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Combs, US

Amy H. Combs, Tarboro, NC US

Patent application numberDescriptionPublished
20080219330Digital subscriber line (DSL) tracking system - Digital Subscriber Line (DSL) concentrating systems and other equipment from various manufacturers may be tracked and monitored with a single DSL tracking tool. The DSL tracking tool functions as part of a system of computing devices and databases with various user interfaces. The DSL tracking tool can perform analyses and generate reports about DSL devices, DSL sites, DSL concentrating systems, and routers to aid service providers in provisioning and maintaining DSL equipment.09-11-2008

Andrew Combs, Apollo Beach, FL US

Patent application numberDescriptionPublished
20110178921METHOD AND SYSTEM FOR MORTGAGE EXCHANGE - A method and system for electronically facilitating real estate transactions by providing accurate representations of the loans a borrower is qualified to receive, which are based on actual data, rather than estimates. All actions required for completing the real estate transaction, from entry of the borrower information to the closing and funding of the loan, are seamlessly integrated. An automated underwriting engine is provided for generating a decision matrix based on user input and/or existing data. An appropriate loan is selected based on the decision matrix, and is communicated to a potential borrower. After a loan is selected, fulfillment processing is performed, and the loan is funded and closed.07-21-2011

Arthur H. Combs, St. Louis, MO US

Patent application numberDescriptionPublished
20110125048METHOD FOR ASSESSING BRAIN FUNCTION AND PORTABLE AUTOMATIC BRAIN FUNCTION ASSESSMENT APPARATUS - A method and apparatus for performing rapid brain assessment may provide emergency triage to head trauma patients by analyzing a combination of spontaneous and evoked brain potentials. The spontaneous and evoked potentials are analyzed, and the results classified, to present a real-time assessment of a patient's brain, diagnosing any potential abnormalities therein.05-26-2011

Bryan S. Combs, Kettering, OH US

Patent application numberDescriptionPublished
20110317178PRINTER AND SCALE WITH INITIALIZATION PROCESS FOR SELECTING RFID FREQUENCY BAND FOR COMMUNICATING WITH RFID LABELS - A control associated with a label printer and RF unit is operable to carry out an RFID frequency selection process in which: (a) a given label is moved into the certain location along the label path; (b) for each of a plurality of frequencies: (i) the RF unit is operated to attempt to read and/or write to the label RFID tag of the given label multiple times; and (ii) the control records success data for attempts made in (b)(i); and (c) the control identifies and selects for subsequent use in operation of the RFID unit a multiplicity of the plurality of frequencies based upon results obtained in steps (b)(i) and (b)(ii).12-29-2011

Cecil Lee Combs, Fort Scott, KS US

Patent application numberDescriptionPublished
20110209369Self-Supporting Sign And Method of Manufacturing Same - Self-supporting signs and methods of manufacturing same are provided herein. In one embodiment, a self-supporting sign comprises a generally planar base portion and a generally planar upper portion extending from the base portion. The upper portion is foldable relative to the base portion about a fold line for movement between a storage configuration in which the base and upper portions are generally coplanar and a use configuration in which the base portion is generally horizontal and the upper portion is raised relative to the base portion. Only folding about the fold line is necessary to move from the storage configuration to the use configuration, and the base and upper portions are sufficiently rigid such that the upper portion remains at the use configuration after being moved to the use configuration. The upper portion may be offset from the base portion between about 50° and 90° when at the use configuration.09-01-2011

Celeste Marie Combs, Burien, WA US

Patent application numberDescriptionPublished
20110252351SYSTEMS AND METHODS FOR CONSUMING, SHARING, AND SYNCHRONIZING TIME BASED INFORMATION - Methods, techniques, and systems for a calendar management system are provided. Some embodiments provide a calendar management system that is configured to receive calendar identification information from a user; access at least one disparate calendaring system, wherein the at least one disparate calendaring system is related to the received calendar identification information; and integrate calendar data from the accessed at least one disparate calendaring system in a calendar environment user interface.10-13-2011

Charles D. Combs, Buffalo, MO US

Patent application numberDescriptionPublished
20090067841FIBER AND WIRE COMMUNICATION SYSTEM - This invention provides a new architecture for a communication system between head-ends and end-users which expands bandwidth and reliability of the communication system. A mux-node receives communication signals from a head-end and forwards the received communication signals to one or more mini-fiber nodes. The connection to the head-end is via a small number of optical fibers and the connections to each of the mini-fiber nodes may be via one or more optical fibers that may provide full duplex communication. The head-end may communicate with the mux-node using digital or digital and analog signals. The mini-fiber nodes may combine the signals received from the head-end with loop-back signals used for local media access control prior to forwarding the signals to the end-users. Upstream data are received by the mini-fiber nodes and transmitted to the mux-node. The mux-node may route upstream communication signals received from the mini-fiber nodes as downstream signals to other mini-fiber nodes also connected to the mux-node without head-end interaction.03-12-2009

