Clarke, GB
Alan Hugh Clarke, County Armagh GB
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20090069494 | Polymer material - A process is described for providing a polymer material by blending as a first component one or more hydrophilic polymers, and as a second component one or more neutralising chemicals, in the complete or substantial absence of water. In the absence of water, the components will not be aqueous solutions. Thus the components can be used in blending processes, and the present invention is able to form many other shapes and forms of material other than laminates on substrates. | 03-12-2009 |
Alastair Clarke, Nantwich GB
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20090292245 | MICROPUMP-OPERATED DRUG DOSING SYSTEM - The present invention relates to a device for injecting a substance into the human or animal body, where the medicament to be injected is removed from a reservoir by generating a subatmospheric pressure. | 11-26-2009 |
20090292247 | PERISTALTIC MICROPUMP WITH EXCHANGEABLE PUMP HEAD - The present invention relates to a device for injecting a pharmaceutical into the human or animal body by means of a simply and quickly exchangeable motorized pump head. | 11-26-2009 |
Alex Clarke, Brentwood GB
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20080200718 | Novel material forming supramolecular structures, process and uses - The invention relates to novel material, forming supramolecular structures below its transition temperature, which contains at least one C=O and/or C=S group and at least one N—H, O—H and/or S—H group and wherein the material has the structure | 08-21-2008 |
Anthony Clarke, Oxfordshire GB
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20090023766 | Pharmaceutical formulation of apomorphine for buccal administration - The present invention provides a kit comprising, in separate compartments of a container, the following components (a) and (b): (a) a combination of apomorphine or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable excipient or carrier; and (b) a solution which comprises a diluent and a pH modifying agent; the components being presented such that they can be combined at the point of use into a formulation which is adjusted to a pH ranging from mildly acidic to alkaline and which is suitable for buccal administration. The formulation is useful in treating Parkinson's disease and in promoting sexual function. | 01-22-2009 |
20100227933 | PHARMACEUTICAL COMPOSITION FORMULATED FOR PRE-GASTRIC ABSORPTION OF MONOAMINE OXIDASE B INHIBITORS - The invention described herein provides a fast dispersing oral solid dosage form containing monoamine oxidase B inhibitor (MAO-B inhibitor) as the active ingredient, and method of treating disease therewith, such as Parkinson's disease. In one embodiment, the monoamine oxidase B inhibitor selegiline or its analogue can be the sole active ingredient in the composition administered. The dosage form composition is formulated to promote absorption through the buccal, sublingual, pharyngeal and/or esophageal mucous membrane tissue, such that at least 5% of the active ingredient is absorbed within one minute of placement in the oral cavity, as determined by a buccal absorption test. Monoamine oxidase B inhibitor compounds administered in accordance with the invention decrease the amount of undesirable metabolites associated with first pass effect of selegiline, for example, such as amphetamine and methamphetamine. The invention provides a number of other advantages over conventional orally administered tablet forms, including administration of monoamine oxidase B inhibitor compounds to patients that have difficulty swallowing. | 09-09-2010 |
Anthony R. Clarke, London GB
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20080241861 | Biological materials and methods useful in the diagnosis and treatment of diseases - The present invention relates to a method of making a β-form of a prion protein which preferably has more β-sheet than α-helix structure and is soluble in the absence of a denaturant and/or is non-aggregated and exhibits partial resistance to digestion with proteinase K. The invention also relates to use of the β-form in medicine, especially for raising antibodies useful in the treatment and/or diagnosis of prion diseases. The invention also relates to methods of screening for compounds which are capable of inhibiting and/or reversing the conversion of the native α-form of a prion protein to a β-form, and to uses of identified compounds in medicine. | 10-02-2008 |
Arthur J. Clarke, Dumfries And Galloway GB
Patent application number | Description | Published |
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20100130319 | BELT AND CHAIN DRIVE WITH KIDNEY-SHAPED TRACTION MEANS - A belt and chain drive for vehicles or for use in drive technology with an input shaft and an output shaft supported on a frame, the input shaft and the output shaft project out of the frame, with the following features: a) gear transmissions with gear wheels, which are embodied as belt and chain drives, are located between the input shaft and the output shaft, b) all of the gear wheels are constantly in rotation during operation, c) the gear transmissions located between the input shaft and the output shaft are embodied as belt and chain drives with toothed belts as traction mechanisms and with pulleys as gear wheels, d) the traction mechanism are reinforced with aramide, Kevlar, carbon fibers or other fibrous materials, is characterized in that e) the traction mechanism is pressed into a kidney-like shape onto the pulleys by at least one component during no-load rotation, and that under the effect of load this component does not touch the traction mechanism, and f) the kidney-like shape of the traction mechanism during no-load rotation is formed by a convex curvature of the driving side and by a concave curvature of the slack side, and g) the kidney-like shape of the traction mechanisms under load is formed by a straight shape of the driving side and by an intensified concave curvature of the slack side. | 05-27-2010 |
Arthur Jack Clarke, Dumfries And Galloway GB
Patent application number | Description | Published |
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20100093450 | Sleeve and Sleeve-Type Flexible Shaft Coupling - A shaft coupling with a flexible annular sleeve, a driver end piece, and a driven end piece. The end pieces have a plurality of axially projecting prongs arranged so that the driver prongs loosely interlock in the spaces between the driven prongs with a gap between each pair of prongs. The sleeve fits snugly around the periphery of the loosely interlocked prongs. Each prong has at least one prong groove in its outer periphery. Each of two peripheral edges may be shaped to form a groove flank, and each set of two adjacent groove flanks on adjacent prongs may form a gap groove. The sleeve has a plurality of inner teeth including a plurality of groove teeth in alternating arrangement with a plurality of gap teeth. The prong grooves and groove teeth mesh, and the gap grooves and gap teeth mesh. Groove teeth may be bigger than gap teeth. | 04-15-2010 |
20100184547 | Debris ejecting sprocket and system - A debris ejecting sprocket comprising a body ( | 07-22-2010 |
Christopher James Clarke, Cheshire GB
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20110126396 | JOINING APPARATUS AND METHOD - A joint is produced in at least two overlapping workpieces (W | 06-02-2011 |
20130205574 | RIVETING METHOD AND APPARATUS - A method of riveting comprising using a punch ( | 08-15-2013 |
20130336745 | SELF-PIERCING RIVET - A self -piercing rivet ( | 12-19-2013 |
Colin John Clarke, Ashford GB
Patent application number | Description | Published |
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20110168201 | THICKENED HAIR COLOURANT AND BLEACHING COMPOSITIONS - The present invention relates to hair colouring and hair bleaching compositions comprising a first component comprising at least one oxidizing agent and a C6 to C16 alkyl glucoside and a second component comprising an anionic surfactant and a fatty alcohol. The compositions surprisingly provide improved hair colourant and bleaching compositions which deliver lift, lightening and colour, whilst minimizing damage and which provide the required viscosity both pre and post mixing of the first and second components. | 07-14-2011 |
David Clarke, Harston GB
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20110173514 | DATA PROTOCOL - A method of transmitting data according to a data transmission protocol wherein the data is transmitted as a plurality of data frames and each data frame includes an error checking field comprising at least two sub-fields, the data of the first sub-field being formed by a first error checking method performed on data of the frame and the data of the second sub-field being formed by a second error checking method performed on the said data of the frame, the first and second methods being such that the data of the first sub-field has different error checking properties from those of the data of the second sub-field. | 07-14-2011 |
David Clarke, Worthing GB
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20100326408 | CONDENSATION CONTROL SYSTEMS AND METHODS - A condensation control system for a vehicle comprises a short route (SR) target module, a long-route (LR) target module, and a humidity adjustment module. The SR target module controls a first opening target for opening of a first exhaust gas recirculation (EGR) valve and a first throttle valve based on a SR target and a SR adjustment. The LR target module controls a second opening target for opening of a second EGR valve and a second throttle valve based on a LR target and a LR adjustment. The humidity adjustment module adjusts the SR and LR adjustments based on a humidity adjustment when condensation is detected in a system that provides a gas to an engine for combustion and determines the humidity adjustment based on a difference between a humidity within the system and a predetermined humidity. | 12-30-2010 |
