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Coifman

Robert E. Coifman, Millville, NJ US

Patent application numberDescriptionPublished
20090007906Methods and Formulations for the Efficient Delivery of Drugs by Nebulizer - Formulations, methods and devices for producing formulations and methods for nebulizer delivery of formulations of water-insoluble drugs and drugs requiring storage in aqueous or other water-miscible pharmaceutically unacceptable vehicles for stability are provided. Also provided are methods for minimizing wastage of drugs administered by nebulizer, and for the achievement of quantitative dosing with diluent from a mass marketed formulations, which because of the mass market is much less costly per dose than formulations manufactured specifically for much lower volume medical use.01-08-2009
20090270752Devices for Measuring Inspiratory Airflow - New applications of unidirectional airflow sensing in devices which measure inspiratory airflow and bidirectional airflow are provided. Such devices can be used for administration of a medication via inhalation, in spirometers and in devices which measure and monitor respiratory ventilation.10-29-2009
20110092840INTELLIGENT AIR FLOW SENSORS - A single sensor capable of detecting both airflow in spirometry and the full range of sound frequencies needed to track clinically relevant breath sounds is provided. The airflow sensor includes a movable flap with one or more integrated strain gauges for measuring displacement and vibration. The airflow sensor is inherently bidirectional. The sensor is an elastic flap airflow sensor that is capable of detecting data needed for both spirometry and auscultation measurements. The sensor is sterilizable and designed for the measurement of human respiratory airflow. The sterilizable sensor is also suitable for non-medical fluid flow metering applications. Additional devices such as sensors for the ambient level of various chemicals, sensors for temperature, sensors for humidity and microphones, may be affixed to the flap. When the strain gauge is placed in a conventional Wheatstone bridge configuration, the sensor can provide the airflow measurements needed for medical spirometry.04-21-2011
20110153620Method and apparatus for improving the transcription accuracy of speech recognition software - A virtual vocabulary database is provided for use with a with a particular user database as part of a speech recognition system. Vocabulary elements within the virtual database are imported from the user database and are tagged to include numerical data corresponding to the historical use of the vocabulary element within the user database. For each speech input, potential vocabulary element matches from the speech recognition system are provided to the virtual database software which creates virtual sub-vocabularies from the criteria according to predefined criteria templates. The software then applies vocabulary element weighting adjustments according to the virtual sub-vocabulary weightings and applies the adjustment to the default weighting provided by the speech recognition system. The modified weightings are returned with the associated vocabulary elements to the speech engine for selection of an appropriate match to the input speech.06-23-2011

Patent applications by Robert E. Coifman, Millville, NJ US

Robert E. Coifman, Milville, NJ US

Patent application numberDescriptionPublished
20110177128IMMUNOTHERAPY COMPOSITIONS AND METHODS OF TREATMENT - Provided are compositions that include one or more natural, recombinant and/or modified allergens; with a pharmaceutically acceptable non-aqueous solvent to form an immunotherapy composition that includes the active ingredient and solvent, wherein the immunotherapy composition is formulated for administration to a subject in need of immunotherapy. The solvent is miscible with water and interstitial fluid. The at least one active ingredient is soluble in the solvent and insoluble in water and in an aqueous phase of interstitial fluid. The present compositions may be administered to a patient for example, as part of an immunotherapy regimen to help induce a state of immunologic tolerance to one or more allergies, or as treatment for an autoimmune disease. Also provided are methods of making such compositions. Further provided are methods that include administering the composition to a mammal.07-21-2011

Ronald Coifman, North Haven, CT US

Patent application numberDescriptionPublished
20090264785Method and Apparatus For Assessing Brain Function Using Diffusion Geometric Analysis - A method of extracting features and classifying a neurological state of a subject is provided. The method includes recording brain electrical activity, organizing the recorded data set into digital documents, computing a diffusion geometry on the data set comprising at least a plurality of diffusion coordinates, and classifying the data set into a neurological state based on the metrics provided by the diffusion coordinates.10-22-2009

Ronald R. Coifman, North Haven, CT US

Patent application numberDescriptionPublished
20090299975SYSTEM AND METHOD FOR DOCUMENT ANALYSIS, PROCESSING AND INFORMATION EXTRACTION - The present invention is directed to a method and computer system for representing a dataset comprising N documents by computing a diffusion geometry of the dataset comprising at least a plurality of diffusion coordinates. The present method and system stores a number of diffusion coordinates, wherein the number is linear in proportion to N.12-03-2009
20100274753METHODS FOR FILTERING DATA AND FILLING IN MISSING DATA USING NONLINEAR INFERENCE - The present invention is directed to a method for inferring/estimating missing values in a data matrix d(q, r) having a plurality of rows and columns comprises the steps of: organizing the columns of the data matrix d(q, r) into affinity folders of columns with similar data profile, organizing the rows of the data matrix d(q, r) into affinity folders of rows with similar data profile, forming a graph Q of augmented rows and a graph R of augmented columns by similarity or correlation of common entries; and expanding the data matrix d(q, r) in terms of an orthogonal basis of a graph Q×R to infer/estimate the missing values in said data matrix d(q, r).on the diffusion geometry coordinates.10-28-2010

Patent applications by Ronald R. Coifman, North Haven, CT US