Patent applications by Charles D. Combs, Buffalo, MO US

Clyde Combs, Satellite Beach, FL US

Patent application numberDescriptionPublished
20080290433Monolithic nuclear event detector and method of manufacture - A PIN diode-based monolithic Nuclear Event Detector and method of manufacturing same for use in detecting a desired level of gamma radiation, in which a PIN diode is integrated with signal processing circuitry, for example CMOS circuitry, in a single thin-film Silicon On Insulator (SOI) chip. The PIN diode is implemented in the p- substrate layer. The signal processing circuitry is located in a thin semiconductor layer and is in electrical communication with the PIN diode. The PIN diode may be integrated with the signal processing circuitry onto a single chip, or may be fabricated stand alone using SOI methods according to the method of the invention.11-27-2008
20110316105Monolithic Nuclear Event Detector and Method of Manufacture - A PIN diode-based monolithic Nuclear Event Detector and method of manufacturing same for use in detecting a desired level of gamma radiation, in which a PIN diode is integrated with signal processing circuitry, for example CMOS circuitry, in a single thin-film Silicon On Insulator (SOI) chip. The PIN diode is implemented in either a p-, intrinsic, or n-substrate layer. The signal processing circuitry is located in a thin semiconductor layer and is in electrical communication with the PIN diode. The PIN diode may be integrated with the signal processing circuitry onto a single chip, or may be fabricated stand alone using SOI methods according to the method of the invention.12-29-2011

Colin Combs, Grand Forks, ND US

Patent application numberDescriptionPublished
20100331330METHODS AND COMPOSITIONS FOR TREATING ISCHEMIC STROKE - A method of treating a cerebrovascular accident in a subject includes administering a therapeutically effective amount of at least one PPARγ agonist or a derivative thereof to the subject after onset of ischemia sufficient to a cause the cerebrovascular accident and prior to reperfusion.12-30-2010

Daniel Combs, Mountain View, CA US

Patent application numberDescriptionPublished
20080299117Treatment Method - The invention provides methods of treating autoimmune diseases using lower doses of anti-CD20 antibodies of 100 mg to 200 mg effective to deplete B cells in the patient.12-04-2008

David Kenneth Combs, Verona, WI US

Patent application numberDescriptionPublished
20090272889METHOD FOR MEASURING FIBER DIGESTIBILITY - Described is a method of measuring fiber digestion in ruminants and calibrating spectrophotometers using the measured fiber digestion values. The method includes the steps of harvesting rumen fluid from at least one ruminant animal and combining the rumen fluid with a primer composition comprising a carbohydrate. The rumen fluid and carbohydrate are then incubated in a sealed container until a pre-determined pressure is achieved within the sealed container. A plant matter sample is digested with the rumen fluid so treated. The digested sample is the measured for absorbance or reflectance using a spectrophotometer. The digestion values and the absorbance or reflectance values are then correlated to construct a standard curve for predicting fiber digestion values using spectrophotometric analysis, preferably NIRS analysis.11-05-2009

Donald Combs, Auburn, NH US

Patent application numberDescriptionPublished
20100165134Arrayed Imaging Systems And Associated Methods - Arrayed imaging systems include an array of detectors formed with a common base and a first array of layered optical elements, each one of the layered optical elements being optically connected with a detector in the array of detectors.07-01-2010

Doug Combs, Spokane, WA US

Patent application numberDescriptionPublished
20090175684CONTAINMENT BERM BRACKET - Containment berms and associated support systems and structures. In one example embodiment, a containment berm bracket includes a substantially rigid first member and a substantially rigid second member. The first member defines a first complementary structure. The second member that defines a second complementary structure and a sidewall clamp. The second complementary structure is configured to releasably engage with the first complementary structure in order that the members can be releasably attached to each other.07-09-2009
20100028081CONTAINMENT BERM BRACKET - Containment berms and associated support systems and structures. In one example embodiment, a containment berm bracket includes a substantially rigid first member and a substantially rigid second member. The first member defines a first complementary structure. The second member that defines a second complementary structure and a sidewall clamp. The second complementary structure is configured to releasably engage with the first complementary structure in order that the members can be releasably attached to each other.02-04-2010

Doug Wayne Combs, Spokane, WA US

Patent application numberDescriptionPublished
20110132421PORTABLE EXPANDABLE SHELTER - In one example, a portable expandable shelter includes an enclosure with one or more movable portions such as a side or end, and further includes a foldable frame configured and arranged for operation in unison with movement of the movable portion of the enclosure. This example of the portable expandable shelter also includes a cover that encloses at least a portion of a space defined by the movable portion and the foldable frame.06-09-2011

Ernest W. Combs, Raleigh, NC US

Patent application numberDescriptionPublished
20090152573Textured encapsulant surface in LED packages - A packaged LED device having a textured encapsulant that is conformal with a mount surface on which at least one LED chip is disposed. The textured encapsulant, which can be textured using an additive or subtractive process, is applied to the LED either prior to or during packaging. The encapsulant includes at least one textured surface from which light is emitted. The textured surface helps to reduce total internal reflection within the encapsulant, improving the extraction efficiency and the color temperature uniformity of the output profile. Several chips can be mounted beneath a single textured encapsulant. A mold having irregular surfaces can be used to form multiple encapsulants over many LEDs simultaneously.06-18-2009