20100332075 | CONDENSATION DETECTION SYSTEMS AND METHODS - A condensation monitoring system for a vehicle comprises a humidity estimation module and a condensation detection module. The humidity estimation module estimates a humidity in one of an air intake system and an exhaust gas recirculation (EGR) system associated with an engine of the vehicle. The condensation detection module generates a condensation signal indicating that condensation is present in the one of the air intake system and the EGR system when the humidity is greater than a predetermined humidity. | 12-30-2010 |
David Julian Clarke, Hartson GB
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20110219145 | NETWORK INTERFACE AND PROTOCOL - A communication interface for providing an interface between a data link and a data processor, the data processor being capable of supporting an operating system and a user application, the communication interface being arranged to: support a first queue of data received over the link and addressed to a logical data port associated with a user application; support a second queue of data received over the link and identified as being directed to the operating system; and analyse data received over the link and identified as being directed to the operating system or the data port to determine whether that data meets one or more predefined criteria, and if it does meet the criteria transmit an interrupt to the operating system. | 09-08-2011 |
David Julian Clarke, Harston GB
Patent application number | Description | Published |
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20110040897 | NETWORK INTERFACE AND PROTOCOL - A communication interface for providing an interface between a data link and a data processor, the data processor being capable of supporting an operating system and a user application, the communication interface being arranged to: support a first queue of data received over the link and addressed to a logical data port associated with a user application; support a second queue of data received over the link and identified as being directed to the operating system; and analyse data received over the link and identified as being directed to the operating system or the data port to determine whether that data meets one or more predefined criteria, and if it does meet the criteria transmit an interrupt to the operating system. | 02-17-2011 |
David Julian Clarke, Cambridge GB
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20090080350 | Mobile radio network - A mobile radio network comprises a plurality of communication points, each of which are capable of communicating with any other communication point. Each communication point has a proximity sensor, a transmitter/receiver ( | 03-26-2009 |
David Stephen Clarke, Cheshire GB
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20110065706 | Therapeutic Agents 812 - A compound of formula I | 03-17-2011 |
David T. Clarke, Hertfordshire GB
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20080199665 | Method of Forming Flexible Electronic Circuits - A multiple layer photosensitive element having at least three differently sensitised photosensitive layers on one side of a support, such as a, transparent flexible support, is imagewise exposed according to a desired circuit pattern and developed to form two layers of conductive track patterns from each photosensitive layer, which may then be connected together by forming vias by drilling or in situ generation. The resulting multiple layer conductive element has application in the field of printed circuit board manufacture or as the backplane electronic element of a flexible display device. | 08-21-2008 |
David Thomas Clarke, Ledbury GB
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20110195522 | ASSAY FOR GENERATION OF A LIPID PROFILE USING FLUORESCENCE MEASUREMENT - The present invention relates to a method of generating a lipid profile for a sample solution. The method comprising: a first step of determining the concentration of total lipoprotein in a first aliquot of the sample using fluorescence analysis; a second step of determining the concentration of total cholesterol in a second aliquot of the sample using fluorescence analysis; and optionally a third step of determining the concentration of HDL in a third aliquot of the sample using fluorescence analysis. The concentrations of the total lipoprotein, and of total cholesterol may be used to calculate other lipid components and thereby generate a lipid profile. The invention also concerns apparatus that may be used to perform the method of the invention. | 08-11-2011 |
David Thomas Clarke, Warrington GB
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20090280500 | Assay for generation of a lipid profile using fluorescence measurement - The present invention relates to a method of generating a lipid profile for a sample solution. The method comprising: a first step of determining the concentration of total lipoprotein in a first aliquot of the sample using fluorescence analysis; a second step of determining the concentration of total cholesterol in a second aliquot of the sample using fluorescence analysis; and optionally a third step of determining the concentration of HDL in a third aliquot of the sample using fluorescence analysis. The concentrations of the total lipoprotein, and of total cholesterol may be used to calculate other lipid components and thereby generate a lipid profile. The invention also concerns apparatus that may be used to perform the method of the invention. | 11-12-2009 |
20110129932 | Lipoprotein Assay - The present invention concerns a method of determining the concentration of total lipoprotein in a sample. The method involves the steps of: (i) adding to an aliquot of the sample a lipophilic dye that binds to lipoproteins in the sample and which when so bound fluoresces under appropriate excitation; and (ii) determining the total lipoprotein concentration in the sample using fluorescence analysis. A method of analysing the lipoprotein content of a sample solution using a dye that discriminates between different types of lipoprotein is also disclosed. | 06-02-2011 |
20140318257 | COMPONENT INSPECTION APPARATUS AND METHOD - A component inspection apparatus and a method for ultrasonic inspection of a component, including low pressure last stage steam turbine blades, are disclosed. The apparatus includes a guide member, a guide adapting member and scanning probes. The guide member includes a first surface and a distal second surface. The first surface is configured to adaptably mirror the shape of portions of the component to be inspected. The guide adapting member is capable of releasably attaching the second surface of the guide member.to be changeable as per the shape of the component. The scanning probes may be located on the guide adapting member in a manner configured to be movable along the second surface of the guide member to generate and receive ultrasonic waves used to inspect the component. | 10-30-2014 |
David W. Clarke, Oxford GB
Patent application number | Description | Published |
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20100107778 | DIGITAL FLOWMETER - A controller for a flowmeter includes an input module operable to receive a sensor signal from a sensor connected to a vibratable flowtube. The sensor signal is related to a fluid flow through the flowtube. The controller also includes a signal processing system operable to receive the sensor signal, determine sensor signal characteristics, and output drive signal characteristics for a drive signal applied to the flowtube. An output module is operable to output the drive signal to the flowtube and a control system is operable to modify the drive signal and thereby maintain oscillation of the flowtube during a transition of the flowtube from a substantially empty state to a substantially full state. | 05-06-2010 |
20120160036 | DIGITAL FLOWMETER - A controller for a flowmeter includes an input module operable to receive a sensor signal from a sensor connected to a vibratable flowtube. The sensor signal is related to a fluid flow through the flowtube. The controller also includes a signal processing system operable to receive the sensor signal, determine sensor signal characteristics, and output drive signal characteristics for a drive signal applied to the flowtube. An output module is operable to output the drive signal to the flowtube and a control system is operable to modify the drive signal and thereby maintain oscillation of the flowtube during a transition of the flowtube from a substantially empty state to a substantially full state. | 06-28-2012 |
20130213143 | DIGITAL FLOWMETER - A control and measurement system for a coriolis flowmeter having a flowtube, a driver adapted to vibrate the flowtube, and a pair of sensors adapted to generate signals indicative of movement of the flowtube when it is being vibrated by the driver, wherein the sensors are positioned relative to one another so the signals from the sensors are indicative of a mass flow rate of fluid through the flowtube. A digital drive signal generator is adapted to generate a variable digital drive signal for controlling operation of the driver. The digital drive signal generator can be adapted to cause the driver to resist motion of the flowtube during a first time period and amplify motion of the flowtube during a second time period. The digital drive signal generator can also be adapted to initiate motion of the flowtube by sending one or more square wave signals to the driver. | 08-22-2013 |
20140114589 | DIGITAL FLOWMETER - A control and measurement system for a coriolis flowmeter having a flowtube, a driver adapted to vibrate the flowtube, and a pair of sensors adapted to generate signals indicative of movement of the flowtube when it is being vibrated by the driver, wherein the sensors are positioned relative to one another so the signals from the sensors are indicative of a mass flow rate of fluid through the flowtube. A digital drive signal generator is adapted to generate a variable digital drive signal for controlling operation of the driver. The digital drive signal generator can be adapted to cause the driver to resist motion of the flowtube during a first time period and amplify motion of the flowtube during a second time period. The digital drive signal generator can also be adapted to initiate motion of the flowtube by sending one or more square wave signals to the driver. | 04-24-2014 |
