CATALOGING - The present disclosure is directed to a mobile device for reporting at least one characteristic of at least one vehicle. The mobile device includes at least one input device, at least one transmitting device configured to transmit the at least one characteristic of the at least one vehicle to a second device, at least one storage device for storing data, and a module stored on the at least one storage device, the module executable by the mobile device and configured to accept user inputs from the at least one input device and catalog each user input with respect to an identified vehicle by causing the apparatus to perform the steps of: generating a first user interface (UI) at least including a field to input an identification data of the identified vehicle; receiving characteristic data from the input device relating to the at least one characteristic of the identified vehicle; and transmitting the characteristic data with reference to the identified vehicle to a database. | 08-07-2014 |
Mark C. Conn, Tarzana, CA US
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20090114084 | LIGHTWEIGHT ARMOR - A lightweight armor system senses a shock wave from an explosive and deploys an inflatable barrier before the arrival of shrapnel from the explosion. The sensor is tuned to frequencies associated with shock waves generated by known Improvised Explosive Devices (IEDs). The shock waves travel at between 25,000 and 30,000 feet per second and arrives at a vehicle before the shrapnel generated by the IED. The sensor generates a signal which is amplified and provided to a plurality of initiators in a plurality of nested pods. The nested pods inflate rapidly and form a barrier over areas requiring protection from the shrapnel. | 05-07-2009 |
Peggy Conn, Chandler, AZ US
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20140011962 | Synthesized Resins and Varnishes and Prepegs and Laminates Made Therefrom - Synthesized base resin compositions that include a raw resin and a maleimide and/or bismaleimide monomer as well as compounded varnishes that include a raw resin or synthesized base resin as well as a monomer, flame retardant and initiator as well as prepregs and laminates made using the synthesized base resin and compounded varnishes. | 01-09-2014 |
20140024278 | Synthesized Resins and Varnishes and Prepegs and Laminates Made Therefrom - Synthesized base resin compositions that include a raw resin and a maleimide and/or bismaleimide monomer as well as compounded varnishes that include a raw resin or synthesized base resin as well as a monomer, flame retardant and initiator as well as prepregs and laminates made using the synthesized base resin and compounded varnishes. | 01-23-2014 |
20140220844 | Prepregs and Laminates Having Homogeneous Dielectric Properties - Resin compositions including one or more base resins and one or more high dielectric constant materials wherein the one or more high dielectric constant materials are present in the resin composition in an amount sufficient to impart the resin composition with a cured Dk that matches the Dk of the reinforcing material to which the resin composition is to be applied to within plus or minus (±) 15% as well as prepregs and laminates made using the resin compositions. | 08-07-2014 |
20150030822 | Prepregs and Laminates Having Homogeneous Dielectric Properties - Prepregs and laminates made from resin compositions having a free resin portion and a resin impregnated reinforcing material portion where the resin includes one or more base resins and one or more high Dk materials wherein the one or more high Dk materials are present in the resin composition in an amount sufficient to impart the resin composition with a cured Dk | 01-29-2015 |
P. Jeffrey Conn, Brenwood, TN US
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20130178458 | SUBSTITUTED (1-(METHYLSULFONYL)AZETIDIN-3-YL)(HETEROCYCLOALKYL)METHANONE ANALOGS AS ANTAGONISTS OF MUSCARINIC ACETYLCHOLINE M1 RECEPTORS - In one aspect, the invention relates to substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs, derivatives thereof, and related compounds, which are useful as antagonists of the muscarinic acetylcholine receptor M | 07-11-2013 |
P. Jeffrey Conn, Brentwood, TN US
Patent application number | Description | Published |
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20090042855 | BENZAMIDE mGluR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME - In one aspect, the invention relates to compounds, including phenylethynylbenzamide derivatives, cycloalkylethynylbenzamide derivatives, styrylbenzamide derivatives, 4-(3-phenyl-1,2,4-oxadiazol-5-yl)benzamide derivatives, 4-(pyridinylethynyl)benzamide derivatives, and N | 02-12-2009 |
20090270362 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME - In one aspect, the invention relates to bicyclic MGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 10-29-2009 |
