Collier
Adrian Collier, Bellevue, WA US
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20150242457 | FLEXIBLE CONTENT DISPLAY - Methods, computer systems, and computer-storage media are provided for flexibly displaying content. Rather than associating content with templates without any account for the content itself, templates are associated with content items based on one or more of the content itself, a template class, and a screen size to display the content item. | 08-27-2015 |
Adrian M. Collier, Bellevue, WA US
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20130007671 | MULTI-FACETED RELATIONSHIP HUBS - Multi-faceted relationship hubs can support browsing an extensible set of relationship types from within a single tool window. A user can switch between relationship types within a single tool window without disrupting user flow by having to change context in a plurality of tool windows. Multiple instances of relationship hubs can be created. Browsing navigation history can be stored, allowing a user to maintain and reacquire relationship contexts. A user can preview the content of one or more files without opening the file. | 01-03-2013 |
Brian B. Collier, Midlothian, VA US
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20140278594 | System and Method for Facilitating Workplace Utilization and Occupancy Management Using Mobile Devices - The present invention provides a system and method for facilitating workplace utilization and occupancy management using mobile devices. The present invention integrates a workplace management component, a sensor or location-based management system and an actual use of space analysis engine to provide significantly enhanced data accuracy regarding use of space, which improves system effectiveness and affects individual behavior. In one embodiment, the location-based management component incorporates global positioning system and/or near-field communication system technologies to determine when a user with a suitable mobile communications device is approaching a real estate resource where a reservation has been made, and in that event, issuing a notification to the user's device prompting action connected to the reservation. By affecting individual behavior, the system produces even greater data accuracy and improved control and management of resources. | 09-18-2014 |
Bryan Collier, Pine, CO US
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20150240577 | SPLIT CARRIER BLOCK AND METHOD - Methods and apparatuses for mounting and/or removing carrier blocks from coiled tubing injector chains are disclosed. The carrier blocks are operable for supporting coil tubing grippers. The method and/or apparatus utilize an assembled coiled tubing injector head chain assembly and/or mounting or removing the carrier blocks with respect to the coiled tubing injector head chain assembly. | 08-27-2015 |
Clark H. Collier, Paola, KS US
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20150032636 | Dissociative Payment Transaction And Receipt System And Methods Of Using Same - A system for authorizing and facilitating payment transactions utilizing a payment device, a merchant terminal, and a payment server. The payment server generates unique, single-use payment credentials and provides the payment credentials to the payment device, which transfers the payment credentials to the merchant terminal. The merchant terminal submits the payment credentials and transaction request to the payment server, which facilitates the transfer of funds between the consumer and the merchant upon validation of the payment credentials. In an alternate use of the system, the payment device requests to open a running bill of charges with the merchant terminal. The payment device or the merchant terminal requests the payment server to close out the bill and finalize the charges. The payment server facilitates the transfer of funds between the consumer and the merchant. The payment server provides automated and manual accounting functions to both the consumer and merchant. | 01-29-2015 |
Craig Shelton Collier, Newport News, VA US
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20150142149 | Method and computer-based tool for composite-structure fabrication design - A computer system and method are provided for generating a composite-structure fabrication design. During execution of the method on the computer system, a plurality of user interfaces prompt a user to enter generic design criteria as well as specific fabrication rules. Both generic design criteria and specified fabrication rules are considered simultaneously when determining candidates for fabrication designs. An optimization routine applied to the candidates yields an optimum fabrication design. | 05-21-2015 |
David Collier, Singapore SG
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20140033624 | SUPPORT APPARATUS FOR UNDERWATER POWER GENERATOR AND METHOD FOR DEPLOYMENT - A support apparatus for support of an underwater power generator is described. The underwater power generator has a power generating portion and the support apparatus includes: a stand adapted for supporting the power generating portion, and comprises a stabiliser including one or more stabilising footing elements adapted to mount one or more monolithic ballast masses; wherein the one or more stabilising footing elements includes a locating region adapted to cooperate with a locating region of the monolithic ballast mass so that the support apparatus in use is weighted down in a selected position on a sea bed. Ballast masses are also described, as are methods for installing the support apparatus and methods for installing power generators on the support apparatus. | 02-06-2014 |
Donald Wayne Collier, Mooresville, IN US
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20140017928 | LOCKABLE MATING CONNECTOR - A connector includes a housing and a locking member slidably mounted on the housing for movement between a mateable position and a locked position. First and second locking components interact to lock the locking sleeve in a locked position. Each of a plurality of deflectable spring arms includes a latching component for latching to a mating connector. At the locked position, each of the spring arms is secured in a latched position. | 01-16-2014 |