20140116155 | DIGITAL FLOWMETER - A control and measurement system for a coriolis flowmeter having a flowtube, a driver adapted to vibrate the flowtube, and a pair of sensors adapted to generate signals indicative of movement of the flowtube when it is being vibrated by the driver, wherein the sensors are positioned relative to one another so the signals from the sensors are indicative of a mass flow rate of fluid through the flowtube. A digital drive signal generator is adapted to generate a variable digital drive signal for controlling operation of the driver. The digital drive signal generator can be adapted to cause the driver to resist motion of the flowtube during a first time period and amplify motion of the flowtube during a second time period. The digital drive signal generator can also be adapted to initiate motion of the flowtube by sending one or more square wave signals to the driver. | 05-01-2014 |
20140116156 | DIGITAL FLOWMETER - A control and measurement system for a coriolis flowmeter having a flowtube, a driver adapted to vibrate the flowtube, and a pair of sensors adapted to generate signals indicative of movement of the flowtube when it is being vibrated by the driver, wherein the sensors are positioned relative to one another so the signals from the sensors are indicative of a mass flow rate of fluid through the flowtube. A digital drive signal generator is adapted to generate a variable digital drive signal for controlling operation of the driver. The digital drive signal generator can be adapted to cause the driver to resist motion of the flowtube during a first time period and amplify motion of the flowtube during a second time period. The digital drive signal generator can also be adapted to initiate motion of the flowtube by sending one or more square wave signals to the driver. | 05-01-2014 |
20140129156 | DIGITAL FLOWMETER - A control and measurement system for a coriolis flowmeter having a flowtube, a driver adapted to vibrate the flowtube, and a pair of sensors adapted to generate signals indicative of movement of the flowtube when it is being vibrated by the driver, wherein the sensors are positioned relative to one another so the signals from the sensors are indicative of a mass flow rate of fluid through the flowtube. A digital drive signal generator is adapted to generate a variable digital drive signal for controlling operation of the driver. The digital drive signal generator can be adapted to cause the driver to resist motion of the flowtube during a first time period and amplify motion of the flowtube during a second time period. The digital drive signal generator can also be adapted to initiate motion of the flowtube by sending one or more square wave signals to the driver. | 05-08-2014 |
Derek Clarke, Bristol GB
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20100288376 | TEMPERATURE RESPONSIVE FLUID FLOW CONTROL DEVICE - A fluid flow control device for regulating the flow of fluid in a passage comprises an annular fixed body having at least one aperture in an annular surface thereof, through which fluid is arranged to flow in use, and a thermally responsive annular valve element mounted concentrically with respect to the fixed body and whose configuration is changeable with temperature so as to control the flow of fluid through the at least one aperture. | 11-18-2010 |
Derek W J Clarke, Bristol GB
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20110103886 | MALE OR FEMALE ELEMENT FOR A CONIC COUPLING - A male or female element ( | 05-05-2011 |
20110103887 | MALE OR FEMALE ELEMENT FOR A CONIC COUPLING - A male or female element ( | 05-05-2011 |
Dougal Clarke, Oxfordshire GB
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20110003610 | Monitoring and Tracking of Wireless Sensor Devices - A healthcare monitoring system includes a plurality of patient wearable sensor devices for the purpose of monitoring physiological data, each sensor device including a radio frequency transceiver. A plurality of base stations are provided at respective fixed locations within a healthcare facility, each base station including a radio frequency transceiver for communicating with one or more of the sensor devices for the purpose of receiving monitored physiological data. A central server is coupled to the base stations for the purpose of receiving and recording monitored physiological data. Each sensor device is arranged in use to attach to a first base station that is within range, and to attach to a second, different base station that is within range when contact with the first base station is lost, attachment of the sensor device to a base station being registered with the central server. | 01-06-2011 |
Eric Daniel Clarke, Berkshire GB
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20100331348 | TROPANE DERIVATIVES USEFUL AS PESTICIDES - Compounds of formula (I) wherein the substituents have the meanings assigned to them in claim | 12-30-2010 |
Gillian Clarke, Middlesex GB
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20110034560 | LIQUID FORMULATIONS OF COMPOUNDS ACTIVE AT SULFONYLUREA RECEPTORS - The invention provides liquid formulations of compounds that act at sulfonylurea receptors that are suitable for intra-venous and intra-arterial infusion. Compounds active at a sulfonylurea receptor include glibenclamide, tolbutamide, repaglinide, nateglinide, meglitinide, midaglizole, LY397364, LY389382, glyclazide, and glimepiride. Liquid formulations may be concentrated solutions suitable for storage; may be diluted (e.g., dilution of 1:1 or 1:1.2) suitable for bolus injections, and may be further diluted (e.g., dilution of 1:10 or 1:20 or more) for intravenous and intra-arterial infusion over an extended period of time. For example, a liquid formulation may include at least about 0.05 mg/ml glibenclamide in a water-based solution including 40% polyethylene glycol 300, 10% Ethanol, 50% water, at about pH 9. The solution may include a buffer, and is suitable for storage in refrigerator or at room temperature. This solution may be diluted 1:1, or more (e.g., 1:20) without precipitation of the glibenclamide. | 02-10-2011 |
Howard Morgan Clarke, Liss GB
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20090071382 | WASTE TREATMENT APPARATUS AND METHOD - In apparatus and method for waste treatment by pyrolysis, treated waste is flushed through a grid ( | 03-19-2009 |
Ian Clarke, Birmingham GB
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20090015729 | Interface Computer for a Stage Lighting System - A stage lighting system with a digital and analog part. The digital part is used to form the image, which can be, for example, a full brightness image. The analog part is used to dim the image, and to carry out failsafe operation. If an error occurs in the digital part, then the analog part prevents the image from being shown. | 01-15-2009 |
Ian Clarke, Walsall GB
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20080225372 | Electronically Controlled Stage Lighting System - A lighting system operating using a digital mirror as its operative device. The digital mirror is used to shape the light which is a passed through advanced optical devices in order to produce an output. | 09-18-2008 |
20100110520 | Electronically Controlled Stage Lighting System - A lighting system operating using a digital mirror as its operative device. The digital mirror is used to shape the light which is a passed through advanced optical devices in order to produce an output. | 05-06-2010 |
20110121737 | Electronically Controlled Stage Lighting System - A lighting system operating using a digital mirror as its operative device. The digital mirror is used to shape the light which is a passed through advanced optical devices in order to produce an output. | 05-26-2011 |
20130050796 | Electronically Controlled Stage Lighting System - A lighting system operating using a digital mirror as its operative device. The digital mirror is used to shape the light which is a passed through advanced optical devices in order to produce an output. | 02-28-2013 |
James Clarke, Colchester GB
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20090274870 | METHOD OF FABRICATING A MEMBRANE HAVING A TAPERED PORE - The present invention relates to a method of fabricating a membrane having a tapered pore, to a polymeric membrane having a tapered pore and to uses of such polymeric membrane. | 11-05-2009 |
20120114925 | METHOD OF FABRICATING A MEMBRANE HAVING A TAPERED PORE - A method of fabricating a membrane having a tampered pore, a polymeric membrane having a tapered pore, and uses of such polymeric membrane are disclosed. The membrane includes apertures of increasing diameter which are aligned with each other to form the tapered pore. | 05-10-2012 |
James Clarke, Oxford GB
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20110177498 | BASE-DETECTING PORE - The invention relates to a mutant α-hemolysin (α-HL) pore which is useful for detecting one or more nucleotides by stochastic sensing. The pore is particularly useful for sequencing DNA or RNA. A molecular adaptor that allows detection of the nucleotide(s) is covalently attached to the pore. The pore is specifically modified to facilitate positioning of the adaptor and may be modified to facilitate covalent attachment. | 07-21-2011 |
20110229877 | ENZYME-PORE CONSTRUCTS - The invention relates to constructs comprising a transmembrane protein pore subunit and a nucleic acid handling enzyme. The pore subunit is covalently attached to the enzyme such that both the subunit and enzyme retain their activity. The constructs can be used to generate transmembrane protein pores having a nucleic acid handling enzyme attached thereto. Such pores are particularly useful for sequencing nucleic acids. The enzyme handles the nucleic acid in such a way that the pore can detect its component nucleotides by stochastic sensing. | 09-22-2011 |
20120064599 | HYBRIDIZATION LINKERS - The invention provides method of covalently coupling two or more moieties, the method comprising: (a) providing a first moiety having covalently attached thereto (i) at least one first linker comprising a first hybridizable region and (ii) at least one first group capable of forming a covalent bond; (b) providing a second moiety having covalently attached thereto (i) at least one second linker comprising a second hybridizable region capable of hybridizing to the first hybridizable region and (ii) at least a second group capable of forming a covalent bond with the first group; (c) contacting the first and second moieties under conditions that allow the first and second hybridizable regions to hybridize and link the moieties; and (d) exposing the linked moieties to conditions that allow the formation of a covalent bond between the first and second groups. | 03-15-2012 |