20100035929 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF - Disclosed are dispyrin analogue compounds useful as H3 receptor activity modulators, methods of making same, pharmaceutical compositions comprising same, and methods of treating neurological and psychiatric disorders associated with histamine H3 receptor activity using same. In one aspect, the disclosed analogues can have a structure represented by a formula: | 02-11-2010 |
20100144858 | Treatment of movement disorders with a metabotropic glutamate 4 receptor positive allosteric modulator - An mGluR4 receptor positive allosteric modulator is useful, alone or in combination with a neuroleptic agent, for treating or preventing movement disorders such as Parkinson's disease, dyskinesia, tardive dyskinesia, drug-induced parkinsonism, postencephalitic parkinsonism, progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, parkinsonian-ALS dementia complex, basal ganglia calcification, akinesia, akinetic-rigid syndrome, bradykinesia, dystonia, medication-induced parkinsonian, Gilles de la Tourette syndrome, Huntington's disease, tremor, chorea, myoclonus, tick disorder, and dystonia. | 06-10-2010 |
20100249167 | ALKYLSULFONYL-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE] ANALOGS AS GLYT1 INHIBITORS, METHODS FOR MAKING SAME, AND USE OF SAME IN TREATING PSYCHIATRIC DISORDERS - In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-30-2010 |
20100261696 | SULFONYL-AZETIDIN-3-YL-METHYLAMINE AMIDE ANALOGS AS GLYT1 INHIBITORS, METHODS FOR MAKING SAME, AND USE OF SAME IN TREATING PSYCHIATRIC DISORDERS - In one aspect, the invention relates to compounds which are useful as as inhibitors of glycine type 1 transporter (G1yT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (G1yT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 10-14-2010 |
20100261773 | 3.3.0 BICYCLIC GlyT1 INHIBITORS AND METHODS OF MAKING AND USING SAME - In one aspect, the invention relates to compounds which are useful as as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 10-14-2010 |
20110124663 | SUBSTITUTED DIOXOPIPERIDINES AND DIOXOPYRROLIDINES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION - In one aspect, the invention relates to compounds having a general structure: | 05-26-2011 |
20110152299 | SUBSTITUTED BENZAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME - Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention | 06-23-2011 |
20110166158 | SUBSTITUTED PHENYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME - Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 07-07-2011 |
20110172227 | ALKYL 3-((2-AMIDOETHYL)AMINO)-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE ANALOGS AS SELECTIVE M1 AGONISTS AND METHODS OF MAKING AND USING SAME - In one aspect, the invention relates to compounds having a general structure: | 07-14-2011 |
20110172247 | SUBSTITUTED HETEROARYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME - Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention | 07-14-2011 |
20110172248 | SUBSTITUTED HETEROARYLAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME - Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 07-14-2011 |
20110183980 | O-BENZYL NICOTINAMIDE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS - In one aspect, the invention relates to O-benzyl nicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 07-28-2011 |
20110294858 | SUBSTITUTED 6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS - In one aspect, the invention relates to substituted 6-methylnicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 12-01-2011 |
20110319429 | SUBSTITUTED 1,1,3,1-TETRAOXIDOBENZO[D][1,3,2]DITHIAZOLES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION - Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and methods of using the compounds. | 12-29-2011 |
20120028955 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME - In one aspect, the invention relates to bicyclic mGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 02-02-2012 |
20120028956 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME - In one aspect, the invention relates to bicyclic mGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 02-02-2012 |
20120172391 | NAPHTHYRIDINONE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS - In one aspect, the invention relates to naphthyridinone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 07-05-2012 |
20120178776 | DIHYDRONAPHTHYRIDINYL(ORGANO)METHANONE ANALOGS AS POSITIVE ALLOSTERIC MGLUR5 MODULATORS - In one aspect, the invention relates to dihydronaphthyridinyl(organo)methanone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 07-12-2012 |
20120184556 | SUBSTITUTED ENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS - Disclosed are substituted benzoimidazolesulfonamides and substituted indolesulfonamides as mGluR4 potentiators. | 07-19-2012 |
