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Clark, MA
Bryan Clark, Westford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100299617 | IDENTITY MANAGEMENT FOR OPEN OVERLAY FOR SOCIAL NETWORKS AND ONLINE SERVICES - Methods and systems can manage the multiple identities used by a user. The user's existing contact lists, website accounts, buddy lists, and the like are analyzed to determine the identities used by the user. A graph is then constructed in order to track and integrate the multiple identities of the user in a social network. The social network graph may then be used by a social network overlay so that the user can share information across their different identities with different users that only know some of the user's multiple identities. | 11-25-2010 |
Bryan W. Clark, Westford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090210870 | SYSTEMS AND METHODS FOR GENERATING ORDERED DOWNLOAD SELECTIONS BASED ON USAGE INFORMATION - Embodiments relate to a platform for generating ordered download selections based on usage information. A download site can provide a selectable or searchable set of applications to download. The download site collects usage information from online desktops operating on a set of clients. The online desktop of each client samples the applications being used on the client at given intervals and reports the client's usage statistics to the download site. The download site aggregates the usage information received from participating clients and collectively orders applications for download, according to usage rank. A work processing application used by the most users in the last day or other period may be listed first, followed by the second-most used, and so forth. The sampling of actual application usage, instead of for instance download totals, allows the download site to provide downloads in an order most closely approximating users' actual usage behavior. | 08-20-2009 |
| 20090222735 | SYSTEMS AND METHODS FOR ENHANCING BROWSER HISTORY USING SYNDICATED DATA FEEDS - Embodiments relate to systems and methods for enhancing browsing history using syndicated data feeds. A browser contains a navigation manager that captures and tracks the URLs (universal resource locators) of the Web sites and subsections of sites that a user visits. The captured URL pathways are stored to a navigation record. In addition, the presence and identify of RSS feeds which the user has chosen to activate is also recorded. Upon return to the same Web site or other location, the navigation manager directs the user to the specific section of the Web site associated with the RSS feed, such as media lists, photography upload sections, or other portions of a Web site. | 09-03-2009 |
Bryan William Clark, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080250342 | SEARCHING DESKTOP OBJECTS BASED ON TIME COMPARISON - Embodiments of the present invention provide a desktop search tool that allows users to efficiently retrieve or locate a desired object on their computer. Users specify their search based on a time context In addition, the desktop search tool may provide its results in a temporal context to assist the user in browsing through the results. | 10-09-2008 |
Bryan William Clark, Westford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090144283 | SYSTEMS AND METHODS FOR GENERATING FILE USAGE INFORMATION - Embodiments relate to systems and methods for tracking local and remote file usage, and aggregating the resulting file usage statistics for presentation to a user. The operating system of a local computer can track and generate local file usage statistics, such as most recently used files and editing time. A Web application or service, such as an email or word processing application or service, can record the file usage data for a user's remote stored or served files. A file usage aggregator module, which can be located or resident in the operating system of the local computer or hosted at a Web site, can receive and combine the local and remote file usage statistics. The file usage aggregator module can generate a display of the aggregated file usage statistics, so that local and remote files are listed in a most-recently used order, on a combined basis. | 06-04-2009 |
| 20090222463 | SYSTEMS AND METHODS FOR A JOURNAL PAGE - An embodiment relates generally to a method of displaying information. The method includes monitoring any user activity within at least one application executing on a computer and detecting a completion of a user activity. The method also includes creating a link to the completed user activity and placing in the link in a time-ordered sequential basis in a journal section of a desktop of the computer. | 09-03-2009 |
| 20090222736 | SYSTEMS AND METHODS FOR A FILTER MODULE FOR A BROWSER HISTORY - An embodiment relates generally to a method of filtering for a browser. The method includes providing a browser with a browser history function, the browser history function configured to store each site web page visited and stored in time sequential order as a browser history. The method also includes providing a filter module for the browser; and applying the filter module to the browser history function to eliminate intermediary web pages from entering the browser history. | 09-03-2009 |
