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Cong, US

Alexander Cong, Blacksburg, VA US

Patent application numberDescriptionPublished
20110282181EXTENDED INTERIOR METHODS AND SYSTEMS FOR SPECTRAL, OPTICAL, AND PHOTOACOUSTIC IMAGING - The present invention relates to the field of medical imaging. More particularly, embodiments of the invention relate to methods, systems, and devices for imaging, including for tomography-based applications. Embodiments of the invention include, for example, a computed tomography based imaging system comprising: (a) at least one wide-beam gray-scale imaging chain capable of performing a global scan of an object and acquiring projection data relating to the object; (b) at least one narrow-beam true-color imaging chain capable of performing a spectral interior scan of a region of interest (ROI) of and acquiring projection data relating to the object; (c) a processing module operably configured for: (1) receiving the projection data; (2) reconstructing the ROI into an image by analyzing the data with a color interior tomography algorithm, aided by an individualized gray-scale reconstruction of an entire field of view (FOV), including the ROI; and (d) a processor for executing the processing module. The extended interior methods and systems for spectral, optical, and photoacoustic imaging presented in this application can lead to better medical diagnoses by providing images with higher resolution or quality, and can lead to safer procedures by providing systems capable of reducing a patient's exposure time to, and thus quantity of, potentially harmful x-rays. Embodiments of the invention also provide tools for real-time tomography-based analyses.11-17-2011

Feng Cong, Quincy, MA US

Patent application numberDescriptionPublished
20120023600COMPOSITIONS AND METHODS OF USE FOR ANTIBODIES OF DICKKOPF-1 - Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.01-26-2012

Feng Cong, Cambridge, MA US

Patent application numberDescriptionPublished
20100254980MOLECULES AND METHODS FOR MODULATING LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6 (LRP6) - The invention discloses LRP6 agonizing or antagonizing binding molecules (e.g., antibodies or a Fab fragments), and their use to facilitate or inhibit Wnt pathway signaling, respectively. Said LRP6 agonizing or antagonizing binding molecules can be used to e.g., diagnose, ameliorate the symptoms of, protect against, and treat Wnt signaling disorders associated with aberrantly low or aberrantly high levels of Wnt pathway signaling, respectively. Non-limiting examples of disorders which can be treated associated with aberrant upregulation of Wnt signaling is cancer (e.g., colon cancer). Non-limiting examples of disorders which can be diagnosed, protected against, and treated include cancers, bone disorders (e.g., osteoporosis and osteoarthritis), diabetes, neurodegenerative diseases such as Alzheimer's disease, and fibrotic disorders.10-07-2010
20100267626METHODS AND COMPOSITIONS FOR MEASURING WNT ACTIVATION AND FOR TREATING WNT-RELATED CANCERS - The present application describes methods of regulating or modulating (e.g., antagonizing or inhibiting) Wnt signaling by administering Axin stabilizers. The application also describes methods of using Axin stabilizers described herein for the treatment, diagnosis, prevention, and/or amelioration of Wnt signaling-related disorders.10-21-2010

Ge Cong, El Cerrito, CA US

Patent application numberDescriptionPublished
20090034822Methods and Apparatus for Characterising Cells and Treatments - Methods, data processing apparatus and computer program products for characterising cells and the affect of treatments administered to cells are disclosed. In particular methods of identifying bi-nuclear cells are described which include capturing an image of a plurality of marked cells and processing image to obtain features of the plurality of cells. The features are analyzed to determine whether the feature is indicative of bi-nuclear cells. Those cells for which the first feature is indicative of bi-nuclear cells are identified as being bi-nuclear. Three algorithms in particular are described. A first algorithm can be used to determine the number of nuclei in an image of a nuclear component by determining the number of concave regions within the outline of the image. A second algorithm uses a measure of the amount of cytoplasmic material between a pair of nuclei to identify bi-nuclear cells. A third algorithm uses the statistics of the spatial distribution of objects to identify isolated pairs of nuclei which can be considered to be from the same cell.02-05-2009