20120225844 | BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to bicyclic triazole and pyrazole lactams, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-06-2012 |
20120245153 | MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION - Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof. | 09-27-2012 |
20120245185 | ARYL AND HETEROARYL SULFONES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION - In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 09-27-2012 |
20120295913 | BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to bicyclic pyrazole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 11-22-2012 |
20130040944 | MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION - Pyrrole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 02-14-2013 |
20130065895 | Pyrazolopyridine, Pyrazolopyrazine, Pyrazolopyrimidine, Pyrazolothiophene and Pyrazolothiazole Compounds as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction - Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 03-14-2013 |
20130079366 | Benzisoxazoles and Azabenzisoxazoles as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction - Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 03-28-2013 |
20130096110 | Pyrazolopyridine, Pyrazolopyrazine, Pyrazolopyrimidine, Pyrazolothiophene and Pyrazolothiazole Compounds as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction - Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 04-18-2013 |
20130123236 | SUBSTITUTED BENZYLSPIROINDOLIN-2-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 - In one aspect, the invention relates to substituted benzylspiroindolin-2-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 05-16-2013 |
20130158078 | Heterocyclic Sulfone MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction - Heterocyclic sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 06-20-2013 |
20130197027 | HETEROCYCLYL-AZABICYCLO[3.2.1]OCTANE ANALOGS AS SELECTIVE M1 AGONISTS AND METHODS OF MAKING AND USING SAME - In one aspect, the invention relates to compounds which are useful as allosteric or bitopic agonists of the M | 08-01-2013 |
20130245043 | SUBSTITUTED IMIDAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-19-2013 |
20130252943 | BICYCLIC OXAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to substituted bicyclic oxazole lactam analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-26-2013 |
20130261107 | BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to novel bicyclic oxazole and thiazole compounds which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions; and methods for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 10-03-2013 |
20130338154 | MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION - Pyrrole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 12-19-2013 |
20130345203 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to substituted bicyclic alkoxy pyrazole analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 12-26-2013 |
20130345204 | SUBSTITUTED BICYCLIC CYCLOALKYL PYRAZOLE LACTAM ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to substituted bicyclic cycloalkyl pyrazole lactam analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 12-26-2013 |
20130345205 | SUBSTITUTED BICYCLIC ARALKYL PYRAZOLE LACTAM ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to substituted bicyclic aralkyl pyrazole lactam analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 12-26-2013 |
20130345206 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to substituted bicyclic alkoxy pyrazole analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 12-26-2013 |
20140057870 | BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to bicyclic triazole and pyrazole lactams, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 02-27-2014 |
20140194471 | SUBSTITUTED 1-BENZYLINDOLIN-2-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC ACETYLCHOLINE M1 RECEPTORS - In one aspect, the invention relates to substituted 1-benzylindolin-2-one analog compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 07-10-2014 |
20140206676 | SUBSTITUTED 4-(1H-PYRAZOL-4-YL)BENZYL ANALOGUES AS POSITIVE ALLOSTERIC MODULATORS OF MACHR M1 RECEPTORS - In one aspect, the invention relates to substituted 4-(1H-pyrazol-4-yl)benzyl analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 07-24-2014 |
20140206707 | 6-ALKYL-N-(PYRIDIN-2-YL)-4-ARYLOXYPICOLINAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME - Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 07-24-2014 |
20140213593 | BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to bicyclic pyrazole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 07-31-2014 |
20140288084 | SUBSTITUTED 2-(4-HETEROCYCLYLBENZYL)ISOINDOLIN-1-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 - In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 09-25-2014 |
