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Coldren, US
Bret A. Coldren, Vista, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20110251568 | PUNCTAL PLUGS FOR CONTROLLED RELEASE OF THERAPEUTIC AGENTS - Disclosed are lacrimal inserts and their method of use for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured for controlled release into the eye by means of an osmotic engine. | 10-13-2011 |
Bret A. Coldren, Jacksonville, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20090306608 | OPHTHALMIC DEVICES FOR THE CONTROLLED RELEASE OF ACTIVE AGENTS - The invention provides devices useful for the delivery of active agents to the eye in a controlled manner. In the devices of the invention, the active agent is present within the device in a continuous or discontinuous concentration gradient. | 12-10-2009 |
| 20110022007 | OPHTHALMIC DEVICES FOR THE CONTROLLED RELEASE OF ACTIVE AGENTS - The invention provides devices useful for the delivery of active agents to the eye in a controlled manner. In the devices of the invention, the active agent is present within the device in a continuous or discontinuous concentration gradient. | 01-27-2011 |
| 20110054418 | Methods and apparatus for pulsatile release of medicaments from a punctal plug - This invention discloses methods and apparatus for providing pulsatile release of active agents via a punctal plug inserted into a punctum. A tube is provided which may be inserted into a cavity of a punctal plug. One or more pulsatile delivery units are arranged in a generally linear fashion within the tube. The pulsatile delivery units include a core comprising the active agent and an encapsulation layer around the core. | 03-03-2011 |
Bruce E. Coldren, West Bloomfield, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20110282492 | METHOD OF CONTROLLING A ROBOTIC TOOL - A method of controlling a robot system includes the steps of providing a tool supported by a moveable mechanism of the robot system, providing a workpiece supported by a holder, generating an image of the workpiece, extracting a data from the image, the data relating to a feature of the workpiece, generating a continuous three-dimensional path along the workpiece using data extracted from the image, and moving the tool along the path. | 11-17-2011 |
Christopher D. Coldren, Denver, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20100196366 | Gefitnib Sensitivity-Related Gene Expression and Products and Methods Related Thereto - Disclosed is the identification, provision and use of a panel of biomarkers that predict sensitivity or resistance to EGFR inhibitors, and products and processes related thereto. In one embodiment, a method is described for selecting a cancer patient who is predicted to benefit from therapeutic administration of an EGFR inhibitor, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitor. Also described is a method to identify molecules that interact with the EGFR pathway to allow or enhance responsiveness to EGFR inhibitors, as well as a plurality of polynucleotides or antibodies for detection of the expression of genes that are indicative of sensitivity or resistance to EGFR inhibitors, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitors. A method to identify a compound with the potential to enhance the efficacy of EGFR inhibitors is also described. | 08-05-2010 |
Dana Coldren, Secor, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20080315008 | Four wire elastomeric seal and fuel injector using same - A fuel injector includes first and second electrical actuators positioned within an injector body. First and second pairs of electrical conductors extend from a socket connector outside of the injector body to the first and second electrical actuators, respectively. The electrical conductors extend through an elastomeric sealing member that seals against fuel leakage from the fuel injector. The elastomeric sealing member provides annular sealing ridges in sealing contact with an access passage of the injector body and includes individual conductor seal passages that form seals around the outer surface of the individual electrical conductors. The elastomeric sealing member includes features that facilitate assembly of the fuel injector in a manner that reduces risk of damage to the sealing strategy. | 12-25-2008 |
| 20100029115 | FOUR WIRE ELASTOMERIC SEAL AND FUEL INJECTOR USING SAME - A fuel injector includes first and second electrical actuators positioned within an injector body. First and second pairs of electrical conductors extend from a socket connector outside of the injector body to the first and second electrical actuators, respectively. The electrical conductors extend through an elastomeric sealing member that seals against fuel leakage from the fuel injector. The elastomeric sealing member provides annular sealing ridges in sealing contact with an access passage of the injector body and includes individual conductor seal passages that form seals around the outer surface of the individual electrical conductors. The elastomeric sealing member includes features that facilitate assembly of the fuel injector in a manner that reduces risk of damage to the sealing strategy. | 02-04-2010 |
Larry A. Coldren, Santa Barbara, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080285603 | TUNABLE LASER SOURCE WITH INTEGRATED OPTICAL MODULATOR - A tunable laser source with integrated optical modulator. The tunable laser source is a widely tunable semiconductor laser that is comprised of an active region on top of a thick, low bandgap, waveguide layer, wherein both the waveguide layer and the active region are fabricated between a p-doped region and an n-doped region. An electro-absorption modulator is integrated into the semiconductor laser, wherein the electro-absorption modulator shares the waveguide layer with the semiconductor laser. | 11-20-2008 |
| 20090262765 | SMALL DIMENSION HIGH-EFFICIENCY HIGH-SPEED VERTICAL-CAVITY SURFACE-EMITTING LASERS - A Vertical-Cavity Surface-Emitting Laser (VCSEL) is disclosed, comprising an optical cavity bounded by a top mirror and a bottom mirror, wherein the top mirror has multiple layers of alternating refractive index, of which the bottom three or more layers of the top mirror are deep oxidation layers having an increased oxidation length, a light emitting active region between the top mirror and the bottom mirror, and an aperture with tapered edges between the active region and the top mirror, wherein the aperture has a thickness, a taper length, an oxide aperture length, a taper angle, and an aperture opening diameter designed to reduce an optical mode's diameter without significantly increasing the optical mode's round trip scattering loss. | 10-22-2009 |
Rex A. Coldren, Phoenix, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20110142017 | Differentiated QoS for Wi-Fi clients connected to a cable/DSL network - The preferred method involves segmenting the routable IP address space of a Cable Modem Termination System (CMTS) to identify clients requiring differentiated QoS by assigning IP addresses from reserved ranges. The IP addresses are assigned to home clients/the Wi-Fi AP and roaming users based on special DHCP options inserted by the Wi-Fi AP DHCP Proxy software on behalf the Wi-Fi AP and home client devices and roaming devices using the Wi-Fi AP. This creates potentially multiple service classes whereby IP addresses from the reserved ranges are included in traffic classifiers that cause packets to map to service flows which provide for differentiated QoS to the Wi-Fi AP owner, home clients and roaming users on the cable access network. | 06-16-2011 |
Richard J. Coldren, New Station, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20110232643 | SYSTEM AND METHOD FOR TREATING LUNG DISEASE USING POSITIVE PRESSURE AIRWAY SUPPORT - A method of treating lung disease, such as asthma or COPD, is provided that includes determining a parameter indicative of a patient's pulmonary mechanics (such as, without limitation, airway resistance or lung compliance), and delivering positive pressure support to the airway of the patient, wherein the pressure level (which may be constant or variable) of the positive pressure support during at least a portion of the inspiratory phase of the patient is determined based on the determined parameter. | 09-29-2011 |