Dorene M. Collier, Tampa, FL US
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20140320739 | Portable Handheld Video Monitors Adapted for Use in Theatrical Performances - Disclosed is a system for generating and synchronizing video across multiple displays during a theatrical performance. In particular, the disclosure relates to individual handheld video monitors that can be arranged to create larger images or video. The system is adapted for use in theatrical performances during which performers manipulate and selectively arrange the monitors to produce differing visual effects. Each of the video monitors includes a computer and associated software for playing back still or video images. A control computer can wirelessly access each of the individual laptops to increase or decrease the rate at which the video or images appear. This allows all of the video monitors to be synchronized during the course of a performance. | 10-30-2014 |
George Collier, Wheatley CA
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20150327457 | HYBRID VARIETIES H1301, H1307, H1310, AND H1311 - Hybrid tomato varieties ‘H1301’, ‘H1307’, ‘H1310’, and ‘H1311’ are described. The ‘H1301’, ‘H1307’, ‘H1310’, and ‘H1311’ tomato varieties are ground-culture hybrid tomato varieties suitable for machine harvest. | 11-19-2015 |
Gordon Bruce Collier, Chungcheongbuk-Do CA
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20150275261 | FORMATION OF IMMOBILIZED BIOLOGICAL LAYERS FOR SENSING - The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate. | 10-01-2015 |
Gregory Collier, Ocean Grove AU
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20090143571 | NOVEL GENES AND THEIR USE IN THE MODULATION OF OBESITY, DIABETES AND ENERGY IMBALANCE - The present invention relates generally to nucleic acid molecules encoding proteins associated with the modulation of obesity, diabetes and/or metabolic energy levels. More particularly, the present invention is directed to nucleic acid molecules and the recombinant and purified proteins encoded thereby and their use in therapeutic and diagnostic protocols for conditions such as obesity, diabetes and energy imbalance. The subject nucleic acid molecules and proteins and their derivatives, homologs, analogs, chemical equivalents and mimetics are proposed as therapeutic and diagnostic agents for obesity, diabetes and energy imbalance. | 06-04-2009 |
Gregory Royce Collier, Barwon Heads AU
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20110003740 | INSULIN SENSITISERS AND METHODS OF TREATMENT - The present invention relates generally to the field of therapy. The invention particularly relates to insulin sensitisers and methods of regulating glucose homeostasis and to the therapeutic or prophylactic treatment of diseases and associated conditions, in which impaired glucose uptake due to insulin resistance is involved or implicated, such as diabetes, syndrome X, hyperglycaemia, vascular disease and kidney disease. The present invention further relates to compounds and agents and compositions thereof for use in the treatment methods. | 01-06-2011 |
20110112167 | THERAPEUTIC AGENTS AND TARGETS - The present invention relates to diagnostic and therapeutic methods in relation to diabetic complications, such as blindness, nephropathy and cardiovascular disease, and inflammatory conditions, such as angina, arthritis, empyema pharyngitis and urinary tract infection. Diagnostic methods involve screening for up regulated expression of decor (Den) or thioredoxin-like protein 19 (TLP 19). Therapeutic methods involve modulation of expression or activity o Den or TLP 19. The invention also relates to screening methods for identifying functional signal sequences to screen for secreted, membrane-bound and exported proteins and cell surface receptors. | 05-12-2011 |
20140011848 | INSULIN SENSITISERS AND METHODS OF TREATMENT - The present invention relates generally to the field of therapy. The invention particularly relates to insulin sensitisers and methods of regulating glucose homeostasis and to the therapeutic or prophylactic treatment of diseases and associated conditions, in which impaired glucose uptake due to insulin resistance is involved or implicated, such as diabetes, syndrome X, hyperglycaemia, vascular disease and kidney disease. The present invention further relates to compounds and agents and compositions thereof for use in the treatment methods. | 01-09-2014 |
Greg Royce Collier, Victoria AU
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20110318270 | DRUG IDENTIFICATION PROTOCOL FOR TYPE 2 DIABETES BASED ON GENE EXPRESSION SIGNATURES - It relates generally to the field of drug identification and evaluation and therapeutic optimization. More particularly, it provides a protocol for identifying compounds useful in the treatment of TNFα associated diabetes or a condition associated with diabetes based on a signature of genomic or proteomic expression. Diagnostic and prognostic protocols for diabetes and conditions associated therewith are also provided. Further, optimization of therapeutic intervention is also provided. | 12-29-2011 |
Jason A. Collier, Cary, NC US
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20160117238 | PREDICTIVE APPROACH TO ENVIRONMENT PROVISIONING - Embodiments of the present invention provide methods, systems, and computer program products for building an environment. Embodiments of the present invention can be used to allocate resources and build an environment such that the environment is built when a user is prepared to test one or more portions of code in the environment. Embodiments of the present invention can be used to reduce the “lag time” developers experience between waiting for the code to be built and for resources to be provisioned, and can also provide a less costly alternative to maintaining and operating dedicated environments. | 04-28-2016 |
20160117629 | PREDICTIVE APPROACH TO ENVIRONMENT PROVISIONING - Embodiments of the present invention provide methods, systems, and computer program products for building an environment. Embodiments of the present invention can be used to allocate resources and build an environment such that the environment is built when a user is prepared to test one or more portions of code in the environment. Embodiments of the present invention can be used to reduce the “lag time” developers experience between waiting for the code to be built and for resources to be provisioned, and can also provide a less costly alternative to maintaining and operating dedicated environments. | 04-28-2016 |
