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| 20100129843 | CHARACTERIZATION OF N-GLYCANS USING EXOGLYCOSIDASES - The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially. | 05-27-2010 |
| 20100151499 | PROTEOLYTIC RELEASE OF GLYCANS - The present disclosure provides strategies for analyzing protein-linked glycans, and particularly for analyzing glycans on cell surface glycoproteins. | 06-17-2010 |
| 20100196940 | METHODS RELATED TO CELL SURFACE GLYCOSYLATION - The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins. | 08-05-2010 |
| 20110213137 | ISOTOPICALLY-LABELED GLYCANS - The present disclosure provides methods of making isotopically-labeled glycans or a mixture of glycans (e.g., a glycan preparation) via reductive amination. Such methods are useful, for example, in the determination of the relative amounts of a glycan species present in two or more glycoprotein preparations using mass spectroscopy. In one aspect, the present disclosure provides a method of making an isotopically-labeled glycan by a glycan with an amine and an isotopically-labeled reducing agent to provide an isotopically-labeled aminated glycan. In certain embodiments, the amine is an isotopically-labeled amine. | 09-01-2011 |
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| 20100175141 | TUNABLE GENETIC SWITCH FOR REGULATING GENE EXPRESSION - The present invention relates generally the field of genetics, in particular methods, compositions and systems for controlling the inducible expression of transgenes, while eliminating background expression of transgene expression. The present invention relates to methods of use of the compositions and systems as disclosed herein for controlling the inducible expression of transgenes while eliminating background expression of transgene expression, such as use in, for example, the in generation of transgenic animals, use in therapeutic application and use in assays. In some embodiments, the present invention relates to a system of controlled expression of RNAi molecules which target binding sites in the untranslated regions of transgene, thereby the expression of the transgene is modulated and leakiness is reduced. The compositions and methods of the present invention can be used to for therapy, prophylaxis, research and diagnostics in diseases and disorders which afflict mammalian species, generation of transgenic animals, in the study of biological processes as well as for enhance performance of agricultural crops. | 07-08-2010 |
| 20100322903 | ENGINEERED BACTERIOPHAGES AS ADJUVANTS FOR ANTIMICROBIAL AGENTS AND COMPOSITIONS AND METHODS OF USE THEREOF - The present invention relates to the treatment and prevention of bacteria and bacterial infections. In particular, the present invention relates to engineered bacteriophages used in combination with antimicrobial agents to potentiate the antimicrobial effect and bacterial killing by the antimicrobial agent. The present invention generally relates to methods and compositions comprising engineered bacteriophages and antimicrobial agents for the treatment of bacteria, and more particularly to bacteriophages comprising agents that inhibit antibiotic resistance genes and/or cell survival genes, and/or bacteriophages comprising repressors of SOS response genes or inhibitors of antimicrobial defense genes and/or expressing an agent which increases the sensitivity of bacteria to an antimicrobial agent in combination with at least one antimicrobial agent, and their use thereof. | 12-23-2010 |
| 20110097721 | IN VIVO GENE SENSORS - Described are methods and compositions for the detection of target genes. The inventors have developed a synthetic nucleic acid sensor-effector gene circuit. In cells without a target gene, the circuit suppresses e.g., effector production, but in the presence of the target gene the suppression is subject to competition, such that the synthetic sensor is de-repressed and permits expression of the effector gene. The methods and compositions described further permit the selective expression of an effector gene in those cells expressing the target gene. In this manner, cells expressing a target gene can be selectively targeted for treatment or elimination. In certain aspects, the methods and compositions described permit the selective expression of an agent such as a therapeutic gene product, in a specifically targeted population of cells in an organism. | 04-28-2011 |
| 20110119259 | NETWORK BIOLOGY APPROACH FOR IDENTIFYING TARGETS FOR COMBINATION THERAPIES - Described herein is a network biology approach useful for the identification of multiple therapeutic targets, which can be targeted simultaneously using an agent (or a plurality of agents) to modulate cellular phenotypes, or in combination with pharmaceutical compounds to improve drug sensitivity and/or reduce drug doses to maintain efficacy while minimizing side effects. The preferred approach disclosed herein relies on first identifying the mediators of a condition of interest, and second, selecting gene combinations that are in competing/parallel pathways as targets for combination therapy. | 05-19-2011 |
| 20120003630 | MODULAR NUCLEIC ACID-BASED CIRCUITS FOR COUNTERS, BINARY OPERATIONS, MEMORY, AND LOGIC - We have created novel engineered genetic counter designs and methods of use thereof that utilize DNA recombinases to provide modular systems, termed single invertase memory modules (SIMMs), for encoding memory in cells and cellular systems. Our designs are easily extended to compute to high numbers, by utilizing the >100 known recombinases to create subsequent modules. Flexibility in our engineered genetic counter designs is provided by daisy-chaining individual modular components, i.e., SIMMs together. These modular components of the engineered genetic counters can be combined in other network topologies to create circuits that perform, amongst other things, logic and memory. Our novel engineered genetic counter designs allow for the maintenance of memory and provide the ability to count between discrete states by expressing the recombinases between their cognate recognition sites. | 01-05-2012 |
