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Clairmont
Bernard Clairmont, Cheshire, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110024183 | COAXIAL-TYPE CABLE FOR OVERHEAD TRANSMISSION - This invention relates to an overhead coaxial-type transmission system. The system includes a coaxial-type conductor, a support structure adapted to support the coaxial-type conductor at a pre-determined elevation above the ground, and a conductor support extending downwardly from the horizontal support such that the coaxial-type conductor is secured thereto. The support structure includes a vertical support secured in the ground and a horizontal support secured to and extending outwardly from the vertical support. | 02-03-2011 |
Caroline A. Clairmont, Cheshire, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20090169517 | Compositions and Methods for Tumor-Targeted Delivery of Effector Molecules - The present application discloses the preparation and use of attenuated tumor-targeted bacteria vectors for the delivery of one or more primary effector molecule(s) to the site of a solid tumor. The primary effector molecule(s) of the invention is used in the methods of the invention to treat a solid tumor cancer such as a carcinoma, melanoma, lymphoma, or sarcoma. The invention relates to the surprising discovery that effector molecules, which may be toxic when administered systemically to a host, can be delivered locally to tumors by attenuated tumor-targeted bacteria with reduced toxicity to the host. The application also discloses to the delivery of one or more optional effector molecule(s) (termed secondary effector molecules) which may be delivered by the attenuated tumor-targeted bacteria in conjunction with the primary effector molecule(s). | 07-02-2009 |
Kevin Clairmont, Cheshire, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20090143283 | Pituitary Adenylate Cyclase Activating Peptide (PACAP) Receptor (VPAC2) Agonists and Their Pharmacological Methods of Use - This invention provides novel peptides that function in vivo as agonists of the VPAC2 receptor. These insulin secretagogue polypeptides are shown to lower blood glucose in vivo more than controls upon glucose challenge. The polypeptides of this invention are also stable in formulation and have long half-lives. The peptides of the present invention provide a new therapy for patients with decreased endogenous insulin secretion, in particular type 2 diabetics. In particular, the invention is a polypeptide selected from a specific group of VPAC2-related polypeptides, or functional equivalents thereof. The invention is also directed to a method of treating a metabolic disease in a mammal comprising administering a therapeutically effective amount of the insulin secretagogue peptides to said mammal. Also disclosed are methods of making the peptides, both recombinant and synthetic. | 06-04-2009 |
| 20090280106 | Pituitary adenylate cyclase acivating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use - This invention provides peptides with novel modifications that provide suitable derivatization sites to improve the pharmacokinetic properties of the peptides. These modified peptides function in vivo as agonists of the VPAC2 receptor. The peptides of the present invention provide a new therapy for patients with decreased endogenous insulin secretion, for example, type 2 diabetics. | 11-12-2009 |
Kevin Clairmont, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120028969 | BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS AND USES THEREOF - The present invention provides compounds of formula (I); | 02-02-2012 |