Christopher F. Clark, Hopkinton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100169401 | FILTER FOR NETWORK INTRUSION AND VIRUS DETECTION - Methods and apparatus to perform string matching for network packet inspection are disclosed. In some embodiments there is a set of string matching slice circuits, each slice circuit of the set being configured to perform string matching steps in parallel with other slice circuits. Each slice circuit may include an input window storing some number of bytes of data from an input data steam. The input window of data may be padded if necessary, and then multiplied by a polynomial modulo an irreducible Galois-field polynomial to generate a hash index. A storage location of a memory corresponding to the hash index may be accessed to generate a slice-hit signal of a set of H slice-hit signals. The slice-hit signal may be provided to an AND-OR logic array where the set of H slice-hit signals is logically combined into a match result. | 07-01-2010 |
Christopher F. Clark, Berlin, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100161536 | PATTERN MATCHING - A method and apparatus to perform pattern matching is provided. The apparatus includes a first storage to store data representing a first set of pattern components, and a second storage to store data representing a second set of pattern components each corresponding to one or more components of the first set of pattern components. A first pattern matcher is configured to detect in an input stream a first component of one or more patterns and to generate a signal indicative of the detection of the first component. A second pattern matcher is configured to receive the signal from the first pattern matcher and to detect if a second component of the one or more patterns of the set of patterns immediately follows the first component in the input stream. | 06-24-2010 |
Cynthia Monesa Clark, Concord, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100016336 | HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE - The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to compositions comprising said human protein tyrosine phosphatase beta (HPTP-β) inhibitors, and to methods for regulating angiogenesis. | 01-21-2010 |
| 20100069448 | HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE - The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to compositions comprising said human protein tyrosine phosphatase beta (HPTP-β) inhibitors, and to methods for regulating angiogenesis. | 03-18-2010 |
| 20110212951 | HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE - The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to compositions comprising said human protein tyrosine phosphatase beta (HPTP-β) inhibitors, and to methods for regulating angiogenesis. | 09-01-2011 |
Edward A. Clark, East Longmeadow, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100109584 | POSITION-SENSORLESS CONTROL SYSTEM AND METHOD OF OPERATION FOR A SYNCHRONOUS MOTOR - This invention provides an advanced position and velocity estimation scheme used in a position-sensorless control system for synchronous operation of an electric motor. The system includes an electric motor having a stator and a rotor; an inverter for powering the electric motor; and a controller for controlling the inverter. The controller utilizes a control system comprising a rotor angle and angular velocity estimation block; an estimated angle error detector block; a field-weakening block; and a torque-to-current converter block, all of which operate to generate control commands for operation of the motor. | 05-06-2010 |
| 20100237808 | EFFICIENT GENERATOR GRID CONNECTION SCHEME POWERING A LOCAL VARIABLE FREQUENCY MOTOR DRIVE - A system for using a generator to simultaneously power a variable frequency motor drive locally and provide clean power to a grid comprising an electric generator supplying alternating current to a power conversion system. The power conversion system includes a converter changing generator AC output to direct current (DC); a capacitor bank that filters the DC from the converter and outputs a DC bus power; a grid inverter capable of replicating grid power from the DC bus power; and an output filter for supplying power to the power grid. A variable frequency motor drive receives DC bus power from the power conversion system. The variable frequency motor drive may be operatively connected to the power conversion system, or integrated therein. | 09-23-2010 |
Edwin Clark, Ashland, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080286780 | Novel compositions and methods for the identification, assessment, prevention and therapy of human cancers - The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent. | 11-20-2008 |
Edwin A. Clark, Ashland, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090136961 | Novel compositions and methods for identification, assessment, prevention, and therapy of ovarian cancer - The present invention is directed to the identification of markers that can be used to determine whether ovarian cancer is sensitive or resistant to a therapeutic agent. In particular, the present invention is directed to the use of certain combinations of markers, wherein the expression of the markers correlates with sensitivity or resistance to a therapeutic agent. Thus, by examining the expression of the individual markers of a marker set, also referred to as the expression profile of the marker set, it is possible to determine whether a therapeutic agent, or combination of agents, will be most likely to reduce the growth rate of the ovarian cancer. | 05-28-2009 |
Edwin A. Clark, Hopkinton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110104664 | BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO MICORTUBULE-STABILIZING AGENTS - Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the microtubule-stabilizing agent is an epothilone or analog or derivative thereof, or ixabepilone. | 05-05-2011 |
Eliana Clark, Boylston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100048455 | Formulations For Therapeutic Administration Of Thyroid Stimulating Hormone (TSH) - This disclosure generally relates to novel formulations containing the active ingredient thyroid stimulating hormone (TSH) having modified pharmacokinetic profiles as compared to prior art formulations. | 02-25-2010 |