Jeffrey S. Collier, Pacific, MO US
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20130263443 | AIR INVERSION AND STEAM CURE OF CURED IN PLACE LINERS APPARATUS - An air inversion and steam cure apparatus for installing a flexible resin impregnated cured in place liner in an existing conduit is provided. The apparatus has a low friction seal between a moving liner and the stationary apparatus gland. The gland is operated and adjusted by displaceable members that move substantially perpendicular to the liner being inverted to engage the moving liner as it passes through the gland. No part of the gland extends into the chamber so that once a pre-shaped gland is adjusted, the pressure on the moving liner is not increased. As the liner reaches the distal end, it enters a sample and porting pipe with an exhaust pipe gland and exhaust pipe and is pierced by a rigid porting tool. Steam is then introduced into the liner to cure the resin and is exhausted through an exhaust hose connected to the porting tool. After cure, steam is replaced with air to cool the liner and the ends are cut to restore service through the existing conduit. | 10-10-2013 |
Joel Collier, Western Springs, IL US
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20140273148 | METHODS AND COMPOSITIONS INVOLVING FIBRILLIZING POLYPEPTIDES FOR NANOFIBERS - Embodiments of the invention are directed to fibrillar adjuvants. For example, epitopes assembled by a synthetic peptide domain into nanofibers comprising a β-fibrillization peptide may elicit high antibody titers in the absence of any adjuvant. In certain embodiments, multiple different antigens may be integrated into polypeptide nanofibers, providing biomaterials with modular and precise composition of bioactive proteins. | 09-18-2014 |
20160074488 | METHODS AND COMPOSITIONS INVOLVING FIBRILLIZING POLYPEPTIDES FOR NANOFIBERS - Embodiments of the invention are directed to fibrillar adjuvants. For example, epitopes assembled by a synthetic peptide domain into nanofibers comprising a β-fibrillization peptide may elicit high antibody titers in the absence of any adjuvant. In certain embodiments, multiple different antigens may be integrated into polypeptide nanofibers, providing biomaterials with modular and precise composition of bioactive proteins. | 03-17-2016 |
Joel H. Collier, Chicago, IL US
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20160074509 | METHODS AND COMPOSITIONS RELATED TO IMMUNOGENIC FIBRILS - Embodiments of the invention are directed to fibrillar adjuvants. Epitopes assembled into nanofibers by a short synthetic fibrillization domain elicited high antibody titers in the absence of any adjuvant. | 03-17-2016 |
John Collier, Rogers, AR US
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20140136255 | Dynamic Task Management - Dynamic task management processes and systems are provided, whereby tasks are assigned to workers discretely, in response to worker-originated requests, on a real-time basis. Tasks are extracted from an aggregate thereof, scheduled into one or more queues, then “pulled” by workers for execution. Comprehensive data for performing each task are monitored, as are worker skills and availability. Each task is matched to an appropriate worker, the assignment being adjusted or modified automatically, to the extent required, to satisfy certain predefined temporal and/or spatial criteria. When a worker signals completion of an assigned task, the next discrete task in the queue matching the worker's skills and/or availability is pulled from the queue and assigned. The invention is useful for managing warehouse and inventory operations, and specifically, the scheduling and assignment of pick tasks among warehouse pickers, for example, in connection with e-commerce order fulfillment. | 05-15-2014 |
John Collier, Orion, MI US
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20130106178 | PARALLEL CONFIGURATION OF SERIES CELLS WITH SEMICONDUCTOR SWITCHING | 05-02-2013 |
20130106357 | INTELLIGENT CHARGING AND DISCHARGING SYSTEM FOR PARALLEL CONFIGURATION OF SERIES CELLS WITH SEMICONDUCTOR SWITCHING | 05-02-2013 |
John K. Collier, Rogers, AR US
Patent application number | Description | Published |
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20140279441 | SYSTEMS AND METHODS FOR SAVING A REMAINDER OF CASH TRANSACTIONS - Exemplary embodiments are directed to systems, methods and non-transitory computer storage mediums for storage of a remainder of at least one cash transaction. The exemplary systems, methods and non-transitory computer storage mediums include an electronically stored consumer account, an electronic payment terminal, and a transaction processing system. The transaction processing system is communicatively linked to the consumer account and the electronic payment terminal for directing saving a value of the remainder of the at least one cash transaction from the electronic payment terminal to the consumer account. Exemplary embodiments are further directed to methods of storing a remainder of at least one cash transaction and non-transitory computer readable medium storing instructions for a processing device for implementing the exemplary methods. | 09-18-2014 |
John Kevin Collier, Rogers, AR US
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20140278627 | FLEXIBLE STORE FULFILLMENT - Aspects described herein relate to a flexible order fulfillment management system that utilizes predefined fulfillment workflows including common business processes. By utilizing predefined workflows including common business processes, the order fulfillment management system is able to drive store-based fulfillment programs efficiently as multiple fulfillment workflows may utilize the same common business processes and a single fulfillment management system may operate workflows in parallel. In addition, such an order fulfillment management system may also be more easily adapted for different retail store environments as the system allows a designer to easily create or modify a fulfillment workflow by selecting predefined common business processes or creating any additional custom business processes. Another aspect described herein relates to a tool that allows a designer of an order fulfillment program to select from a group of predefined common business processes to create workflows associated with an order fulfillment program. | 09-18-2014 |
