Patent application number | Description | Published |
20100255538 | ANTIBODIES TO INSULIN-LIKE GROWTH FACTOR I RECEPTOR - The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention. | 10-07-2010 |
20110014207 | COMBINATION TREATMENT FOR NON-HEMATOLOGIC MALIGNANCIES - The present invention relates to a therapeutic method for the treatment of non-hematologic malignancies comprising administering anti-IGF-1R antibodies, particularly human anti-IGF-1R antibodies, to a patient, in conjunction with the administration of at least one other therapeutic agent. The invention further relates to pharmaceutical compositions comprising these antibodies and methods of using such compositions thereof for treatment. | 01-20-2011 |
20120005767 | ANTIBODIES TO INSULIN-LIKE GROWTH FACTOR I RECEPTOR - The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention. | 01-05-2012 |
20140120089 | ANTIBODIES TO INSULIN-LIKE GROWTH FACTOR I RECEPTOR - The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention. | 05-01-2014 |
Patent application number | Description | Published |
20100064894 | FUEL SYSTEM AND METHOD OF REDUCING EMISSION - A fuel system includes a fuel deoxygenator for removing oxygen from a liquid fuel. A vaporizer is in fluid communication with the fuel deoxygenator. The vaporizer vaporizes at least a portion of the liquid fuel to produce vaporized fuel. At least a portion of the vaporized fuel pre-mixes with oxidizer to reduce formation of undesirable emissions. | 03-18-2010 |
20120186256 | MIXER ASSEMBLY FOR A GAS TURBINE ENGINE - A mixer assembly for a gas turbine engine is provided, including a main mixer with fuel injection holes located between at least one radial swirler and at least one axial swirler, wherein the fuel injected into the main mixer is atomized and dispersed by the air flowing through the radial swirler and the axial swirler. | 07-26-2012 |
20120186258 | MIXER ASSEMBLY FOR A GAS TURBINE ENGINE - A mixer assembly for a gas turbine engine is provided, including a main mixer, and a pilot mixer having an annular housing in which a corner is formed between an aft portion of the housing and a bulkhead wall in which a corner recirculation zone is located to stabilize and anchor the flame of the pilot mixer. The pilot mixer can further include features to cool the annular housing, including in the area of the corner recirculation zone. | 07-26-2012 |
20130232978 | FUEL AIR PREMIXER FOR GAS TURBINE ENGINE - A fuel-air premixer for a combustor of a turbine engine includes a central passage along an axis. The central passage is operable to communicate an unswirled airflow. An outer annular passage is located around the axis and includes a multiple of first swirl vanes that are operable to communicate a first swirled airflow in a first direction. An inner annular passage is located around the axis between the central passage and the outer annular passage. The inner annular passage includes a multiple of second swirl vanes that are operable to communicate a second swirled airflow in a second direction different than the first direction. | 09-12-2013 |
20130264075 | FIRE SUPPRESSION SYSTEM WITH VARIABLE DUAL USE OF GAS SOURCE - An exemplary fire suppression system includes a sprinkler nozzle. At least one conduit is connected to the nozzle for delivering a fire suppression fluid to the nozzle. The conduit and the nozzle establish a discharge path. A pneumatically driven pump is connected with the conduit for pumping fluid into the conduit. A gas source provides pressurized gas to the pump for driving the pump. The gas source also provides gas to the discharge path for achieving a desired discharge of the fluid from the nozzle. A controller selectively controls at least one of (i) the gas provided to the pump, which controls the fluid pressure in the conduit, or (ii) the gas provided to the nozzle or the conduit, which controls the gas pressure delivered to the nozzle. | 10-10-2013 |
20140013763 | FUEL-AIR PRE-MIXER WITH PREFILMER - A fuel-air premixer for a combustor of a gas turbine engine includes a central passage disposed along an axis and operable to communicate a first airflow and an outer annular passage about the axis operable to communicate a second airflow. The fuel-air premixer further includes an inner annular passage about the axis and between the central passage and the outer annular passage for communicating fuel flow. The inner annular passage including an inner exit angled for directing fuel flow toward the axis into a mixer passage downstream of the outer and inner exits for mixing the fuel flow with the first and second airflows. | 01-16-2014 |