Eugene H. Clark, Belmont, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080270438 | MEDICAL LABORATORY REPORT MESSAGE GATEWAY - A gateway enables medical (including genetic and genomic) laboratories and health care providers (collectively “clients”) to communicate electronic messages with each other without developing and maintaining an interface for each peer. The gateway translates messages sent between the parties. The gateway receives messages from each sender in a form, and containing diagnostic codes, preferred by the sender. For each received message, the gateway ascertains an intended receiving client. Each client may specify one or more receivers (such as applications) that are to receive messages sent to the client, as well as a separate form, and optionally a set of codes, for each receiver. For each receiver, the gateway generates translated messages, according to the receiver's preferred form and/or codes. The gateway sends the translated messages to each of the designated receivers. The gateway may include a validation component to check incoming messages to ensure the messages include required information and that information values are valid or acceptable. The gateway may include an exception handler that notifies a sending client if a message from the client fails to be translated or sent correctly. The gateway may maintain a repository in which the gateway stores copies of messages the gateway sent or would have sent to clients. The gateway provides an interface, such as a secure web interface, to this repository. Clients may access messages or lists of messages, especially messages the clients are not otherwise capable of receiving, through this interface. The gateway may store copies of some of the data that flows through the gateway in a bioinformatics database, which may be automatically analyzed by the gateway or queried for research or patient care purposes. | 10-30-2008 |
| 20110119309 | Medical Laboratory Report Message Gateway - A gateway enables medical (including genetic and genomic) laboratories and health care providers (collectively “clients”) to communicate electronic messages with each other without developing and maintaining an interface for each peer. The gateway translates messages sent between the parties. The gateway receives messages from each sender in a form, and containing diagnostic codes, preferred by the sender. For each received message, the gateway ascertains an intended receiving client. Each client may specify one or more receivers (such as applications) that are to receive messages sent to the client, as well as a separate form, and optionally a set of codes, for each receiver. For each receiver, the gateway generates translated messages, according to the receiver's preferred form and/or codes. The gateway sends the translated messages to each of the designated receivers. The gateway may include a validation component to cheek incoming messages to ensure the messages include required information and that information values are valid or acceptable. The gateway may include an exception handler that notifies a sending client if a message from the client fails to be translated or sent correctly. The gateway may maintain a repository in which the gateway stores copies of messages the gateway sent or would have sent to clients. The gateway provides an interface, such as a secure web interface, to this repository. Clients may access messages or lists of messages, especially messages the clients are not otherwise capable of receiving, through this interface. The gateway may store copies of some of the data that flows through the gateway in a bioinformatics database, which may be automatically analyzed by the gateway or queried for research or patient care purposes. | 05-19-2011 |
Eugene Haskell Clark, Belmont, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080256030 | FINE-GRAINED AUTHORIZATION FRAMEWORK - A system and method for controlling access to an instance method on an instance-specific basis by intercepting an invocation of the instance method on an instance. | 10-16-2008 |
Gary Clark, Middleton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100054908 | TOOL MOUNTING DEVICE AND METHOD OF MOUNTING A TOOL - A device and method for temporarily mounting a tool to a member such as an upright board without the need for any prior attachments to the board. A member securing element attached to the tool is secured to the upright board when gripping surfaces engage opposite sides of the board as a result of rotation of the tool brought about by an off-set center of gravity. | 03-04-2010 |
George H. Clark, Woburn, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090246342 | METHOD FOR PROCESSING FLUID DAIRY, FRUIT OR VEGETABLE JUICES AND BEVERAGE CONCENTRATES FORMULATED FOR BEVERAGE PRODUCTS INTENDED FOR HUMAN CONSUMPTION TO PROTECT AGAINST DELIBERATE CONTAMINATION WITH PATHOGENIC AGROTERRORISM AGENTS - A method for purifying fluids without compromising the components of the fluid is disclosed. Fluid dairy, fruit, vegetable and/or beverage concentrates are processed using pasteurization and filtration steps selectively applied to separate phase-separated components of the fluid to eliminate contaminants including agro- and biological terrorism contaminants such as bacteria and viruses. | 10-01-2009 |