20140186823 | MUTANT PORES - The invention relates to mutant forms of Msp. The invention also relates to nucleic acid characterisation using Msp. | 07-03-2014 |
20140262784 | COUPLING METHOD - The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing. | 09-18-2014 |
20150068904 | MUTANT LYSENIN PORES - The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using lysenin. | 03-12-2015 |
James Anthony Clarke, Colchester GB
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20090167288 | Formation of Layers of Amphiphilic Molecules - To form a layer separating two volumes of aqueous solution, there is used an apparatus comprising elements defining a chamber, the elements including a body of non-conductive material having formed therein at least one recess opening into the chamber, the recess containing an electrode. A pre-treatment coating of a hydrophobic fluid is applied to the body across the recess. Aqueous solution, having amphiphilic molecules added thereto, is flowed across the body to cover the recess so that aqueous solution is introduced into the recess from the chamber and a layer of the amphiphilic molecules forms across the recess separating a volume of aqueous solution introduced into the recess from the remaining volume of aqueous solution. | 07-02-2009 |
20110120871 | Formation of Layers of Amphiphilic Molecules - To form a layer separating two volumes of aqueous solution, there is used an apparatus comprising elements defining a chamber, the elements including a body of non-conductive material having formed therein at least one recess opening into the chamber, the recess containing an electrode. A pre-treatment coating of a hydrophobic fluid is applied to the body across the recess. Aqueous solution, having amphiphilic molecules added thereto, is flowed across the body to cover the recess so that aqueous solution is introduced into the recess from the chamber and a layer of the amphiphilic molecules forms across the recess separating a volume of aqueous solution introduced into the recess from the remaining volume of aqueous solution. | 05-26-2011 |
20140329693 | FORMATION OF LAYERS OF AMPHIPHILIC MOLECULES - To form a layer separating two volumes of aqueous solution, there is used an apparatus comprising elements defining a chamber, the elements including a body of non-conductive material having formed therein at least one recess opening into the chamber, the recess containing an electrode. A pre-treatment coating of a hydrophobic fluid is applied to the body across the recess. Aqueous solution, having amphiphilic molecules added thereto, is flowed across the body to cover the recess so that aqueous solution is introduced into the recess from the chamber and a layer of the amphiphilic molecules forms across the recess separating a volume of aqueous solution introduced into the recess from the remaining volume of aqueous solution. | 11-06-2014 |
Jeremy Guy Clarke, Bath GB
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20100034890 | COMBINATIONS OF FORMOTEROL AND FLUTICASONE PROPIONATE FOR ASTHMA - A pharmaceutical composition comprising (A) formoterol or a pharmaceutically acceptable salt thereof or a solvate of formoterol or said salt and (B) fluticasone propionate, suitable for use in the treatment of inflammatory or obstructive airways diseases. | 02-11-2010 |
Joe Clarke, Glasgow GB
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20080226450 | Turbine with Coaxial Sets of Blades - A turbine ( | 09-18-2008 |
Kieran Clarke, Oxfordshire GB
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20110033387 | METHOD OF DETERMINATION OF PDH ACTIVITY AND IMAGING MEDIA FOR USE IN SAID METHOD - The invention relates to a method of determination of PDH activity by | 02-10-2011 |
Kiernan Clarke, Oxford GB
Patent application number | Description | Published |
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20100298294 | KETONE BODIES AND KETONE BODY ESTERS AS BLOOD LIPID LOWERING AGENTS - The subject disclosure provides compositions for reducing serum cholesterol and/or triglyceride levels in subjects. These compositions can comprise racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol or R-1,3 butandiol alone and can be, optionally, administered in conjunction with a low fat diet to a subject. Alternatively, compositions comprising racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol, R-1,3 butandiol or combinations thereof can be formulated as nutritional supplements (also referred to as nutritional compositions) or incorporated into therapeutic compositions containing a) anti-hypertensive agents; b) anti-inflammatory agents; c) glucose lowering agents; or d) anti-lipemic agents) which are administered to a subject, optionally in combination with a low fat diet, in order to cause a reduction or lowering of: serum cholesterol levels; triglyceride levels; serum glucose levels, serum homocysteine levels, inflammatory proteins (e.g., C reactive protein) and/or hypertension in treated subjects. Alternatively, compositions disclosed herein can be administered alone, or in combination with other therapeutic agents to prevent or reverse vascular disease. | 11-25-2010 |
Lionel Clarke, Chester GB
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20100000483 | GASOLINE COMPOSITIONS - The present invention provides a method for decreasing the vapour pressure of a gasoline composition comprising admixing with a gasoline base fuel, from 0.5 to 30 vol. %, based on the overall gasoline composition, of ethyl valerate. | 01-07-2010 |
20140059923 | FUEL COMPOSITION - A fuel composition comprising: a diesel base fuel; from 1 to 10% v/v of a fatty acid alkyl ester; and more than 10% v/v of an ether component, the ether component comprising one or more ether compounds having in the range of from 8 to 12 carbon atoms and selected from compounds of formula I | 03-06-2014 |
Lyndon John Clarke, Edinburgh GB
Patent application number | Description | Published |
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20110179341 | METHOD AND APPARATUS FOR COMPRESSION AND NETWORK TRANSPORT OF DATA IN SUPPORT OF CONTINUOUS AVAILABILITY OF APPLICATIONS - Methods and apparatus for compressing data for network transport in support of continuous availability of applications are described. One computer-implemented method of compressing data includes receiving a current instance of data in an input buffer. A candidate chunk of data is selected from the input buffer. A signature hash is computed from a signature length range of data within the candidate chunk. A matching dictionary entry having a matching signature hash from a multi-tiered dictionary is identified. The matching dictionary entry prospectively identifies a location of a prior occurrence of a selected range of consecutive symbols including the signature length range of data within at least one of the current instance of data and a prior instance of data in the input buffer. A dedupe processed representation of the instance of data is formed wherein a dedupe item is substituted for the selected range of consecutive symbols if the selected range is verified as recurring. The dedupe item identifies the location of the prior occurrence of the selected range in accordance with the matching dictionary entry. | 07-21-2011 |
20120023209 | METHOD AND APPARATUS FOR SCALABLE AUTOMATED CLUSTER CONTROL BASED ON SERVICE LEVEL OBJECTIVES TO SUPPORT APPLICATIONS REQUIRING CONTINUOUS AVAILABILITY - A computer-implemented method for managing the state of a multi-node cluster includes receiving an event indicative of a possible change in a current cluster state. A goal cluster state is identified if the current cluster state does not meet a service level objective. The goal cluster state includes a replication tree for replication among the member nodes of the goal cluster state. A transition plan for transitioning from the current cluster state to the goal cluster state is generated. The transition plan is executed to transition from the current cluster state to the goal cluster state. | 01-26-2012 |
Michael Wymark Clarke, Halstead GB
Patent application number | Description | Published |
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20090006842 | Sealing Electronic Data Associated With Multiple Electronic Documents - The description generally provides for systems and methods for a mobile communication network. Archives of seals can be sealed to protect the integrity of the seals and facilitate validation in the event a sealing party's sealed registration document is revoked. A document can be sealed multiple times to nest seals within other seals. Specific evidentiary metadata can be included by the sealing party. A main document including or associated with other documents can be sealed as a collection of documents. The seal of the main document can include external references to the files included in the main document to verify the external files were not changed or altered. | 01-01-2009 |
Neil Clarke, Abingdon GB
Patent application number | Description | Published |
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20110140695 | FLATTENED GRADIENT COIL FOR MRI SYSTEMS - A gradient coil and an insert gradient coil for a magnetic resonance imaging system include a primary coil. The primary coil includes an upper primary coil portion and a lower primary coil portion, the lower primary coil portion being less curved in cross-section than the upper primary coil portion. The gradient coil also includes a shielding coil disposed outside of the primary coil. The shielding coil includes an upper shielding coil portion and a lower shielding coil portion, the lower shielding coil portion being less curved in cross-section than the upper shielding coil portion. | 06-16-2011 |
Neil Clarke, Oxford GB
Patent application number | Description | Published |
