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Clarke, IE

Aidan Clarke, Dublin IE

Patent application numberDescriptionPublished
20090013305GENERATING A SUBSET MODEL FROM A MODEL - A technique for identifying a minimum number of model elements associated with a model for generating a subset model of the model that includes receiving a model, a set of model elements and a set of dependency types associated with the model; assigning a collector component to each of the received model elements; locating a model element dependent on the received model element by one of the received dependency types; receiving from each collector a dependent model element, and for each dependent model element, determining whether the dependent model element has been collected by another collector with the same dependency type and updating a subset model list with the collected dependent model element to build a list of collected dependent model elements for generating a subset model in response to a negative determination.01-08-2009

Colin Clarke, Dublin IE

Patent application numberDescriptionPublished
20110317158CYTOLOGICAL METHOD FOR ANALYZING A BIOLOGICAL SAMPLE BY RAMAN SPECTROSCOPY - Provided herein are systems and methods that permit low resolution Raman spectroscopy to be used for detection of biological components within cells in order to classify the cells, for example, as premalignant, malignant, or benign.12-29-2011

Conor Clarke, Dublin IE

Patent application numberDescriptionPublished
20100017328Transaction processing - A transaction processing system for the real time authorization of payment transactions, The system comprises a verification system (01-21-2010

David Clarke, Patrickswell IE

Patent application numberDescriptionPublished
20120133025APPARATUS FOR ELECTROSTATIC DISCHARGE PROTECTION - An apparatus includes an electrostatic discharge (ESD) protection device configured to protect a circuit from ESD conditions. The protection device includes an emitter region having a first diffusion polarity; a collector region laterally spaced apart from the emitter region, and having the first diffusion polarity; and a barrier region interposed laterally between the emitter region and the collector region while contacting the emitter region. The barrier region has a second diffusion polarity opposite from the first diffusion polarity. The device can further include a base region having the second diffusion polarity, and laterally surrounding and underlying the emitter region and the barrier region. The barrier region can have a higher dopant concentration than the base region, and block a lateral current flow between the collector and emitter regions, thus forming a vertical ESD device having enhanced ESD performance.05-31-2012

David J. Clarke, Limerick IE

Patent application numberDescriptionPublished
20110101444ELECTROSTATIC PROTECTION DEVICE - An apparatus including an electrostatic discharge (ESD) protection device comprising a semiconductor having first, second and third regions arranged to form a transistor, wherein the first region is doped with a first impurity of a first conductivity type and is separated from the second region which is doped with a second impurity of a second conductivity type opposite the first type, and wherein a dimensional constraint of the regions defines an operational threshold of the ESD protection device. In one example, the separation between a collector and an emitter of a bipolar transistor defines a trigger voltage to cause the electrostatic discharge protection device to become conducting. In another example, a width of a bipolar transistor base controls a holding voltage of the electrostatic discharge protection device.05-05-2011

Eoin F. Clarke, Westmeath IE

Patent application numberDescriptionPublished
20080255391Chiral Phosphorus Compounds - A process for the stereoselective preparation of a P-chiral four-co-ordinated phosphorus compound, the process comprising reacting a first reactant selected from the group consisting of a chiral alcohol, chiral amine or chiral thiol, with a second reactant comprising a P-chiral three-co-ordinated phosphorus compound, in the presence of an electrophile.10-16-2008

Frank Clarke, Galway IE

Patent application numberDescriptionPublished
20100264050Packaging for a Stent Delivery System - The present invention relates to a method of packaging and a packaging system for treated stents which minimise the level of exposure of the stents to oxygen, moisture and light. The package comprises two compartments, the compartments being in communication with each other via a breathable membrane.10-21-2010