| 20110244076 | CARBONATED DAIRY NUTRIENT BEVERAGE AND METHOD OF MAKING A CARBONATED DAIRY NUTRIENT BEVERAGE TO SUPPLY THE SAME NUTRITION OF SKIM MILK IN THE HUMAN DIET - Carbonated dairy nutrient beverage solutions that supply essential nutrients in the human diet are disclosed. The solutions may contain per 8 oz., calcium, magnesium and potassium ions in the form of salts, vitamins A, D, C, and optionally lutein, zeaxanthin and folic acid in specified amounts to provide dietary supplementation. Sweeteners, stabilizers and flavors can also be added to enhance flavor, sensory appeal, mouth-feel, ingredient solubilization and product appearance. A method of making the beverages is also described. A method of using Carbon Dioxide and Nitrogen to reduce bacterial counts and reduce degradation of essential nutrients in dairy beverages with or without pasteurization is also disclosed. | 10-06-2011 |
Heather Clark, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100041067 | Reaction Sensing in Living Cells - Chemical reactions occurring within a living cell are measured in a manner that does not affect the viability of the cell or the reaction under study. In one embodiment, one or more sensors are introduced into the cell and/or covalently associated with the exterior cell membrane. The sensor(s) emit an observable signal indicating a value of a parameter associated with the chemical reaction, e.g., the concentration of a reaction product. Because cell viability is not compromised, the cell may be stimulated (e.g., by subjection to an agonist or antagonist, a pathogen, a pharmaceutical compound, or a potential toxin) so as to affect the reaction under study. | 02-18-2010 |
| 20100227334 | Reaction sensing in living cells - Chemical reactions occurring within a living cell are measured in a manner that does not affect the viability of the cell or the reaction under study. In one embodiment, one or more sensors are introduced into the cell and/or covalently associated with the exterior cell membrane. The sensor(s) emit an observable signal indicating a value of a parameter associated with the chemical reaction, e.g., the concentration of a reaction product. Because cell viability is not compromised, the cell may be stimulated (e.g., by subjection to an agonist or antagonist, a pathogen, a pharmaceutical compound, or a potential toxin) so as to affect the reaction under study. | 09-09-2010 |
Heather A. Clark, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090142274 | Intracellular nanosensors and methods for their introduction into cells - The invention provides ion-selective sensors capable of selectively measuring ions, e.g., Na | 06-04-2009 |
| 20090155183 | Sensors for the detection of diols and carbohydrates - The systems and methods disclosed herein include a sensor particle for detecting the presence of a chelatable analyte, such as glucose, wherein the sensor comprises a chromophore and a fluorescent component, such as a quantum dot. The sensor particle further comprises moieties that bind both a clelatable analyte and chromophore reversibly and competitively. In the presence of the chelatable analyte, the moieties bind the analyte, and release the chromophore. The chromophore absorbs photons of one wavelength in a free state but of a different wavelength in a bound state, and is selected to operate with the fluorescent component such that the chromophore absorbs emissions of the fluorescent substance in only one of the bound and unbound states. In certain aspects, the invention comprises methods for detecting the presence of a chelatable analyte in a medium such as water, blood plasma and urine, using the sensor particles of the invention. | 06-18-2009 |
| 20100105075 | SYSTEMS AND METHODS OF VOLTAGE-GATED ION CHANNEL ASSAYS - Systems and methods are provided for optically measuring ion concentrations in biological samples. The systems and methods employ polymer-based optical ion sensors that include ion-selective ionophores and a pH sensitive chromionophore. Electrodes are providing for electrically stimulating the biological samples. | 04-29-2010 |
| 20100221188 | Coated sensors and methods related thereto - The invention provides coated sensors for detecting the presence of analytes. The sensor comprises one or more fluorescent sources, such as one or more quantum dots or one or more fluorescent dyes, a polymeric matrix, a surface coating, and one or more analyte sensing components. The surface coating may be a conformal polymeric film, permeable to the analyte, which may be deposited via a solventless process such as initiated chemical vapor deposition or photoinitiated chemical vapor deposition. The surface coating may increase the biocompatibility of the sensor, reduce nonspecific protein adsorption, and/or sequester functional sensor components within the sensor. The invention also provides methods for detecting the presence of an analyte with coated sensors of the invention. | 09-02-2010 |
| 20110189770 | Endosome-Disrupting Compositions and Conjugates - The present invention is directed to an endosome-disrupting conjugate, and methods of delivery of said conjugate to cells. The conjugates of the invention comprise a payload and an endosome-disrupting component of which the latter comprises a plurality of moieties that react under acidic conditions, e.g., within an endosome, to release gaseous endosome-disrupting molecules, e.g., CO | 08-04-2011 |
Ian Ross Clark, Watertown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090198419 | SUSPENDED SEAT AUTOLOCKING - An apparatus meant to be incorporated into a suspension system of a suspended seat of a vehicle acts to slow movement of the seat or to stop and hold the seat against movement along at least one axis in response to an indication of the vehicle traveling at a relatively slow speed or an indication of the vehicle's speed of travel being decreased. The indication may be received from various sources including manually-operated controls, sensors and/or controller devices within the vehicle relaying their status. | 08-06-2009 |