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20080271839 | METHOD AND TOOL FOR CREATING A PASSIVE SHIM LOCATION WITHIN A GRADIENT COIL - A method for creating a passive shim location in a gradient coil assembly of a magnetic resonance imaging system includes placing at least one tool in a volume between an inner gradient coil assembly and an outer gradient coil assembly. The tool includes an inner core and an outer sleeve. The inner core is removably housed in the outer sleeve. The volume is then filled with a bonding material. Once the bonding material has cured, the inner core is removed from the outer sleeve. The outer sleeve may also be removed from the volume. | 11-06-2008 |
20120108433 | SUPERCONDUCTING MAGNET COIL SUPPORT WITH COOLING AND METHOD FOR COIL-COOLING - A superconducting magnet coil support with cooling and a method for coil cooling are provided. One superconducting coil support arrangement includes a superconducting coil and at least one support beam supporting the superconducting coil and defining a tank for storing a cooling fluid therein. The superconducting coil support arrangement further includes a plurality of cooling tubes coupled to the superconducting coil and connected to the at least one support beam, wherein the plurality of cooling tubes are configured to transfer the cooling fluid therethrough. | 05-03-2012 |
Neil Clarke, Sheffield GB
Patent application number | Description | Published |
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20080272348 | Palletised Loads of Containers - A device for use on palletised loads of containers for maintaining tension in vertical strapping comprises a rectangle ( | 11-06-2008 |
20100038611 | WIRE TERMINATION DEVICE - A wire termination device ( | 02-18-2010 |
20100229698 | WIRE PULLING AND TENSIONING TOOL - A tool for pulling a wire (W) through a connector (C) or a terminal has a pair of levers ( | 09-16-2010 |
Nicholas S. Clarke, Harpenden GB
Patent application number | Description | Published |
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20100016138 | SYSTEM AND METHOD FOR PRODUCING A CROSS-FOLD IN FOLDED SHEET MATERIAL - A cross-fold system for use in combination with a device for folding sheet material and includes a rigid guide structure having a stationary reaction surface for supporting and guiding folded sheet material along a feed path between a sheet feed mechanism and a tensioning mechanism. Furthermore, the cross-fold system includes a paper break assembly disposed between the sheet feed mechanism and the tensioning mechanism. The paper break assembly, furthermore, includes an abrasion bar disposed transversely of the feed path and in opposed relation to the rigid guide. Moreover, the paper break assembly is repositionable from an active position to an inactive position such that, in the active position, the abrasion bar pressingly engages the sheet material against the stationary reaction surface of the guide assembly, and, in the inactive position, the abrasion bar permits the sheet material to pass to the tensioning mechanism without engaging the sheet material. When the paper break assembly is in the active position, the tensioning mechanism is operative to pull the folded sheet material across the abrading bar to yield the adhesive bond between the reinforcing fibers of the sheet material. As such, a subsequent cross-fold of the folded sheet material is facilitated. | 01-21-2010 |
Paul Clarke, Redditch GB
Patent application number | Description | Published |
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20100139383 | APPARATUS AND METHOD FOR MONITORING TYRE WEAR - A fleet management system for monitoring the tread depth of a plurality of tyres in use in a fleet of vehicles, includes an electronic database of information relevant to the depth of tread for each of a plurality of tyres in use in a fleet of vehicles, an apparatus ( | 06-10-2010 |
Paul A. Clarke, Burgess Hill GB
Patent application number | Description | Published |
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20080215685 | Network communication apparatus for providing a user with a paging message - A network communications system comprises a number of user stations, coupled via a data network to a number of service provider host systems. The user stations are registered as client stations at the host system of a service provider, with the host system maintaining a database of registered client station identification data. The host system additionally maintains a directory of the client stations that are on-line at a given time, determined from periodic messages sent to the host by each client station. Callers wishing to contact a client station ( | 09-04-2008 |
Paul Francis Clarke, Northumberland GB
Patent application number | Description | Published |
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20110023900 | TOBACCO SMOKE FILTER - A tobacco smoke filter or filter element comprising a cylindrical plug of a substantially homogeneous filtering material of circumference between 14.0 and 23.2 mm, wherein the substantially homogeneous filtering material comprises a plurality of randomly oriented staple fibres. | 02-03-2011 |
20120067359 | TOBACCO SMOKE FILTER - A tobacco smoke filter or filter element comprising: a tobacco smoke filtering material including paper; and a flavour enhancing additive. | 03-22-2012 |
20130112216 | TOBACCO SMOKE FILTER - A stand alone tobacco smoke filter or filter element for use with a smoking article comprising a wrapper engaged around a longitudinally extending core of tobacco smoke filtering material, wherein at least one end of the wrapper extends beyond the end of the core around which it is engaged, to define a cavity at the end of the filter which faces the smoking article in use. | 05-09-2013 |
Paul G. Clarke, Hampshire GB
Patent application number | Description | Published |
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20100091788 | CONFIGURATION FOR MESSAGING MULTIPLEXED CHANNEL INSTANCES WITH VARYING CONNECTION SPEEDS - A method, system and article of manufacture are disclosed for selecting a channel instance for connecting a client with a server in a multi-channel instance computer system. In this computer system, when a new channel instance is used for connecting the client with one of the servers, defined channel information is established for the channel instance. The method of this invention comprises the steps of, when a new connection request is made, locking existing channel information; and after said locking, scanning through a list of channel connections for one of the channel instances that is a candidate for said connection request. In response to finding a candidate channel instance, which is in the process of connecting, the connection request is queued against the candidate channel instance. When the candidate channel instance does not complete connecting within a defined or determined time period, a new channel instance is used for the connection request. | 04-15-2010 |
20100095006 | EFFICIENT SELECTION OF A MESSAGING MULTIPLEXED CHANNEL INSTANCE - A method, system and article of manufacture are disclosed for selecting a channel instance for connecting a client application with a server application in a multi-channel computer system. In this computer system, when a new channel instance is used to connect one of the client applications with one of the server applications, defined channel instance information is established for the channel instance. The method of this invention comprises the steps of when a new application connection request is made, locking existing channel instance information; and after said locking, scanning through a list of channel instance connections for one of the channel instances that is a candidate channel instance for that new application connection request. The method comprises the further steps of, in response to finding a candidate channel instance, determining whether the candidate channel instance is suitable for the new application connection request. | 04-15-2010 |
20100095022 | FLEXIBLE PROCEDURE FOR QUIESCING MULTIPLEXED CLIENT - A method, system and article of manufacture are disclosed for quiescing multiplexed client messaging conversations. The invention uses plural independent mutexes to stop the application sends from both ends of a client/server channel, while allowing unsolicited control flows from the server to client to also be handled and quiesced. Once the channel is quiesced a channel-wide renegotiation, such as SSL secret key reset, can flow. The channel can then restart, again with the possibility of unsolicited server to client flows. The preferred embodiment of the invention provides a number of important advantages. For example, this embodiment allows channel-wide negotiation flows to occur on a multiplexed channel without the need to wait for application conversations to complete. It also allows channel-wide negotiation flows to occur on a multiplexed channel on which unsolicited server to client flows can occur. | 04-15-2010 |
Paul Richard Clarke, Surrey GB
Patent application number | Description | Published |
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20100045025 | One and Two-Part Printable EM Tags - The present invention relates to methods of assembly, labeling and programming decoupled EM tags used in the tagging and tracking of items wherein the tags including a printable label portion and a decoupler portion which are combined after printing on the surface of and programming a programmable device associated with the label portion. | 02-25-2010 |
20120181341 | One and Two-Part Printable EM Tags - The present invention relates to methods of assembly, labeling and programming decoupled EM tags used in the tagging and tracking of items wherein the tags including a printable label portion and a decoupler portion which are combined after printing on the surface of and programming a programmable device associated with the label portion. | 07-19-2012 |
Paul Richard Clarke, Hampshire GB
Patent application number | Description | Published |