Ernie Combs, Raleigh, NC US

Patent application numberDescriptionPublished
20090116252THERMAL SURFACE MOUNTING OF MULTIPLE LEDS ONTO A HEATSINK - A LED package employs a heatsink (05-07-2009

Fredrick C. Combs, Shawnee, OK US

Patent application numberDescriptionPublished
20090054151Game Topper - The subject matter of this specification can be embodied in, among other things, a method that includes monitoring, at a game topper, a signal transmitted between a gaming device and a remote gaming management system, associating at least a portion of the signal with media, and outputting the media to a user of the gaming device using the game topper.02-26-2009
20090299833Messaging Gaming Patrons - The subject matter of this specification can be embodied in, among other things, a method that includes monitoring game play information transmitted from a gaming device to a server. The monitored information specifies a gaming patron's interactions with the gaming device. The method also includes recording, in a data store of the server, player information comprising the game play information for the gaming patron and a communication device identifier that specifies a communication device associated with the gaming patron. The method includes generating at the server an electronic message that includes one or more offers personalized for the gaming patron based on the recorded player information and transmitting, using a messaging interface, the electronic message to the communication device specified by the communication device identifier.12-03-2009

Geoffrey W. Combs, Canal Winchester, OH US

Patent application numberDescriptionPublished
20090054991TRANSFORAMINAL LUMBAR INTERBODY FUSION CAGE - A spinal cage system for inserting a spinal cage assembly into a spine to separate and support adjacent spinal vertebrae, includes a first cage member; a second cage member; and an articulating mechanism adapted to connect the first cage member to the second cage member and to permit the first and second cage members to move relate to each other. An insertion instrument is adapted to capture the spinal cage assembly for insertion of the spinal cage assembly into a spine and to rotate the first and second cage members relative to each other to achieve a desired orientation in the spine.02-26-2009

George Combs, Goldsboro, NC US

Patent application numberDescriptionPublished
20110031013SECURITY LATCH DEVICE FOR A TRANSFORMER BOX - A security latch device is provided. The device includes a bracket for being attached to a structure and having an outwardly extending flange having a lock pin slot defined therein, a hinged assembly defining a first hinged portion for being attached to the structure and a second hinged portion for being cooperatively engaged with the bracket, the second hinged portion defining a slot for allowing pass-through of the outwardly extending flange of the bracket, and a cup for attaching to the second portion of the hinged assembly and defining a cavity therein and an aperture therethrough that is in general alignment with the lock pin slot of the bracket so that the lock pin is configured for being received in the cavity and extending through the aperture of the cup and the lock pin slot of the bracket for securing the hinged assembly to the bracket.02-10-2011

Gregg Combs, Monmouth, OR US

Patent application numberDescriptionPublished
20100328758Electrophoretic Display Device - A multi-stable electrophoretic display device has a plurality of pixels and comprises a first substrate and a second substrate. The substrates are spaced apart from each other and enclose a layer of an electrophoretic medium comprising a liquid crystal material having finely divided pigment particles dispersed therein. The device further comprises electrodes for formation of a pixel area outline and applying an electric field across at least some of the electrophoretic medium in the pixel area. The electrodes occupy substantially less than the entire field of view of the display pixels and can be used to effect switching between a first optical state in which most incident light on a pixel does not impinge on a pigment particle, and a second optical state in which most incident light on a pixel impinges on pigment particles.12-30-2010

Gregg A. Combs, Monmouth, OR US

Patent application numberDescriptionPublished
20100090943Electrophoretic Display Apparatus and Method - An electrophoretic display apparatus includes an array of cells each comprising first and second electrodes and a plurality of electrophoretic particles disposed between the electrodes, wherein the particles are dispersed in a host fluid and are multistable in positions between the electrodes; and drive circuitry in electrical communication with each of the electrodes. The drive electronics are configured to transition addressed cells of the array from a first optical state to a second optical state with a plurality of successive write signals.04-15-2010
20110149376ELECTRO-OPTICAL DISPLAY SYSTEMS - Electro-optical display systems are disclosed. An electro-optical display system may include a display volume containing a fluid having a plurality of colorant particles; a dielectric layer adjacent the display volume, the dielectric layer including recessed regions configured to contain the plurality of colorant particles; a plurality of electrodes configured to selectively move the plurality of colorant particles between a compacted position in which all or nearly all of the plurality of colorant particles are in the recessed regions, and a spread position in which all or nearly all of the plurality of colorant particles are spread across the display volume; and at least one color filter configured to absorb at least one wavelength of light.06-23-2011