| 20090218867 | Plant Suspension System with Weight Compensation - An apparatus meant to be incorporated into a suspension system suspending a plant (i.e., an overall plant that includes a physical plant and possibly a load that the physical plant supports) of a vehicle acts to alter the spring constant of at least one spring of the suspension system in response to changes in the weight of the plant so that a resonant frequency of the at least one spring isolating the plant from a jolt encountered by the vehicle during travel remains substantially unchanged despite changes to the weight of the plant. | 09-03-2009 |
| 20110181069 | Active Suspension Seat Floor Plate - An active suspension seat is mounted to a floor of a vehicle with a floor plate having a lower portion through which is formed a first plurality of apertures positioned about the lower portion to correspond to the manner in which mounting features are positioned about the floor of the vehicle, and having an upper portion through which is formed a second plurality of apertures positioned about the upper portion to correspond to the manner in which apertures are positioned about a lower frame of the active suspension seat, and to enable the active suspension seat to be coupled to the floor plate by inserting fasteners through the second plurality of apertures from locations external to the lower frame. | 07-28-2011 |
James D. Clark, Acton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100022536 | Inhibitors of Cytosolic Phospholipase A2 - This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A | 01-28-2010 |
| 20100029645 | Inhibitors of Cytosolic Phospholipase A2 - This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A | 02-04-2010 |
| 20100035957 | Methods for the Use of Inhibitors of Cytosolic Phospholipase A2 - This invention provides methods for the use of substituted indole compounds of the general formula: | 02-11-2010 |
Mary Ann Clark, Woburn, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090246342 | METHOD FOR PROCESSING FLUID DAIRY, FRUIT OR VEGETABLE JUICES AND BEVERAGE CONCENTRATES FORMULATED FOR BEVERAGE PRODUCTS INTENDED FOR HUMAN CONSUMPTION TO PROTECT AGAINST DELIBERATE CONTAMINATION WITH PATHOGENIC AGROTERRORISM AGENTS - A method for purifying fluids without compromising the components of the fluid is disclosed. Fluid dairy, fruit, vegetable and/or beverage concentrates are processed using pasteurization and filtration steps selectively applied to separate phase-separated components of the fluid to eliminate contaminants including agro- and biological terrorism contaminants such as bacteria and viruses. | 10-01-2009 |
| 20110244076 | CARBONATED DAIRY NUTRIENT BEVERAGE AND METHOD OF MAKING A CARBONATED DAIRY NUTRIENT BEVERAGE TO SUPPLY THE SAME NUTRITION OF SKIM MILK IN THE HUMAN DIET - Carbonated dairy nutrient beverage solutions that supply essential nutrients in the human diet are disclosed. The solutions may contain per 8 oz., calcium, magnesium and potassium ions in the form of salts, vitamins A, D, C, and optionally lutein, zeaxanthin and folic acid in specified amounts to provide dietary supplementation. Sweeteners, stabilizers and flavors can also be added to enhance flavor, sensory appeal, mouth-feel, ingredient solubilization and product appearance. A method of making the beverages is also described. A method of using Carbon Dioxide and Nitrogen to reduce bacterial counts and reduce degradation of essential nutrients in dairy beverages with or without pasteurization is also disclosed. | 10-06-2011 |
Michael P. Clark, Concord, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100029634 | Chemokine Receptor Modulators - The invention provides compounds of Formula (I) | 02-04-2010 |
Paul Clark, Wellesley, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100322899 | METHODS OF IMPROVING CENTRAL NERVOUS SYSTEM FUNCTIONING - Methods of causing an improvement in central nervous system function are provided. The methods include administering an aliquot of stem cells to the patient, the cells being derived from blood, e.g., umbilical cord blood. In some cases a growth factor is administered with the cells. | 12-23-2010 |
Paul T. Clark, Wellesley, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090181087 | Use of human cord blood-derived pluripotent cells for the treatment of disease - The present invention features methods of organ tissue regeneration using pluripotent cells derived from umbilical cord blood, compositions of these pluripotent cells, methods for further transforming these cells, and uses for these transformed cells. | 07-16-2009 |
Peter Clark, Boxborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110181797 | WAFER-LEVEL FABRICATION OF LIQUID CRYSTAL OPTOELECTRONIC DEVICES - Liquid crystal optoelectronic devices are produced by fabricating a wafer-level component structure and affixing a plurality of discrete components to a surface structure prior to singulating the individual devices therefrom. After singulation, the individual devices include a portion of the wafer-level fabricated structure and at least of the discrete components. The wafer-level structure may include a liquid crystal and controlling electrodes, and the discrete components may include fixed lenses or image sensors. The discrete components may be located on either or both of two sides of the wafer-level structure. Multiple liquid crystal layers may be used to reduce nonuniformities in the interaction with light from different angles, and to control light of different polarizations. The liquid crystal devices may function as optoelectronic devices such as tunable lenses, shutters or diaphragms. | 07-28-2011 |