20140138102 | EFFERVESCENT FIRE SUPPRESSION - An exemplary fire suppression system includes a nozzle body configured to carry a fire suppressing fluid to be discharged from a first orifice array and a second orifice array. Gas bubbles can be introduced through a bubbler into the fire suppressing fluid to establish a bubbly mixture in the nozzle. Each first orifice in the first orifice array has a first flow property and is configured to receive the bubbly mixture and through effervescent atomization yield a first fire suppression mist from the first orifice array. Each second orifice in the second orifice array has a second different flow property and is configured to receive the bubbly mixture and through effervescent atomization yield a second fire suppression mist from the second orifice array. The first fire suppression mist and the second fire suppression mist are configured to provide a selected fire suppression nozzle discharge. | 05-22-2014 |
20150121882 | MIXER ASSEMBLY FOR A GAS TURBINE ENGINE - A mixer assembly for a gas turbine engine is provided, including a main mixer with fuel injection holes located between at least one radial swirler and at least one axial swirler, wherein the fuel injected into the main mixer is atomized and dispersed by the air flowing through the radial swirler and the axial swirler. | 05-07-2015 |
20150219338 | COMBUSTOR ASSEMBLY FOR A TURBINE ENGINE - A combustor assembly includes a first wall, a second wall, a bulkhead and a plurality of fuel injectors. The bulkhead forms a combustion chamber with the first and the second walls. The fuel injectors are configured with the first wall in a unique and/or a fluctuating pattern. | 08-06-2015 |
Patent application number | Description | Published |
20130291983 | ENHANCED FLUE GAS DAMPER MIXING DEVICE - A gas mixing device has a plurality of interleaved rows of adjustable louvers. When at least two flowing gas streams are received that are desired to be mixed, the louvers of each row directs the gas streams in a direction different from that of the adjacent rows, mixing the gas streams. When effectively only a single flowing gas stream is received, the louvers are positioned vertically thereby reducing the pressure drop across the gas mixing device. | 11-07-2013 |
20130312858 | FLOW CONTROL GRID - A flow control grid includes a plurality of channel assemblies connected to one another. Each of the plurality of channel assemblies defines a flow straightening section and a flow turning section. The flow turning section has an arcuate segment and a first substantially flat segment. The first substantially flat segment is positioned in the flow straightening section. The arcuate segment extends outwardly from the flow straightening section. | 11-28-2013 |
20140208994 | FLUID DISTRIBUTION AND MIXING GRID FOR MIXING GASES - A grid for distributing and mixing fluids in a duct includes a plurality of lances arranged in a first plane and configured to be positioned transverse to a direction of a first fluid flowing outside of the lances and within a predetermined flow area. Each of the plurality of lances has at least one first inlet and a plurality of outlet nozzles. One or more of the outlet nozzles is directed generally in the flow direction of the first fluid outside of the lances, and is configured to discharge a second fluid therefrom. | 07-31-2014 |
20150056118 | FLUE GAS STREAM BYPASS DURING SELECTIVE CATALYTIC REDUCTION IN A POWER PLANT - A system includes a selective catalytic reactor and a bypass line. The selective catalytic reactor is located downstream of a furnace that generates flue gases. The selective catalytic reactor reduces nitrogen oxides to nitrogen. The bypass line is in fluid communication with the selective catalytic reactor. The bypass line contacts an input line to the selective catalytic reactor-, where the bypass line is adapted to handle a volume of flue gases diverted from the selective catalytic reactor. A first control damper is disposed at an inlet to the selective catalytic reactor; and a second control damper is disposed at an inlet to the bypass line. The first control damper and the second control damper interact to divide the flue gas stream between the selective catalytic reactor and the bypass line in a ratio to reduce the amount of sulfur trioxide released from the system to a desirable value. | 02-26-2015 |
20150064083 | INJECTOR GRID FOR HIGH AND LOW DUST ENVIRONMENT SELECTIVE CATALYTIC REDUCTION SYSTEMS - A method and an arrangement | 03-05-2015 |