| Patent application number | Description | Published |
|---|
| 20080286238 | Recombinant Adenovirus Expressing A Gene Encoding Streptolysin O Proetin and Anti-Cancer Composition Comprising Same - A recombinant adenovirus expressing a streptolysin O (SLO) protein comprising a SLO gene; a promoter operably linked to the SLO gene; a polyadenylation signal sequence; and an adenovirus genome lacking E1 gene effectively kills a cancer cell by expressing a pore-forming toxin, SLO protein, and, therefore, is useful for the suicide cancer gene therapy. | 11-20-2008 |
| 20090189652 | Frequency Multiplier - A frequency multiplier is disclosed. A plurality of voltage regulators each regulate levels of voltages at first and second common nodes in response to a corresponding one of input signals from a voltage-controlled delay line. An input buffer charges the first node or discharges the second node in response to a feedback signal. An output buffer regulates a level of a voltage at an output node and outputs a frequency-multiplied clock signal and the feedback signal corresponding to the voltage level of the output node. A discharge circuit discharges the first node before a rising edge of each of the input signals from the voltage-controlled delay line is inputted. A charge circuit charges the second node before the rising edge of each of the input signals from the voltage-controlled delay line is inputted. | 07-30-2009 |
| 20090202623 | GENE THERAPY FOR CANCER USING SMALL INTERFERING RNA SPECIFIC TO ANT2 AND A METHOD TO OVERCOME TOLERANCE TO ANTITUMOR AGENT - The present invention relates to a small interfering RNA (siRNA) suppressing the expression of adenine nucleotide trnaslocator 2 (ANT2) gene and an anticancer agent containing the same. Particularly, the invention relates to ANT2 siRNA comprising a sense sequence selected from the nucleotide sequences of ANT2 mRNA, a hairpin loop sequence and an antisense sequence binding complementarily to the said sense sequence and an anticancer agent containing the same. ANT2 siRNA of the present invention inhibits the expression of ANT2 gene, suggesting that it inhibits the growth of cancer cells exhibiting high level of ANT2. Therefore, ANT2 siRNA of the invention can be effectively used for gene therapy for cancer treatment and further prevents the anticancer effect from decreasing by anticancer drug resistance of cancer cells. | 08-13-2009 |
| 20100222263 | ATAP PEPTIDES, NUCLEIC ACIDS ENCODING THE SAME AND ASSOCIATED METHODS OF USE - Disclosed herein are nucleic acid sequences that encode pro-apoptotic polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of proliferative disorders and bacterial infections using the nucleic acids and proteins of the invention. | 09-02-2010 |
| 20100244914 | CLOCK GENERATOR TO REDUCE LONG TERM JITTER - A clock generator includes a controller, a digital phase locked loop (PLL) circuit, a charge pump phase locked loop (PLL) circuit and a divider. The controller generates a division factor and a first internal clock signal in response to a low-frequency reference clock signal and a multiplication factor. The digital PLL circuit generates a second internal clock signal in response to the reference clock signal, the division factor and the first internal clock signal. The charge pump PLL circuit generates a plurality of third internal clock signals by using the second internal clock signal. The divider generates a high-frequency clock signal in response to a phase selection signal, the division factor and the third internal clock signals. | 09-30-2010 |
| 20110102219 | SUCCESSIVE APPROXIMATION ANALOG/DIGITAL CONVERTER AND TIME-INTERLEAVED SUCCESSIVE APPROXIMATION ANALOG/DIGITAL CONVERTER - A successive approximation analog/digital converter includes a sample & hold part sampling and holding an intensity of an analog input signal using a single clock cycle of a clock signal; a first comparator comparing the intensity of the analog input signal with comparison voltages determined according to estimated digital values per clock cycle following an operating clock cycle of the sample & hold part; a second comparator comparing the intensity of the analog input signal with a value equal to ½ of a preset reference voltage in the latter half of the operating clock cycle of the sample & hold part; a successive approximation register determining a value of an MSB of a digital value to be converted according to the comparison result of the second comparator and values of bits successive to the MSB according to the comparison result of the first comparator, and generating the estimated digital values by applying estimated values to undetermined bits; and a digital/analog converter generating the comparison voltages using the estimated digital values and the reference voltage. | 05-05-2011 |