Patent applications by Ge Cong, El Cerrito, CA US

Guojing Cong, Ossining, NY US

Patent application numberDescriptionPublished
20080282232Iterative, Non-Uniform Profiling Method for Automatically Refining Performance Bottleneck Regions in Scientific Code - A method for profiling performance of a system includes steps of: monitoring execution of the system at multiple points during the system's operation; analyzing results derived from the monitoring in order to provide analyzed results; reconfiguring the monitoring non-uniformly according to the analyzed results; and repeatedly performing iterations of the above steps until a particular event occurs. The iterations may be terminated upon: reaching a specified level of analysis precision, determining a source of one or more performance bottlenecks, determining a source of unexpectedly high output or low completion time, completing a predefined number of iterations, reaching an endpoint of an application, or having performed iterations for a specified period of time.11-13-2008
20090177642METHOD AND SYSTEM FOR AUTOMATED DETECTION OF APPLICATION PERFORMANCE BOTTLENECKS - A system for detecting performance bottlenecks in a target application. In response to receiving hotspot selections from a user interface, bottleneck rules are extracted from a database. A hotspot is a region of source code that exceeds a time threshold to execute in the target application. Metrics needed to evaluate the bottleneck rules extracted from the database are identified. The identified metrics are computed. It is determined whether each bottleneck rule extracted from the database is evaluated to true using the computed metrics for hotspots in the target application. In response to determining that a bottleneck rule is evaluated to true using an appropriate computed metric corresponding to the bottleneck rule, a bottleneck description is created for the bottleneck rule. Then, the bottleneck description is sent to the user interface.07-09-2009
20100180255PROGRAMMABLE FRAMEWORK FOR AUTOMATIC TUNING OF SOFTWARE APPLICATIONS - A target application is automatically tuned. A list of solutions for identified performance bottlenecks in a target application is retrieved from a storage device. A plurality of modules is executed to compute specific parameters for solutions contained in the list of solutions. A list of modification commands associated with specific parameters computed by the plurality of modules is generated. The list of modification commands associated with the specific parameters is appended to a command sequence list. The list of modification commands is implemented in the target application. Specific source code regions corresponding to the identified performance bottlenecks in the target application are automatically tuned using the implemented list of modification commands. Then, the tuned target application is stored in the storage device.07-15-2010
20100287536PROFILING APPLICATION PERFORMANCE ACCORDING TO DATA STRUCTURE - During runtime of a binary program file, streams of instructions are executed and memory references, generated by instrumentation applied to given ones of the instructions that refer to memory locations, are collected. A transformation is performed, based on the executed streams of instructions and the collected memory references, to obtain a table. The table lists memory events of interest for active data structures for each function in the program file. The transformation is performed to translate memory addresses for given ones of the instructions and given ones of the data structures into locations and variable names in a source file corresponding to the binary file. At least the memory events of interest are displayed, and the display is organized so as to correlate the memory events of interest with corresponding ones of the data structures.11-11-2010

Patent applications by Guojing Cong, Ossining, NY US

Guojing Cong, Yorktown Heights, NY US

Patent application numberDescriptionPublished
20120124585Increasing Parallel Program Performance for Irregular Memory Access Problems with Virtual Data Partitioning and Hierarchical Collectives - A method for increasing performance of an operation on a distributed memory machine is provided. Asynchronous parallel steps in the operation are transformed into synchronous parallel steps. The synchronous parallel steps of the operation are rearranged to generate an altered operation that schedules memory accesses for increasing locality of reference. The altered operation that schedules memory accesses for increasing locality of reference is mapped onto the distributed memory machine. Then, the altered operation is executed on the distributed memory machine to simulate local memory accesses with virtual threads to check cache performance within each node of the distributed memory machine.05-17-2012

Hong Cong, Sunnyvale, CA US

Patent application numberDescriptionPublished
20120062984GENERATING LASER PULSES BASED ON CHIRPED PULSE AMPLIFICATION - Techniques and devices for producing short laser pulses based on chirped pulse amplification.03-15-2012