Gerry Clarke, Co. Galway IE

Patent application numberDescriptionPublished
20110071616Stent Including a Toggle Lock Strut - A tubular stent includes cylindrical rings disposed adjacent to each other and coupled to each other by a plurality of longitudinal segments. Each cylindrical ring includes circumferentially oriented toggle lock struts. The toggle lock struts include a first arm and a second arm coupled together at an elbow. When the stent is in a compressed configuration for delivery, the toggle lock struts are bent at the elbow such that the first arm is disposed at an angle of less than 180 degrees relative to the second arm. Upon radial expansion of the stent, the toggle lock struts are unbent to a straight configuration and permitted to relax slightly beyond the straight configuration to a locked configuration such that the angle between the first arm and the second arm changes from less than 180 degrees to more than 180 degrees.03-24-2011
20120010691Particle Embedded Polymer Stent and Method of Manufacture - A particle embedded polymer stent and method of manufacture, which includes a stent delivery system having a catheter; a balloon operably attached to the catheter; and a polymer stent disposed on the balloon, the stent comprising struts interconnected to form a tubular body. Each of the struts includes in cross section a drug-free core region; and a drug region surrounding and immediately adjacent to the core region, the drug region including drug particles. The drug-free core region and the drug region are made of a single polymer, the single polymer having a drug-safe softening temperature.01-12-2012

Patent applications by Gerry Clarke, Co. Galway IE

Gerry Clarke, Gortachalla IE

Patent application numberDescriptionPublished
20080234831Bioresorbable Stent and Method of Making - A method of making a polymeric stent includes providing a molding apparatus including a central core pin and a plurality of slides, wherein each of the slides includes grooves on an inner surface the slide, wherein the grooves are formed in the shape of the stent. A molten polymer is injected into the grooves and allowed to solidify. The slides are moves away from the central core pin and the solidified polymer, in the shape of a stent, is removed. The central core also may or may not include corresponding grooves depending on the desired cross section of struts and crowns of the stent.09-25-2008

Gerry Clarke, Moycullen IE

Patent application numberDescriptionPublished
20080234800Stent Including a Toggle Lock - A stent includes cylindrical rings disposed adjacent to each other. Each cylindrical ring includes longitudinal segments that may be disposed generally parallel to a longitudinal axis of the stent. The longitudinal segments are coupled to each other by toggle lock struts. The toggle lock struts are disposed substantially at the center of the circumferentially adjacent longitudinal segments. When the stent is in a compressed state for delivery, the toggle lock struts are bent such that the longitudinal segments are disposed close to each other. Upon expansion of the stent, the toggle lock struts straighten such that the longitudinal segments are disposed father apart form each other.09-25-2008
20100268320Endovascular Implant Having an Integral Graft Component and Method of Manufacture - A covered stent including an endovascular implant having a polymeric stent structure with an integrally formed membrane-like graft component, also referred to as a stent-graft, and methods of manufacturing the one-piece stent-graft by an injection molding process. A molding system for creating the polymeric stent structure is injected with a melt stream of moldable material that is forced between a parting line of the molding system to create a thin, flexible membrane-like structure within the open areas or interstitial spaces of the molded stent structure. The stent-graft so created is a one-piece, unified structure molded from a polymeric material in a single manufacturing step.10-21-2010

Greg Clarke, Blessington IE

Patent application numberDescriptionPublished
20110290418HYDROGEN PEROXIDE COMPLEXES AND THEIR USE IN THE CURE SYSTEM OF ANAEROBIC ADHESIVES - Provided is a complex of hydrogen peroxide and at least one compound represented by Formula I:12-01-2011

James Clarke, Banbridge IE

Patent application numberDescriptionPublished
20100042739CONFIRMATION OF DELIVERY OF CONTENT TO AN HTTP/TCP DEVICE - A method to confirm delivery of data to a receiving device via a sending socket is disclosed. One embodiment of the method comprises determining when a predetermined amount of data has been removed from a send buffer of the sending socket and sending a confirmation when the predetermined amount of data has been removed from the send buffer. Other embodiments are described and claimed.02-18-2010

John Clarke, Tipperary IE

Patent application numberDescriptionPublished
20110020404DIAGNOSTIC METHOD AND KIT - The invention relates to methods for diagnosis of tuberculosis in an animal, the methods comprising determining the presence or absence of, or an immune response to a group of antigens comprising (i) the group consisting of Rv3616 antigen, MPB70 antigen, MPB83 antigen, and ESAT 6 antigen; or (ii) at least seven of the antigens of the group consisting of Rv3616 antigen, MPB70 antigen, MPB83 antigen, ESAT 6 antigen, CFP10 antigen, α crystalline 2 antigen, PE35 antigen, and PPE68 antigen. Also provided is a method for the diagnosis of the presence of tuberculosis in a reservoir animal e.g. a badger, said method comprising determining the presence or absence of, or an immune response to Rv3616 antigen, MPB70 antigen, and MPB83 antigen. Kits for carrying out the methods are also provided.01-27-2011

