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Coles
Daniel Coles, Mainz DE
| Patent application number | Description | Published |
|---|---|---|
| 20110043010 | SENSOR ASSEMBLY FOR A MOVABLE SEAT - A slide assembly includes a first member and a second member support for movement relative to the first member. The slide assembly also includes a sensor supported on one of the first member and the second member and a target supported on the other of the first member and the second member. The sensor generates a signal when the target is within a detection bounds. The slide assembly is characterized in that cooperating guides are supported relative to the sensor and the target and are engageable with one another to maintain a predetermined alignment between the sensor and the target. | 02-24-2011 |
Graeme Douglas Coles, Christchurch NZ
| Patent application number | Description | Published |
|---|---|---|
| 20100065669 | MILLING AND DRYING APPARATUS INCORPORATING A CYCLONE - A cyclone comprising: an upper cylindrical portion which opens into the wider end of a lower frustro-conical portion, with the longitudinal axes of said upper and lower portions aligned and substantially vertical; a primary air inlet into the cyclone arranged such that the inlet air is substantially tangential to the circumference of the cyclone; an exhaust outlet at or adjacent the top of the cylindrical portion; a control valve associated with said exhaust outlet and capable of partially or completely shutting off said exhaust outlet; a secondary air inlet associated with the narrow end of the frustro-conical portion and provided with an airflow stabilising device which is adapted to admit a stream of air substantially along or spirally around the longitudinal axis of the cyclone; means for removing processed product from the cyclone; means for moving said airflow stabilising device into and out of the narrow end of the frustro-conical portion during product processing and/or between product processing. | 03-18-2010 |
Graeme Douglas Coles, Amberley NZ
| Patent application number | Description | Published |
|---|---|---|
| 20110000631 | PROCESSING OF LIGNOCELLULOSIC AND RELATED MATERIALS - A method for processing lignocellulosic precursors that includes the following steps: | 01-06-2011 |
John G. Coles, Tornoto CA
| Patent application number | Description | Published |
|---|---|---|
| 20110059479 | MODULATION OF THE INTEGRIN LINKED KINASE SIGNALING PATHWAY TO PROMOTE CARDIAC CELL PROLIFERATION AND SELF-RENEWAL - The invention relates to a process for identification, amplification and differentiation of cardiac stem cells by utilizing an ILK based protocol. The invention further relates to a process for post myocardial infarction (IVII) remodeling by way of the integrin linked kinase (ILK) signaling pathway. Still further, the invention relates to a process for affecting an ability to control and/or manipulate stem cell frequency, cellular fate, self-renewal, multilineage differentiation, and potential for oncogenesis in cardiac tissue derived from embryonic stem cells, fetal tissue or adult tissue comprising modulation of ILK signaling amplification whereby stem cell renewal and expansion results. | 03-10-2011 |
John G. Coles, Toronto CA
| Patent application number | Description | Published |
|---|---|---|
| 20080214799 | Biosynthetic platform for cardioprotective stress response in human fatal heart tissue - The present invention is directed toward elucidation of a human fetal gene expression program in response to simulated ischemia/reperfusion (I/R) in order to identify molecular targets which account for the innate cardioprotection exhibited by the fetal phenotype. | 09-04-2008 |
| 20080274491 | Modulation of the Integrin Linked Kinase Signaling Pathway to Promote Cardiac Cell Proliferation and Self-Renewal - Modulation of the integrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases. More specifically, a process to instigate beneficial human cardiac hypertrophy or for post myocardial infarction (MI) remodeling comprising illiciting an overexpression of ILK, is described. The ILK signaling pathway is also used as a means for cardiac stem cell proliferation and self-renewal | 11-06-2008 |
| 20090203769 | Modulation of the integrin-linked kinase signaling pathway provides beneficial human cardiac hypertrophy and post myocardial infarction remodeling - Modulation of the integrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases. More specifically, a process for mediating a broadly adaptive form of human cardiac hypertrophy and a protective process for post myocardial infarction (MI), both comprising illiciting an overexpression of ILK, are described. Upregulation of ILK is also used in a process for affecting ILK mediated reduction of infarct size and beneficial increase in the left ventricular mass post MI. | 08-13-2009 |
| 20110117185 | METHODS FOR TREATING OR PREVENTING HEART DAMAGE WITH INTEGRIN-LINKED KINASE (ILK) COMPOSITIONS - The present invention generally provides methods for administering a composition having an ILK-based protein or peptide having a sequence that is at least 90% homologous to wild-type human integrin-linked kinase (ILK) protein for use in treating or administering to cardiac cells in vitro or in vivo. The ILK-based protein or peptide may further have a mutation or substitution at a position corresponding to amino acid position 211 of wild-type human ILK replacing the arginine (R) with an alanine (A). The present invention further provides compositions having polynucleotides encoding such proteins or peptides. Various vectors, delivery reagents and the like are also provided for use in delivering the compositions to cells. The compositions administered to cells in vitro or in vivo according to present methods may be used to treat, prevent, etc., heart failure, ischemic disease, cardiomyopathy, etc. | 05-19-2011 |
John W. C. Coles, Oakville CA
| Patent application number | Description | Published |
|---|---|---|
| 20100078517 | LANDING GEAR WITH LOCKING STEERING SYSTEM - A landing gear system for an aircraft comprises a truck beam ( | 04-01-2010 |
Peter John Coles, Mississauga CA
| Patent application number | Description | Published |
|---|---|---|
| 20080206336 | Novel Composition Comprising Rosiglitazone and Another Antidiabetic Agent - An oral dosage form comprising an erodable core, which core comprises Compound A or a pharmaceutically acceptable salt or solvate thereof and another antidiabetic agent, the core having a coating with one or more openings, characterised in that the coating is erodable under predetermined pH conditions; a process for preparing such a dosage form and the use of such a dosage form in medicine. | 08-28-2008 |
Richard Coles, Tarlac City PH
| Patent application number | Description | Published |
|---|---|---|
| 20090165292 | Integrated circuit dismounter - The present invention provides a system and method for providing a improved device for dismounting integrated circuits for rework tools in the fabrication and manufacture of hard disk drives. Embodiments of the present invention include a vacuum cap with suction capabilities for dismounting the integrated circuits. The vacuum cap includes a cylindrical portion with a vacuum path for holding a rod-like vacuum cylinder which when pressurized causes the integrated circuit to dismount. Embodiments of the present invention further include a light weight aluminum heat-shield that is disposed around the vacuum cap to protect the vacuum cap from excessive heat and to preserve the suction capabilities of the vacuum cap. In one embodiment the heat shield acts as a stopper to prevent the vacuum cap from moving upwards and helps the vacuum cap from absorbing multiple mechanical stress in order to protect the vacuum cylinder from being damaged. | 07-02-2009 |