Jason Cong, Pacific Palisades, CA US

Patent application numberDescriptionPublished
20110029942Soft Constraints in Scheduling - A method for implementing soft constraints in scheduling comprises receiving a description of circuit behavior. The description is un-timed. A scheduling solution is generated for use in scheduling the description. The scheduling solution includes scheduling variables and an objective function. The scheduling variables schedule the time of at least one operation. The objective function includes a penalty term and constraints comprising at least one hard constraint and at least one soft constraint. The constraints are created on the scheduling variables. The penalty term comprises a slack variable representing violations of the constraints. The penalty term measures the design cost of violating the soft constraint. Following generation of the scheduling solution, the description is scheduled by applying the scheduling solution to the description. Timing information of the description is provided as an output of the scheduling.02-03-2011

Lianhui Cong, Northfield, NH US

Patent application numberDescriptionPublished
20100259589INERT UV INKJET PRINTING - Enhanced printing solutions are enabled by providing ultraviolet curing conditions without requiring complete evacuation of atmospheric oxygen. Increased ink coverage and adjusted surface appearance are also provided.10-14-2010
20110045199RADIATION CURABLE INK COMPOSITIONS - The radiation curable ink compositions exhibit fasting curing, high flexibility and good adhesion to a broad range of substrates. The ink compositions include a dendritic or hyperbranched polyester acrylate component, which is present in an amount of 10-45% by weight and has a functionality of greater than 5. The compositions further include an oligomer component, a monomer component, a photoinitiator component, a colorant component, and an additive component. The compositions have a viscosity of not greater than 40 cP at 25° C. The radiation curable compositions are suitable for inkjet printing on a variety of substrates.02-24-2011

Mei Cong, Madison, WI US

Patent application numberDescriptionPublished
20080248516Method for Using Division Arrested Cells in Screening Assays - Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal transduction assays, and are especially useful in large scale, high throughput assays.10-09-2008
20100203561METHOD FOR USING DIVISION ARRESTED CELLS IN SCREENING ASSAYS - Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal transduction assays, and are especially useful in large scale, high throughput assays.08-12-2010
20110275101METHOD FOR USING DIVISION ARRESTED CELLS IN SCREENING ASSAYS - Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal transduction assays, and are especially useful in large scale, high throughput assays.11-10-2011

Patent applications by Mei Cong, Madison, WI US

Peijun Cong, San Jose, CA US

Patent application numberDescriptionPublished
20100080733NEEDLE ASSEMBLY FOR ASPIRATING AND DISPENSING FROM SEALED CONTAINERS - A needle assembly has at least one guide member supported by a first body for sliding movement between an extended position and a retracted position. A second body is attached to the guide member. A biasing member biases the guide member to the extended position. A liquid handling needle is coupled to the first body so sliding movement of the guide member toward the retracted position retracts the second body relative to the liquid handling needle. The second body is adapted to contact a sealed receptacle. The biasing member urges the guide member toward said extended position during insertion and during said removal of the needle from the receptacle whereby the second body remains in contact with the sealed receptacle as the guide member moves from its extended position to its retracted position during said insertion and from its retracted position to its extended position during said removal.04-01-2010

Patent applications by Peijun Cong, San Jose, CA US

Peng Cong, Plymouth, MN US

Patent application numberDescriptionPublished
20110125077OPTICAL STIMULATION THERAPY - Methods of delivering optical stimulation to a target tissue from an optical stimulation device are provided. One method comprises sensing a temperature at the optical stimulation device or proximate to the optical stimulation device, and adjusting the delivery of light to the target tissue based on the sensed temperature. Another method comprises delivering the light to the target tissue with an optical light guide and sensing bioelectric signals with a sense electrode, wherein the optical light guide and the sense electrode each comprise a material that produces substantially no induced current in an electromagnetic field. Another method comprises delivering light from a light source of an optical stimulation device to a window of the optical stimulation device, delivering the light from the window to an optical light guide optically connected to the window, and delivering the light to a target tissue via the optical light guide.05-26-2011
20110125078OPTICAL STIMULATION THERAPY - A method for delivering optical stimulation comprises transfecting a target tissue with a light-sensitive channel protein sensitive to light in a wavelength range, delivering light in the wavelength range to the target tissue via an optical stimulation device, substantially simultaneously with delivering light to the target tissue, sensing bioelectric signals, determining a patient therapeutic state based on the bioelectric signals, and adjusting the delivery of the light to the target tissue based on the sensed patient therapeutic state.05-26-2011

