Clairmont
Bernard Clairmont, Cheshire, MA US
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20110024183 | COAXIAL-TYPE CABLE FOR OVERHEAD TRANSMISSION - This invention relates to an overhead coaxial-type transmission system. The system includes a coaxial-type conductor, a support structure adapted to support the coaxial-type conductor at a pre-determined elevation above the ground, and a conductor support extending downwardly from the horizontal support such that the coaxial-type conductor is secured thereto. The support structure includes a vertical support secured in the ground and a horizontal support secured to and extending outwardly from the vertical support. | 02-03-2011 |
Caroline A. Clairmont, Cheshire, CT US
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20090169517 | Compositions and Methods for Tumor-Targeted Delivery of Effector Molecules - The present application discloses the preparation and use of attenuated tumor-targeted bacteria vectors for the delivery of one or more primary effector molecule(s) to the site of a solid tumor. The primary effector molecule(s) of the invention is used in the methods of the invention to treat a solid tumor cancer such as a carcinoma, melanoma, lymphoma, or sarcoma. The invention relates to the surprising discovery that effector molecules, which may be toxic when administered systemically to a host, can be delivered locally to tumors by attenuated tumor-targeted bacteria with reduced toxicity to the host. The application also discloses to the delivery of one or more optional effector molecule(s) (termed secondary effector molecules) which may be delivered by the attenuated tumor-targeted bacteria in conjunction with the primary effector molecule(s). | 07-02-2009 |
Curtis G. Clairmont, Waterloo CA
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20150038273 | HOCKEY STICK WITH PLASTIC WEAR STRIP - The hockey stick has a plastic wear strip along the bottom edge of the blade of the stick. Preferably the wear strip is of polyurethane having a flexural modulus in the range of 300 to 550 MPa at room temperature and 1200 to 1400 MPa at −30 degrees Celsius. In a goaltender's stick having a foam core, the wear strip is inserted in a mold and integrally formed with the core of the stick. The wear strip preferably is manufactured via a RIM process, then the core of the stick is molded with the wear strip and stick shaft in position, and then conventional finishing steps are applied, with fiberglass overlays for example. | 02-05-2015 |
Fred H. Clairmont, Plano, TX US
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20150352786 | SELECTIVE COMPOSITE MANUFACTURING FOR COMPONENTS HAVING MULTIPLE MATERIAL PROPERTIES - A method of forming a component having multiple material properties includes forming, by additive manufacturing, a particle containment structure on a base layer; filling the particle containment structure with a first layer of particles, the layer of particles being contained by the particle containment structure; curing the first layer of particles; repeating the forming the particle containment structure, filling the particle containment structure with one or more additional layers of particles and curing the one or more additional layers of particles until a desired component dimension is achieved; forming, by additive manufacturing, a cover to encapsulate any exposed particles; and fully curing the particle containment structure, particles and cover. | 12-10-2015 |
Kevin Clairmont, Cambridge, MA US
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20120028969 | BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS AND USES THEREOF - The present invention provides compounds of formula (I); | 02-02-2012 |
Kevin Clairmont, Cheshire, CT US
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20090143283 | Pituitary Adenylate Cyclase Activating Peptide (PACAP) Receptor (VPAC2) Agonists and Their Pharmacological Methods of Use - This invention provides novel peptides that function in vivo as agonists of the VPAC2 receptor. These insulin secretagogue polypeptides are shown to lower blood glucose in vivo more than controls upon glucose challenge. The polypeptides of this invention are also stable in formulation and have long half-lives. The peptides of the present invention provide a new therapy for patients with decreased endogenous insulin secretion, in particular type 2 diabetics. In particular, the invention is a polypeptide selected from a specific group of VPAC2-related polypeptides, or functional equivalents thereof. The invention is also directed to a method of treating a metabolic disease in a mammal comprising administering a therapeutically effective amount of the insulin secretagogue peptides to said mammal. Also disclosed are methods of making the peptides, both recombinant and synthetic. | 06-04-2009 |
20090280106 | Pituitary adenylate cyclase acivating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use - This invention provides peptides with novel modifications that provide suitable derivatization sites to improve the pharmacokinetic properties of the peptides. These modified peptides function in vivo as agonists of the VPAC2 receptor. The peptides of the present invention provide a new therapy for patients with decreased endogenous insulin secretion, for example, type 2 diabetics. | 11-12-2009 |
Kevin Clairmont, Acton, MA US
Patent application number | Description | Published |
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20140171363 | BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS AND USES THEREOF - The present invention provides compounds of formula (I); | 06-19-2014 |