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20110037541 | Switchable Radiation Enhancement and Decoupling - A device capable of enhancing an electric field to drive an electromagnetic tag into operation is switchable between states to control operation of the tag. Enhancement is provided by a dielectric cavity structure defined between first and second conducting layers. Different states of the device may have different resonant frequencies and read ranges according to the characteristics of the enhancement. As such a container can be provided which includes a tag which switches states on opening, allowing improved tracking characteristics. | 02-17-2011 |
20110121079 | Electromagnetic Radiation Decoupler - An electromagnetic radiation decoupler for decoupling radiation in the wavelength range λ | 05-26-2011 |
20140117093 | Electromagnetic Radiation Decoupler - An electromagnetic radiation decoupler for decoupling radiation in the wavelength range λ | 05-01-2014 |
Peter David Clarke, Bristol GB
Patent application number | Description | Published |
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20090158990 | PAYLOAD DEPLOYMENT SYSTEM FOR A SUBMARINE - A payload deployment system for a vessel, such as a submarine, which includes a cable extending between a piston in a piston tube and an ejection element in an ejection tube, wherein the ejection tube is suitable for holding the payload, such as a torpedo. The system is arranged such that movement of the piston in the piston tube causes movement of the cable which, in turn, exerts a force on the ejection element to move it in the ejection tube to eject the payload from the ejection tube. | 06-25-2009 |
Peter Jonathan Clarke, Oxon GB
Patent application number | Description | Published |
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20100016168 | APPARATUS AND METHOD FOR TRANSPORTING CRYOGENICALLY COOLED GOODS OR EQUIPMENT - In an apparatus and method for transporting cryogenically cooled goods or equipment, a cryostat containing the cryogenically cooled goods or equipment and partially filled with liquid cryogen is provided with a cryogenic refrigerator for active cooling; and auxiliary equipment sufficient to maintain the cryogenic refrigerator in operation, are all mounted on a transportable carrier such that the transportable carrier may be transported with the cryogenic refrigerator in operation without connection of any of the cryostat, refrigerator and auxiliary equipment to any supplies located off of the transportable carrier. | 01-21-2010 |
Peter Reginald Clarke, West Sussex GB
Patent application number | Description | Published |
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20100092706 | INJECTION MOULD AND INJECTION MOULDING METHOD - An injection mould for injection moulding an article having a base and a sidewall, the injection mould comprising: first and second mould parts which are adapted to be connected together in a closed configuration so as to define a mould cavity there between, the mould cavity having a base portion and a sidewall portion, an injector for injecting into the mould cavity molten material to be moulded into the article, at least one portion of one of the first and second mould parts being movable when the first and second mould parts are in the closed configuration so as to vary the volume of the mould cavity, an actuator for selectively moving the at least one portion of one of the first and second mould parts in first and second directions so as to increase and reduce, respectively, the volume of the mould cavity. | 04-15-2010 |
20140295119 | PREFORMS FOR BLOW MOULDING - A preform for blow moulding to form a container, the preform being formed of a thermoplastic material, the preform comprising a neck finish at an open end of the preform, an elongate body section and a closed end, wherein the body section has elongate, longitudinally extending inner and outer surfaces each centered about a longitudinal axis of the preform, the inner and outer surfaces defining therebetween a wall of the body section, wherein the wall of the body section has at least one locally thickened portion along the body section, the locally thickened portion being thicker than adjacent first and second thinner portions at respective opposite longitudinal ends of the thickened portion, the thickened portion having an inner surface portion which is nearer to the longitudinal axis than respective first and second inner surface portions of the first and second thinner portions. | 10-02-2014 |
20140346709 | HEATING PREFORMS - An apparatus for reheating and conditioning an elongate preform for forming a blow moulded container, said apparatus comprising: a receiver including an elongate annular non-cylindrical inner surface portion, wherein the surface portion defines a cavity and is adapted to engage with an elongate outer surface of an elongate preform to transfer heat thereto by conduction from said surface portion, wherein the surface portion includes a three-dimensional relief to provide substantially non-uniform contact between the receiver and the elongate preform; and means for heating said receiver. | 11-27-2014 |
Philip Clarke, Leatherhead GB
Patent application number | Description | Published |
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20080291758 | READ-LEVELING IMPLEMENTATIONS FOR DDR3 APPLICATIONS ON AN FPGA - Circuits, methods, and apparatus for transferring data from a device's input clock domain to a core clock domain. One example achieves this by using a retiming element between input and core circuits. The retiming element is calibrated by incrementally sweeping a delay and receiving data at each increment. Minimum and maximum delays where data is received without errors are averaged. This average can then be used to adjust the timing of a circuit element inserted in an input path between an input register clocked by an input strobe signal and an output register clocked by a core clock signal. In one example, an input signal may be delayed by an amount corresponding to the delay setting. In other examples, each input signal is registered using an intermediate register between the input register and the output register, where a clock signal is delayed by an amount corresponding to the delay setting. | 11-27-2008 |
Philip Clarke, East Horsley GB
Patent application number | Description | Published |
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20090296503 | READ-LEVELING IMPLEMENTATIONS FOR DDR3 APPLICATIONS ON AN FPGA - Circuits, methods, and apparatus for transferring data from a device's input clock domain to a core clock domain. One example achieves this by using a retiming element between input and core circuits. The retiming element is calibrated by incrementally sweeping a delay and receiving data at each increment. Minimum and maximum delays where data is received without errors are averaged. This average can then be used to adjust the timing of a circuit element inserted in an input path between an input register clocked by an input strobe signal and an output register clocked by a core clock signal. In one example, an input signal may be delayed by an amount corresponding to the delay setting. In other examples, each input signal is registered using an intermediate register between the input register and the output register, where a clock signal is delayed by an amount corresponding to the delay setting. | 12-03-2009 |
Philip Graham Clarke, Oxford GB
Patent application number | Description | Published |
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20110212939 | Heterocyclic GPCR Agonists - Compounds of formula (I) or pharmaceutically acceptable salts thereof, are GPCR (GPR119) agonists and are useful as for the treatment of diabetes and obesity. | 09-01-2011 |
Philip James Clarke, Harrow GB
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20090182659 | Method of selling using auction style bidding - The invention relates to an auction like bidding process establishing the value of an asset; the sale of the asset going to whomever pays first. This differs from the established auction protocol where the seller is obliged to pass the asset to the highest bidder. With this method, the seller's contractual obligation does not limit the seller to transferring ownership rights to the participants in the bidding process. | 07-16-2009 |
Richard Clarke, Cambridge GB
Patent application number | Description | Published |
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20110131690 | Scanning Ion Conductance Microscopy - The subject invention concerns methods for interrogating a surface using scanning ion conductance microscopy (SICM). In one embodiment, a method of the invention comprises the steps of: | 06-02-2011 |
20130312143 | SCANNING ION CONDUCTANCE MICROSCOPY USING SURFACE ROUGHNESS FOR PROBE MOVEMENT - A method for interrogating a surface using scanning ion conductance microscopy (SICM), comprising the steps of: | 11-21-2013 |
Robert J. Clarke, East Peckham GB
Patent application number | Description | Published |
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20090008804 | Power semiconductor package - A power semiconductor package that includes a semiconductor die having at least two power electrodes and a conductive clip electrically and mechanically coupled to each power electrode. | 01-08-2009 |
20090174058 | CHIP SCALE PACKAGE - A method for manufacturing a semiconductor package that includes forming a frame inside a conductive can, the frame being unwettable by liquid solder. | 07-09-2009 |
Robert W. Clarke, Swansea GB
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20110190096 | Stretching Apparatus - The invention relates to a stretching apparatus which is used to stretch the posterior muscles and tendons by means of powered stretching movements. The apparatus comprises a body ( | 08-04-2011 |
Robin Clarke, Northwich GB
Patent application number | Description | Published |
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20110139107 | SPARK IGNITION DEVICE FOR AN INTERNAL COMBUSTION ENGINE AND CENTRAL ELECTRODE ASSEMBLY THEREFOR - A spark ignition device includes a ceramic insulator with a metal shell surrounding at least a portion of the ceramic insulator. A ground electrode is attached to the shell. The ground electrode has a ground electrode sparking tip spaced from a central sparking tip by a spark gap. A first terminal is arranged in electrical communication with the central sparking tip and is configured for electrical connection with a power source. The device further includes a second terminal configured for electrical connection with the power source. The second terminal is spaced from the first terminal, with the second terminal being arranged in electrical communication with the first terminal. A heater element brings the first terminal in electrical communication with the second terminal and completes an electrical circuit. The heater element has a resistance greater than the first and second terminals thereby producing a significant source of heat. | 06-16-2011 |
