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Coleman, PA

Catherine S. Coleman, Hershey, PA US

Patent application numberDescriptionPublished
20100092998METHODS AND COMPOSITIONS RELATING TO E3 RING-E2 FUSION PROTEINS - Compositions are provided according to embodiments of the present invention which include an isolated fusion protein including an E3 protein RING motif bonded to an UCE E2 protein. In preferred embodiments, the C-terminus of the E3 protein RING motif is bonded to the N-terminus of the UCE E2 protein by an intervening peptide linker. Optionally, the peptide linker is 5-50 amino acids. Preferred is a peptide linker of 15-20 amino acids. Methods of identifying ubiquitylation modulators are provided according to embodiments of the present invention which include contacting an isolated fusion protein including an E3 protein RING motif bonded to an UCE E2 protein with a ubiquitylation substrate in the presence of a test substance. Ubiquitylation of the ubiquitylation substrate is then detected to determine the effect of the test substance on ubiquitylation of the ubiquitylation substrate.04-15-2010

Charles M. Coleman, Pittsburgh, PA US

Patent application numberDescriptionPublished
20110266206Integrated Blood Specimen Processor - A blood specimen processor by means of which blood specimens are collected into a collection tube containing an anticoagulant and a molded buoy of predetermined density between 1.045 and 1.084 with an embedded water swellable o-ring that expands to form a robust seal in a leucocyte density gradient between the buoy's outer surface and tube's inner surface. The buoy is made of a first resin and a second resin, the first resin having a lower density than the second resin, the first resin and the second resin being present in such amounts and relative proportions so that the body has an overall density between 1.045 and 1.084 and preferably, a center of gravity below a geometric center of the body. When the blood specimen contained in the processor is centrifuged, the buoy is thrust through the separating blood and the developing interface of erythrocytes, leucocytes, and plasma. A reproducible gradient develops that builds a reproducible buffy coat ring around the upper trough at the junction of the edge of the separator buoy and the tube wall. The relative proportions of resin are controlled to create a separator buoy of a desired density so that after centrifugation the buffy coat or other cells of interest will be above the water swellable o-ring.11-03-2011

Charles R. Coleman, Pittsburgh, PA US

Patent application numberDescriptionPublished
20080261011MICROPOROUS MATERIAL CONTAINING A SECURITY FEATURE - Provided is a microporous material, e.g., a microporous sheet material, having a matrix of polyolefin, finely-divided, substantially water insoluble particulate filler, a network of interconnecting pores communicating throughout the microporous material, and at least one retrospectively identifiable taggant material embedded within the matrix, wherein the polyolefin is present in the microporous material in an amount of 20 to 60 weight percent, based on the weight of the microporous material. The taggant material provides a marker, signature or code that is capable of retrospective identification by machine, instrument or by the naked eye. Articles including the microporous material and processes for preparing the microporous material also are provided.10-23-2008
20080286593MULTI-LAYER ARTICLES PREPARED FROM MICROPOROUS MATERIALS - Provided is a multi-layer article including (1) a sheet of microporous material having opposing surfaces, and (2) an adhesive composition applied over at least a portion of at least one of the surfaces of the sheet. The microporous material contains (A) a polymeric matrix component of 5 to 100 weight percent of low melt flow index polypropylene; 0 to 90 weight percent of ultrahigh molecular weight polyethylene; and 0 to 90 weight percent of high density polyethylene; (B) a finely divided, particulate filler component dispersed throughout the polymeric matrix (A) including siliceous and non-siliceous materials; and (C) a network of interconnecting pores communicating substantially throughout the microporous material, the pores constituting 10 to 80 percent by volume of the microporous material, wherein the weight ratio of filler component (B) to polymeric matrix component (A) ranges from 0.1 to 10.0.11-20-2008
20090311504MICROPOROUS MATERIALS AND MULTI-LAYER ARTICLES PREPARED THEREFROM - A microporous material is provided in the form of a singly extruded microporous sheet having opposing first and second surfaces, comprising: 12-17-2009
20110127763MICROPOROUS MATERIAL CONTAINING A SECURITY FEATURE - Provided is a microporous material, e.g., a microporous sheet material, having a matrix of polyolefin, finely-divided, substantially water insoluble particulate filler, a network of interconnecting pores communicating throughout the microporous material, and at least one retrospectively identifiable taggant material embedded within the matrix, optionally the at least one taggant being unique to an end user for the microporous material, wherein the polyolefin is present in the microporous material in an amount of 20 to 35 weight percent, based on the weight of the microporous material. The taggant material provides a marker, signature or code that is capable of retrospective identification by machine, instrument or by the naked eye. Articles including the microporous material and processes for preparing the microporous material also are provided.06-02-2011