John R. Collier, Wellesley Hills, MA US
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20150044210 | MODIFIED MICROBIAL TOXIN RECEPTOR FOR DELIVERING AGENTS INTO CELLS - We described a novel system of targeted cell therapy with a protein toxin, such as anthrax toxin, that has been modified to re-direct it to a desired cell target instead of its natural cell target. The system can be used for, e.g., targeted killing of undesired cells in a population of cells, such as cancer or overly active immune system cells. | 02-12-2015 |
20160052976 | MODIFIED MICROBIAL TOXIN RECEPTOR FOR DELIVERING AGENTS INTO CELLS - We described a novel system of targeted cell therapy with a protein toxin, such as anthrax toxin, that has been modified to re-direct it to a desired cell target instead of its natural cell target. The system can be used for, e.g., targeted killing of undesired cells in a population of cells, such as cancer or overly active immune system cells. | 02-25-2016 |
John R. Collier, Orion, MI US
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20140285936 | BATTERY MANAGEMENT SYSTEM FOR ELECTRIC VEHICLE - A battery management system for a vehicle having an electrically powered motor that is powered by a plurality of battery cells includes an electrical system for providing voltage and current from the battery cells to an electrical motor. A control is operable to at least one of (a) cause fuses of the electrical system to be the weakest link in the electrical system only during a failure event, (b) disconnect the battery cells from the battery management system only during a failure event, (c) separate the driving of balancing resistors into first and second stages, with the first stage comprising cell balancing control and the second stage comprising cell balancing with reverse voltage protection and (d) provide single stage reverse voltage protection to limit or effectively eliminate an electrical conduction path through a low impedance balancing circuit. | 09-25-2014 |
Judi Collier, New South Wales AU
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20090199499 | COMPOSITE BUILDING BLOCK HAVING MOISTURE BARRIER AND INSULATION ELEMENT - A construction block for use in the construction of elemental structures, including a body having a bottom surface, a top surface, end surfaces, an outer surface which forms part of an outer surface of a structure and an inner face. At least one formation on or in at least the inner face and/or at least one of the end faces receives and retains at least one insulating element. The insulating element provides thermal insulation for the structure formed from such construction blocks. | 08-13-2009 |
Julia Collier, Addison, TX US
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20150250709 | Skin Lightening Compositions - Disclosed are compositions and methods for their use that include a combination of | 09-10-2015 |
Julia Collier, Dallas, TX US
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20130315846 | COSMETIC COMPOSITIONS - Disclosed are compositions and methods for their use that can be used indivisually or in combination in a regimen format. The compositions have the ability to treat a wide range of skin conditions. | 11-28-2013 |
Keith Collier, Crozet, VA US
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20140087353 | Systems and Methods for Evaluating Technical Articles - The system includes an evaluation server configured to receive an article from an author. The article is then distributed to one or more reviewers who are technically qualified to evaluate the article. Further, the reviewers are provided with a scorecard that provides for specific aspects to be evaluated. Each reviewer completes his or her evaluation and submits his or her scores to the evaluation server. The evaluation server compiles the scores from each of the reviewers and calculates an aggregate score for the article. The server may be further configured to match the submitted articles with various technical journals that may be interested in the article. The server may give journals the ability to monitor articles that come through the process and that match a set of journal-definable requirements. The system may also provide authors with a list of matching journals. | 03-27-2014 |
20140087354 | Systems and Methods for Evaluating Technical Articles - The system includes an evaluation server configured to receive an article from an author. The article is then distributed to one or more reviewers who are technically qualified to evaluate the article. Further, the reviewers are provided with a scorecard that provides for specific aspects to be evaluated. Each reviewer completes his or her evaluation and submits his or her scores to the evaluation server. The evaluation server compiles the scores from each of the reviewers and calculates an aggregate score for the article. The server may be further configured to match the submitted articles with various technical journals that may be interested in the article. The server may give journals the ability to monitor articles that come through the process and that match a set of journal-definable requirements. The system may also provide authors with a list of matching journals. | 03-27-2014 |
Kelly N. Collier, West Mifflin, PA US
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20150148727 | LOW-PROFILE, POSTURAL CORRECTIVE GARMENT FOR THERAPEUTIC RELIEF OF LOW BACK PAIN AND MECHANICAL LUMBAR DISORDERS - Postural corrective device including a flexible back support system incorporated into a body suit that trains self-corrective habits through proprioceptive feedback, offering gentle reminders to create awareness of what the wearer's body is doing. | 05-28-2015 |
Kelly N. Collier, Pittsburgh, PA US