Robin Clarke, Cheshire GB
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20110037372 | SPARK IGNITION DEVICE WITH IN-BUILT COMBUSTION SENSOR - A spark plug having an integral gasoline combustion sensor is disclosed. The spark plug includes a center electrode assembly with a terminal stud at one end and a center electrode with a sparking surface at an opposite end; a generally tubular insulator surrounding the center electrode assembly; a shell surrounding the insulator and having along its length a turn-over on a first end, a barrel having an outer surface and barrel shoulder on a gasket flange thereof, a threaded portion, and a ground electrode; and a piezo sensor assembly located on the barrel shoulder proximate the outer surface of the barrel which includes a lower electrode contact, a piezo transducer, an upper electrode contact, an isolator having a convex upper surface, and an upper bushing which is attached to the barrel. | 02-17-2011 |
Roger William Clarke, Histon GB
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20110073106 | DRY POWDER INHALER - An Inhaler for delivering an aerosolised dose of a powdered drug for inhalation by a user is disclosed. The inhaler comprises a drug entreinment device to a receive a package having a piercable lid containing a dose to be delivered, the device including a drug outlet tube terminating with a primary piercing element to pierce an opening in said lid when a package is located in the inhaler, a secondary piercing member to pierce a plurality of peripheral openings in said lid and, an airflow path to enable the supply of a charge of gas into the package via said peripheral openings to scour the interior of a pierced package such that all or substantially all of the dose is entrained in the gas and flows out of the package via the drug outlet tube. A medicament pack is also disclosed. | 03-31-2011 |
20110132358 | INHALER - An inhaler is disclosed. It comprises a housing to receive a strip of blisters each having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator operable to sequentially move each blister into alignment with a blister piercing member. The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway. | 06-09-2011 |
20130220321 | INHALER - An inhaler is disclosed. It comprises a housing to receive a strip of blisters each having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator operable to sequentially move each blister into alignment with a blister piercing member. The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway. | 08-29-2013 |
20130312747 | INHALER - An inhaler is disclosed. It comprises a housing to receive a strip of blisters each having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator operable to sequentially move each blister into alignment with a blister piercing member. The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway. | 11-28-2013 |
Roger William Clarke, Cambridge GB
Patent application number | Description | Published |
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20080264415 | Inhaler - An inhaler ( | 10-30-2008 |
20090090362 | Blister piercing element for dry powder inhaler - A blister piercing element for puncturing the Hd of a blister containing a dose of medicament for inhalation by a user is disclosed. The piercing element comprising an outlet opening for the passage of medicament entrained in an airflow out of the blister and, a piercing head extending beyond and overhanging the opening that cuts a flap in a lid of a blister and pushes it away from the opening during insertion. | 04-09-2009 |
20120132205 | INHALER - An inhaler comprising a housing to receive a strip having a plurality of blisters is disclosed. Each blister has a puncturable lid and contains a dose of medicament for inhalation by a user. A mouthpiece is pivotally mounted to the housing through which a dose of medicament is inhaled by a user. The inhaler also has an actuating mechanism including a lever operable to sequentially move each blister into alignment with a blister piercing member depending from the mouthpiece. The actuating lever is also operable to cause the mouthpiece to pivot so that the blister piercing member punctures the lid of an aligned blister so that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it, via the mouthpiece, into the user's airway. | 05-31-2012 |
20120138055 | INHALER - An inhaler comprising a housing to receive a strip having a plurality of blisters is disclosed. Each blister has a puncturable lid and contains a dose of medicament for inhalation by a user. A mouthpiece is pivotally mounted to the housing through which a dose of medicament is inhaled by a user. The inhaler also has an actuating mechanism including a lever operable to sequentially move each blister into alignment with a blister piercing member depending from the mouthpiece. The actuating lever is also operable to cause the mouthpiece to pivot so that the blister piercing member punctures the lid of an aligned blister so that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it, via the mouthpiece, into the user's airway. | 06-07-2012 |
Sean P. Clarke, Highmoor Cross GB
Patent application number | Description | Published |
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20100299928 | Shaving Razor Comb Guard for a Trimming Blade - A shaving razor blade unit including a housing having a primary guard at a front of the housing and a primary cap at an upper surface at a back of the housing. One or more primary shaving blades are positioned between the primary guard and the primary cap. A trimming blade is mounted at the back of the housing and has a cutting edge. A trimming comb guard is located at the back of the housing. The trimming comb guard has a plurality of projections along a length of the trimming comb guard defining a plurality of open slots extending generally perpendicular to the cutting edge. The open slots have a minimum width of about 0.20 mm to about 0.49 mm for allowing the free passage of hair during shaving. | 12-02-2010 |
Sean Peter Clarke, Highmoor GB
Patent application number | Description | Published |
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20100083510 | Shaving Razors and Cartridges - A shaving cartridge has a housing with at least one blade having a blade edge. The housing has a first guard in front of the blade with a plurality of projections defining a plurality of open slots extending generally transverse to the blade edge. The open slots have a width of about 0.20 mm to about 0.49 mm and a pitch of about 0.40 mm to about 0.85 mm for allowing the free passage of hair during shaving. | 04-08-2010 |
Sean Peter Clarke, Highmoor Cross GB
Patent application number | Description | Published |
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20100236071 | Manually Actuable Liquid Dispensing Razor - The invention features a razor for dispensing a fluid during shaving. The razor includes a handle, a razor cartridge, and a fluid dispensing member joined to the cartridge. The handle includes a cavity for housing a fluid and a manually-actuated pump to displace the fluid from the cavity through a supply channel to an opening at the proximal end of the handle. The razor cartridge includes a cartridge connecting structure attached to the housing, at least one blade positioned in the housing, and an aperture that extends from the rear surface to the front surface of the housing. The fluid dispensing member has a dispensing channel with an opening at a supply end and an opening at a dispensing end. The supply end is configured to engage the opening in the supply channel. The dispensing end projects outwardly and extends to or adjacent to the aperture in the housing. | 09-23-2010 |
20100236072 | Manually Actuable Liquid Dispensing Razor - The invention features a razor for dispensing a fluid during shaving. The razor includes a razor cartridge that is engageable to a handle. The razor cartridge has a housing, a cartridge connecting structure attached to the housing; at least one blade positioned in the housing; and an aperture that extends from the rear surface to the front surface of the housing. The handle has a cavity for housing a fluid; a manually-actuated pump located along the length of the handle, and a fluid dispensing member having a channel in fluid communication with the pump and having an opening at a terminal end. The fluid dispensing member projects outwardly from the proximal end of the handle such that the terminal end extends to or adjacent to the aperture in the housing. Actuation of the pump displaces fluid from the cavity to or adjacent to the front surface of the housing. | 09-23-2010 |
20110146079 | Razor Cartridge With Non-Cutting Element - A novel razor cartridge includes at least one non-cutting element disposed anywhere within a blade array between a guard and a cap and/or in a blade position of a frame providing skin/hair management. This non-cutting element allows the fine-tuning of parameters such as blade-skin contact, hair orientation, blade spans and rinse-through gaps in manners that improve shaving comfort, closeness, efficiency, and/or rinse-ability. The non-cutting element may include projections, fin-like elements, comb-like features having teeth, exfoliation or lubricating capabilities. By having a fixed non-cutting element disposed midway in a blade array, a multi-stage cartridge is provided with a middle control point with potentially different functionality before and after the non-cutting element. The non-cutting element is not attached to another blade in the blade array though it may be manufactured as a modified blade support, attached to a blade support, or as part of the frame or the clips. | 06-23-2011 |
20110219621 | Hair Removal Device - The invention features a hair removal device, such as a razor for dispensing a fluid during use. The hair removal device includes a fluid dispensing member which comprises an elongated elastomeric contact member for dispensing the fluid onto the skin in a wide and flat layer of fluid. | 09-15-2011 |