Patent applications by Charles R. Coleman, Pittsburgh, PA US

David Coleman, Murrysville, PA US

Patent application numberDescriptionPublished
20080226154SYSTEMS AND METHODS FOR PRODUCING CARBONACEOUS PASTES USED IN THE PRODUCTION OF CARBON ELECTRODES - Systems and methods for producing a carbonaceous paste are provided. The systems and methods may include a paste control system that obtains an image of the carbonaceous paste and determines whether operational parameters associated with paste production require adjustment. One or more operational variables may be adjusted based on the obtained images to facilitate production of the carbonaceous paste.09-18-2008

Fitzpatrick Coleman, Sharon Hill, PA US

Patent application numberDescriptionPublished
20120122069COACHS PLAY SYSTEMS - A visual coaching system for sports comprising a touch screen electronic device and a sports play application. The sports play application as used on touch screen electronic device allows coach-user to overlay a drawn play over a video such that the coach-user can review a previously played sports maneuver. The touch screen electronic device is usable to inform at least one assistant about at least one situation, with the coach-user being able to convey a message without moving. The sports play application allows the coach-user to stream and record live games such that the coach-coach-user can view replays. The touch screen electronic device as connected to a communicator provides an accessible network preferably enabling the coach-user to monitor live activities of player(s) and can send information from a first touch screen electronic device to at least an authorized second touch screen electronic device.05-17-2012

Paul J. Coleman, Wallington, PA US

Patent application numberDescriptionPublished
20090124641Mitotic Kinesin Inhibitors - The present invention relates to fluorinated 2-aminomethylquinazolinone derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.05-14-2009

Paul J. Coleman, Harleysville, PA US

Patent application numberDescriptionPublished
20090239843Bridged diazepan orexin receptor antagonists - The present invention is directed to bridged diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.09-24-2009
20100035931TRIPYRIDYL CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS - The present invention is directed to tripyridyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.02-11-2010
20100063056BIPYRIDINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS - The present invention is directed to bipyridyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.03-11-2010
20100152191CYCLOPROPYL PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS - The present invention is directed to cyclopropyl proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.06-17-2010
20100168134PYRIDYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS - The present invention is. directed to pyridyl piperidine compounds of formula (I) which are antagonists of orexin receptors, and which are useful' in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.07-01-2010
20100197652PYRIDINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS - The present invention is directed to pyridyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.08-05-2010
20110165075INTEGRIN TARGETING AGENTS AND IN-VIVO AND IN-VITRO IMAGING METHODS USING THE SAME - The invention provides a family of agents that target integrins, which can be used as imaging agents and/or therapeutic agents. The agents can be used to image angiogenesis, inflammation or other physiological processes in a subject.07-07-2011
20110201591ISONICOTINAMIDE OREXIN RECEPTOR ANTAGONISTS - The present invention is directed to isonicotinamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.08-18-2011
201102016322,5-Disubstituted Piperidine Orexin Rceptor Antagonists - The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.08-18-2011
201102016522,4-Disubstituted Pyrrolidine Orexin Receptor Antagonists - The present invention is directed to 2,4-disubstituted pyrrolidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.08-18-2011
201102077472,5-Disubstituted Phenyl Carboxamide Orexin Receptor Antagonists - The present invention is directed to 2,5-disubstituted phenyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.08-25-2011
20110301140Pyridine Carboxamide orexin Receptor Antagonists - The present invention is directed to pyridyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.12-08-2011
201103129612,5-Disubstituted Morpholine Orexin REceptor Antagonists - The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).12-22-2011
20120046289Pyridazine Carboxamide Orexin Receptor Antagonists - The present invention is directed to pyridazine carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.02-23-2012
20120065211ALKOXY TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS - The present invention is directed to alkoxy tetrahydro-pyridopyrimidine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.03-15-2012

Patent applications by Paul J. Coleman, Harleysville, PA US

William J. Coleman, Stewartstown, PA US

Patent application numberDescriptionPublished
20110252686High Reliability Extractor Depressor for Use in Handguns - A high reliability extractor depressor assembly for use in handguns which significantly reduces the effect of recoil on the extractor depressor plunger assembly. These positive effects are accomplished by the following: (a) designing a new longer piece (standoff bar) of greater mass, (b) redistributing the mass from the rear of the assembly to the front, (c) designing a new shorter piece (extractor depressor plunger), (d) reversing the location of the longer piece (standoff bar) and the shorter piece (extractor depressor plunger) in the assembly, (e) increasing total mass of the assembly, and (f) changing the balance of the assembly by shifting mass to the rear of the spring.10-20-2011