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20160030222 | Ankle-Foot Flexion Device - The invention relates to an ankle-foot flexion device that is configurable to provide both plantar flexion and dorsiflexion support. A leading loop and base loop are adapted to engage the foot and ankle and can be constructed of elastic material. Tension straps provide a pulling force between the base loop and a leg cuff. The tension straps are adjustable and can be positioned according to the needs of a particular user. | 02-04-2016 |
Kevin D. Collier, Mount Carmel, TN US
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20140004653 | Pseudo-Schottky photovoltaic cell by wet-printing a conductive paint | 01-02-2014 |
Lee Collier, Knoxville, TN US
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20130240449 | DEVICE FOR MATERIAL PURIFICATION - Systems and methods for purification of radiotracers and non-radioactive materials produced by both microfluidic, conventional, semi-automated and manual synthesis systems are described herein. | 09-19-2013 |
Michael A. Collier, Bedford, NH US
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20150122532 | HIGH TEMPERATURE MULTILAYER FLEXIBLE PRINTED WIRING BOARD - In various embodiments, high temperature printed circuit boards are disclosed. In one embodiment, a high temperature printed circuit board (PCB) comprises a first reinforced pre-impregnated layer and a second reinforced pre-impregnated layer. The first reinforced pre-impregnated layer and the second reinforced pre-impregnated layer comprise a plurality of glass fibers having a warp and a weft and impregnated with a polyimide high-temperature resin adhesive. A flexible metal-clad polyimide laminate material is located between the first reinforced pre-impregnated layer and the reinforced second pre-impregnated layer. The flexible metal-clad polyimide laminate material comprises a plurality of conductive traces. A polyimide film is disposed over the first pre-impregnated layer and the second pre-impregnated layer. | 05-07-2015 |
Michael David Collier, Lake Oswego, OR US
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20140201024 | Visual Shopping - Systems and methods are provided for customizing consumer products. A display device may present a rendering of a customizable product to a user. The display device may also present a set of customizations on a scrollable axis. An input interface such as a touch interface may receive a selection of at least one customization from the user, and the rendering of the product may be updated to display the customizations selected by the user. An electronic file may be generated that includes product manufacturing details, which indicate the customizations selected by the user. The product may be an article of footwear, and a printer may print the selected customizations on the article of footwear. | 07-17-2014 |
Michael Orlando Collier, Franklin, TN US
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20130314023 | WIND ENERGY FAN-TURBINE GENERATOR FOR ELECTRIC AND HYBRID VEHICLES - A wind energy generator for electric and hybrid vehicles can expand the limited driving range of vehicles between charges, reduce the need for petroleum-based products, and reduce or eliminate emissions. The wind turbine utilizes the wind power created by the vehicle traveling at moderate to high speeds. The power created is either used for charging the battery system or it can be stored in the battery system for future use. This expands the driving range of the vehicle before needing recharging and/or additional fuel. The system of the present invention is designed to be compact and discreet, generally incorporating into the vehicle's appearance. | 11-28-2013 |
Michelle Collier, Bedford, NH US
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20150124246 | SYSTEM AND METHOD FOR IDENTIFYING FIBER SEQUENCE IN A MULTI-FIBER OPTICAL CABLE - A system, method and apparatus for identifying fiber sequence in a multi-fiber optical cable are disclosed. The system may include an OTDR device, a receiver, and a launch box. The receiver may comprise a plurality of receiver-fibers differentiated from each other by length. Each receiver-fiber is connected to a fiber of the cable. The launch-box enables the connection of the OTDR device to each of the fibers. A user may connect the output of the OTDR to each of the front ports of a front-connector and collects a trace for each front port. The traces may comprise a marker identifying, by length, the receiver-fiber connected to the fiber. A computer program may be used to compare the traces with each other and to determine a fiber sequence in the tested multi-fiber cable. The determined sequence may be displayed on the OTDR display. | 05-07-2015 |
Paul Anthony Collier, Western Australia AU
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20100028313 | COMPOSITIONS AND METHODS FOR TREATMENT OF SKIN DISORDERS - The present invention concerns methods and compositions for prophylactic or therapeutic treatment of skin disorders by administering therapeutically or prophylactically effective amounts of a probiotic. The present invention is also concerned with the treatment of symptoms of skin disorders. | 02-04-2010 |
Peter Collier, Bilpin AU
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20100047492 | BUILDING BLOCKS - A cementitious mix for preparing a building block wherein the mix includes the ingredients; sand, cement, sawdust and water; wherein said sawdust comprises the greater proportion of the mix constituents; and wherein the dry density of the mix ranges between 700 kg/m | 02-25-2010 |
Peter Collier, New South Wales AU
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20090199499 | COMPOSITE BUILDING BLOCK HAVING MOISTURE BARRIER AND INSULATION ELEMENT - A construction block for use in the construction of elemental structures, including a body having a bottom surface, a top surface, end surfaces, an outer surface which forms part of an outer surface of a structure and an inner face. At least one formation on or in at least the inner face and/or at least one of the end faces receives and retains at least one insulating element. The insulating element provides thermal insulation for the structure formed from such construction blocks. | 08-13-2009 |
Rachel Collier, Belleville CA