Qiang Cong, Sunnyvale, CA US

Patent application numberDescriptionPublished
20110027274ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF - Antiproliferative compounds having a structure represented by formula (II), where n, R02-03-2011

Ruth Cong, Palo Alto, CA US

Patent application numberDescriptionPublished
20110055968NOVEL BACILLUS THURINGIENSIS CRYSTAL POLYPEPTIDES, POLYNUCLEOTIDES, AND COMPOSITIONS THEREOF - The present invention provides insecticidal polypeptides related to shuffled 03-03-2011
20120117690NOVEL BACILLUS THURINGIENSIS CRYSTAL POLYPEPTIDES, POLYNUCLEOTIDES, AND COMPOSITIONS THEREOF - The present invention provides insecticidal polypeptides related to shuffled 05-10-2012

Patent applications by Ruth Cong, Palo Alto, CA US

Shi Cong, Issaquah, WA US

Patent application numberDescriptionPublished
20100082550AGGREGATION OF WRITE TRAFFIC TO A DATA STORE - A method and a processing device are provided for sequentially aggregating data to a write log included in a volume of a random-access medium. When data of a received write request is determined to be suitable for sequentially aggregating to a write log, the data may be written to the write log and a remapping tree, for mapping originally intended destinations on the random-access medium to one or more corresponding entries in the write log, may be maintained and updated. At time periods, a checkpoint may be written to the write log. The checkpoint may include information describing entries of the write log. One or more of the checkpoints may be used to recover the write log, at least partially, after a dirty shutdown. Entries of the write log may be drained to respective originally intended destinations upon an occurrence of one of a number of conditions.04-01-2010
20100082918LOG MANAGER FOR AGGREGATING DATA - A processing device and a machine-implemented method may be provided for sequentially aggregating, or writing, data to a log included in a data store. The log may store multiple log entries. Each of the log entries may include an entry metadata portion, describing a respective log entry, and an entry payload data portion. The entry metadata portion may include a log sequence number, corresponding to a log entry at a particular position in the log. A library of log-related processes may be provided, along with an application program interface to permit a calling application program to call any of the log related processes. The log-related processes may be called during a boot mode, a user mode, and a kernel mode.04-01-2010
20110197016Aggregation of Write Traffic to a Data Store - A method and a processing device are provided for sequentially aggregating data to a write log included in a volume of a random-access medium. When data of a received write request is determined to be suitable for sequentially aggregating to a write log, the data may be written to the write log and a remapping tree, for mapping originally intended destinations on the random-access medium to one or more corresponding entries in the write log, may be maintained and updated. At time periods, a checkpoint may be written to the write log. The checkpoint may include information describing entries of the write log. One or more of the checkpoints may be used to recover the write log, at least partially, after a dirty shutdown. Entries of the write log may be drained to respective originally intended destinations upon an occurrence of one of a number of conditions.08-11-2011
20120102265Aggregation of Write Traffic to a Data Store - A method and a processing device are provided for sequentially aggregating data to a write log included in a volume of a random-access medium. When data of a received write request is determined to be suitable for sequentially aggregating to a write log, the data may be written to the write log and a remapping tree, for mapping originally intended destinations on the random-access medium to one or more corresponding entries in the write log, may be maintained and updated. At time periods, a checkpoint may be written to the write log. The checkpoint may include information describing entries of the write log. One or more of the checkpoints may be used to recover the write log, at least partially, after a dirty shutdown. Entries of the write log may be drained to respective originally intended destinations upon an occurrence of one of a number of conditions.04-26-2012