John Clarke, Claregalway IE

Patent application numberDescriptionPublished
20120095396Drug Eluting Medical Device Utilizing Bioadhesives - A medical balloon having an inner surface and an outer surface comprising a first coating composition comprising at least one therapeutic agent, the first coating composition disposed on the balloon outer surface and forming an interface between the balloon outer surface and the first coating composition and a second coating composition comprising a bioadhesive, the second coating composition disposed on the first coating composition so as to not affect the interface between the balloon outer surface and the first coating composition, the bioadhesive selected so as to adhere to body tissue, and methods of making the same.04-19-2012

John Clarke, Galway IE

Patent application numberDescriptionPublished
20090081271MEDICAL DEVICES HAVING A FILTER INSERT FOR CONTROLLED DIFFUSION - An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a pre-formed filter insert disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device in vivo.03-26-2009
20090081272MEDICAL DEVICES HAVING A METAL PARTICULATE COMPOSITION FOR CONTROLLED DIFFUSION - An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a particulate composition disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device into a subject.03-26-2009
20090123521Medical devices having coatings for controlled therapeutic agent delivery - According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.05-14-2009
20110008260Use of Nanocrystals for Drug Delivery from a Balloon - A drug delivery balloon (01-13-2011
20110130829Medical Devices Containing Therapeutic Agents - The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices.06-02-2011

John T. Clarke, Kiniska IE

Patent application numberDescriptionPublished
20090028785MEDICAL DEVICES WITH COATINGS FOR DELIVERY OF A THERAPEUTIC AGENT - Described herein are implantable coated medical devices, such as intravascular stents, for delivering therapeutic agents to the body tissue of a patient, and methods for making such medical devices. In particular, described herein are implantable coated medical devices comprising a substrate having a surface, and a coating disposed upon the surface that comprises a coating composition that includes a releasable metal oxide. The coating is free of polymer or a particular type of polymer that is not a part of any releasable metal oxide.01-29-2009
20090118821ENDOPROSTHESIS WITH POROUS RESERVOIR AND NON-POLYMER DIFFUSION LAYER - An endoprosthesis such as a coronary stent includes a porous reservoir of drug, e.g., a porous layer formed of a ceramic and an overlayer formed of ceramic or metal for controlling elution of drug from the reservoir.05-07-2009

John T. Clarke, Co. Galway IE

Patent application numberDescriptionPublished
20110160659Drug-Delivery Balloons - Drug-delivery balloons, as well as related medical devices and methods, are disclosed.06-30-2011

John T. Clarke, Galway IE

Patent application numberDescriptionPublished
20100008970Drug-Eluting Endoprosthesis - A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.01-14-2010

John T. Clarke, Claregalway IE

Patent application numberDescriptionPublished
20090017188METHODS FOR MAKING DRUG-ELUTING MEDICAL DEVICES - The present invention is directed to medical implants that are configured to controllably release therapeutic agent to a target site of a patient and methods of making these implants. Embodiments of the present invention may include a method comprising the steps of providing a tube having a wall with inner and outer surfaces and defining a passageway, forming an opening through the wall of the tube, applying a porous coating layer to at least one of the inner and outer surfaces of the tube, and loading a therapeutic agent solution into the passageway so that therapeutic agent passes through the opening and into the porous coating layer. The method may also include removing portions of the tube to form the implantable medical device, which may be a stent.01-15-2009
20110251590BALLOON CATHETERS WITH FIBERS FOR DELIVERY OF THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME - A medical device comprises a catheter with an expandable member, fibers extending from the outer surface of the expandable member, and therapeutic agent coated on the fibers or carried in the spaces between the fibers. Upon expansion of the expandable member, the therapeutic agent is delivered from the medical device. A surfactant may be coated on the fibers. A method of manufacturing comprises coating the outer surface of an expandable member with a metallic layer, coating the metallic layer with at least one polymeric layer, forming a plurality of holes in at least one polymeric layer, forming fibers in the holes, and removing at least one polymeric layer.10-13-2011