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20130297037 | SURGICAL ORTHOPEDIC IMPLANTS MADE FROM WEAR-RESISTANT COBALT-CHROMIUM-MOLYBDENUM ALLOYS - A surgical implant component comprising an implant component body manufactured from an alloy comprising from about 23 to about 33 wt % Cr, from about 8 to about 20 wt % Mo, from about 0.05 to about 1.5 wt % Si, from about 0.35 to about 3.5 wt % C, from about 40 to about 60 wt % Co, and incidental impurities. The implant component alloy has an atomic % ratio of (Cr+Mo+Nb)/Co of at least 0.59, a matrix metallurgical microstructure comprising between about 45% and about 85% by volume face-centered cubic structure, and between about 15% and about 55% by volume hexagonal close-packed structure; and a Rockwell C hardness of greater than 35. A method for manufacturing a surgical implant component body for a surgical implant by a manufacturing method selected from the group consisting of casting, forging, and powder metallurgy pressing-plus-sintering from an alloy. | 11-07-2013 |
20150283295 | POROUS COATING FOR SURGICAL ORTHOPEDIC IMPLANTS - A surgical implant component comprising an implant component body manufactured from a Co-based substrate alloy comprising Co, Cr, Mo, Si, and C, and a coating on a bone-ingrowth surface of the component body manufactured from a Co-based coating alloy comprising Co, Cr, Mo, Si, C and B. The coating is a network of fused particles of the Co-based coating alloy with spherical particles, irregular aspherical particles, and between about 35 and about 70 volume % porosity. A method of manufacturing the foregoing surgical implant component. | 10-08-2015 |
Robert J. Collier, Hanover, NH US
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20140219926 | Biodegradable Iron Oxide Nanoparticle Gel for Tumor Bed Therapy - A biodegradable iron oxide nanoparticle gel for hyperthermia treatment of cancer includes a polysaccharide-based carrier matrix and starch-coated iron oxide nanoparticles. The gel has sufficient deformability to integrate into a diffuse tumor site, adheres to tissue and has sufficient mechanical properties to remain in place during hyperthermia treatment. The gel releases iron oxide nanoparticles for uptake by cancerous cells at the tumor margin. | 08-07-2014 |
Robert J. Collier, Wellesley, MA US
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20130336974 | METHOD FOR DELIVERING AGENTS INTO CELLS USING BACTERIAL TOXINS - The invention provides compositions and methods for delivering a bioactive moiety comprising at least one non-natural component into a cell cytosol of an eukaryotic cell. The bioactive moiety is linked to an A component of a bacterial toxin, a functional wild-type or modified fragment thereof, or an A component surrogate or mimetic. For delivery, the cell is contacted with the linked bioactive moiety and a corresponding B component of the bacterial toxin or a functional fragment thereof. | 12-19-2013 |
Robert J. Collier, Tucson, AZ US
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20150196507 | CONTROL OF MILK PRODUCTION AND MAMMARY INVOLUTION - The present invention is a method for increasing serotonin activity in mammary glands such that involution of milk secretion of the same mammary glands occurs. The present invention further is a composition that can be implanted, or infused into the mammary glands to cause involution of milk secretion. | 07-16-2015 |
Ryan Collier, Seattle, WA US
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20130304506 | SYSTEM AND METHOD FOR MANAGING HEALTH RISKS - A method and system for tracking health care metrics over time is disclosed which involves aggregating health related data via computer in a common computer database, de-identifying persons in the data in the database to remove personally identifiable information (PII) and personal Health information (PHI), matching de-identified persons with the related data, analyzing the matched de-identified persons and related data to generate populations utilizing risk, condition, and appropriateness of care algorithms, stratifying the population into predefined groups, identifying opportunities for health improvement, disseminating the opportunities to the persons in the groups; and tracking the groups over time to ascertain success of the opportunities disseminated. | 11-14-2013 |
Sam Jay Collier, New Albany, IN US
Patent application number | Description | Published |
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20160023881 | RECIRCULATING METHOD AND SYSTEM FOR BEVERAGE DISPENSER - Disclosed are dispensing methods and systems for beverages that improve the quality (i.e., maintain desired temperature) of product dispensed by employing periodic recirculation of stagnant product, while reducing energy usage. The methods and systems use a recirculating pump associated with a first device that provides periodic power supply to the recirculation pump. The first device may comprise a device selected from a timer, a relay or a controller. The methods and systems may include a second device in association with the first device, and the second device senses a condition in the system and determines and measures a parameter of the condition. The second device signals the first device to periodically supply power to the recirculation pump based on the determined and measured parameter of the sensed condition. Preferably, the second device senses a parameter of pressure, temperature, electric current and/or voltage and product dispense-patterns. | 01-28-2016 |
Steven Collier, Lexington, MA US
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20130260426 | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF ARMODAFINIL - The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenyl-methyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess. | 10-03-2013 |
Steven J. Collier, Singapore SG
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20120149073 | Ketoreductase Polypeptides for the Preparation of Phenylephrine - The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine. | 06-14-2012 |
20120190086 | KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS - The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α chloroalcohols from α chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides. | 07-26-2012 |