20110258855 | Shaving Razor - A shaving razor has a housing joined to a handle, one or more blades mounted in the housing and a light source. The light source projects a defined image of a line segment indicating the exact location of a blade edge on the skin of a user enabling the user to properly align the blade edge on the skin during shaving. | 10-27-2011 |
20120233863 | SHAVING RAZORS AND CARTRIDGES - A shaving cartridge has a housing with at least one blade having a blade edge. A first guard is in front of the blade. The first guard has a plurality of projections defining a plurality of open slots extending generally transverse to the blade edge. Each slot has a leading end portion for receiving hairs and a trailing end portion for feeding the hairs to the blade. The projections are stepped with a height of the projections that define the leading end portion of the slots that is less than a height of the projections that define the trailing end portion of the slots. | 09-20-2012 |
Sean Peter Clarke, Oxfordshire GB
Patent application number | Description | Published |
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20080289185 | Razors - A razor, especially a safety razor, comprises a fluid delivery system including a pump ( | 11-27-2008 |
20080307660 | Pivotally Actuated Pump Driven Liquid Dispensing Shaving Razor - A shaving razor comprising: | 12-18-2008 |
20090320293 | Manually Actuable Liquid Dispensing Razor With Degradable Shaving Aid - A shaving razor suitable for preparing hair and skin for shaving, the razor comprising: a handle including a proximal end, a distal end, and a manually-actuated pump located therebetween and wherein said handle comprises a cavity; a razor cartridge having a skin contacting surface and a rear surface, said cartridge comprising a housing; at least one blade disposed across a span of the housing; a degradable shaving aid portion surrounding a periphery of said housing on said skin contacting surface; and wherein a feeding channel feeds a liquid shaving aid from said pump to a disposal point within said cartridge for dispensing said liquid shaving aid to the hair and skin. | 12-31-2009 |
Simon Clarke, Sheffield GB
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20090269349 | ANTIGENIC POLYPEPTIDES - The invention relates to a method for the identification of antigenic polypeptides, typically opsonic antigens, expressed by pathogenic microbes; vaccines comprising said antigens; and therapeutic antibodies directed to said antigenic polypeptides. | 10-29-2009 |
20100166792 | Antigenic Polypeptides - The invention relates to a method for the identification of antigenic polypeptides expressed by pathogenic microbes; vaccines comprising said polypeptides; recombinant methods to manufacture said polypeptides; and therapeutic antibodies directed to said polypeptides. | 07-01-2010 |
Stephan William Clarke, Lancashire GB
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20080283531 | Dispensing Device - A dispensing device comprising a housing having an upper loading chamber, a dispensing chamber located beneath the loading chamber and a gate means movable between a first, open position and second, closed position to allow selective communication of the loading chamber and the dispensing chamber, entry to the lower chamber being by means of door means, the device further comprising a locking means which prevents the door means from opening when the gate is in the open position and which prevents opening of the gate means, when the door means is open. | 11-20-2008 |
Stephen John Clarke, Wales GB
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20100310717 | METHOD OF PREPARING A FULLY COOKED FARINACEOUS PRODUCT - The present invention provides a method that enables the preparation of fully cooked farinaceous products with sensory properties that are comparable to those of fried products, but having a substantially lower fat content than their fried counterparts. More particularly, the invention relates a method of preparing a fully cooked farinaceous food product, said method comprising the successive steps of: | 12-09-2010 |
20120219669 | READY-TO-EAT FARINACEOUS PRODUCT AND A METHOD FOR THE PREPARATION THEREOF - The invention provides a method of preparing a ready-to-eat farinaceous food product, said method comprising the successive steps of: a) preparing a farinaceous dough by mixing flour, water and optionally one or more other bakery ingredients; b) dividing the dough into one or more dough portions; c) shaping the one or more dough portions into one or more shaped dough pieces; d) proving the dough pieces; e) contacting 30-60% of the total surface area of the one or more shaped dough pieces with hot oil during a period of at least 10 seconds to produce one or more partially fried dough pieces comprising a fried surface area and a non-fried surface area; and f) baking said one or more partially fried dough pieces to produce one or more baked dough pieces; where in a layer of edible material is applied to 40-70% of the surface area of the shaped dough pieces, the partially fried dough pieces or the baked dough pieces and wherein the surface area of the final ready-to-eat product that is not covered by the layer of edible material is fried surface area. This method achieves a significant reduction in fat uptake during preparation of the ready-to-eat farinaceous product without introducing a perceptible adverse effect on product quality. Another aspect of the invention relates to ready-to-eat food product comprising a body of baked farinaceous dough, 40-70% of the surface area of said body of baked dough being coated with a layer of edible material, wherein the surface of the baked dough body that is not coated with the layer of edible material is fried surface area and wherein at least 70 wt. % of the surface of the baked dough body that is covered with the layer of edible material is non-fried. | 08-30-2012 |
Stephen William Clarke, Lancashire GB
Patent application number | Description | Published |
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20100193538 | DISPENSING DEVICE - A dispensing device comprises a loading chamber ( | 08-05-2010 |
20140292493 | INDICATOR DEVICE - An indicator device (D) comprises a base ( | 10-02-2014 |
Steven J. Clarke, Cambridge GB
Patent application number | Description | Published |
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20090204912 | GENEERAL PURPOSE INFINITE DISPLAY CANVAS - Expanding and contracting a display screen container. Data is stored in a computer readable medium. The data represents a screen container such as a graphical desktop user interface displayable to a user on a computer display of a computing device. Data is stored representing artifacts, including one or more application graphical user interface artifacts for applications that are instantiated on the computing device. Information is stored specifying locations where each of the artifacts should be graphically located in the screen container. The graphical size of screen container is determined by the locations of the artifacts. Based on user input, a portion of the screen container is displayed to the user on the computer display of the computing device. The screen container may be expanded or contracted based on opening or closing graphical user interface artifacts, adding or removing artifacts, or repositioning artifacts. | 08-13-2009 |
Steven John Clarke, Fulbourn GB
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20090322739 | Visual Interactions with Analytics - Visual interaction with an analytics-driven model view composition application. The application includes a data-model binding component that binds input data to model parameters, an analytics solver component that solves for remaining unknown model parameters, and a view composition component that generates a view composition using the model parameters. In one visual interaction, various solutions of the model are provided in alternative views of various view compositions in a single integrated composition. In another interaction, regardless of whether there are multiple view compositions illustrated in a single integrated view, there might be visual prompts in the view composition that suggest an adjustment to make that might move the value of a particular model parameter in a desired direction. | 12-31-2009 |
Terence Clarke, East Sussex GB
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20090096447 | ELECTRIC POTENTIAL SENSOR FOR USE IN THE DETECTION OF NUCLEAR MAGNETIC RESONANCE SIGNALS - The present invention provides nuclear magnetic resonance apparatus comprising means for applying a static magnetic field (H | 04-16-2009 |
Tim Clarke, Aberdeen GB
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20110037229 | PACKING ELEMENT - A sealing element for a packer is described. The sealing element comprises an annular body having an internal surface defining a throughbore, the internal surface adapted to engage a mandrel having a mandrel diameter. The annular body internal surface defines first and second regions, the throughbore diameter of the regions being less than the mandrel diameter. | 02-17-2011 |
20110101615 | SEALING APPARATUS - A sealing apparatus for sealing a well bore is described. The sealing apparatus comprises a sealing element adapted to be moved from a run-in configuration to a set configuration, a first back-up layer and at least one second back-up layer sandwiched between the sealing element and the first back-up layer. The at least one second back-up layer comprises a thinner material than the first back-up layer. The first back-up layer and the at least one second back-up layer are adapted to be moved from the run-in configuration to the set configuration under the action of the sealing element. | 05-05-2011 |
Tim Clarke, Compton-Surrey GB
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20100101972 | PACKAGING - A container ( | 04-29-2010 |
Timothy Clarke, Aberdeen GB
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20100101776 | IMPROVED SEALING APPARATUS - A sealing apparatus for sealing an annulus is described. The apparatus comprises a first sealing element ( | 04-29-2010 |