Gregg Alan Combs, Monmouth, OR US

Patent application numberDescriptionPublished
20090115814Fluid-dispensing Devices And Methods - An embodiment includes determining a temperature change of a fluid-ejecting substrate, and determining a mass of fluid ejected from the fluid-ejecting substrate from the temperature change of the fluid-ejecting substrate.05-07-2009
20100245981ELECTRO-OPTICAL DISPLAY - A display system encompasses electrodes that induce a convective flow of a carrier fluid that transports a colorant species that is suspended in the carrier fluid. At least one of the convection flow, speed, and direction of the colorant species is controlled by operation of the electrodes.09-30-2010
20110120749TRANSPARENT CONDUCTOR STRUCTURE - A transparent conductor structure includes a transparent, insulating substrate and a discontinuous, transparent conducting layer established on the substrate. The discontinuous conducting layer is partitioned into a plurality of segments, each of which has a thickness ranging from about 1 nm to about 10 μm. Two or more of the segments are connected together by i) a metal trace disposed on or between them, or ii) a mesh, formed from a plurality of metal traces, disposed across a surface of the segments.05-26-2011
20110261435ELECTRONIC INKS AND DISPLAYS AND IMAGE DISPLAYING METHODS - An electronic ink containing charged particles includes a combination of resin particles, a pigment, and a charge director. The resin particles exhibit an average particle size less than 1.0 micron and contain a resin that exhibits a molecular weight of 500 to 20,000. The pigment is loaded on the resin particles. The charge director can physically associate with the resin particles. The charged particles may be negative or positive.10-27-2011
20110304905ELECTRO-OPTICAL DISPLAY - A display system encompasses electrodes that induce a convective flow of a carrier fluid that transports a colorant species that is suspended in the carrier fluid. At least one of the convection flow, speed, and direction of the colorant species is controlled by operation of the electrodes.12-15-2011

Patent applications by Gregg Alan Combs, Monmouth, OR US

Gregg Alan Combs, Corvallis, OR US

Patent application numberDescriptionPublished
20110266347ELECTRONIC INKS AND DISPLAYS AND IMAGE DISPLAYING METHODS - An electronic ink containing charged particles includes a combination of resin particles, a pigment, and a charge director. The resin particles exhibit an average particle size less than 1.0 micron and contain a resin that exhibits a molecular weight of 500 to 20,000. The pigment is loaded on the resin particles. The charge director can physically associate with the resin particles. The charged particles may be negative or positive.11-03-2011

Jacquelyn S. Combs, Sparks, NV US

Patent application numberDescriptionPublished
20090131168Systems and methods for improving a button assembly - A button assembly is described. The button assembly includes a light emitting device that emits light. The button assembly further includes a lens cap that protects the light emitting device from being damaged. The lens cap has a top surface, a first cap side, a second cap side, a third cap side, and a fourth cap side. The second cap side connected to the first cap side, the third cap side connected to the second cap side, and the fourth cap side connected to the first cap side and the third cap side to form a plane. A first perpendicular distance between the plane and a first point on the top surface is different than a second perpendicular distance between the plane and a second point on the top surface. Additionally, a system for increasing life of a pixel is described.05-21-2009

James D. Combs, Winchester, KY US

Patent application numberDescriptionPublished
20080220227Coated printing stock for use as labels and the like - A label incorporates slip agent and antistat directly into the polymer layers from which the label is constructed.09-11-2008
20090107622METHOD OF PRODUCING CUT-AND-STACK LABELS - A method is provided of producing cut-and-stack labels from a web of printing stock. The method includes the steps of printing indicia on a first face of the web, laminating a protective film to the web over the printed first face, applying an antistat to the laminated web and drying the antistat. This is followed by the slitting of the web into at least two narrow webs. The narrow webs are then dusted with an offset powder, cut into sheets of predetermined length and finished into cut-and-stack labels.04-30-2009
20090301636CUT-AND-STACK LABEL MADE FROM SHRINK FILM AND RELATED METHODS - A cut-and-stack label includes a cut-and-stack sheet sized for feeding by cut-and-stack labeling equipment and labeling an individual container. The cut-and-stack sheet includes a first shrink film layer having a first face and a second shrink film layer having a second face. The first face of the first shrink film layer is laminated to the second face of the second shrink film layer. Printing is provided on at least one of the first and second faces. A method of producing cut-and-stack labels and a method of labeling a container are also provided.12-10-2009
20100170618CUT-AND-STACK LABEL MADE FROM SHRINK FILM AND RELATED METHODS - A cut-and-stack label includes a cut-and-stack sheet sized for feeding by cut-and-stack labeling equipment and labeling an individual container. The cut-and-stack sheet includes a first shrink film layer having a first face and a second shrink film layer having a second face. The first face of the first shrink film layer is laminated to the second face of the second shrink film layer. Printing is provided on at least one of the first and second faces. A method of producing cut-and-stack labels and a method of labeling a container are also provided.07-08-2010
20100181021METHOD OF PRODUCING CUT-AND-STACK LABELS - A method of reducing costs associated with production of cut-and-stack labels includes: (a) stacking first and second webs of printing stock; (b) cutting the stacked webs into two sheets of desired length; and (c) temporarily welding the sheets together during cutting so as to provide the two sheets with sufficient stiffness to be properly transferred to a skid. The method allows production of cut-and-stack labels from printing stock of reduced thickness thereby reducing material costs associated with label production.07-22-2010
20110304132CUT AND STACK LABELS OF LAMINATED FILM - A cut and stack label includes a layer of polymer shrink film printing stock having a first face carrying a printed message and a second, opposite face, a clear polymer shrink film laminated to the first face over that printed message and a coating of an anti-static formulation over the clear polymer shrink film and/or the second face. A dusting or layer of offset powder is also provided.12-15-2011

