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Combs, PA

Andrew P. Combs, Kennett Square, PA US

Patent application number	Description	Published
20080214546	N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE - The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.	09-04-2008
20090197869	AZEPINE INHIBITORS OF JANUS KINASES - The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.	08-06-2009
20090215766	TETRACYCLIC INHIBITORS OF JANUS KINASES - The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.	08-27-2009
20100015178	1,2,5-OXADIAZOLES AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE - The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.	01-21-2010
20110015212	PYRIMIDINONES AS PI3K INHIBITORS - The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.	01-20-2011
20110086835	Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-5-yl-amines as janus kinase inhibitors - The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.	04-14-2011
20110165188	N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE - The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.	07-07-2011
20110172279	N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE - The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.	07-14-2011
20110183985	SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS - The present invention provides fused aryl and heteroaryl derivatives of Formula I:	07-28-2011
20110190319	SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS - The present invention provides fused derivatives of Formula I:	08-04-2011
20110281884	FUSED DERIVATIVES AS PI3KDELTA INHIBITORS - The present invention provides fused derivatives that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.	11-17-2011
20110311479	MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME - The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.	12-22-2011
20110312979	FUSED PYRROLE DERIVATIVES AS PI3K INHIBITORS - The present invention provides fused pyrrole derivatives of Formula I:	12-22-2011
20120014989	PYRROLO[2,3-b]PYRIDIN-4-YL-AMINES AND PYRROLO[2,3-b]PYRIMIDIN-5-YL-AMINES AS JANUS KINASE INHIBITORS - The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.	01-19-2012
20120058079	1,2,5-Oxadiazoles as Inhibitors of Indoleamine 2,3-Dioxygenase - The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.	03-08-2012

Andrew Paul Combs, Kennett Square, PA US

Patent application number	Description	Published
20090286778	MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS - The present invention relates to macrocyclic compounds of Formula I:	11-19-2009
20100190804	MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS - The present invention relates to macrocyclic compounds of Formula I:	07-29-2010
20110251215	MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS - The present invention relates to macrocyclic compounds of Formula I:	10-13-2011

George Combs, Mcmurray, PA US

Patent application number	Description	Published
20120083554	COLD-PRESSED MATS OF LIGNOCELLULOSIC MATERIAL HAVING IMPROVED COLD TACK AND A PROCESS FOR THEIR PRODUCTION - Cold-pressed mats of lignocellulosic material having a Push Off Test extension equal to at least 85% of that of a mat made with a urea-formaldehyde resin are produced from a lignocellulosic material and binder system. These mats are produced at ambient temperature by separately adding each component of the binder system to the lignocellulosic material, blending the lignocellulosic material and binder system to coat the lignocellulosic material with the binder system, forming the coated lignocellulosic material into the desired form and applying pressure to the formed lignocellulosic material to obtain the desired thickness. The binder system includes: (i) at least one polyfunctional isocyanate and (ii) at least one aqueous dispersion of an adhesive or tackifier.	04-05-2012

John A. Combs, Wyomissing, PA US

Patent application number	Description	Published
20100141003	CHAIR LIFT - A lift chair is provided which includes a frame having four legs and a back rest portion. A seat has a front portion pivotally attached to the frame and has a rear portion which can be lifted upwardly. The seat movable from a first generally horizontal sitting position to a second angled lift position where the rear portion of said seat is lifted upwardly. Arm rests members are movably attached to opposite sides of the frame. Each arm rest member has a generally horizontal arm rest portion and a vertical activating rod member. The arm rests are movable from a first upper vertical position to a second lower vertical position. A rope and pulley system is provided which includes a pulley attached to a lower end of each activating rod and additional pulleys are attached to the frame. A rope is attached to the rear portion of the seat and extends around the pulleys. When a user pushes downwardly on the arm rests, the arm rests together with the rope and pulleys cause the rear portion of said seat to be lifted upwardly thus helping the user to stand up and get out of the chair.	06-10-2010