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Combrink
Keith Combrink, Arlington, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090143373 | QUINOLONE CARBOXYLIC ACID-SUBSTITUTED RIFAMYCIN DERIVATIVES - The compounds include substituted rifamycin derivatives in which a quinolone carboxylic acid pharmacophore is covalently bonded to a benzoxazinorifamycin or a spiropiperidinorifamycin. The rifamycin derivatives are useful as antimicrobial agents and are effective against a number of human and veterinary Gram positive and Gram negative pathogens. The advantage of the inventive compounds is that both the rifamycin and quinolone antibacterial pharmacophores are co-delivered with matched pharmacokinetics to the targeted pathogens of interests. Delivery of multiple antibacterial pharmacophores simultaneously to the targeted pathogens has the maximum chance of achieving synergy and minimizing the development of resistance to the antibiotics given. | 06-04-2009 |
| 20090281088 | BICYCLIC NITROIMIDAZOLE-SUBSTITUTED PHENYL OXAZOLIDINONES - The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as | 11-12-2009 |
Keith D. Combrink, Arlington, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20120046285 | BRADYKININ RECEPTOR AGONISTS AND USES THEREOF TO TREAT OCULAR HYPERTENSION AND GLAUCOMA - The invention provides compositions and methods for treating and/or preventing ocular disorders associated with increased intraocular pressure. In particular, the compounds are bradykinin agonists. | 02-23-2012 |
Ronél Combrink, Vanderbijlpark ZA
| Patent application number | Description | Published |
|---|---|---|
| 20100061905 | REMOVAL OF HYDROGEN CYANIDE FROM SYNTHESIS GAS - A process ( | 03-11-2010 |
Ronél Combrink, Vanderbijlpark ZA
| Patent application number | Description | Published |
|---|---|---|
| 20100061905 | REMOVAL OF HYDROGEN CYANIDE FROM SYNTHESIS GAS - A process ( | 03-11-2010 |