Patent applications by Shi Cong, Issaquah, WA US

Shuxin Cong, Lynnwood, WA US

Patent application numberDescriptionPublished
20110085167SURFACE PLASMON RESONANCE SPECTROMETER WITH AN ACTUATOR DRIVEN ANGLE SCANNING MECHANISM - Instruments and methods relating to surface plasmon imaging are described. An instrument comprises a semi-circular rail and a driving mechanism. The driving mechanism is attached to a light source mount and a detector mount, and both the light source mount and the detector mount are attached to the semi-circular rail with connectors. Each connector allows the light source mount and detector mount to slide along the rail. The synchronous movement of the light source mount and the detector mount changes the angle of incidence of a light beam from the light source with respect to the plane of the sample surface on the sample stage.04-14-2011

Shuxin Cong, Bellevue, WA US

Patent application numberDescriptionPublished
20090262355SURFACE PLASMON RESONANCE SYSTEM AND APPARATUS FOR INTERROGATING A MICROARRAY - According to an embodiment, an SPR analysis system includes a housing enclosing with a fluid supply volume substantially enclosed within the housing, a flow cell module configured to receive reagents and analyte from the fluid supply volume, and an enclosed optics assembly configured to interrogate a microarray portion of the flow cell module.10-22-2009
20090262356USER INTERFACE AND METHOD FOR USING AN SPR SYSTEM - According to an embodiment, an SPR analysis system includes an SPR analysis system control computer program having a graphical user interface and configured to control the operation of an SPR analysis apparatus. According to an embodiment, an SPR data analysis computer program includes an SPR microarray video viewer and a sensorgram generator responsive to the SPR video.10-22-2009

Wenxiang Cong, Christiansburg, VA US

Patent application numberDescriptionPublished
20100310037Multi-Parameter X-Ray Computed Tomography - The present invention relates to the field of x-ray imaging. More particularly, embodiments of the invention relate to methods, systems, and apparatus for imaging, which can be used in a wide range of applications, including medical imaging, security screening, and industrial non-destructive testing to name a few. Specifically provided as embodiments of the invention are systems for x-ray imaging comprising: a) a first collimator-and-detector assembly having a first operable configuration to provide at least one first dataset comprising primary x-ray signals as a majority component of its data capable of being presented as a first image of an object subjected to x-ray imaging; b) a second collimator-and-detector assembly having a second operable configuration or wherein the first collimator-and-detector assembly is adjustable to a second configuration to provide at least one second dataset comprising primary and dark-field x-ray signals as a majority component of its data capable of being presented as a second image of the object; and c) a computer operably coupled with the collimator-and-detector assemblies comprising a computer readable medium embedded with processing means for combining the first dataset and the second dataset to extract the dark-field x-ray signals and produce a target image having higher contrast quality than the images based on the first or second dataset alone. Such systems can be configured to comprise at least two collimator-and-detector assemblies or configurations differing with respect to collimator height, collimator aperture, imaging geometry, or distance between an object subjected to the imaging and the collimator-and-detector assembly.12-09-2010
20110282181EXTENDED INTERIOR METHODS AND SYSTEMS FOR SPECTRAL, OPTICAL, AND PHOTOACOUSTIC IMAGING - The present invention relates to the field of medical imaging. More particularly, embodiments of the invention relate to methods, systems, and devices for imaging, including for tomography-based applications. Embodiments of the invention include, for example, a computed tomography based imaging system comprising: (a) at least one wide-beam gray-scale imaging chain capable of performing a global scan of an object and acquiring projection data relating to the object; (b) at least one narrow-beam true-color imaging chain capable of performing a spectral interior scan of a region of interest (ROI) of and acquiring projection data relating to the object; (c) a processing module operably configured for: (1) receiving the projection data; (2) reconstructing the ROI into an image by analyzing the data with a color interior tomography algorithm, aided by an individualized gray-scale reconstruction of an entire field of view (FOV), including the ROI; and (d) a processor for executing the processing module. The extended interior methods and systems for spectral, optical, and photoacoustic imaging presented in this application can lead to better medical diagnoses by providing images with higher resolution or quality, and can lead to safer procedures by providing systems capable of reducing a patient's exposure time to, and thus quantity of, potentially harmful x-rays. Embodiments of the invention also provide tools for real-time tomography-based analyses.11-17-2011