20140364409 | SUBSTITUTED PYRAZOLO[3',4':4,5]THIENO[2,3-C]PYRIDAZIN-3-AMINE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 - In one aspect, the invention relates to substituted pyrazolo[3′,4′:4,5]thieno[2,3-c]pyridazine-3-amine analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 12-11-2014 |
20150216863 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to substituted bicyclic alkoxy pyrazole analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 08-06-2015 |
P. Jeffrey Conn, Nashville, TN US
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20140329838 | SUBSTITUTED IMIDAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 11-06-2014 |
20150018309 | SUBSTITUTED 5-AMINOTHIENO[2,3-C]PYRIDAZINE-6-CARBOXAMIDE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 - In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 01-15-2015 |
20150266866 | Substituted Bicyclic Heteroaryl Carboxamide Analogs As Mglur5 Negative Allosteric Modulators - Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-24-2015 |
20150361081 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 3 - Described are negative allosteric modulators of metabotropic glutamate receptor 3 (mGlu | 12-17-2015 |
P. Michael Conn, Portland, OR US
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20100144605 | RESCUE OF GONADOTROPIN RELEASING HORMONE RECEPTOR MUTANTS - Herein disclosed is a method of rescuing gonadotropin-releasing hormone receptor (GnRHR) mutants with IN3 or a mimetic thereof. IN3 significantly rescues 11 missense mutations as assessed by radioligand binding and by IP production. Such rescue occurred despite widely disparate loci along the receptor. In addition, many altered GnRH receptors (terminally truncated, internal deletions, or lacking the ability to form bridges to form tertiary structure) were rescued with IN3. | 06-10-2010 |
20110065661 | PHARMACOPERONES FOR CORRECTING DISEASE STATES INVOLVING PROTEIN MISFOLDING - This application relates to methods of identifying pharmacoperone agents that can restore function to a misfolded protein, such as a misfolded protein that causes disease. Also disclosed are methods of using such pharmacoperone agents to treat a disease or disorder that results from the misfolded protein. | 03-17-2011 |
Randall S. Conn, Avon, IN US
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20120010791 | CLOSED-LOOP TRANSMISSION INTEGRATION WITH FORWARD AND/OR REVERSE ASSIST SYSTEM - The present invention provides a method of reducing the output speed of a transmission in a vehicle, whereby the transmission includes a speed sensor and a controller and the vehicle includes a proximity sensor. The method includes measuring the output speed with the speed sensor and comparing the measured output speed to an output speed threshold. The controller receives throttle percentage and compares the throttle percentage to a throttle threshold. The method further includes receiving an input signal from the proximity sensor and comparing the input signal to a signal threshold. The output speed of the transmission can be controlled based on the values of the measured output speed, throttle percentage, and input signal. | 01-12-2012 |
20150192201 | SYSTEM FOR ADJUSTING FLUID VOLUME IN A TRANSMISSION AND METHOD THEREOF - The present disclosure provides a method for increasing a volume of hydraulic fluid in a reservoir of a transmission. The method includes providing a retarder mounted to the transmission, an accumulator including an internal cavity, a piston disposed in the internal cavity of the accumulator, a solenoid, a valve, and a controller. The method also includes enabling the solenoid from an off state to an on state, transferring fluid pressure from the valve to the piston, and moving the piston from a first position to a second position in the internal cavity. The method further includes discharging an amount of hydraulic fluid from the internal cavity of the accumulator to the reservoir and increasing the volume of hydraulic fluid in the reservoir. | 07-09-2015 |
Randall S. Conn, Indianapolis, IN US
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20090000670 | CENTRIFUGE AND VENTING SYSTEM FOR A TRANSMISSION - A transmission having a shaft driven by a prime mover such as an engine or motor is provided. The transmission includes a first stationary element for supporting the shaft for rotation, and a torque transmitting device connectable to the shaft and rotatable about an axis. The torque transmitting device is actuated by a hydraulic fluid. A first passage is connected to the torque transmitting device and is in communication with the hydraulic fluid. The first passage extends radially inward from the torque transmitting device. A vent passage is located within the first stationary element and is in communication with the first passage. Rotation of the torque transmitting device about the axis separates entrained air from the fluid and urges air radially inward through the first passage and into the vent passage, thereby removing air from the hydraulic fluid and circuit. | 01-01-2009 |