Patent applications by James D. Combs, Winchester, KY US

James Lee Combs, Lexington, KY US

Patent application numberDescriptionPublished
20090086173Peripheral With Projection Display - A device for projection of an operations panel comprises a printer portion, a media feedpath extending through the printer portion having a media input and a media output, an image projector forming an image on one of the media input or an image receiving surface, the image projector defining an operations panel for making operation selections.04-02-2009

Patent applications by James Lee Combs, Lexington, KY US

James R. Combs, Mowreystown, OH US

Patent application numberDescriptionPublished
20120097054Method And Apparatus For Forming Carbon Dioxide Particles Into Blocks - An apparatus for forming a block from carbon dioxide particle is configured to allow changing between precise thicknesses with very little downtime, utilizing both weight based and volumetric dosing. A spacer supports the lower ejection piston during block forming, with a shuttle discharging particles into the forming chamber while simultaneously pushing a previously formed block on to a conveyor. In one embodiment, the shuttle dosing cavity has a volume that is greater than the volume of the forming chamber volume, which allows more pellets, volumetrically, to be dosed into the dosing cavity than the volume of the forming cavity.04-26-2012

Jonathan D. Combs, Austin, TX US

Patent application numberDescriptionPublished
20120079237Saving Values Corresponding to Parameters Passed Between Microcode Callers and Microcode Subroutines from Microcode Alias Locations to a Destination Storage Location - An apparatus of one aspect includes a microcode storage, a microcode subroutine stored in the microcode storage, and a microcode caller of the microcode subroutine stored in the microcode storage. The microcode caller has a save microinstruction that indicates a destination storage location. The apparatus also includes microcode alias locations. Each of the microcode alias locations is operable to store a value. The value in the microcode alias location corresponds to a parameter passed between the microcode caller and the microcode subroutine. The apparatus includes save logic coupled with the microcode alias locations to receive the values from the microcode alias locations. The save logic is operable, responsive to the save microinstruction, to save the values from the microcode alias locations in the destination storage location indicated by the save microinstruction.03-29-2012
20120079248Aliased Parameter Passing Between Microcode Callers and Microcode Subroutines - An apparatus of an aspect includes a plurality of microcode alias locations and a microcode storage. A microinstruction of a microcode subroutine is stored in the microcode storage. The microinstruction has an indication of a microcode alias location. A microcode caller of the microcode subroutine is also stored in the microcode storage. The microcode caller is operable to specify a location of a parameter in the microcode alias location that is indicated by the microinstruction of the microcode subroutine. The apparatus also includes parameter location determination logic that is coupled with the microcode alias locations. The parameter location determination logic is operable, responsive to the microinstruction of the microcode subroutine, to receive the indication of the microcode alias location from the microinstruction and determine the location of the parameter specified in the microcode alias location indicated by the microinstruction.03-29-2012
20120079255INDIRECT BRANCH PREDICTION BASED ON BRANCH TARGET BUFFER HYSTERESIS - Methods and apparatus to perform efficient indirect branch prediction operations are described. In one embodiment, a branch target buffer (BTB) stored a target address and a bimodal hysteresis counter for an indirect branch that has been encountered by a front-end of the processor during a time period. An indirect branch prediction logic then generates a prediction for an instruction corresponding to a indirect branch based on the stored bimodal hysteresis counter of the BTB. Other embodiments are also claimed and disclosed.03-29-2012

Katherin E. Combs, San Antonio, TX US

Patent application numberDescriptionPublished
20110097330Novel Gene Disruptions, Compostitions and Methods Relating Thereto - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.04-28-2011

Katherin E. Combs, Spring, TX US

Patent application numberDescriptionPublished
20080311107Novel Gene Disruptions, Compositions and Methods Relating Thereto - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.12-18-2008
20090113564Genetically Engineered and Phenotyped Mice and Stem Cell Clones for Producing the Same - The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.04-30-2009
20090196876Novel Gene Disruptions, Compositions and Methods Relating Thereto - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.08-06-2009
20090293137Novel Gene Disruptions, Compositions and Methods Relating Thereto - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO 1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.11-26-2009
20090313707Novel Gene Disruptions, Compositions and Methods Relating Thereto - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.12-17-2009
20110173708NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.07-14-2011
20110182883NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.07-28-2011
20120005766Methods of identifying agents that modulate phenotypes related to disruptions, of a gene encoding PRO235 polypeptide - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; cyc abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.01-05-2012
20120030776NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.02-02-2012