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| 20120089612 | FLEXIBLE FULLY INTEGRATED REAL-TIME DOCUMENT INDEXING - A system for real-time document indexing is provided that includes a browser that is executing on a client system. The browser includes functionalities allowing it to communicate with a remote computer system. A query interface executes within the framework of the browser. The query interface receives one or more query searches from an end-user and sends the one or more query searches to be processed by the remote computer system. The remote computer system sends to the query interface the results of the one or more query searches via the browser. The query interface assigns the results of the one or more query searches to a folder where the folder includes a unique identifier. The query interface indexes the results of the one or more query searches to the unique identifier of the folder. | 04-12-2012 |
| 20120089676 | LIVE DATA FORM VIEWING AND UPDATING SYSTEM - A live data form system is provided that includes a client that executes a browser that receives one or more user requests to view or update a live data form being stored remotely. The live data form includes a plurality of data blocks having information that defines the live data form. The browser issues a first message with respect to viewing or updating the live data form. A server receives the first message and executes a first routine that analyzes the contents of the first message and formulates one or more query statements associated with a data block to be executed by one or more remote databases. When the one or more remote databases finish performing the one or more query statements, the server issues a second message to the browser that includes the results of the one or more query statements executed by the one or more remote databases via the client to either view or update the live data form. | 04-12-2012 |
| 20120089706 | MOBILE FILE UPLOADER - A mobile file uploading system is provided that includes a browser receiving a request to upload one or more selective files and issues a first message. A server receives the first message and determines whether the first message is requesting a download of a first software application, and if so, the server downloads to the user desktop the first software application where the browser executes the first software application. A file upload module is created when the browser completely executes the first software application. The file upload module manages uploading the one or more selective files from the user desktop to the server when a second message is sent by the browser. The file upload module initiates communications with the server and also issues one or more file system calls to a file system on the user desktop to retrieve the one or more selective files for uploading. | 04-12-2012 |
| 20120089901 | HIGH PERFORMANCE CROSS PLATFORM DOCUMENT VIEWING - A document viewing system is provided that includes a browser receiving one or more user requests to view a document being stored remotely. The browser issues a first request to a server for metadata associated with the document and based on the received metadata determines a selective number of tiles needed for viewing the document. The browser issues a second request to the server requesting the selective number of tiles for viewing the document. The selective number tiles are only those tiles available for viewing in a viewing area in the browser. The server sends the selective number of tiles in parallelized fashion to the browser. The browser receives the selective number of tiles from the server and displays the document to a user. | 04-12-2012 |
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| 20090047544 | Method of preparing pressureless sintered, highly dense boron carbide materials - In a method of preparing a boron carbide material, boron carbide powder is washed with essentially pure water at an elevated temperature to generate washed boron carbide powder. The washed boron carbide powder is combined with a sintering aid. The mixture of the boron carbide powder and the sintering aid is pressed to form a shaped material, and the shaped material is sintered. A sintered boron carbide material comprises a boron carbide component that includes boron carbide, elemental carbon, and not more than about 0.6 wt % of oxygen on the basis of the total weight of the boron carbide component. The sintered boron carbide material has a density of at least about 99% of the theoretical density. Another sintered boron carbide material comprises a boron carbide component that includes boron carbide, silicon carbide, elemental carbon, and not more than about 0.3 wt % oxygen on the basis of the total weight of the boron carbide component, and has a density of at least about 97% of the theoretical density. | 02-19-2009 |
| 20110160035 | METHOD OF PREPARING PRESSURELESS SINTERED, HIGHLY DENSE BORON CARBIDE MATERIALS - In a method of preparing a boron carbide material, boron carbide powder is washed with essentially pure water at an elevated temperature to generate washed boron carbide powder. The washed boron carbide powder is combined with a sintering aid. The mixture of the boron carbide powder and the sintering aid is pressed to form a shaped material, and the shaped material is sintered. A sintered boron carbide material comprises a boron carbide component that includes boron carbide, elemental carbon, and not more than about 0.6 wt % of oxygen on the basis of the total weight of the boron carbide component. The sintered boron carbide material has a density of at least about 99% of the theoretical density. Another sintered boron carbide material comprises a boron carbide component that includes boron carbide, silicon carbide, elemental carbon, and not more than about 0.3 wt % oxygen on the basis of the total weight of the boron carbide component, and has a density of at least about 97% of the theoretical density. | 06-30-2011 |