20090241645 | SYSTEM AND METHOD FOR DETERMINING TRANSMISSION OIL TYPE - Transmission oil type may be determined based on the opening time of a transmission latch valve and on oil temperature. An opening time of a latch valve positioned between an oil reservoir and one or more torque transmitting devices of a transmission is determined in response to a command to open the latch valve. A temperature of oil supplied by the latch valve from the oil reservoir to the one or more torque transmitting devices in response to the command to open the latch valve is also determined. The latch valve opening time and oil temperature are monitored over a range of oil temperatures to collect opening times of the latch valve at each of a plurality of oil temperatures within the range of oil temperatures. The transmission oil type is then determined based on the opening times of the latch valve at each of the plurality of oil temperatures. | 10-01-2009 |
20090277253 | HYDRAULIC FLUID DETERMINATION SYSTEM AND METHOD - A system for determining the type of hydraulic fluid employed in a transmission includes a translating valve, a valve position sensor, a hydraulic fluid temperature sensor, and a controller. The valve position sensor is operable to measure the actual time the valve takes to translate within the hydraulic fluid. The controller is operable to compare the actual time of valve translation to an expected time of valve translation. If the actual time of valve translation is different than the expected time of valve translation to a predetermined degree, the controller is operable to signal an operator of the motor vehicle or a service technician that the hydraulic fluid being used in the transmission is not meeting operating expectations. | 11-12-2009 |
Richard Harvey Conn, Channing, MI US
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20080264592 | Creping foil for redirecting dust - A creping foil having a machine direction, cross machine direction, and Z-direction normal to a plane formed by machine direction and cross machine directions. The creping foil also has a front face, back face, and bottom side. The front face has one or more top conduits with one or more upper pipes integrally mounted therein. The one or more upper pipes are rotatable about an axis in the cross machine direction and have one or more upper diameter holes. The bottom side has one or more bottom conduits with one or more lower pipes integrally mounted therein. The one or more lower pipes are rotatable about an axis in the cross machine direction and have one or more lower diameter holes. | 10-30-2008 |
Robert O. Conn, San Jose, CA US
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20140144971 | In System Reflow of Low Temperature Eutectic Bond Balls - Low temperature bond balls connect two structures having disparate coefficients of linear thermal expansion. An integrated circuit is made to heat the device such that the low temperature bond balls melt. After melting, the bond balls solidify, and the device is operated with the bond balls solidified. In one example, one of the two structures is a semiconductor substrate, and the other structure is a printed circuit board. The integrated circuit is a die mounted to the semiconductor substrate. The bond balls include at least five percent indium, and the integrated circuit is an FPGA loaded with a bit stream. The bit stream configures the FPGA such that the FPGA has increased power dissipation, which melts the balls. After the melting, a second bit stream is loaded into the FPGA and the FPGA is operated in a normal user-mode using the second bit stream. | 05-29-2014 |
Robert O. Conn, Hawaii, HI US
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20090267183 | Through-substrate power-conducting via with embedded capacitance - When integrated circuits are mounted on a substrate, little space is often available for the required large number of bypass capacitors. A novel substrate structure therefore includes many closely spaced through-holes that extend from a first surface of the substrate to a second surface of the substrate. Each through-hole includes a first conducting layer, a dielectric layer, and a second conducting layer. The first and second conducting layers and the intervening dielectric layer constitute a via having a substantial capacitance (one picofarad). Some of the many vias provide bypass capacitance directly under the integrated circuits. A first set of vias supplies power from a power bus bar on one side of the substrate to the integrated circuits on the other side. A second set of vias sinks current from the integrated circuits on the other side, through the substrate, and to a ground bus bar on the one side. | 10-29-2009 |