Patent applications by Katherin E. Combs, Spring, TX US

Katherine Helen Combs, Cincinnati, OH US

Patent application numberDescriptionPublished
20090197789ACETYLATION OF CHITOSAN - A process for making modified N-acetylated chitosan comprising the steps of: 08-06-2009

Patent applications by Katherine Helen Combs, Cincinnati, OH US

Kathleen Combs, Milford, CT US

Patent application numberDescriptionPublished
20100292117HIGH EMOLLIENT LAMELLAR COMPOSITIONS RESISTANT TO VISCOSITY AND PHASE STRUCTURE DETERIORATION AFTER LOW TEMP STORAGE AND/OR FREEZE-THAW CYCLE - The invention comprises a liquid lamellar composition comprising surfactant, a specific lamellar structuring system, emollient, and specific structurant.11-18-2010

Kerry Combs, Wallingford, CT US

Patent application numberDescriptionPublished
20090082392Substituted Carboxylic Acids - The present invention relates to compounds and pharmaceutically acceptable salts of formula (I):03-26-2009

Patent applications by Kerry Combs, Wallingford, CT US

Michael D. Combs, Bluff City, TN US

Patent application numberDescriptionPublished
20110264463ACTIVITY NOTIFICATION SYSTEM AND METHOD - The activity notification process includes a first step of selecting an activity center on a home screen of a home station. The home screen of the home station has a plurality of selectable activity center choices, the selection thereof generating a plurality of selectable patient location options. The next step includes selecting one of the location options to send a message to an activity station of the activity center, the home station touch screen returning to its home screen with the activity center being predominantly highlighted thereon. The activity station generates an alert window providing directions to a location. The predominately highlighted activity center on the home station touch screen is deselected, only when the message has been answered, thereby returning the home screen thereon to a state that does not show the predominant highlights, the deselection providing verification that the message has been answered. The activity center may be disabled until the required activity is completed. The activity notification system is particularly adapted for use in a physician or dental office.10-27-2011

Michael T. Combs, Shady Spring, WV US

Patent application numberDescriptionPublished
20100175691PROCESS FOR RECYCLING CELLULOSE ACETATE ESTER WASTE - A process for recycling cellulose acetate ester waste comprising the steps of: providing a reactor, adding cellulose acetate ester waste and a hydrolyzing agent to the reactor to create an agent/waste mixture followed by hydrolyzing the cellulose acetate ester waste by agitating and heating the agent/waste mixture for a period of time to create a hydrolyzed mixture. The hydrolyzing agent is then distilled and/or separated from the hydrolyzed mixture followed by separating and removing solid material from the hydrolyzed mixture to create a water soluble product stream which includes monosaccharides, polysaccharides, partially hydrolyzed cellulose, acetic acid, or combinations thereof. The water soluble product stream is then collected.07-15-2010

Richard D. Combs, Pompane Beach, FL US

Patent application numberDescriptionPublished
20090254480SYSTEM AND METHOD FOR PREVENTING GIFT FRAUD - A gift card uses a fraud code stored on a magnetic stripe of the card to prevent fraudulent transactions. When the gift card is purchased at a POS terminal at a merchant location, a gift card account number stored on the magnetic stripe is read, and sent to a gift card system. The gift card system activates the card and generates the fraud code and returns it to the POS terminal, where a card encoder writes the fraud code onto the magnetic stripe. When the gift card is used to conduct a transaction, the transaction is permitted only if a valid fraud code is stored on the magnetic stripe.10-08-2009

Richard T. Combs, Villa Hills, KY US

Patent application numberDescriptionPublished
20100094776Combined Loan and Investment System and Method - A combined loan and investment program comprises a computer processor and program code configured to be executed by the computer processor to process financial loan and investment data by calculating from the data interest and principal loan payments on a loan principal at a given rate and term, calculating investment performance data on a periodic principal investment deposit at a given rate and calculating loan principal amortization parameters as a function of the investment performance data. The present invention provides a method for paying off a mortgage and simultaneously generating wealth via an investment account by making a payment to a mortgagee, dividing the payment, applying a first portion of the payment to satisfy the interest due on the mortgage, applying a second portion of the payment to an investment account, allowing the investment account to grow and applying a portion of the investment account to satisfy the mortgage.04-15-2010

Robert A. Combs, Deephaven, MN US

Patent application numberDescriptionPublished
20110270576Method to detect angle sensor performance degradation through dither monitoring - A method for detecting angle sensor performance degradation in a flow angle measurement device in moving platform, such as aircraft and watercraft, as well as stationary platforms. Sensor dither in a flow angle measurement device is used to detect operational performance degradation of the sensor as a result of dynamic response changes caused by damaged or degraded mechanical components.11-03-2011