Peter P. Clark, Boxborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100039532 | In Flight Autofocus System And Method - A camera module and method for focusing a tunable lens configured to continuously vary its optical power in response to a drive signal. A drive circuit generates the drive signal so that the tunable lens performs a continuous scan of its optical power. An image sensor is configured to acquire light images passing through the tunable lens, and to convert the light images to image signals during the continuous scan. A processor is configured to generate focus scores of the acquired light images using the image signals during the continuous scan. The processor is configured to determine from the focus scores a peak focus score achieved or achievable, and to instruct the drive circuit to adjust the drive signal so that the tunable lens settles at a value of the optical power that corresponds to the peak focus score. | 02-18-2010 |
| 20110090415 | TUNABLE LIQUID CRYSTAL OPTICAL DEVICE - A liquid crystal optical device has a layered structure with split liquid crystal layers having alignment surfaces that define in a liquid crystal material pre-tilt angles of opposite signs. Four liquid crystal layers can provide two directions of linear polarization. In the case of a lens, the device can be a gradient index lens, and the alignment surfaces can have a spatially uniform pre-tilt. | 04-21-2011 |
Rachael A. Clark, Belmont, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110274649 | T-CELL VACCINATION WITH VIRAL VECTORS VIA MECHANICAL EPIDERMAL DISRUPTION - Attenuated, replication-deficient viruses such as vaccinia viruses are used to deliver an exogenous viral, bacterial, parasitic or tumor antigen to an epidermal tissue such as the skin, lungs or gastrointestinal tract, which has been mechanically disrupted, in an amount effective to elicit or stimulate a cell mediated immune response. The epidermal tissue may be mechanically disrupted by a device such as a scarification needle or an abrader device. The epidermis may be mechanically disrupted prior to, at the same time, or immediately after the administration of the vaccine. The vaccine can be used to induce immunity against a pathogen, such as a virus, bacteria, or parasite, or against a cancer in a subject that has or is at risk of developing cancer. In some embodiments a co-stimulatory molecule, a growth factor, an adjuvant and/or a cytokine is administered before, with or after the viral vaccine. In some embodiments, the co-stimulatory molecule is co-expressed with the antigen by the virus. | 11-10-2011 |
Roger Clark, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110269714 | Polycyclic Tetracycline Compounds - The present invention is directed to a compound represented by Structural Formula (I): | 11-03-2011 |
Roger B. Clark, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100105671 | C7-fluoro substituted tetracycline compounds - The present invention is directed to a compound represented by Structural Formula (A): | 04-29-2010 |
| 20110118302 | PREPARATION AND USE OF BIPHENYL-4-YL-CARBONYLAMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY - This invention relates to certain biphenyl-4-yl carbonylamino acid compounds, compositions, and methods for treating or preventing obesity and related diseases. | 05-19-2011 |
Sarah L. Clark, Somerville, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100116422 | METHOD OF FORMING LARGE DIAMETER THERMOPLASTIC SEAL - A method of forming a seal ring includes heating an extruded rod to a temperature above a glass transition temperature. The extruded rod has first and second ends. The method further includes bending the extruded rod into a circular structure while the temperature is above the glass transition temperature, joining the first and second ends of the extruded rod to form a semi-finished ring, and annealing the semi-finished ring. | 05-13-2010 |
| 20100117310 | LARGE DIAMETER THERMOPLASTIC SEAL - A seal ring includes a weld and a thermoplastic material. The thermoplastic material has a weld elongation-at-break of at least 3%. The thermoplastic material can have a glass transition temperature of at least 100° C. The thermoplastic material with the weld can have a weld elongation-at-break of at least 3%. The seal ring can have a circumference of at least 0.62 meters. The seal ring can have a coefficient of friction of not greater than 0.45. | 05-13-2010 |
Scott Clark, Pittsfield, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090068255 | USE OF MATRIX METALLOPROTEINASE INHIBITORS IN SKIN CARE - The application of matrix metalloproteinase (MMP) inhibitors to the skin inhibits the degradation of proteins found in the skin including collagen, elastin, and other basement membrane and extracellular matrix protein. MMP inhibitors may be used in both cosmetic compositions and pharmaceutical compositions for application to skin. MMP inhibitors are formulated with a cosmetically suitable vehicle or pharmaceutically acceptable excipient for application to the skin as creams, lotions, ointments, solutions, face masks, etc. As cosmetics, the inventive MMP inhibitor compositions are applied to the skin to prevent or reduce the appearance of wrinkles, pigmentation changes, loss of elasticity, or other effects associated with aging or sun damage. As pharmaceuticals, the inventive MMP inhibitor compositions may also be applied to the skin to treat or prevent a skin disease (e.g., proliferative disease, inflammatory disease). | 03-12-2009 |
Shelby Clark, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110213629 | CAR SHARING - Among other things, through an online site, owners of assets and borrowers of assets can arrange sharing transactions with respect to the assets. Online confirmation is provided to the owners and the borrowers that the arranged sharing transactions have been covered by insurance. Completion of the arranged sharing transactions is managed using information from electronic devices associated with the assets. | 09-01-2011 |