20100283559 | Multiple-layer signal conductor - A multiple-layer signal conductor has increased surface area for mitigation of skin effect. Parallel extending elongated strips of conductive material are placed in parallel layers and are separated by a thin layer of dielectric. The elongated strips are conductively connected to one another by regularly spaced vias such that a single signal conductor with multiple conductive layers is formed. During high-speed signaling, the skin effect causes current to concentrate near the surfaces of conductors. The multiple-layer signal conductor, however, has increased surface area with respect to its total cross-sectional area. The effective cross-sectional area which is conductive during high-speed signaling is therefore increased, leading to positive effects on transmission line resistance, heating, signal integrity and signal propagation delay. The multiple-layer signal conductor sees special use on silicon circuit boards and can conduct signals at ten gigahertz or greater for distances of up to five inches without rebuffering or termination. | 11-11-2010 |
Robert O. Conn US
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20110183469 | Integrated semiconductor substrate structure using incompatible processes - A plurality of FPGA dice is disposed upon a semiconductor substrate. In order both to connect thousands of signal interconnect lines between the plurality of FPGA dice and to supply the immense power required, it is desired that the substrate construction include two different portions, each manufactured using incompatible processes. The first portion is a signal interconnect structure containing a thin conductor layers portion characterized as having a plurality of thin, fine-pitch conductors. The second portion is a power connection structure that includes thick conductors and vertical through-holes. The through-holes contain conductive material and supply power to the FPGA dice from power bus bars located at the other side of the semiconductor substrate. The portions are joined at the wafer level by polishing the wafer surfaces within a few atoms of flatness and subsequent cleaning. The portions are then fusion bonded together or combined using an adhesive material. | 07-28-2011 |
20110266034 | Preventing breakage of long metal signal conductors on semiconductor substrates - An apparatus includes a volume of insulator disposed over a top surface of a semiconductor substrate, a tube of soft dielectric, and a metal conductor. The insulator has a hardness of more than approximately three gigaPascals (gPa) and the soft dielectric has a hardness of less than three gPa. The tube of soft dielectric and the metal conductor are both embedded within the volume of insulator. The tube defines a central volume and the metal conductor extends in a direction through the central volume for a distance of at least one inch. The metal conductor is encircled by the soft dielectric when the apparatus is viewed in a cross-sectional plane perpendicular to the direction. The metal conductor may include a plurality of bend portions. The metal conductor does not break when the apparatus is temperature cycled over a range from zero to eighty five degrees Celsius. | 11-03-2011 |
Robert O. Conn, Hakalau, HI US
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20100187665 | Integral metal structure with conductive post portions - A plurality of FPGA dice is disposed upon a semiconductor substrate. In order to supply the immense power required by the plurality of FPGA dice, power is routed through the semiconductor substrate vertically from thick metal layers and large integral metal structures located on the other side of the semiconductor substrate. Because the semiconductor substrate has a different coefficient of thermal linear expansion than metal layers in contact with the substrate, delamination may occur when the structure is subject to changes in temperature. To prevent delamination of metal layers connected to the semiconductor substrate and in electrical contact with the integral metal structures, the integral metal structures are manufactured with an array of post portions. During changes in temperature, the post portions of the integral metal structures bend and slide relative to metal layers connected to the semiconductor substrate and prevent linear stresses that may otherwise cause delamination. | 07-29-2010 |