Robert C. Combs, Redmond, WA US

Patent application numberDescriptionPublished
20090240972MODELING RECURRING EVENTS IN A DATA STORE - Time-related properties may be modeled independent of a base object. Rather than storing time properties with the object, they may be stored independently. A given object may be stored once, even if it has a recurrent time property. The description of a “meeting,” for example, may be stored once. Each occurrence of that object over time may be stored in a “timeslot” (object occurs at time ‘t’ on day ‘d’). If it is a recurring property, recurrence information may be stored independently. “Exception” information may be stored independently as well.09-24-2009
20100174808NETWORK PRESENCE OFFLOADS TO NETWORK INTERFACE - A computing device that has a network interface that performs a subset of possible networking functions while the computing device is in a sleep mode. The subset of functions may be simply implemented on the network interface, yet to substantially reduce the frequency with which the computing device has to wake up to perform networking functions. The subset of functions may be selected to maintain a network presence of the computing device while the device is in sleep mode, and may include responding to requests for MAC information, sending keep-alive messages or exchanging security information that, in accordance with network protocols, has a limited lifetime that would otherwise expire while the computing device is in sleep mode.07-08-2010
20120030252MODELING RECURRING EVENTS IN A DATA STORE - Time-related properties may be modeled independent of a base object. Rather than storing time properties with the object, they may be stored independently. A given object may be stored once, even if it has a recurrent time property. The description of a “meeting,” for example, may be stored once. Each occurrence of that object over time may be stored in a “timeslot” (object occurs at time ‘t’ on day ‘d’). If it is a recurring property, recurrence information may be stored independently. “Exception” information may be stored independently as well.02-02-2012

Patent applications by Robert C. Combs, Redmond, WA US

Rodney G. Combs, Wildwood, MO US

Patent application numberDescriptionPublished
20120039908Control of Protein Glycosylation and Compositions and Methods Relating Thereto - The invention relates to novel methods for controlling the glycosylation of a protein and the protein produced thereby. An exemplary method of the invention comprises producing a protein comprising a decreased level of glycosylation, e.g., the protein comprises fewer glycans or fewer saccharides at the glycosylation site, by culturing a host cell expressing the protein in the presence of a glycosylation inhibitor. In an exemplary method of the invention, the biological characteristics of the protein are altered by the decreased level of glycosylation, e.g., the binding of the protein with its target ligand is modified.02-16-2012

Stanley Combs, Comanche, OK US

Patent application numberDescriptionPublished
20080197605Method for Constructing and Treating Subterranean Formations - A method for servicing a well comprises providing at least one trailer, providing at least one towing vehicle, providing servicing equipment, supporting the equipment with the trailer, and moving the towing vehicle, so as to move the trailer along with the equipment. The combination gross weight rating or combination gross vehicle weight of the trailer and the towing vehicle may be less than 26,001 pounds or less than less than the commercial drivers license threshold, under the Federal Motor Carrier Safety Administration's regulations.08-21-2008

Steve Alan Combs, White Lake, MI US

Patent application numberDescriptionPublished
20100187282Floor Stapler Shoe - A floor stapler shoe used in the installation of hardwood floors includes a shoe body and a pair or more antifriction components. The shoe body is designed to receive and connect with a floor stapler. One of the pair of antifriction components contacts a tongue of a floor board when in use, and the other of the pair of antifriction components contacts an upper surface of the floor board when in use. The antifriction components can be a bearing, a pad composed of antifriction material, or both.07-29-2010

Steven Donald Combs, Lexington, KY US

Patent application numberDescriptionPublished
20090186652Camera Cell Phone With Integrated Wireless Mouse - An improvement to a cellular camera phone comprising a source of illumination positioned adjacent to the camera unit and configured to illuminate a portion of an underlying surface within the field of view the camera unit; programming effective to (a) collect a current tracking image frame, (b) compare the current tracking image frame with a prior tracking image frame, (c) compute a relative displacement between the tracking image frames, and (d) store the current tracking image frame as a prior tracking image frame; and a wireless peripheral interface, wherein the wireless peripheral interface communicates the relative displacement to a computer. Also, a method of retrofitting a cellular camera phone to provide wireless mouse functionality comprising the steps of providing an accessory unit for engagement with the cellular phone configured to position a source of illumination adjacent to the camera unit and to illuminate a portion of an underlying surface within the field of view the camera unit; providing the aforedescribed programming, and providing programming to communicate the relative displacement to a computer.07-23-2009

Steven Larue Combs, Schuyler, VA US

Patent application numberDescriptionPublished
20080264095Cold Room With Roof-Top Support Platform - A cold room building is disclosed having a prefabricated insulated housing (10-30-2008