20120238772 | PROCESS FOR AND INTERMEDIATES IN THE PREPARATION OF CANFOSFAMIDE AND ITS SALTS - A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity. | 09-20-2012 |
20130017580 | Synthesis of Prazole Compounds - The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides. | 01-17-2013 |
20130029385 | Processes Using Amino Acid Dehydrogenases and Ketoreductase-Based Cofactor Regenerating System - The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare L-tert-leucine using a leucine dehydrogenase. | 01-31-2013 |
20130164794 | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXAMINE - The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker. | 06-27-2013 |
Steven J. Collier, Lexington, MA US
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20130302859 | Engineered imine reductases and methods for the reductive animation of ketone and amine compounds. - The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds. | 11-14-2013 |
20140199735 | BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF - The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof. | 07-17-2014 |
Steven J. Collier, Tanglin Park SG
Patent application number | Description | Published |
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20100069651 | PROCESS FOR PRODUCTION OF DELTA-9-TETRAHYDROCANNABINOL - The present invention relates to a process for preparation of a delta-9-tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the delta-9-tetrahydrocannabinol compound or derivative thereof. Another aspect of the present invention relates to a process for preparation of a cannabidiol or cannabidiolate compound involving reacting a first starting compound with a second starting compound in the presence of a metal triflate catalyst, under conditions effective to form the cannabidiol or cannabidiolate compound. The present invention also relates to a compound of the formula: | 03-18-2010 |
20110263878 | PROCESS FOR PRODUCTION OF DELTA-9-TETRAHYDROCANNABINOL - The present invention relates to a process for preparation of a delta-9-tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the delta-9-tetrahydrocannabinol compound or derivative thereof. Another aspect of the present invention relates to a process for preparation of a cannabidiol or cannabidiolate compound involving reacting a first starting compound with a second starting compound in the presence of a metal triflate catalyst, under conditions effective to form the cannabidiol or cannabidiolate compound. The present invention also relates to a compound of the formula: | 10-27-2011 |
Steven J. Collier, Concord, MA US
Patent application number | Description | Published |
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20140308732 | KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS - The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α-chloroalcohols from α-chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides | 10-16-2014 |
20140322769 | BIOCATALYSTS FOR THE PREPARATION OF HYDROXY SUBSTITUTED CARBAMATES - The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides. | 10-30-2014 |
20150031094 | POLYNUCLEOTIDES ENCODING ENGINEERED KETOREDUCTASE POLYPEPTIDES - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine. | 01-29-2015 |
20150037851 | VARIANT LOVD POLYPEPTIDES AND THEIR USES - The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound | 02-05-2015 |
20150056668 | SYNTHESIS OF PRAZOLE COMPOUNDS - The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides. | 02-26-2015 |
20150072383 | BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS - The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered polypeptides having transaminase activity, polynucleotides encoding the polypeptides, methods of the making the polypeptides, and methods of using the polypeptides for the biocatalytic conversion of ketone substrates to amine products. The present enzymes have been engineered to have one or more residue differences as compared to the amino acid sequence of the naturally occurring transaminase of | 03-12-2015 |
20150118719 | BIOCATALYSTS AND METHODS FOR HYDROXYLATION OF CHEMICAL COMPOUNDS - The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered proline hydroxylase biocatalysts, polynucleotides encoding the biocatalysts. methods of their preparation, and processes for preparing hydroxylated compounds using these engineered biocatalysts. | 04-30-2015 |
20150218527 | BIOCATALYSTS FOR EZETIMIBE SYNTHESIS - The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides. | 08-06-2015 |
20150240217 | KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS - The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α-chloroalcohols from α-chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides | 08-27-2015 |
20150240276 | VARIANT LOVD POLYPEPTIDES AND THEIR USES - The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound | 08-27-2015 |
20150259718 | LOV-D ACYLTRANSFERASE MEDIATED ACYLATION - Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented. | 09-17-2015 |
20150284749 | PROCESSES USING AMINO ACID DEHYDROGENASES AND KETOREDUCTASE-BASED COFACTOR REGENERATING SYSTEM - The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare L-tert-leucine using a leucine dehydrogenase. | 10-08-2015 |
20150299671 | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE - The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine. | 10-22-2015 |
20150329835 | BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF - The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof. | 11-19-2015 |
20150329837 | ENGINEERED BIOCATALYSTS AND METHODS FOR SYNTHESIZING CHIRAL AMINES - The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents. | 11-19-2015 |
20150344850 | BIOCATALYSTS FOR THE PREPARATION OF HYDROXY SUBSTITUTED CARBAMATES - The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides. | 12-03-2015 |
20150344854 | BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS - The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents. | 12-03-2015 |
20160040140 | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS - The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds. | 02-11-2016 |
20160076008 | SYNTHESIS OF PRAZOLE COMPOUNDS - The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides. | 03-17-2016 |