20110239456 | In system reflow of low temperature eutectic bond balls - Low temperature bond balls connect two structures having disparate coefficients of linear thermal expansion. An integrated circuit is made to heat the device such that the low temperature bond balls melt. After melting, the bond balls solidify, and the device is operated with the bond balls solidified. In one example, one of the two structures is a semiconductor substrate, and the other structure is a printed circuit board. The integrated circuit is a die mounted to the semiconductor substrate. The bond balls include at least five percent indium, and the integrated circuit is an FPGA loaded with a bit stream. The bit stream configures the FPGA such that the FPGA has increased power dissipation, which melts the balls. After the melting, a second bit stream is loaded into the FPGA and the FPGA is operated in a normal user-mode using the second bit stream. | 10-06-2011 |
20140049193 | Accelerator Having Acceleration Channels Formed Between Covalently Bonded Chips - An accelerator assembly includes a first chip and a second chip. An acceleration channel is formed into a surface of a first side of the first chip. The first side of the first chip is covalently bonded to a first side of the second chip such that the channel is a tubular void between the first and second chips. The channel has a tubular inside sidewall surface, substantially no portion of which is a metal surface. The channel has length-to-width ratio greater than five, and a channel width less than one micron. There are many substantially identical channels that extend in parallel between the first and second chips. In one specific example, the assembly is part of a Direct Write On Wafer (DWOW) printing system. The DWOW printing system is useful in semiconductor processing in that it can direct write an image onto a 300 mm diameter wafer in one minute. | 02-20-2014 |
Scott D. Conn, White Lake, MI US
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20090121517 | FALSE DIVISION BAR FOR MINIMIZING WIND THROB NOISE - A false division bar assembly for minimizing wind noise generated during movement of a vehicle including a retractable rear window. The assembly includes a division bar mountable in a vehicle rear door window opening to create at least two air passages on opposite sides of the division bar within the vehicle rear door window opening, to thereby minimize wind noise generated during movement of the vehicle when the vehicle front windows are closed with the vehicle rear windows being opened. | 05-14-2009 |
Sharon T. Conn, Scottsdale, AZ US
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20090012993 | USING VIEWTYPES FOR ACCESSING INSTANCE DATA STRUCTURED BY A BASE MODEL - Disclosed is a technique for manipulating instance data of a base model. A ViewType, a root object representing an object of the base model, and an operation are received. Whether the ViewType and the root object are compatible is determined. When the ViewType and the root object are compatible, the operation is applied to the instance data of the base model while using the ViewType to traverse the instance data. | 01-08-2009 |
20090112920 | SYSTEM AND ARTICLE OF MANUFACTURE FOR DEFINING AND GENERATING A VIEWTYPE FOR A BASE MODEL - Disclosed is a technique for processing a base model. The base model is received. Then, the base model is used to create a ViewType comprising a ViewType object, one or more ViewList objects corresponding to classes in the base model, and one or more ViewElem objects corresponding to attributes in the base model. | 04-30-2009 |
Timothy W. Conn, Veneta, OR US
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20110180330 | DRILLING ASSEMBLY WITH UNDERREAMING BIT AND METHOD OF USE - Embodiments provide apparatuses and methods for drilling and underreaming, particularly to underreamer expansion bits. Underreamer drill assemblies and underreaming bits manufactured in accordance with various embodiments may help to resist over-excavating or undermining, which may result in a more stable bore hole. | 07-28-2011 |
20110253456 | REVERSE CIRCULATION HAMMER WITH MODULAR BIT - Embodiments provide apparatuses and methods for excavation and drilling, particularly reverse circulation hammers and bits. Reverse circulation hammers and bits manufactured in accordance with various embodiments may help to prevent fatigue and breaking of the bit during a drilling operation, may prevent clogging of return holes, may provide higher efficiency drilling operations, and may provide modular bit designs that may be interchanged to suit a particular drilling operation. | 10-20-2011 |
William Conn, Valley Center, CA US
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20140346381 | VALVE WITH LATCHING RETURN SPRING - A valve according to an exemplary aspect of the present disclosure includes, among other things, a return spring. A latch mechanism includes a first magnet and a second magnet. One of the first and second magnets magnetically latches to the other first and second magnets in response to a control signal to minimize decompression of said return spring. | 11-27-2014 |