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Clague
David S. Clague, Livermore, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110104763 | Sequential Addition of Short DNA Oligos In DNA-Polymerase-Based Synthesis Reactions - A method of fabricating a DNA molecule of user-defined sequence. The method comprises the steps of preselecting a multiplicity of DNA sequence segments that will comprise the DNA molecule of user-defined sequence, separating the DNA sequence segments temporally, and combining the multiplicity of DNA sequence segments with at least one polymerase enzyme wherein the multiplicity of DNA sequence segments join to produce the DNA molecule of user-defined sequence. Sequence segments may be of length n, where n is an even or odd integer. In one embodiment the length of desired hybridizing overlap is specified by the user and the sequences and the protocol for combining them are guided by computational (bioinformatics) predictions. In one embodiment sequence segments are combined from multiple reading frames to span the same region of a sequence, so that multiple desired hybridizations may occur with different overlap lengths. In one embodiment starting sequence fragments are of different lengths, n, n+1, n+2, etc. | 05-05-2011 |
David S. Clague, San Luis Obispo, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090194420 | Systems and Methods for Separating Particles and/or Substances from a Sample Fluid - Systems and methods for separating particles and/or toxins from a sample fluid. A method according to one embodiment comprises simultaneously passing a sample fluid and a buffer fluid through a chamber such that a fluidic interface is formed between the sample fluid and the buffer fluid as the fluids pass through the chambers the sample fluid having particles of interest therein; applying a force to the fluids for urging the particles of interest to pass through the interface into the buffer fluid; and substantially separating the buffer fluid from the sample fluid. | 08-06-2009 |
Robert Clague, Sugar Land, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20100186653 | Extended-deck jack-up - An offshore structure has stabilizing deck extension members formed as watertight bodies and extending along a port peripheral wall and starboard peripheral wall of the hull. The stabilizing members add stability without substantially increasing weight of the structure. Each of the stabilizing members has an inverted triangle cross-sectional configuration wherein the water plane area of the stabilizing members increases from a lower portion toward an upper portion. | 07-29-2010 |