Xinri Cong, Germantown, MD US

Patent application numberDescriptionPublished
20110022331Assay Information Management Methods and Devices - The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.01-27-2011

Yanping Cong, Bedford, MA US

Patent application numberDescriptionPublished
20090081144COSMETIC COMPOSITIONS - A topical composition having (i) an isolated polypeptide having the sequence of SEQ ID NO: 1 or a functional equivalent thereof, and (ii) a cosmetically acceptable carrier; and use thereof.03-26-2009

Yingzi Cong, Birmingham, AL US

Patent application numberDescriptionPublished
20100129386Composotions And Methods For The Identification And Treatment Of Immune-Mediated Inflammatory Diseases - Compositions and methods for the therapy and diagnosis of immune-mediated inflammatory diseases, including inflammatory bowel disease (IBD), Crohn's disease and ulcerative colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention or treatment of immune-mediated inflammatory disease.05-27-2010

Yonghua Cong, Aliso Viejo, CA US

Patent application numberDescriptionPublished
20080231378RING OSCILLATOR WITH ULTRA-WIDE FREQUENCY TUNING RANGE - Methods and systems for tuning an oscillator are disclosed and may comprise dividing a desired frequency range of a delay-cell based ring oscillator into segments, and tuning the delay-cell based ring oscillator over an ultra-wide frequency range by utilizing these divided segments. The enabled segment may determine the frequency range and the oscillator may be tuned within these segments. The delay may be adjusted utilizing a negative skew technique, and may be controlled by one or more digital codes. The oscillating frequency within each segment may be adjusted utilizing a control voltage or control current. The voltage or current may be buffered and utilized as a common supply of the delay cells.09-25-2008

Zhepeng Cong, Vancouver, WA US

Patent application numberDescriptionPublished
20090272719SYSTEM AND METHOD FOR PEDESTAL ADJUSTMENT - A pedestal positioning assembly system for use in a substrate processing system includes a pedestal rigidly attached to a pedestal shaft, a reference rigidly attached to the substrate processing system, a lateral adjustment assembly to adjust a lateral location of the pedestal relative to the reference, and a vertical adjustment assembly to adjust a tilt of the pedestal relative to the reference. The lateral adjustment assembly and the vertical adjustment assembly are external to a processing chamber and are coupled to the pedestal disposed within the processing chamber through the pedestal shaft. The reference can be a ring and the lateral adjustment assembly substantially centers the pedestal within the ring. A method of adjusting a pedestal includes leveling the pedestal, translating the pedestal, calibrating the pedestal height to a preheat ring level, and checking the level and location of the pedestal while rotating the pedestal.11-05-2009
20090276097NON-CONTACT SUBSTRATE SUPPORT POSITION SENSING SYSTEM AND CORRESPONDING ADJUSTMENTS - A substrate processing system includes an optical measurement assembly coupled to an exterior of a processing chamber that has a portion that is transparent. The processing chamber includes a reference object and a pedestal for supporting a work piece. The optical measurement assembly measures a lateral location, a height and a tilt of the pedestal by transmitting light into the processing chamber through the transparent portion of the processing chamber and detecting a reflected light from both the reference object and the portion of the pedestal after the reflected light leaves the chamber through the transparent portion of the processing chamber. A method of adjusting a pedestal includes analyzing the reflected light and leveling the pedestal, translating the pedestal, calibrating the pedestal height to a preheat ring level, and checking the level and location of the pedestal in response to the analyzed reflected light.11-05-2009