Tracy M. Clark, Bedford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100186618 | TRANSPORT SYSTEM POWERED BY SHORT BLOCK LINEAR SYNCHRONOUS MOTORS - Aspects of the invention provide a transport system powered by short block Linear Synchronous Motors (LSMs). The use of short blocks allows vehicles to move under precise control even when they are in close proximity to each other. The design allows the vehicles to be propelled and guided while negotiating sharp turns and negotiating merge and diverge switches. A coreless LSM can be used to create propulsive force without attractive force so as to allow a relatively high drag vehicle suspension, such as a vehicle sliding on a smooth surface. | 07-29-2010 |
| 20100236445 | TRANSPORT SYSTEM POWERED BY SHORT BLOCK LINEAR SYNCHRONOUS MOTORS AND SWITCHING MECHANISM - Aspects of the invention provide a transport system powered by short block Linear Synchronous Motors (LSMs). The use of short blocks allows vehicles to move under precise control even when they are in close proximity to each other. The design allows the vehicles to be propelled and guided while negotiating sharp turns and negotiating merge and diverge switches. A coreless LSM can be used to create propulsive force without attractive force so as to allow a relatively high drag vehicle suspension, such as a vehicle sliding on a smooth surface. Further aspects of the invention provide a switching member that is selectively moveable relative to a guideway in order to change a magnetic force acting on the vehicle transverse to a direction of motion of the vehicle. | 09-23-2010 |
William A. Clark, Winchester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110041609 | Offset Detection and Compensation for Micromachined Inertial Sensors - Error sources relating to the drive signal applied to the resonator of an inertial sensor, such as in-phase offset errors relating to the drive signal and/or electronic pass-through of the drive signal to accelerometer sense electronics, are detected by modulating the drive signal and sensing accelerometer signals that are induced by the modulated drive signal. Error sources related to aerodynamics of an inertial sensor resonator are detected by modulating the distance between the resonator and the underlying substrate and sensing accelerometer signals that are induced by such modulation. Compensating signals may be provided to substantially cancel errors caused by such error sources. | 02-24-2011 |
| 20110115498 | Detection and Mitigation of Particle Contaminants in MEMS Devices - Detecting and/or mitigating the presence of particle contaminants in a MEMS device involves including MEMS structures that in normal operation are robust against the presence of particles but which can be made sensitive to that presence during a test mode prior to use, e.g., by switching the impedance of sensitive structures between an exceptionally sensitive condition during test and a normal sensitivity during operation; surrounding sensitive nodes with guard elements that are at the same potential as those nodes during operation, thereby offering protection against bridging particles, but are at a very different potential during test and reveal the particles by their resulting leakage currents; extending the sensitive nodes to interdigitate with or otherwise extend adjacent to the guard structures, which neither contribute to nor detract from the device operation but cover otherwise open areas with detection means during test; and/or converting benign areas in which particles might become trapped undetectably by electric fields during test to field-free regions by extending otherwise non-functional conductive layers so that the particles can then be moved into detection locations by providing some mechanical disturbance. | 05-19-2011 |
William Albert Clark, Winchester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100058861 | Piezoelectric Transducers and Inertial Sensors using Piezoelectric Transducers - Transducers comprising a frame structure made of piezoelectric material convert energy, through piezoelectric effect, between electrostatic energy associated with voltage differential between the electrodes sandwiching the frame structure and mechanical energy associated with deformation of the frame structure. Inertial sensors such as gyroscopes and accelerators, including inertial sensors comprising ring resonators, utilize said transducers both to generate oscillations of their resonators and to sense the changes in such oscillations produced, in the sensors' frame of reference, by Coriolis forces appearing due to the movement of the sensors. | 03-11-2010 |
William R. Clark, Southbridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110016093 | OPERATING SYSTEM RESTORATION USING REMOTE BACKUP SYSTEM AND LOCAL SYSTEM RESTORE FUNCTION - A computer performs a backup operation copying user files and system files to a separate backup system for persistent storage. The system files include restore-point files from a system area of a source system storage device, the restore-point files created by the computer's operating system and being copies of constituent files of the operating system at a point in time. In a subsequent restoration operation, the computer is operated in a limited-functionality recovery mode including (a) executing a recovery program from a recovery storage device to restore the restore-point files from the recovery storage device to a system area of a target system storage device, and (b) executing a system restore function with selected restored restore-point files to restore the operating system. Subsequently, the computer is operated in a full-functionality operating mode including (a) executing the restored operating system, and (b) executing the recovery program to restore the user files from the recovery storage device to the computer. | 01-20-2011 |