Terry Lee Combs, Alpharetta, GA US

Patent application numberDescriptionPublished
20090157022ABSORBENT ARTICLES HAVING A WETNESS INDICATOR - Absorbent articles including a wetness indicator are generally described. The wetness indicator of the present invention is configured to expand toward the skin of the wearer (i.e., in the z-direction of the absorbent article perpendicular to the plane of the absorbent article) upon contact with a liquid. However, the expansion of the wetness indicator is substantially limited to the z-direction. That is, the wetness indicator does not substantially expand in any direction parallel with the plane of the article (i.e., the x- and y-directions). As such, the wetness indicator does not significantly interfere with the absorbent capabilities of the absorbent article. Thus, the wetness indicator can be included within conventional absorbent articles without significantly sacrificing the absorbency characteristics of the article.06-18-2009
20090157032ABSORBANT ARTICLES HAVING A COMPRESSED TABLET - Absorbent articles including a compressed tablet are generally described. The compressed tablet of the present invention is configured to expand toward the skin of the wearer (i.e., in the z-direction of the absorbent article perpendicular to the plane of the absorbent article) upon contact with a liquid. However, the expansion of the compressed tablet is substantially limited to the z-direction. That is, the compressed tablet does not substantially expand in any direction parallel with the plane of the article (i.e., the x- and y-directions). As such, the compressed tablet does not significantly interfere with the absorbent capabilities of the absorbent article. Thus, the compressed tablet can be included within conventional absorbent articles without significantly sacrificing the absorbency characteristics of the article.06-18-2009

Vincent Combs, Kettering, OH US

Patent application numberDescriptionPublished
20090249714Precast concrete modular stairwell tower - A multi-story building is constructed by first erecting at least one modular stairwell tower on a concrete base pad. The tower includes a number of horizontally alternating precast concrete modular stairwell units arranged in a stack and corresponding to twice the number of floors in the building. Each stairwell unit includes a precast reinforced concrete tower section having opposite side walls and opposite end walls defining an open top and an open bottom and a height generally equal to one half the vertical distance between two adjacent floors. An inclined stairway and a horizontal landing platform are formed within each tower section and are rigidly connected to the walls. Anchor members are embedded in the base pad and in upper and lower portions of the walls of each tower section, and adjacent anchor members are connected by weld plates. Each stairwell unit has a handrail supported by the corresponding stairway.10-08-2009

William G. Combs, Eugene, OR US

Patent application numberDescriptionPublished
20100024254WATERPROOF, BREATHABLE SHOE - A waterproof, breathable shoe is disclosed, having a shaped polymeric upper to accommodate the wear's foot, as well as layers to provide other properties to the shoe. At least five layers make up the shoe upper: (1) an innermost woven fabric; (2) an air permeable rubber layer; (3) an air permeable waterproof, four-way stretch membrane layer; (4) a structured air mesh layer; and (5) an outer woven fabric.02-04-2010

William J. Combs, Minnetonka, MN US

Patent application numberDescriptionPublished
20080228094Heart Monitoring Systems, Apparatus and Methods Adapted to Detect Myocardial Ischemia - Embodiments include heart monitoring systems, apparatus, and methods adapted to detect myocardial ischemia. An apparatus includes at least one first-tier sensor/analyzer adapted to sense a first input related to cardiac function, and to produce a first-tier trigger signal when the first input indicates myocardial ischemia. In an embodiment, a first-tier sensor/analyzer includes an ECG sensor/analyzer. In another embodiment, a first-tier sensor/analyzer includes a patient activator. An apparatus further includes at least one second-tier sensor/analyzer adapted to sense a second input related to cardiac function, and to produce a second-tier trigger signal when the second input indicates myocardial ischemia. In an embodiment, a second-tier sensor-analyzer includes a heart sound sensor/analyzer. A triggering element is adapted to produce a response-invoking signal in response to the first-tier trigger signal and the second-tier trigger signal. The response-invoking signal may invoke a patient alert, a message to an external system, and/or a cardiac stimulus.09-18-2008
20100023081Comprehensive System for Detection of Coronary Syndrome, Cardiac Ischemia and Myocardial Infarction - Heart-monitoring systems, apparatus, and methods adapted to detect CS, CI and/or MI. In one embodiment, a system comprising at least two first-tier sensors capable of measuring and converting into signals at least two aspects related to cardiac function, at least one second-tier sensor that is also a first-tier sensor, at least one signal processor capable of transmitting a first-tier and second-tier trigger signal when coronary syndrome, cardiac ischemia or myocardial infarction has been detected, at least one communication device capable of communicating, at least one control element adapted to produce a first-tier and second-tier trigger signal when at least one first-tier sensor exceeds its threshold signal level, to exclude the signal from the first-tier sensor that exceeded its threshold and lower at least one threshold of the at least one first-tier sensor is provided.01-28-2010
20100222840SYSTEM AND METHOD OF AV INTERVAL SELECTION IN AN IMPLANTABLE MEDICAL DEVICE - An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.09-02-2010
20110022108SYSTEM AND METHOD OF AV INTERVAL SELECTION IN AN IMPLANTABLE MEDICAL DEVICE - An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.01-27-2011
20110152964SYSTEM AND METHOD OF AV INTERVAL SELECTION IN AN IMPLANTABLE MEDICAL DEVICE - An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.06-23-2011

Patent applications by William J. Combs, Minnetonka, MN US

William J. Combs, Galena, OH US

Patent application numberDescriptionPublished
20100114230Method and Apparatus to Detect Ischemia With A Pressure Sensor - The present disclosure provides an apparatus and method of detecting ischemia with a pressure sensor. The method can include obtaining a pressure signal and determining a pressure rate of change. The method can also include identifying at least one of impaired relaxation and impaired contractility in order to detect ischemia.05-06-2010