20160083759 | ENGINEERED KETOREDUCTASE POLYPEPTIDES - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine. | 03-24-2016 |
Steven James Collier, 02-04 Tanglin Park SG
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20110053941 | IDO Inhibitors - Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunosuppression associated with an infectious disease, e.g., HIV-I infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein. | 03-03-2011 |
Steven James Collier, The Galen SG
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20110111468 | VARIANT LOVD POLYPEPTIDES AND THEIR USES - The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound | 05-12-2011 |
Steven James Collier, Singapore SG
Patent application number | Description | Published |
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20100151534 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)—N,N-dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine. | 06-17-2010 |
20100173369 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine. | 07-08-2010 |
20120244582 | LOV-D ACYLTRANSFERASE MEDIATED ACYLATION - Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented. | 09-27-2012 |
20130005017 | POLYNUCLEOTIDES ENCODING ENGINEERED KETOREDUCTASE POLYPEPTIDES - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine. | 01-03-2013 |
20130130351 | VARIANT LOVD POLYPEPTIDES AND THEIR USES - The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound | 05-23-2013 |
20130177962 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3 HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)—N,N-dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine. | 07-11-2013 |
Thomas Lee Collier, Chester, NH US
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20160061787 | AUTOMATED ANALYSIS SYSTEMS - The disclosure relates to systems and methods for performing high performance liquid chromatography (HPLC) on a liquid sample. The methods include automatically, using a computer, controlling a liquid sample including a plurality of components to flow through a first flow path in a system for HPLC. Flowing through the first flow path includes flowing the liquid sample through a capture column. The capture column is capable of trapping at least some of the components of the liquid sample. The method includes automatically, using the computer, controlling a solvent to flow through a second flow path in the system for HPLC. Flowing through the second flow path includes flowing the solvent through the capture column to elute the trapped components from the capture column; flowing the solvent and eluted components through an analysis column capable of separating the eluted components; and flowing the separated components to a detector. | 03-03-2016 |
Timothy Collier, Cleveland, OH US
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20150331000 | COMPOSITIONS AND METHODS FOR PURIFICATION AND DETECTION OF HDL AND APOA1 - The present invention provides methods, kits, and compositions for purifying HDL molecules from a sample (e.g., blood sample) using HDL tagging molecules comprising an HDL lipophilic core binding peptide (e.g., portion of ApoA1) and an affinity tag. The present invention also provides methods, kits, and compositions for detecting non-fragmented ApoA1 with mass spectrometry. The present invention further provides methods, kits, and compositions for tagging HDL molecules in a sample with detectably labeled ApoA1 molecules such that the ratio of detectably labeled ApoA1 molecules to native ApoA1 proteins may be determined. | 11-19-2015 |
20160084856 | HDL-ASSOCIATED PROTEIN EXTRACTION AND DETECTION - Provided herein are compositions, systems, and methods for extracting and detecting at least one HDL-associated protein (e.g., ApoA1) from a sample (e.g., plasma or serum sample). In certain embodiments, a strong organic acid and hydrophilic organic solvent are mixed with the sample; after centrifugation, the supernatant is transferred to a second container where it is mixed with a non-polar organic solvent; after centrifugation, the lower aqueous layer is transferred to a third container; and then at least a portion of the transferred aqueous layer is subjected to a detection assay such that at least one HDL-associated protein is detected. | 03-24-2016 |
Victoria Collier, Somerset, NJ US
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20130288678 | FEMTOCELL SERVICE REGISTRATION, ACTIVATION, AND PROVISIONING - A femto cell service framework is employed for registration, activation, and provisioning of femtocell service. An account management service enables femtocell account creation, and registration thereof. Registration includes validation of wireless coverage for a location of operation of a femto AP, and validation of availability enhanced 911 (E911) service. As part of registration provisioning, record(s) are updated to indicate registration status. Connection of femto AP to a network interface triggers activation process; the femto AP delivers an activation request. A femto network validates registration of the connected femto AP and conducts a location tolerance check of a received actual location of the femto AP and a registered location. Upon tolerance validation, a cell identifier and radio frequency channel(s) are assigned to femto AP. When femto AP radiates wireless signal, network activation status indicators are provisioned. Handling of errors that arise during registration or activation is provided. | 10-31-2013 |
William Randolph Collier, Esterel CA
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20110102974 | Modular multilevel raised floor electro-mechanical distribution system - The subject invention is directed to an improved modular multilevel raised floor electro-mechanical distribution system for installation in building structures including, but not limited to, data centers and similar rooms having high heat loads requiring usually dedicated cooling systems and usually having extensive data cabling and wiring. In addition to a walking and equipment support surface, the invention provides dedicated levels, isolated from one another and positioned under the walking surface, for distribution of electrical services, including data, on the one hand, and conditioned air, on the other. | 05-05-2011 |