William T. Clark, Lancaster, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110155419 | Enhanced Data cable with cross-twist cabled core profile - A cable exhibiting reduced crosstalk between transmission media includes a core having a profile with a shape which defines spaces or channels to maintain a spacing between transmission media in a finished cable. The core is formed of a conductive material to further reduce crosstalk. A method of producing a cable introduces a core as described above into the cable assembly and imparts a cable closing twist to the assembly. | 06-30-2011 |
William T. Clark, Leominster, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080251276 | DATA CABLE WITH CROSS-TWIST CABLED CORE PROFILE - Cables including a plurality of twisted pairs of insulated conductors and a jacket surrounding the plurality of twisted pairs of insulated conductors, the jacket including a plurality of protrusions extending away from an inner circumferential surface of the jacket toward a center of the cable. The plurality of protrusions are configured so as to hold the plurality of twisted pairs away from the inner circumferential surface of the jacket, and may provide an air gap between the plurality of twisted pairs of insulated conductors and the inner circumferential surface of the jacket, thereby reducing susceptibility of the plurality of twisted pairs to alien near end crosstalk. | 10-16-2008 |
| 20090014202 | DATA CABLE WITH CROSS-TWIST CABLED CORE PROFILE - Cables including a plurality of twisted pairs of insulated conductors, a separator disposed among the plurality of twisted pairs so as to physically separate a first twisted pair from a second twisted pair, and a jacket surrounding the plurality of twisted pairs and the separator. The jacket may include a plurality of protrusions extending away from an inner circumferential surface of the jacket toward a center of the cable. The plurality of protrusions are configured so as to hold the plurality of twisted pairs away from the inner circumferential surface of the jacket, and may provide an air gap between the plurality of twisted pairs of insulated conductors and the inner circumferential surface of the jacket, thereby reducing susceptibility of the plurality of twisted pairs to alien near end crosstalk. In one example, a boundary of the air gap adjacent the inner circumferential surface of the jacket is arc shaped. | 01-15-2009 |
| 20090071690 | ELECTRICAL CABLE COMPRISING GEOMETRICALLY OPTIMIZED CONDUCTORS - A number of examples of insulated conductors having geometrically optimized shapes and form factors, that may be used in twisted-pair cables and other types of communication cable to enhance the performance of, and/or reduce the cost of manufacturing such cables. | 03-19-2009 |
| 20090071691 | TWISTED PAIR CABLE HAVING IMPROVED CROSSTALK ISOLATION - A cable that provides reduced alien crosstalk between similar twisted pairs in cables that are in close proximity to one another and/or crosstalk between twisted pairs of the cable. In one example, a cable includes first, second and third twisted pairs, a shaped filler including a body portion and a plurality of tines extending outward from the body portion, the plurality of tines defining a plurality of channels in which the twisted pairs are individually disposed, and an outer jacket surrounding the twisted pairs and the shaped filler, wherein the shaped filler is constructed such that the body portion provides a first spacing between the first twisted pair and the second twisted pair, and one of the plurality of tines provides a second spacing between the second twisted pair and the third twisted pair, with the filler configured such that the second spacing is substantially smaller than the first spacing. | 03-19-2009 |
| 20090120664 | DATA CABLE WITH CROSS-TWIST CABLED CORE PROFILE - Cables including a plurality of twisted pairs of insulated conductors, a separator disposed among the plurality of twisted pairs so as to physically separate a first twisted pair from a second twisted pair, and a jacket surrounding the plurality of twisted pairs and the separator. The jacket may include a plurality of protrusions extending away from an inner circumferential surface of the jacket toward a center of the cable. The plurality of protrusions are configured so as to hold the plurality of twisted pairs away from the inner circumferential surface of the jacket, and may provide an air gap between the plurality of twisted pairs of insulated conductors and the inner circumferential surface of the jacket. In one example, a boundary of the air gap adjacent the inner circumferential surface of the jacket is arc shaped. | 05-14-2009 |
| 20100147550 | DATA CABLE WITH STRIATED JACKET - Cables including a plurality of twisted pairs of insulated conductors, a separator disposed among the plurality of twisted pairs so as to physically separate a first twisted pair from a second twisted pair, and a jacket surrounding the plurality of twisted pairs and the separator. The jacket may include a plurality of protrusions extending away from an inner circumferential surface of the jacket toward a center of the cable. The plurality of protrusions are configured so as to hold the plurality of twisted pairs away from the inner circumferential surface of the jacket, and may provide an air gap between the plurality of twisted pairs of insulated conductors and the inner circumferential surface of the jacket. | 06-17-2010 |