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Clapham
Bruce Clapham, Lindenhurst, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20090253670 | AMIDE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF - The invention relates to novel amide derivatives that are positive allosteric modulators of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions. | 10-08-2009 |
| 20100286109 | AMIDE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF - The invention relates to novel amide derivatives that are positive allosteric modulators of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions. | 11-11-2010 |
David Clapham, Wellesley, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090104604 | SPERM-SPECIFIC CATION CHANNEL, CATSPER2, AND USES THEREFOR - Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders. | 04-23-2009 |
David Clapham, Hertfordshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20110136798 | Crystalline Forms Of A Pyridine Derivative - The invention relates to 4-methylbenzenesulfonate salt of the compound of formula (I) | 06-09-2011 |
David E. Clapham, Wellesley, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080311578 | System for screening eukaryotic membrane proteins - The present invention provides methods and compositions for expressing eukaryotic membrane proteins. | 12-18-2008 |
| 20090249499 | SPERM-SPECIFIC CATION CHANNEL, CATSPER4, AND USES THEREFOR - Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper4 activity, methods of genotyping subjects with respect to CatSper4, and methods of diagnosing and treating CatSper4-mediated disorders, including infertility. Related business methods are also disclosed. | 10-01-2009 |
Neil Clapham, Slough GB
| Patent application number | Description | Published |
|---|---|---|
| 20100097402 | MAP DATA COMPARISON DEVICE - A map data comparison device by which a plurality of map data is presented including: a first retrieval member which retrieves a first map data; a second retrieval member which retrieves a second map data; a display member which displays the first map data and the second map data in the vicinity of each other; an operation member by which a first display status of either of the first map data or the second map data is operated; and a follow-processing member which changes a second display status of the other one of the first map data or the second map data so as to follow the operation of the operation member. | 04-22-2010 |
Paul Clapham, Paxton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100249022 | STRATEGY FOR CLONING AND EXPRESSING THE EXTRACELLULAR DOMAINS OF RECEPTORS AS SOLUBLE PROTEINS - The present invention relates generally to soluble G protein-coupled receptor constructs. More specifically, the invention relates to soluble chemokine receptors, and soluble HIV co-receptors in particular. The invention is generally useful for designing and constructing soluble GPCR, which may be used to identify binding molecules. The invention also relates to methods of treating and/or preventing a disease or disorder associated with impaired function of such a receptor. The invention thus provides compositions and methods for therapeutic applications, such as vaccine. | 09-30-2010 |